Selumetinib Sulfate in Treating Woman With Recurrent Low-Grade Ovarian Cancer or Peritoneum Cancer

Part of paid clinical trials in Los Angeles, California.

Sponsor
National Cancer Institute (NCI)
Study ID
NCT00551070
Phase
PHASE2
Status
Completed

Conditions

  • Borderline Ovarian Serous Tumor
  • Low Grade Ovarian Serous Adenocarcinoma
  • Micropapillary Serous Carcinoma
  • Primary Peritoneal Carcinoma
  • Primary Peritoneal Low Grade Serous Adenocarcinoma
  • Recurrent Borderline Ovarian Surface Epithelial-Stromal Tumor

Eligibility Criteria

Sex
FEMALE
Age
19 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Laboratory Biomarker Analysis — OTHER
    Correlative studies
  • Pharmacological Study — OTHER
    Correlative studies
  • Selumetinib — DRUG
    Given PO
  • Selumetinib Sulfate — DRUG
    Given PO

Study Details

This phase II trial studies the side effects and how well selumetinib sulfate works in treating patients with low-grade ovarian cancer that has come back (recurrent). Selumetinib sulfate may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.

Key Dates

Start date
Dec 17, 2007
Status verified
Nov 2020
Primary completion
Jul 23, 2013
Completion
Nov 13, 2020

Study Design

Enrollment
52 participants (actual)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Treatment (selumetinib sulfate)
    Patients receive selumetinib sulfate PO BID on days 1-28. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.

Primary Outcome Measure

Tumor Response [ Time Frame: Every other cycle ]

Locations (49)

FacilityCityStateZIPSite coordinators
USC / Norris Comprehensive Cancer CenterLos AngelesCalifornia90033-
Stanford Cancer Institute Palo AltoPalo AltoCalifornia94304-
Hartford HospitalHartfordConnecticut06102-
The Hospital of Central ConnecticutNew BritainConnecticut06050-
Beebe Medical CenterLewesDelaware19958-
Christiana Care Health System-Christiana HospitalNewarkDelaware19718-
University of Chicago Comprehensive Cancer CenterChicagoIllinois60637-
Hinsdale Hematology Oncology Associates IncorporatedHinsdaleIllinois60521-
Saint Vincent Hospital and Health Care CenterIndianapolisIndiana46260-
Maine Medical Center-Bramhall CampusPortlandMaine04102-
Christiana Care - Union HospitalElktonMaryland21921-
Beth Israel Deaconess Medical CenterBostonMassachusetts02215-
Brigham and Women's HospitalBostonMassachusetts02115-
Dana-Farber Cancer InstituteBostonMassachusetts02215-
Massachusetts General Hospital Cancer CenterBostonMassachusetts02114-
Bronson Battle CreekBattle CreekMichigan49017-
Spectrum Health Big Rapids HospitalBig RapidsMichigan49307-
Cancer Research Consortium of West Michigan NCORPGrand RapidsMichigan49503-
Mercy Health Saint Mary'sGrand RapidsMichigan49503-
Spectrum Health at Butterworth CampusGrand RapidsMichigan49503-
Holland Community HospitalHollandMichigan49423-
Mercy Health Mercy CampusMuskegonMichigan49444-
Mercy Health Partners-Hackley CampusMuskegonMichigan49442-
Munson Medical CenterTraverse CityMichigan49684-
Metro Health HospitalWyomingMichigan49519-
University of Mississippi Medical CenterJacksonMississippi39216-
Cancer Research for the Ozarks NCORPSpringfieldMissouri65804-
CoxHealth South HospitalSpringfieldMissouri65807-
Mercy Hospital SpringfieldSpringfieldMissouri65804-
Washington University School of MedicineSt LouisMissouri63110-
Cooper Hospital University Medical CenterCamdenNew Jersey08103-
Memorial Sloan Kettering Cancer CenterNew YorkNew York10065-
Carolinas Medical Center/Levine Cancer InstituteCharlotteNorth Carolina28203-
Novant Health Presbyterian Medical CenterCharlotteNorth Carolina28204-
Gynecologic Oncology NetworkGreenvilleNorth Carolina27834-
Case Western Reserve UniversityClevelandOhio44106-
Cleveland Clinic Cancer Center/Fairview HospitalClevelandOhio44111-
Cleveland Clinic FoundationClevelandOhio44195-
MetroHealth Medical CenterClevelandOhio44109-
Mount Carmel Health Center WestColumbusOhio43222-
Ohio State University Comprehensive Cancer CenterColumbusOhio43210-
Riverside Methodist HospitalColumbusOhio43214-
Miami Valley HospitalDaytonOhio45409-
Hillcrest Hospital Cancer CenterMayfield HeightsOhio44124-
UH Seidman Cancer Center at Lake Health Mentor CampusMentorOhio44060-
University of Oklahoma Health Sciences CenterOklahoma CityOklahoma73104-
Oklahoma Cancer Specialists and Research Institute-TulsaTulsaOklahoma74146-
Abington Memorial HospitalAbingtonPennsylvania19001-
M D Anderson Cancer CenterHoustonTexas77030-

Find similar trials in Los Angeles, CA

By research site
USC / Norris Comprehensive Cancer Center· Los Angeles, CAStanford Cancer Institute Palo Alto· Palo Alto, CAHartford Hospital· Hartford, CTThe Hospital of Central Connecticut· New Britain, CTBeebe Medical Center· Lewes, DEChristiana Care Health System-Christiana Hospital· Newark, DE

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