Selumetinib in Treating Patients With Recurrent or Persistent Endometrial Cancer

Part of paid clinical trials in Los Angeles, California.

Sponsor
National Cancer Institute (NCI)
Study ID
NCT01011933
Phase
PHASE2
Status
Completed

Conditions

  • Endometrial Adenocarcinoma
  • Endometrial Adenosquamous Carcinoma
  • Endometrial Clear Cell Adenocarcinoma
  • Recurrent Uterine Corpus Carcinoma

Eligibility Criteria

Sex
FEMALE
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Diagnostic Laboratory Biomarker Analysis — OTHER
    Correlative studies
  • Selumetinib — DRUG
    Given PO

Study Details

This phase II trial is studying how well selumetinib works in treating patients with recurrent or persistent endometrial cancer that has come back or is persistent. Selumetinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.

Key Dates

Start date
Sep 30, 2009
Status verified
Jul 2019
Primary completion
Jan 31, 2016
Completion
Jan 31, 2016

Study Design

Enrollment
54 participants (actual)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Treatment (selumetinib)
    Patients receive selumetinib PO twice daily on days 1-28. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity. Blood and archived tumor tissue samples are collected for biomarker studies.

Primary Outcome Measure

Number of Participants With or Without Progression-free Survival for > 6 Months by Response Evaluation Criteria for Solid Tumors (RECIST) [ Time Frame: > 6 months from study entry ]

Locations (72)

FacilityCityStateZIPSite coordinators
Los Angeles County-USC Medical CenterLos AngelesCalifornia90033-
USC / Norris Comprehensive Cancer CenterLos AngelesCalifornia90033-
University of Colorado Cancer Center - Anschutz Cancer PavilionAuroraColorado80045-
Hartford HospitalHartfordConnecticut06102-
Smilow Cancer Hospital Care Center at Saint FrancisHartfordConnecticut06105-
The Hospital of Central ConnecticutNew BritainConnecticut06050-
MedStar Washington Hospital CenterWashington D.C.District of Columbia20010-
Rush University Medical CenterChicagoIllinois60612-
University of Chicago Comprehensive Cancer CenterChicagoIllinois60637-
Sudarshan K Sharma MD Limted-Gynecologic OncologyHinsdaleIllinois60521-
Memorial Medical CenterSpringfieldIllinois62781-
Indiana University/Melvin and Bren Simon Cancer CenterIndianapolisIndiana46202-
Saint Vincent Oncology CenterIndianapolisIndiana46260-
Medical Oncology and Hematology Associates-West Des MoinesCliveIowa50325-
Mercy Cancer Center-West LakesCliveIowa50325-
Iowa Lutheran HospitalDes MoinesIowa50316-
Iowa Methodist Medical CenterDes MoinesIowa50309-
Iowa-Wide Oncology Research Coalition NCORPDes MoinesIowa50309-
Medical Oncology and Hematology Associates-Des MoinesDes MoinesIowa50309-
Medical Oncology and Hematology Associates-LaurelDes MoinesIowa50314-
Mercy Medical Center - Des MoinesDes MoinesIowa50314-
University of Iowa/Holden Comprehensive Cancer CenterIowa CityIowa52242-
Mercy Medical Center-West LakesWest Des MoinesIowa50266-
Methodist West HospitalWest Des MoinesIowa50266-7700-
Menorah Medical CenterOverland ParkKansas66209-
Saint Luke's South HospitalOverland ParkKansas66213-
Kansas City NCI Community Oncology Research ProgramPrairie VillageKansas66208-
MedStar Franklin Square Medical Center/Weinberg Cancer InstituteBaltimoreMaryland21237-
Michigan Cancer Research Consortium CCOPAnn ArborMichigan48106-
Saint Joseph Mercy HospitalAnn ArborMichigan48106-0995-
Oakwood Hospital and Medical CenterDearbornMichigan48124-
Saint John Hospital and Medical CenterDetroitMichigan48236-
Genesys Regional Medical Center-West Flint CampusFlintMichigan48532-
Hurley Medical CenterFlintMichigan48502-
Allegiance HealthJacksonMichigan49201-
Borgess Medical CenterKalamazooMichigan49001-
Bronson Methodist HospitalKalamazooMichigan49007-
West Michigan Cancer CenterKalamazooMichigan49007-
Sparrow HospitalLansingMichigan48912-
Saint Mary Mercy HospitalLivoniaMichigan48154-
Saint Joseph Mercy OaklandPontiacMichigan48341-
Saint Joseph Mercy Port HuronPort HuronMichigan48060-
Saint Mary's of MichiganSaginawMichigan48601-
Saint John Macomb-Oakland HospitalWarrenMichigan48093-
University of Mississippi Medical CenterJacksonMississippi39216-
Heartland Hematology and Oncology Associates IncorporatedKansas CityMissouri64118-
North Kansas City HospitalKansas CityMissouri64116-
Research Medical CenterKansas CityMissouri64132-
Saint Joseph Health CenterKansas CityMissouri64114-
Saint Luke's Hospital of Kansas CityKansas CityMissouri64111-
Truman Medical CenterKansas CityMissouri64108-
Saint Luke's East - Lee's SummitLee's SummitMissouri64086-
Liberty HospitalLibertyMissouri64068-
Heartland Regional Medical CenterSaint JosephMissouri64506-
Saint Joseph Oncology IncSaint JosephMissouri64507-
Cancer Research for the Ozarks NCORPSpringfieldMissouri65804-
CoxHealth South HospitalSpringfieldMissouri65807-
Washington University School of MedicineSt LouisMissouri63110-
Women's Cancer Center of NevadaLas VegasNevada89169-
State University of New York Downstate Medical CenterBrooklynNew York11203-
University of CincinnatiCincinnatiOhio45267-
Riverside Methodist HospitalColumbusOhio43214-
University of Oklahoma Health Sciences CenterOklahoma CityOklahoma73104-
Oklahoma Cancer Specialists and Research Institute-TulsaTulsaOklahoma74146-
Abington Memorial HospitalAbingtonPennsylvania19001-
Bryn Mawr HospitalBryn MawrPennsylvania19010-
Paoli Memorial HospitalPaoliPennsylvania19301-
Lankenau Medical CenterWynnewoodPennsylvania19096-
Main Line Health NCORPWynnewoodPennsylvania19096-
Women and Infants HospitalProvidenceRhode Island02905-
Lyndon Baines Johnson General HospitalHoustonTexas77026-1967-
M D Anderson Cancer CenterHoustonTexas77030-

Find similar trials in Los Angeles, CA

By research site
Los Angeles County-USC Medical Center· Los Angeles, CAUSC / Norris Comprehensive Cancer Center· Los Angeles, CAUniversity of Colorado Cancer Center - Anschutz Cancer Pavilion· Aurora, COHartford Hospital· Hartford, CTSmilow Cancer Hospital Care Center at Saint Francis· Hartford, CTThe Hospital of Central Connecticut· New Britain, CT

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