Temozolomide, Vincristine, and Irinotecan in Treating Young Patients With Refractory Solid Tumors

Part of paid clinical trials in Birmingham, Alabama.

Sponsor
Children's Oncology Group
Study ID
NCT00138216
Phase
PHASE1
Status
Completed

Conditions

  • Brain and Central Nervous System Tumors
  • Unspecified Childhood Solid Tumor, Protocol Specific

Eligibility Criteria

Sex
ALL
Age
1 Year - 21 Years
Healthy Volunteers
Not accepted

Interventions

Study Details

RATIONALE: Drugs used in chemotherapy, such as temozolomide, vincristine, and irinotecan, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more tumor cells. PURPOSE: This phase I trial is studying the side effects and best dose of irinotecan when given together with temozolomide and vincristine in treating young patients with refractory solid tumors.

Key Dates

Start date
Oct 31, 2005
Status verified
Feb 2014
Primary completion
Jun 30, 2009
Completion
Jan 31, 2011

Study Design

Enrollment
42 participants (actual)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Oral Irinotecan, temozolomide and vincristine sulfate
    see detailed description

Primary Outcome Measure

Determine maximum tolerated dose (MTD) of oral irinotecan [ Time Frame: length of study ]

Locations (16)

FacilityCityStateZIPSite coordinators
Lurleen Wallace Comprehensive Cancer at University of Alabama - BirminghamBirminghamAlabama35294-
Children's Hospital of Orange CountyOrangeCalifornia92868-
Stanford Cancer CenterStanfordCalifornia94305-5824-
Children's Memorial Hospital - ChicagoChicagoIllinois60614-
Indiana University Melvin and Bren Simon Cancer CenterIndianapolisIndiana46202-5289-
Dana-Farber/Harvard Cancer Center at Dana Farber Cancer InstituteBostonMassachusetts02115-
Masonic Cancer Center at University of MinnesotaMinneapolisMinnesota55455-
Mayo Clinic Cancer CenterRochesterMinnesota55905-
Herbert Irving Comprehensive Cancer Center at Columbia University Medical CenterNew YorkNew York10032-
SUNY Upstate Medical University HospitalSyracuseNew York13210-
Cincinnati Children's Hospital Medical CenterCincinnatiOhio45229-3039-
Oregon Health and Science University Cancer InstitutePortlandOregon97239-3098-
Lehigh Valley Hospital - MuhlenbergBethlehemPennsylvania18107-
Children's Hospital of PhiladelphiaPhiladelphiaPennsylvania19104-9786-
Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - DallasDallasTexas75390-
Children's Hospital and Regional Medical Center - SeattleSeattleWashington98105-

Find similar trials in Birmingham, AL

By research site
Lurleen Wallace Comprehensive Cancer at University of Alabama - Birmingham· Birmingham, ALChildren's Hospital of Orange County· Orange, CAStanford Cancer Center· Stanford, CAChildren's Memorial Hospital - Chicago· Chicago, ILIndiana University Melvin and Bren Simon Cancer Center· Indianapolis, INDana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute· Boston, MA

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