A Longitudinal Study of Familial Hypereosinophilia (FE): Natural History and Markers of Disease Progression

Part of paid clinical trials in Bethesda, Maryland.

Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Study ID
NCT00091871
Status
Recruiting
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Conditions

  • Eosinophilia
  • Hypereosinophilic Syndrome

Eligibility Criteria

Sex
ALL
Age
1 Year - 100 Years
Healthy Volunteers
Accepted

Study Details

Eosinophils are a type of white blood cell. Elevated eosinophil levels can damage the heart, nerves, and other organs, in the syndrome known as hypereosinophilic syndrome (HES). Some individuals have a hereditary form of HES known as familial eosinophilia (FE). More research on the causation and mechanisms of HES is needed in order to design more effective and less toxic therapies. This study will investigate FE and its genetic causes, damage mechanisms, and disease markers (such as blood test abnormalities). It will enroll approximately 50 individuals (both adults and children) from a previously studied family with FE. This is a long-term study of indefinite duration. Participants will undergo yearly clinical examinations including medical history, physical examination, bloodwork, EKG, echocardiogram, and pulmonary function tests, with additional or more frequent examinations and tests as required. In addition, participants will donate blood and tissue for research purposes. Both adult and child participants will donate blood. At the initial evaluation, adult participants will donate bone marrow. During the study, some adult participants will also undergo a limited number of leukaopheresis sessions, in which blood is donated from one arm, the blood is separated into red blood cells and other components, and the red blood cells are returned into the donor's other arm.

Key Dates

Start date
Jun 8, 2005
Status verified
Apr 2026

Study Design

Enrollment
50 participants (estimated)

Arms

  • Arm: Affected family members
    Family members with peripheral blood eosinophilia
  • Arm: Unaffected family members
    Family members without peripheral blood eosinophilia

Primary Outcome Measure

To study the natural history of familial hypereosinophilia (FE) [ Time Frame: 30 years ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
National Institutes of Health Clinical CenterBethesdaMaryland20892
For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR)
[email protected]
800-411-1222

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By research site
National Institutes of Health Clinical Center· Bethesda, MD

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