Cardiotoxicity of Cancer Therapy (CCT)

Part of paid clinical trials in Philadelphia, Pennsylvania.

Sponsor
Abramson Cancer Center at Penn Medicine
Study ID
NCT01173341
Status
Enrolling By Invitation

Conditions

Eligibility Criteria

Sex
FEMALE
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Echocardiography — DIAGNOSTIC_TEST
    Prior to chemotherapy, prior to and after anthracyclines, every 6 weeks during trastuzumab, and yearly for up to 10 years.
  • Blood Collection — OTHER
    Drawn at first chemo treatment and periodically during treatment (exact schedule varies with clinically ordered treatment plan), then annually for up to 10 years. Blood is banked for future biomarker testing.
  • Symptoms Questionnaire — OTHER
    Survey collected at first chemotherapy, periodically during therapy (exact schedule determined by clinically ordered treatment regimen), and annually for up to 10 years.

Study Details

The objective of this study is to define the clinical significance of mechanistic biomarkers (including Neuregulin-1Beta) and novel echocardiographic measures of cardiac function in predicting the incident risk of cancer therapy cardiotoxicity.

Key Dates

Start date
Jul 31, 2010
Status verified
Feb 2026
Primary completion
Apr 30, 2037
Completion
Apr 30, 2037

Study Design

Enrollment
700 participants (estimated)

Arms

  • Arm: Subgroup 2
    Subgroup2 represents will undergo trastuzumab therapy only
  • Arm: Subgroup 1
    Subgroup 1 are anthracycline only treated patients.
  • Arm: Subgroup 3
    Subgroup 3 are patients that will undergo trastuzumab therapy with anthracyclines.

Primary Outcome Measure

Cardiac dysfunction or signs or symptoms of heart failure [ Time Frame: 15 years ]

Locations (1)

FacilityCityStateZIPSite coordinators
Abramson Cancer Center of the University of PennsylvaniaPhiladelphiaPennsylvania19104-

Find similar trials in Philadelphia, PA

By condition
Breast cancer
By specialty
OncologyBreast oncologyWomen's health
By research site
Abramson Cancer Center of the University of Pennsylvania· Philadelphia, PA

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