Natural History of Treated Neurocysticercosis and Long-Term Outcomes

Conditions

• Cysticercosis
• Neurocysticercosis

Eligibility Criteria

Sex

ALL

Age

3 Years - 99 Years

Healthy Volunteers

Accepted

Study Details

Neurocysticercosis is a brain disease due to the larval stage of the pork tapeworm (Taenia solium). The most common symptoms patient experience from infection inside the substance of the brain (parenchymal disease) are seizures and headaches. When the infection is either inside the fluid pockets inside the brain (ventricular disease) or in the space around the brain (subarachnoid disease) patients can have chronic headaches, relapsing aseptic meningitis, hydrocephalus, stroke, and may require neurosurgical intervention. The purpose of this study is to treat patients with anthelmintic therapy (praziquantel and/or albendazole) and anti-inflammatories in alignment with currently accepted best practices and guidelines, depending on the neurocysticercosis subtype. The purpose of the study is to better understand and characterize clinical, biologic, and management factors during treatment that influence long term outcomes. In order to understand this further we collect patient clinical information, patient survey responses, blood, urine samples, and additional cerebral spinal fluid if already being collected for clinical care....

Key Dates

Start date

Oct 7, 1985

Status verified

Mar 2026

Study Design

Enrollment

500 participants (estimated)

Arms

• Arm: Arm 1
  Subarachnoid (racemose) neurocysticercosis
• Arm: Arm 2
  Ventricular without other viable disease
• Arm: Arm 3
  Parenchymal cyst(s)--non-calcified parenchymal disease at time of referral
• Arm: Arm 4
  Calcified parenchymal disease with symptoms (seizures)
• Arm: Arm 5
  Calcified parenchymal disease without symptoms
• Arm: Arm 6
  Endemic exposure--subjects with compatible epidemiologic exposure to T. solium

Primary Outcome Measure

The primary objective is to characterize the biochemical and clinical course of neurocysticercosis (NCC) during and after treatment with long-term follow-up. [ Time Frame: Ongoing ]

Central Contacts

• Perla M Adames Castillo, R.N.
  (301) 402-8495
  [email protected]
• Elise M O'Connell, M.D.
  (301) 761-5413
  [email protected]

Locations (1)

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