Suberoylanilide Hydroxamic Acid in Treating Patients With Stage IIIB, Stage IV, or Recurrent Non-Small Cell Lung Cancer

Part of paid clinical trials in Green Bay, Wisconsin.

Sponsor
National Cancer Institute (NCI)
Study ID
NCT00138203
Phase
PHASE2
Status
Completed

Conditions

  • Recurrent Non-small Cell Lung Cancer
  • Stage IIIB Non-small Cell Lung Cancer
  • Stage IV Non-small Cell Lung Cancer

Eligibility Criteria

Sex
ALL
Age
19 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • vorinostat — DRUG
    Given PO
  • laboratory biomarker analysis — OTHER
    Correlative studies

Study Details

This phase II trial is studying how well suberoylanilide hydroxamic acid works in treating patients with stage IIIB, stage IV, or recurrent non-small cell lung cancer. Drugs used in chemotherapy, such as suberoylanilide hydroxamic acid, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Suberoylanilide hydroxamic acid may also stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.

Key Dates

Start date
Jun 30, 2005
Status verified
Jan 2018
Primary completion
Dec 31, 2008
Completion
Dec 31, 2008

Study Design

Enrollment
16 participants (actual)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Treatment (vorinostat)
    Patients receive oral suberoylanilide hydroxamic acid once daily on days 1-14. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.

Primary Outcome Measure

Response Per RECIST Criteria [ Time Frame: Time from treatment initiation until the end of treatment. The median number of cycles was 3 (range 1-27) ]

Locations (5)

FacilityCityStateZIPSite coordinators
St. Vincent Regional Cancer Center CCOPGreen BayWisconsin54307-3508-
Gundersen LutheranLa CrosseWisconsin54601-
University of Wisconsin Hospital and ClinicsMadisonWisconsin53792-
UW Health Oncology - 1 South ParkMadisonWisconsin53715-
Holy Family Memorial HospitalManitowocWisconsin54221-

Find similar trials in Green Bay, WI

By research site
St. Vincent Regional Cancer Center CCOP· Green Bay, WIGundersen Lutheran· La Crosse, WIUniversity of Wisconsin Hospital and Clinics· Madison, WIUW Health Oncology - 1 South Park· Madison, WIHoly Family Memorial Hospital· Manitowoc, WI

Related Studies