Radiation Therapy Plus Chemotherapy Followed by Surgery in Treating Patients With Locally Advanced Cancer of the Rectum

Conditions

• Colorectal Cancer

Eligibility Criteria

Sex

ALL

Age

18 Years - N/A

Healthy Volunteers

Not accepted

Interventions

• fluorouracil — DRUG
• irinotecan hydrochloride — DRUG
• conventional surgery — PROCEDURE
• radiation therapy — RADIATION

Study Details

RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. It is not yet known which regimen of radiation therapy plus chemotherapy is more effective for rectal cancer. PURPOSE: Randomized phase II trial to compare two regimens of radiation therapy plus chemotherapy followed by surgery in treating patients who have locally advanced cancer of the rectum.

Key Dates

Start date

Feb 28, 2001

Status verified

Dec 2002

Primary completion

Dec 31, 2003

Study Design

Allocation

RANDOMIZED

Primary purpose

TREATMENT

Locations (216)

Find similar trials in Birmingham, AL

Related Studies

• Evaluation for NCI Surgery Branch Clinical Research Protocols
  Recruiting · National Cancer Institute (NCI) · Bethesda, Maryland
• Gastrointestinal Biomarkers in Tissue and Biological Fluid Samples From Colorectal Cancer Patients
  Recruiting · Vanderbilt University Medical Center · Nashville, Tennessee
• ColoCare Study - Colorectal Cancer Cohort
  Recruiting · University of Utah · Los Angeles, California
• Feasibility of the LUM Imaging System for Detection of Gastrointestinal Cancers
  PHASE1/PHASE2 · Recruiting · Lumicell, Inc. · Boston, Massachusetts