Comparison Study of Rituximab Plus Sargramostim to Rituximab Alone for Relapsed Follicular B-cell Lymphoma, a Form of Non-Hodgkin's Lymphoma
Part of paid clinical trials in Birmingham, Alabama.
- Sponsor
- Genzyme, a Sanofi Company
- Study ID
- NCT00308087
- Phase
- PHASE2
- Status
- Terminated
Conditions
- Lymphoma, Follicular
Eligibility Criteria
- Sex
- ALL
- Age
- 18 Years - N/A
- Healthy Volunteers
- Not accepted
Interventions
- Sargramostim (Leukine) — DRUGSargramostim 250 μg, administered subcutaneously (SC) 3 times weekly for 8 weeks, beginning at least 1 hour before the first dose of rituximab
- Rituximab — DRUGFour doses of rituximab 375 mg/m2, administered intravenously (IV) once weekly for 4 weeks
Study Details
The purpose of this study is to evaluate whether treatment with rituximab plus sargramostim will be more effective than rituximab alone.
Key Dates
- Start date
- May 31, 2006
- Status verified
- Dec 2013
- Primary completion
- Jun 30, 2009
- Completion
- Jun 30, 2009
Study Design
- Enrollment
- 75 participants (actual)
- Allocation
- RANDOMIZED
- Intervention model
- PARALLEL
- Primary purpose
- TREATMENT
Arms
- Active Comparator: Rituximab
- Experimental: Rituximab + Sargramostim
Primary Outcome Measure
Number of Participants With a Complete Response or Unconfirmed Complete Response at Week 8 With Confirmation at Week 12 [ Time Frame: Week 8 (confirmed at Week 12) ]
Locations (21)
| Facility | City | State | ZIP | Site coordinators |
|---|---|---|---|---|
| - | Birmingham | Alabama | 35234 | - |
| - | Huntsville | Alabama | 35805 | - |
| - | Los Angeles | California | 90095 | - |
| - | Montebello | California | 90640 | - |
| - | Pleasant Hill | California | 94523 | - |
| - | Gainesville | Florida | 32610-0254 | - |
| - | Jacksonville | Florida | 32207 | - |
| - | Ocala | Florida | 34474 | - |
| - | Tampa | Florida | 33612 | - |
| - | Chicago | Illinois | 60612 | - |
| - | Elk Grove Village | Illinois | 60007 | - |
| - | Springfield | Illinois | 62703 | - |
| - | Indianapolis | Indiana | 46202 | - |
| - | New Albany | Indiana | 47150 | - |
| - | Duluth | Minnesota | 55805-1984 | - |
| - | Fresh Meadows | New York | 11365 | - |
| - | New York | New York | 10019 | - |
| - | Columbus | Ohio | 43235 | - |
| - | Hershey | Pennsylvania | 17033-0850 | - |
| - | Philadelphia | Pennsylvania | 19104 | - |
| - | Houston | Texas | 77030 | - |
Related Studies
- A Study of LY4152199 in Participants With Previously Treated B-cell Malignancies (BAF_FRontier-1 )PHASE1 · Not Yet Recruiting · Eli Lilly and Company · Duarte, California