Capecitabine, Vinorelbine, and Trastuzumab in Treating Patients With Metastatic Breast Cancer

Part of paid clinical trials in Scottsdale, Arizona.

Sponsor
Alliance for Clinical Trials in Oncology
Study ID
NCT00093808
Phase
PHASE2
Status
Completed

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

Study Details

RATIONALE: Drugs used in chemotherapy, such as capecitabine and vinorelbine, work in different ways to stop tumor cells from dividing so they stop growing or die. Monoclonal antibodies such as trastuzumab can locate tumor cells and either kill them or deliver tumor killing substances to them without harming normal cells. Giving capecitabine and vinorelbine together with trastuzumab may kill more tumor cells. PURPOSE: This phase II trial is studying how well giving capecitabine and vinorelbine together with trastuzumab works in treating patients who have metastatic breast cancer.

Key Dates

Start date
Aug 31, 2004
Status verified
Jan 2017
Primary completion
Dec 31, 2008
Completion
May 31, 2013

Study Design

Enrollment
47 participants (actual)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: capecitabine + vinorelbine + trastuzumab
    Patients receive oral capecitabine twice daily on days 1-14, vinorelbine IV over 6-10 minutes on days 1 and 8, and trastuzumab (Herceptin\^®) IV over 30-90 minutes on day 1. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity. Patients are followed every 3 months until disease progression and then every 6 months for up to 5 years.

Primary Outcome Measure

Confirmed Response Rate [ Time Frame: Up to 5 years ]

Locations (147)

FacilityCityStateZIPSite coordinators
Mayo Clinic ScottsdaleScottsdaleArizona85259-5499-
Mayo Clinic - JacksonvilleJacksonvilleFlorida32224-
Rush-Copley Cancer Care CenterAuroraIllinois60504-
St. Joseph Medical CenterBloomingtonIllinois61701-
Graham HospitalCantonIllinois61520-
Memorial HospitalCarthageIllinois62321-
Eureka Community HospitalEurekaIllinois61530-
Galesburg Clinic, PCGalesburgIllinois61401-
Galesburg Cottage HospitalGalesburgIllinois61401-
Mason District HospitalHavanaIllinois62644-
Hopedale Medical ComplexHopedaleIllinois61747-
Joliet Oncology-Hematology Associates, Limited - WestJolietIllinois60435-
McDonough District HospitalMacombIllinois61455-
-MolineIllinois61265-
Trinity Cancer Center at Trinity Medical Center - 7th Street CampusMolineIllinois61265-
BroMenn Regional Medical CenterNormalIllinois61761-
Community Cancer CenterNormalIllinois61761-
Community Hospital of OttawaOttawaIllinois61350-
Oncology Hematology Associates of Central Illinois, PC - OttawaOttawaIllinois61350-
Cancer Treatment Center at Pekin HospitalPekinIllinois61554-
CCOP - Illinois Oncology Research AssociationPeoriaIllinois61615-
Methodist Medical Center of IllinoisPeoriaIllinois61636-
Oncology Hematology Associates of Central Illinois, PC - PeoriaPeoriaIllinois61615-
OSF St. Francis Medical CenterPeoriaIllinois61637-
Proctor HospitalPeoriaIllinois61614-
Illinois Valley Community HospitalPeruIllinois61354-
Perry Memorial HospitalPrincetonIllinois61356-
St. Margaret's HospitalSpring ValleyIllinois61362-
Carle Cancer Center at Carle Foundation HospitalUrbanaIllinois61801-
CCOP - Carle Cancer CenterUrbanaIllinois61801-
Elkhart General HospitalElkhartIndiana46515-
Howard Community HospitalKokomoIndiana46904-
Center for Cancer Therapy at LaPorte Hospital and Health ServicesLa PorteIndiana46350-
Saint Anthony Memorial Health CentersMichigan CityIndiana46360-
CCOP - Northern Indiana CR ConsortiumSouth BendIndiana46601-
Memorial Hospital of South BendSouth BendIndiana46601-
Saint Joseph Regional Medical CenterSouth BendIndiana46617-
McFarland Clinic, PCAmesIowa50010-
-BettendorfIowa52722-
Cedar Rapids Oncology AssociatesCedar RapidsIowa52403-
CCOP - Iowa Oncology Research AssociationDes MoinesIowa50309-
John Stoddard Cancer Center at Iowa Lutheran HospitalDes MoinesIowa50316-
John Stoddard Cancer Center at Iowa Methodist Medical CenterDes MoinesIowa50309-
Medical Oncology and Hematology Associates at John Stoddard Cancer CenterDes MoinesIowa50309-
Medical Oncology and Hematology Associates at Mercy Cancer CenterDes MoinesIowa50314-
Mercy Cancer Center at Mercy Medical Center - Des MoinesDes MoinesIowa50314-
Mercy Capitol HospitalDes MoinesIowa50307-
Mercy Cancer Center at Mercy Medical Center - North IowaMason CityIowa50401-
McCreery Cancer Center at Ottumwa RegionalOttumwaIowa52501-
Mercy Medical Center - Sioux CitySioux CityIowa51104-
Siouxland Hematology-Oncology Associates, LLPSioux CityIowa51101-
St. Luke's Regional Medical CenterSioux CityIowa51104-
Hickman Cancer Center at Bixby Medical CenterAdrianMichigan49221-
CCOP - Michigan Cancer Research ConsortiumAnn ArborMichigan48106-
Saint Joseph Mercy Cancer CenterAnn ArborMichigan48106-0995-
Oakwood Cancer Center at Oakwood Hospital and Medical CenterDearbornMichigan48123-2500-
Green Bay Oncology, Limited - EscanabaEscanabaMichigan49431-
Genesys Hurley Cancer InstituteFlintMichigan48503-
Hurley Medical CenterFlintMichigan48503-
Van Elslander Cancer Center at St. John Hospital and Medical CenterGrosse Pointe WoodsMichigan48236-
Dickinson County Healthcare SystemIron MountainMichigan49801-
Foote Memorial HospitalJacksonMichigan49201-
Haematology-Oncology Associates of Ohio and Michigan, PCLambertvilleMichigan48144-
Sparrow Regional Cancer CenterLansingMichigan48912-1811-
St. Mary Mercy HospitalLivoniaMichigan48154-
Community Cancer Center of MonroeMonroeMichigan48162-
Mercy Memorial Hospital - MonroeMonroeMichigan48162-
St. Joseph Mercy OaklandPontiacMichigan48341-2985-
Mercy Regional Cancer Center at Mercy HospitalPort HuronMichigan48060-
Seton Cancer Institute at Saint Mary's - SaginawSaginawMichigan48601-
Lakeland Regional Cancer Care Center - St. JosephSaint JosephMichigan49085-
St. John Macomb HospitalWarrenMichigan48093-
-AlexandriaMinnesota56308-
MeritCare BemidjiBemidjiMinnesota56601-
Fairview Ridges HospitalBurnsvilleMinnesota55337-
Mercy and Unity Cancer Center at Mercy HospitalCoon RapidsMinnesota55433-
CCOP - DuluthDuluthMinnesota55805-
Duluth Clinic Cancer Center - DuluthDuluthMinnesota55805-1983-
Miller - Dwan Medical CenterDuluthMinnesota55805-
Fairview Southdale HospitalEdinaMinnesota55435-
-Fergus FallsMinnesota56537-
Mercy and Unity Cancer Center at Unity HospitalFridleyMinnesota55432-
Hutchinson Area Health CareHutchinsonMinnesota55350-
Meeker County Memorial HospitalLichfieldMinnesota55355-
HealthEast Cancer Care at St. John's HospitalMaplewoodMinnesota55109-
Minnesota Oncology Hematology, PA - MaplewoodMaplewoodMinnesota55109-
Hennepin County Medical Center - MinneapolisMinneapolisMinnesota55415-
Virginia Piper Cancer Institute at Abbott - Northwestern HospitalMinneapolisMinnesota55407-
Hubert H. Humphrey Cancer Center at North Memorial Outpatient CenterRobbinsdaleMinnesota55422-2900-
Mayo Clinic Cancer CenterRochesterMinnesota55905-
CentraCare Clinic - River CampusSaint CloudMinnesota56303-
Coborn Cancer CenterSaint CloudMinnesota56303-
CCOP - Metro-MinnesotaSaint Louis ParkMinnesota55416-
Park Nicollet Cancer CenterSaint Louis ParkMinnesota55416-
HealthEast Cancer Care at St. Joseph's HospitalSaint PaulMinnesota55102-
Regions Hospital Cancer Care CenterSaint PaulMinnesota55101-
United HospitalSaint PaulMinnesota55102-
St. Francis Cancer Center at St. Francis Medical CenterShakopeeMinnesota55379-
Ridgeview Medical CenterWaconiaMinnesota55387-
HealthEast Cancer Care at Woodwinds Health CampusWoodburyMinnesota55125-
Minnesota Oncology Hematology, PA - WoodburyWoodburyMinnesota55125-
Cancer Resource Center - LincolnLincolnNebraska68510-
Alegant Health Cancer Center at Bergan Mercy Medical CenterOmahaNebraska68124-
CCOP - Missouri Valley Cancer ConsortiumOmahaNebraska68106-
Creighton University Medical CenterOmahaNebraska68131-2197-
Immanuel Medical CenterOmahaNebraska68122-
Bismarck Cancer CenterBismarckNorth Dakota58501-
Medcenter One Hospital Cancer Care CenterBismarckNorth Dakota58501-
Mid Dakota Clinic, PCBismarckNorth Dakota58501-
St. Alexius Medical Center Cancer CenterBismarckNorth Dakota58502-
CCOP - MeritCare HospitalFargoNorth Dakota58122-
MeritCare BroadwayFargoNorth Dakota58122-
Altru Cancer Center at Altru HospitalGrand ForksNorth Dakota58201-
Wood County Oncology CenterBowling GreenOhio43402-
Lima Memorial HospitalLimaOhio45804-
Northwest Ohio Oncology CenterMaumeeOhio43537-
St. Luke's HospitalMaumeeOhio43537-
St. Charles Mercy HospitalOregonOhio43616-
Toledo Clinic - OregonOregonOhio43616-
Firelands Regional Medical CenterSanduskyOhio44870-
North Coast Cancer Care, IncorporatedSanduskyOhio44870-
Flower Hospital Cancer CenterSylvaniaOhio43560-
Mercy Hospital of TiffinTiffinOhio44883-
CCOP - Toledo Community HospitalToledoOhio43617-
Medical University of Ohio Cancer CenterToledoOhio43614-
St. Vincent Mercy Medical CenterToledoOhio43608-
Toledo Clinic, Incorporated - Main ClinicToledoOhio43623-
Toledo HospitalToledoOhio43606-
Fulton County Health CenterWauseonOhio43567-
Morgan Cancer Center at Lehigh Valley Hospital - Cedar CrestAllentownPennsylvania18105-
Geisinger Cancer Institute at Geisinger HealthDanvillePennsylvania17822-0001-
Allegheny Cancer Center at Allegheny General HospitalPittsburghPennsylvania15212-
Geisinger Medical Group - Scenery ParkState CollegePennsylvania16801-
Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical CenterWilkes-BarrePennsylvania18711-
Rapid City Regional HospitalRapid CitySouth Dakota57701-
Avera Cancer InstituteSioux FallsSouth Dakota57105-
Medical X-Ray Center, PCSioux FallsSouth Dakota57105-
Sanford Cancer Center at Sanford USD Medical CenterSioux FallsSouth Dakota57117-5039-
Fredericksburg Oncology, IncorporatedFredericksburgVirginia22401-
Green Bay Oncology, Limited at St. Mary's HospitalGreen BayWisconsin54303-
Green Bay Oncology, Limited at St. Vincent Hospital Regional Cancer CenterGreen BayWisconsin54301-3526-
St. Mary's Hospital Medical Center - Green BayGreen BayWisconsin54303-
St. Vincent Hospital Regional Cancer CenterGreen BayWisconsin54307-3508-
Franciscan Skemp Healthcare - La Crosse CampusLa CrosseWisconsin54601-
Bay Area Cancer Care Center at Bay Area Medical CenterMarinetteWisconsin54143-
Green Bay Oncology, Limited - Oconto FallsOconto FallsWisconsin54154-
Green Bay Oncology, Limited - Sturgeon BaySturgeon BayWisconsin54235-

Find similar trials in Scottsdale, AZ

By condition
Breast cancer
By specialty
OncologyBreast oncologyWomen's health
By research site
Mayo Clinic Scottsdale· Scottsdale, AZMayo Clinic - Jacksonville· Jacksonville, FLRush-Copley Cancer Care Center· Aurora, ILSt. Joseph Medical Center· Bloomington, ILGraham Hospital· Canton, ILMemorial Hospital· Carthage, IL

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