Studies of Skin Microbes in Healthy People and in People With Skin Conditions

Part of paid clinical trials in Bethesda, Maryland.

Sponsor
National Human Genome Research Institute (NHGRI)
Study ID
NCT00605878
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
2 Years - 100 Years
Healthy Volunteers
Accepted

Study Details

This study will examine microbes (e.g., bacteria, fungi, viruses) that live on human skin and how microbes contribute to health and disease. It will analyze healthy human skin and how the these microorganisms might change in patients with atopic dermatitis (AD), a skin condition also known as eczema. Healthy volunteers, as well as patients with moderate to severe eczema (AD), between 2 and 40 years of age may be eligible for this study. We also wish to enroll children and adults aged 2-40 who have been diagnosed with inherited immune disorders known as HIES (hyperimmunoglobulin-E syndrome), WAS (Wiskott-Aldrich syndrome), or DOCK8 immunodeficiency because they frequently have skin problems similar to AD. Eligible participants undergo the following tests and procedures: * Medical family and medication history * Skin examination * Blood tests (research blood as well as serum IgE, and complete blood count) * Skin samples to analyze microbes. Samples are obtained by the following methods: swabbing the skin with a cotton swab; scraping (scratching) the skin gently with a blade to remove only the outermost skin layers; and, only in adults, biopsy (surgical removal) of a small skin sample less than 1/4-inch (5 mm) in diameter. * Nose swabs to analyze microbes. * Patients with eczema may have photographs of their skin taken to help monitor the skin rashes. Participants may be contacted periodically for follow-up studies. Patients with atopic dermatitis may have additional skin samples collected to examine changes in the skin bacteria over time and during all of the stages of eczema. In addition, patients who have a flare of their eczema are asked to undergo a skin sample collection as soon as possible.

Key Dates

Start date
Jan 22, 2008
Status verified
Dec 2025

Study Design

Enrollment
530 participants (estimated)

Arms

  • Arm: Grouo 3
    Healthy (pediatric) controls
  • Arm: Group 1
    Healthy (adult) volunteers
  • Arm: Group 2
    AD patients
  • Arm: Group 4
    Patients diagnosed with the primary immunodeficiency hyperIgE syndrome (HIES)
  • Arm: Group 5
    Patients diagnosed with the primary immunodeficiency Wiskott-Aldrich Syndrome (WAS)
  • Arm: Group 6
    Patients diagnosed with the combined immunodeficiency associated with DOCK8 mutation (DOCK8)

Primary Outcome Measure

Primary Immunodeficiency [ Time Frame: Ongoing ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
National Institutes of Health Clinical CenterBethesdaMaryland20892
For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR)
[email protected]
800-411-1222

Find similar trials in Bethesda, MD

By condition
Atopic dermatitis / eczema
By specialty
DermatologyRheumatologyAutoimmune disease
By research site
National Institutes of Health Clinical Center· Bethesda, MD

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