MRI Study of Musculoskeletal Function

Part of paid clinical trials in Bethesda, Maryland.

Sponsor
National Institutes of Health Clinical Center (CC)
Study ID
NCT00051857
Status
Recruiting
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Conditions

  • Abnormalities
  • Imaging
  • Patellofemoral Pain Syndrome

Eligibility Criteria

Sex
ALL
Age
5 Years - 95 Years
Healthy Volunteers
Accepted

Study Details

This study will use magnetic resonance imaging (MRI) and ultrasound images to study how muscles, tendons, and bones work together to cause motion. The procedure is one of several tools being developed to characterize normal and impaired musculoskeletal function, with the goal of developing improved methods of diagnosis and treatment of movement disorders. Healthy normal volunteers must be age 5 to unlimited, with or without joint impairment, may be eligible for this study. Volunteers with joint impairment may not have serious injury to the joint being studied, previous surgery on the joint being studied, or extreme pain at the joint being studied. MRI uses a strong magnet and radio waves to create images of the inside of the body. The subject lies on a long narrow couch inside a metal cylinder (the scanner) for up to 3 hours while the scanner gathers data. Earplugs are worn to muffle loud noises caused by electrical switching of radiofrequency circuits used in the scanning process. A special pad or tube may be placed over or around the region being scanned to improve the quality of the data. The subject will be asked to repeatedly move a specific joint, such as the knee, for brief periods, usually less than 5 minutes. The subject can communicate via intercom with the person performing the study at all times during the procedure, and may request to stop the study at any time.

Key Dates

Start date
Mar 5, 2003
Status verified
Jan 2026

Study Design

Enrollment
750 participants (estimated)

Arms

  • Arm: 1/Healthy Controls
    Subjects 5 years old and up with musculoskeletal impairment, pathology, or variant.
  • Arm: 2/Healthy Volunteers
    Subjects 5 years old and up without musculoskeletal impairment, pathology, or variant.

Primary Outcome Measure

Dynamic MRI measures of in vivo tissue velocity, bone and muscle, during dynamic tasks of knee flexion/extension [ Time Frame: End of study ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
National Institutes of Health Clinical CenterBethesdaMaryland20892-

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