Comprehensive Genomic Analysis in Tissue Samples From Patients With Recurrent or Stage IV Non-small Cell Lung Cancer

Part of paid clinical trials in Bay City, Michigan.

Sponsor
Barbara Ann Karmanos Cancer Institute
Study ID
NCT02178163
Status
Recruiting
Apply to this trial

Conditions

  • Recurrent Non-small Cell Lung Cancer
  • Stage IV Non-small Cell Lung Cancer

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • cytology specimen collection procedure — OTHER
    Correlative studies
  • laboratory biomarker analysis — OTHER
    Correlative studies

Study Details

This research trial studies comprehensive genomic analysis in tissue samples from patients with non-small cell lung cancer that has come back or is stage IV. Comprehensive genomic analysis may identify specific gene mutations (changes in deoxyribonucleic acid \[DNA\]) and help doctors to tailor treatment to target the specific mutations.

Key Dates

Start date
Aug 1, 2014
Status verified
Jul 2025
Primary completion
Jul 31, 2027
Completion
Jul 31, 2027

Study Design

Enrollment
1,020 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER

Arms

  • Experimental: Ancillary-Correlative (comprehensive genomic analysis)
    Patients undergo collection of tissue samples for genomic analysis via mass spectrometry, PCR, and microarray. Based on the results of the genomic analysis, patients may begin therapy.

Primary Outcome Measure

Proportion of patients receiving therapy based on genomic analyses among all eligible patients [ Time Frame: Up to 21 days ]

Central Contacts

  • Gerold Bepler, M.D.
    (313) 576-8665

Locations (11)

FacilityCityStateZIPSite coordinators
KCI at McLaren Bay RegionBay CityMichigan48708
800-527-6266
KCI at Mclaren Bloomfield HillsBloomfield HillsMichigan48302
1800-527-6266
KCI At McLaren ClarkstonClarkstonMichigan48346
1-800-527-6266
Barbara Ann Karmanos Cancer InstituteDetroitMichigan48201
Gerold Bepler, M.D.
[email protected]
800-527-6266
Gerold Bepler, M.D., PhD. (PRINCIPAL_INVESTIGATOR)
Ammar Sukari, M.D. (SUB_INVESTIGATOR)
Hirva Mamdani, M.D. (SUB_INVESTIGATOR)
Jonathan D. Abramson, M.D. (SUB_INVESTIGATOR)
Shalini Thoutreddy, M.D. (SUB_INVESTIGATOR)
Samir Alsawah, M.D. (SUB_INVESTIGATOR)
Sai Bikkina, M.D. (SUB_INVESTIGATOR)
Rana Bilbeisi, M.D, (SUB_INVESTIGATOR)
Elena Coppola, M.D. (SUB_INVESTIGATOR)
Salman Fateh, M.D. (SUB_INVESTIGATOR)
Sandeep Grewal, M.D. (SUB_INVESTIGATOR)
Youssef Hanna, M.D. (SUB_INVESTIGATOR)
Christian Hyde, M.D. (SUB_INVESTIGATOR)
Frank Knechtl, M.D. (SUB_INVESTIGATOR)
Cheryl Kovalski, M.D. (SUB_INVESTIGATOR)
Elizabeth Layhe, M.D. (SUB_INVESTIGATOR)
Mohammed Masri, M.D. (SUB_INVESTIGATOR)
Seraphim Pallas, M.D. (SUB_INVESTIGATOR)
Anup Lal, M.D. (SUB_INVESTIGATOR)
Dipesh Uprety, M.D. (SUB_INVESTIGATOR)
Brooke Spencer (Trotter), M.D. (SUB_INVESTIGATOR)
Numan Fateh, M.D. (SUB_INVESTIGATOR)
Borys Hrinczenko, M.D. (SUB_INVESTIGATOR)
Daniel Isaac, D.O. (SUB_INVESTIGATOR)
Jatin Rana, M.D. (SUB_INVESTIGATOR)
Ashley Matusz-Fisher, M.D. (SUB_INVESTIGATOR)
Faras Alsawah, M.D. (SUB_INVESTIGATOR)
Tarik Hadid, M.D. (SUB_INVESTIGATOR)
Irene Connolly, M.D. (SUB_INVESTIGATOR)
Orimisan Adekolujo, M.D. (SUB_INVESTIGATOR)
Kalub Fedak, M.D. (SUB_INVESTIGATOR)
KCI at McLaren FlintFlintMichigan48532
1-800-527-6266
KCI at McLaren Greater Lansing, Mid Michigan PhysiciansLansingMichigan48910
(517) 975-9500
KCI at McLaren Lapeer RegionLapeerMichigan48446
1-800-527-6266
KCI at McLaren MacombMount ClemensMichigan48043
1-800-527-6266
KCI at McLaren Central MichiganMount PleasantMichigan48858
1-800-527-6266
KCI at Northern MichiganPetoskeyMichigan49770
1-800-527-6266
KCI at McLaren Port HuronPort HuronMichigan48060
800-527-6266

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KCI at McLaren Bay Region· Bay City, MIKCI at Mclaren Bloomfield Hills· Bloomfield Hills, MIKCI At McLaren Clarkston· Clarkston, MIBarbara Ann Karmanos Cancer Institute· Detroit, MIKCI at McLaren Flint· Flint, MIKCI at McLaren Greater Lansing, Mid Michigan Physicians· Lansing, MI

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