Phenotype/Genotype Correlations in Movement Disorders

Part of paid clinical trials in Bethesda, Maryland.

Sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
Study ID
NCT00018889
Status
Recruiting
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Conditions

  • Movement Disorder

Eligibility Criteria

Sex
ALL
Age
2 Years - 100 Years
Healthy Volunteers
Not accepted

Study Details

The goal of this protocol is to identify families with inherited movement disorders and evaluate disease manifestations to establish an accurate clinical diagnosis by using newest technological advances and investigate the underlying molecular mechanisms. Studies of inherited movement disorders in large families with good genealogical records are especially valuable. Patients with diseases of known molecular basis will be genotyped in order to investigate phenotype/genotype correlation. Patients with disease of unknown or incomplete genetic characterization will be studied with a hope of contributing to the identification of specific disease-causing genes and genetic mechanisms responsible for a specific disorder.

Key Dates

Start date
Oct 22, 2001
Status verified
Apr 2026

Study Design

Enrollment
2,500 participants (estimated)

Arms

  • Arm: Patients 1
    Patients with diseases of known molecular basis will be genotyped in order to investigate phenotype/genotype correlations.
  • Arm: Patients 2
    Patients with disease of unknown or incomplete genetic characterization.
  • Arm: Subjects
    Subjects older than 2 years old with movement disorders and their family members

Primary Outcome Measure

The primary outcome measure is the phenotypic and genotypic characterizations of patients and family members with movement disorders. [ Time Frame: 10 Years ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
National Institutes of Health Clinical CenterBethesdaMaryland20892
For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR)
[email protected]
800-411-1222

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By research site
National Institutes of Health Clinical Center· Bethesda, MD

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