Role of Genetic Factors in the Development of Lung Disease

Part of paid clinical trials in Bethesda, Maryland.

Sponsor
National Heart, Lung, and Blood Institute (NHLBI)
Study ID
NCT00001532
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
2 Years - 90 Years
Healthy Volunteers
Accepted

Study Details

This study is designed to evaluate the genetics involved in the development of lung disease by surveying genes involved in the process of breathing and examining the genes in lung cells of patients with lung disease. The study will focus on defining the distribution of abnormal genes responsible for processes directly involved in different diseases affecting the lungs of patients and healthy volunteers. Optional CT Sub-study The standard CT scan will be compared to the low dose radiation CT scan for the 150 subjects enrolled in the sub-study to assess the variation between the two techniques. Specifically, the quantitative computer aided detection of lung CT abnormalities from LAM can be compared to assess whether low radiation dose CT exams is an alternative to conventional CT to monitor disease status. This optional sub-study will be offered to up to 100 adult subjects with lung disease and up to 50 children age 9 and older with CF. Children will not be enrolled in the optional CT sub-study unless they have had a standard CT scan for medical purposes to use in comparison. One additional low dose radiation CT scan of the chest may be done as part of this sub-study when these subjects have their next annual CT scan....

Key Dates

Start date
Sep 13, 1996
Status verified
Feb 2026

Study Design

Enrollment
3,500 participants (estimated)

Arms

  • Arm: 1
    Subjects with pulmonary disease or possible pulmonary disease and Relatives
  • Arm: 2
    Healthy

Primary Outcome Measure

evaluating the role of hereditary factor [ Time Frame: 1 year ]

Central Contacts

Locations (2)

FacilityCityStateZIPSite coordinators
National Institutes of Health Clinical CenterBethesdaMaryland20892
Tatyana Worthy, B.S.
[email protected]
301-827-1376
Suburban HospitalBethesdaMaryland20814-

Find similar trials in Bethesda, MD

By condition
Asthma
By specialty
PulmonologyLung disease
By research site
National Institutes of Health Clinical Center· Bethesda, MDSuburban Hospital· Bethesda, MD

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