Studies of Brain Function and Course of Illness in Pediatric Bipolar Disorder

Conditions

• Mood Disorder

Eligibility Criteria

Sex

ALL

Age

7 Years - 60 Years

Healthy Volunteers

Not accepted

Interventions

• Lithium — DRUG

Study Details

This study seeks to learn more about the symptoms of severe mood dysregulation in children and adolescents ages 7-17. Children and adolescents with severe mood dysregulation (SMD) display chronic anger, sadness, or irritability, as well as hyperarousal (such as insomnia, distractibility, hyperactivity) and extreme responses to frustration (such as frequent, severe temper tantrums). Researchers will describe the moods and behaviors of children with these symptoms and use specialized testing and brain imaging to learn about the brain changes associated with this disorder.

Key Dates

Start date

Jan 1, 2002

Status verified

May 2026

Study Design

Enrollment

2,350 participants (estimated)

Arms

• Arm: Children/adolescents with ADHD
  Children/adolescents with ADHD
• Arm: Children/Adolescents with DMDD or subthreshold DMDD
  Children/Adolescents with DMDD or subthreshold DMDD
• Arm: Children/adolescents with MDD
  Children/adolescents with MDD
• Arm: Healthy volunteer adults
  Healthy volunteer adults
• Arm: Healthy volunteer children/adolescents
  Healthy volunteer children/adolescents
• Arm: Parents of children/adolescents with DMDD or subthreshold DMDD
  Parents of children/adolescents with DMDD or subthresdhold DMDD

Primary Outcome Measure

To examine between-group differences in clinical, behavioral, genetic, neuroanatomical, and neurophysiological variables [ Time Frame: 20 years ]

Central Contacts

• Melissa A Brotman, Ph.D.
  (301) 496-8281
  [email protected]

Locations (1)

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