T-Cell-Depleted Allogeneic Stem Cell Transplantation After Immunoablative Induction Chemotherapy and Reduced-Intensity Transplantation Conditioning in Treating Patients With Hematologic Malignancies

Part of paid clinical trials in Bethesda, Maryland.

Sponsor
National Institutes of Health Clinical Center (CC)
Study ID
NCT00080925
Phase
PHASE1
Status
Completed

Conditions

  • Chronic Myeloproliferative Disorders
  • Leukemia
  • Lymphoma
  • Multiple Myeloma and Plasma Cell Neoplasm
  • Myelodysplastic Syndromes
  • Myelodysplastic/Myeloproliferative Neoplasms

Eligibility Criteria

Sex
ALL
Age
18 Years - 55 Years
Healthy Volunteers
Not accepted

Interventions

  • filgrastim — BIOLOGICAL
  • graft-versus-tumor induction therapy — BIOLOGICAL
  • rituximab — BIOLOGICAL
  • therapeutic allogeneic lymphocytes — BIOLOGICAL
  • cyclophosphamide — DRUG
  • cyclosporine — DRUG
  • cytarabine — DRUG
  • doxorubicin hydrochloride — DRUG
  • etoposide — DRUG
  • fludarabine phosphate — DRUG
  • prednisone — DRUG
  • vincristine sulfate — DRUG
  • peripheral blood stem cell transplantation — PROCEDURE

Study Details

RATIONALE: Donor peripheral stem cell transplantation may be able to replace bone marrow and immune cells that were destroyed by chemotherapy. Sometimes the transplanted cells from a donor are rejected by the body's normal cells. Eliminating the T cells from the donor cells before transplanting them and giving cyclosporine may prevent this from happening. PURPOSE: This phase I trial is studying the side effects of T-cell-depleted allogeneic stem cell transplantation after immunoablative induction chemotherapy and reduced-intensity transplantation conditioning (chemotherapy) in treating patients with hematologic malignancies.

Key Dates

Start date
Feb 29, 2004
Status verified
Mar 2012
Completion
Dec 31, 2010

Study Design

Enrollment
20 participants (estimated)
Primary purpose
TREATMENT

Locations (1)

FacilityCityStateZIPSite coordinators
Warren Grant Magnuson Clinical Center - NCI Clinical Trials Referral OfficeBethesdaMaryland20892-1182-

Find similar trials in Bethesda, MD

By condition
Leukemia (other)
By specialty
OncologyBlood cancer
By research site
Warren Grant Magnuson Clinical Center - NCI Clinical Trials Referral Office· Bethesda, MD

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