Analysis of HIV-1 Replication During Antiretroviral Therapy

Conditions

• HIV

Eligibility Criteria

Sex

ALL

Age

18 Years - 99 Years

Healthy Volunteers

Not accepted

Study Details

This study will determine if the level of virus in HIV-infected patients taking antiretroviral medications for prolonged periods decreases or persists at a stable level. It will also examine whether new gene changes (mutations) occur during drug suppression. HIV-infected patients who are 18 years of age or older, have been enrolled in another NIH protocol, have been suppressed on antiretroviral therapy and have very low levels of virus in their blood may be eligible for this 5-year (or more) study. Participants come to the NIH Clinical Center about every 6 months for a physical examination, routine and research blood tests and leukapheresis to collect white blood cells for T cell analysis. For leukapheresis, blood is collected through a vein much like donating whole blood, but the blood is directed through a machine that separates and extracts the white cells and returns the rest of the blood components to the patient. Patients may also have an optional third clinic visit each year for another blood draw.

Key Dates

Start date

Nov 17, 2008

Status verified

Sep 2025

Study Design

Enrollment

70 participants (estimated)

Arms

• Arm: Patients
  HIV-infected patients who are 18 years of age or older, have been enrolled in another NIH protocol.

Primary Outcome Measure

We plan to investigate the relationship of HIV-1 viral RNA levels and genetic variation in patients on antiretroviral therapy over prolonged periods. [ Time Frame: every 6 months ]

Locations (1)

Find similar trials in Bethesda, MD

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