Orlando, FL Clinical Trials Report — April 2026

For individuals in Orlando, FL, considering participation in clinical research, April 2026 presents a critical window of opportunity, particularly for those looking to join studies before enrollment concludes. Across the city, 54 clinical trials are slated to close within the next 90 days. This urgency is especially relevant for healthy volunteers, as 13 of these rapidly closing studies are still actively seeking participants without specific health conditions. With a total of 704 clinical trials currently recruiting in Orlando across 363 research facilities, there are many opportunities, but some require swift action.

New Research Opportunities in April

This month, Orlando saw the opening of 6 new clinical trials, a decrease from the 12 trials that launched in March 2026. Despite this dip, these new studies offer significant advancements, particularly in metabolic health and oncology. Drug trials account for 4 of the new studies, with 2 classified as "OTHER" type trials.

Several high-profile new trials have opened in Orlando, including significant Phase 2 and Phase 3 studies from major sponsors:

• Novo Nordisk A/S is sponsoring NCT07533175, "AMAZE 2: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Type 2 Diabetes Lose Weight." This important Phase 3 study, aiming for 630 participants, seeks to determine if NNC0487-0111 is safe and effective for treating individuals with excess body weight and type 2 diabetes. Participants will receive weekly injections of either the study medicine or a placebo.
• Hanmi Pharmaceutical Company Limited is initiating NCT07527650, "Study to Evaluate HM15275 in Subjects With Type 2 Diabetes Mellitus." This Phase 2 clinical trial, designed for 180 participants, will evaluate the efficacy, safety, and tolerability of HM15275 in individuals with type 2 diabetes mellitus over a 36-week period.

Other new trials this month are exploring a range of conditions, including low back pain, metastatic prostate cancer, obesity, and overweight. Notably, sponsors like AstraZeneca, Pfizer, AdventHealth Translational Research Institute, and the University of Central Florida are also involved in new research efforts.

Opportunities for Healthy Volunteers

For individuals without a specific medical condition, there are valuable opportunities to contribute to medical science. Of the 6 new trials launched this month, 2 are actively seeking healthy volunteers. Across Orlando, a total of 72 clinical trials are currently recruiting healthy participants, providing numerous avenues for those interested in supporting medical research. Remember, 13 healthy volunteer trials are closing within 90 days, so prompt inquiry is recommended for these.

Orlando's Leading Research Facilities

Orlando is home to a robust network of research institutions that consistently run a high volume of clinical trials. These facilities are key destinations for individuals seeking to participate in medical research:

• AdventHealth Orlando (63 trials)
• Arnold Palmer Hospital for Children (40 trials)
• Nemours Children's Hospital (37 trials)
• Orlando Health Cancer Institute (36 trials)
• Orlando Health (33 trials)
• University of Central Florida (28 trials)
• AdventHealth (25 trials)
• Research Site (24 trials)
• Orlando Clinical Research Center (16 trials)
• Advent Health (15 trials)
• Florida Cancer Specialists (12 trials)
• Advent Health Orlando (11 trials)

These institutions offer a broad spectrum of research, from pediatric care at Arnold Palmer Hospital for Children and Nemours Children's Hospital, to oncology at Orlando Health Cancer Institute and Florida Cancer Specialists, and diverse medical fields across the AdventHealth and Orlando Health systems, as well as the University of Central Florida.

Trials Closing Soon: Conditions to Note

Patients managing certain health conditions also face impending deadlines to join research. Trials focused on various conditions, including kidney health, digestive disorders, and mental health, are among those with limited time remaining for enrollment. Conditions with trials closing soon include:

• Renal impairment (3 trials)
• Healthy (2 trials)
• Hepatic impairment (2 trials)
• Irritable bowel syndrome with constipation (IBS-C) (2 trials)
• Major depressive disorder (2 trials)
• Breast cancer (2 trials)
• Advanced breast cancer (2 trials)
• Child (1 trial)
• Attention-deficit/hyperactivity disorder (1 trial)
• Advanced NSCLC (1 trial)

As mentioned, 13 of these closing trials are still accepting healthy volunteers, offering a chance to contribute to medical understanding without a specific diagnosis.

Expanding Your Search: Nearby Florida Cities

While Orlando offers a significant array of clinical trial opportunities, individuals may also find options in other communities across Florida. Compared to Orlando's 704 recruiting trials, other cities with active studies include Miami (16 trials), Tampa (10 trials), Jacksonville (7 trials), Gainesville (3 trials), Miami Lakes (3 trials), Sarasota (2 trials), Fort Myers (2 trials), and Boca Raton (2 trials). Orlando remains a central hub for clinical research within the state.

Participation in clinical trials is open to a diverse range of individuals. Of the 6 new trials launched this month, 6 include older adults, ensuring that senior populations have ample opportunity to contribute to medical science. Additionally, 1 new trial is specifically designed for male participants. Industry sponsors continue to drive significant research efforts in Orlando, accounting for 4 of the new trials this month, alongside 2 academic or "OTHER" sponsors.

As we move further into spring, Orlando's commitment to advancing medical research remains strong, offering diverse opportunities for patients and healthy volunteers alike to contribute to the development of future treatments.