Genetic Risk Factors Associated With Antiphospholipid Antibody Syndrome

Part of paid clinical trials in Durham, North Carolina.

Sponsor
Duke University
Study ID
NCT00482794
Status
Recruiting
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Conditions

  • Antiphospholipid Syndrome

Eligibility Criteria

Sex
ALL
Age
N/A - N/A
Healthy Volunteers
Not accepted

Study Details

Antiphospholipid antibody syndrome (APS) is characterized by the presence of antiphospholipid antibodies, which are proteins in the blood that interfere with the body's ability to perform normal blood clotting. Clinical problems associated with antiphospholipid antibodies include an increased risk for the formation of blood clots in the lungs or deep veins of the legs, stroke, heart attack, and recurrent miscarriages. It is possible that some people with APS have a genetic predisposition for developing the syndrome. This study will use a genetic strategy to identify potential inherited risk factors for the development of APS by recruiting people with APS who have family members also affected by the syndrome or by another autoimmune disorder, such as lupus or rheumatoid arthritis.

Key Dates

Start date
Jun 30, 2006
Status verified
May 2026
Primary completion
Mar 31, 2029
Completion
Mar 31, 2029

Study Design

Enrollment
2,800 participants (estimated)

Arms

  • Arm: 1
    Individuals with APS who also have one or more of their family members affected specifically by APS
  • Arm: 2
    Individuals with APS who also have one or more of their family members affected by another type of autoimmune disorder, such as lupus or rheumatoid arthritis.
  • Arm: 3
    Individuals with APS and no family or no family affected with APS or another autoimmune disorder

Primary Outcome Measure

characterize genetic risk factors associated with the development of familial antiphospholipid antibody syndrome. [ Time Frame: duration of the study ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Duke University Medical CenterDurhamNorth Carolina27710
Thomas L. Ortel, MD, PhD (PRINCIPAL_INVESTIGATOR)
Silke Schmidt, PhD (PRINCIPAL_INVESTIGATOR)

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By research site
Duke University Medical Center· Durham, NC

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