Paid Clinical Trials in South Carolina

South Carolina has 1,276 paid clinical trials enrolling now across cities including Charleston, Greenville and Columbia. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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1,276 clinical trials

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Efficacy and Safety of Zanidatamab With Standard-of-care Therapy Against Standard-of-care Therapy for Advanced HER2-positive Biliary Tract Cancer

for Biliary Tract Cancer

21 locations incl. Duarte

Sponsor: Jazz Pharmaceuticals

Sex: All·Age: 18+

Code: NCT06282575·Phase 3·Recruiting

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A Phase 2 Study to Evaluate MORF-057 in Adults With Moderately to Severely Active Crohn's Disease

for Inflammatory Bowel Diseases

25 locations incl. Lancaster

Sponsor: Morphic Therapeutic, Inc. (A Wholly Owned Subsidiary of Eli Lilly and Company)

Sex: All·Age: 18 - 85

Code: NCT06226883·Phase 2·Recruiting

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Safety and Efficacy of Mesenchymal Stem Cells Associated With Chronic Pancreatitis Pain

for Chronic Pancreatitis

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18 - 75

Code: NCT06205342·EARLY_Phase 1·Recruiting

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Study of Sotorasib, Panitumumab and FOLFIRI Versus FOLFIRI With or Without Bevacizumab-awwb in Treatment-naïve Participants With Metastatic Colorectal Cancer With KRAS p.G12C Mutation

for Metastatic Colorectal Cancer

Drug: Bevacizumab

26 locations incl. Chandler

Sponsor: Amgen

Sex: All·Age: 18+

Code: NCT06252649·Phase 3·Recruiting

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Testing the Addition of BMS-986016 (Relatlimab) to the Usual Immunotherapy After Initial Treatment for Recurrent or Metastatic Nasopharyngeal Cancer

for Metastatic Nasopharyngeal Carcinoma

Drug: Relatlimab

83 locations incl. Dublin

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06029270·Phase 2·Recruiting

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Safety Evaluation of Prismocitrate 18 in Patients Receiving CRRT

for Regional Citrate Anticoagulation (RCA)

14 locations incl. Birmingham

Sponsor: Vantive Health LLC

Sex: All·Age: 18+

Code: NCT05399537·Phase 3·Recruiting

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Case Series on the Clinical Performance of VA Clavicle and Clavicle Hook Plate 2.7 Systems

for Clavicle

3 locations incl. Grand Rapids

Sponsor: AO Innovation Translation Center

Sex: All·Age: 18+

Code: NCT04921865·Recruiting

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Switch or Quit R01

for Cigarette Smoking

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 21+·Accepts healthy volunteers

Code: NCT06373679·Recruiting

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Efficacy and Safety of Rexlemestrocel-L Combined With HA* in Participants With Moderate to Severe Chronic Low Back Pain

for Degenerative Disc Disease

39 locations incl. Phoenix

Sponsor: Mesoblast, Ltd.

Sex: All·Age: 18+

Code: NCT06325566·Phase 3·Recruiting

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Continuation Protocol for Obstructive Sleep Apnea (OSA)

for OSA

93 locations incl. Birmingham

Sponsor: Apnimed

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06566820·Phase 3·Enrolling By Invitation

Trial of Naltrexone/Bupropion for the Treatment of Methamphetamine Use Disorder

for Methamphetamine-dependence

11 locations incl. Little Rock

Sponsor: National Institute on Drug Abuse (NIDA)

Sex: All·Age: 18 - 65

Code: NCT06233799·Phase 3·Recruiting

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Dichoptic Treatment for Amblyopia in Children 4 to 7 Years of Age

for Amblyopia

73 locations incl. Birmingham

Sponsor: Jaeb Center for Health Research

Sex: All·Age: 4 - 7

Code: NCT06380517·Phase 3·Recruiting

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Intervention to Improve Utilization of Extended Venous Thromboembolism Prophylaxis After Cancer Surgery

for Venous Thromboembolism

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT06451003·Recruiting

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Global Paradise System US Post Approval Study

for Hypertension

39 locations incl. Sacramento

Sponsor: ReCor Medical, Inc.

Sex: All·Age: 18+

Code: NCT06297291·Recruiting

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A Study Using Nivolumab, in Combination With Chemotherapy Drugs to Treat Nasopharyngeal Carcinoma (NPC)

for Stage II Nasopharyngeal Carcinoma AJCC v8

Drug: Nivolumab

76 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: Up to 21

Code: NCT06064097·Phase 2·Recruiting

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ARTEMIS - A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With a Heart Attack

for Cardiovascular Risk

Drug: Ziltivekimab

208 locations incl. Alexander City

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18+

Code: NCT06118281·Phase 3·Recruiting

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QL vs LAI for Palatoplasty

for Post-operative Pain

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 6 - 18

Code: NCT06420336·Recruiting

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A Study to Evaluate the Efficacy and Safety of Bimekizumab Compared to Ustekinumab in Children and Adolescents From 6 Years to Less Than 18 Years of Age With Moderate to Severe Plaque Psoriasis

for Moderate to Severe Plaque Psoriasis

Drug: Bimekizumab

9 locations incl. Fountain Valley

Sponsor: UCB Biopharma SRL

Sex: All·Age: 6 - 17

Code: NCT06425549·Phase 3·Recruiting

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Efficacy and Safety of a New Formulation of Oral Cladribine Compared With Placebo in Participants With Generalized Myasthenia Gravis (MyClad)

for Generalized Myasthenia Gravis

21 locations incl. Phoenix

Sponsor: Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany

Sex: All·Age: 18+

Code: NCT06463587·Phase 3·Recruiting

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Non-interventional Study of Patients With Transthyretin (ATTR) Amyloidosis

for Transthyretin Amyloidosis

30 locations incl. La Jolla

Sponsor: AstraZeneca

Sex: All·Age: 18 - 130

Code: NCT06465810·Recruiting

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A Phase 3 Study to Evaluate Petosemtamab Compared With Investigator's Choice Monotherapy in Previously Treated Head and Neck Squamous Cell Carcinoma Patients (LiGeR-HN2)

for Head and Neck Squamous Cell Carcinoma

Drug: Petosemtamab

61 locations incl. Mobile

Sponsor: Merus B.V.

Sex: All·Age: 18+

Code: NCT06496178·Phase 3·Recruiting

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Adding Nivolumab to Usual Treatment for People With Advanced Stomach or Esophageal Cancer, PARAMUNE Trial

for Advanced Esophageal Adenocarcinoma

Drug: Nivolumab

371 locations incl. Little Rock

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06203600·Phase 2, Phase 3·Recruiting

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Enzalutamide Implants (Enolen) in Patients With Prostate Cancer

for Prostate Adenocarcinoma

7 locations incl. Chicago

Sponsor: Alessa Therapeutics Inc.

Sex: Male·Age: 21+

Code: NCT06257693·Phase 1·Recruiting

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The Golazo® Peripheral Atherectomy System for a Safe and Effective Atherectomy (GREAT Trial)

for Peripheral Arterial Disease

20 locations incl. Scottsdale

Sponsor: Avantec Vascular

Sex: All·Age: 18+

Code: NCT06321575·Recruiting

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tFUS Induced Transient Scotoma for Individual Dosing

for Healthy

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18 - 70·Accepts healthy volunteers

Code: NCT06426498·Recruiting

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A Study to Investigate the Efficacy and Safety of Anifrolumab Administered as Subcutaneous Injection and Added to Standard of Care Compared With Placebo Added to Standard of Care in Adult Participants With Idiopathic Inflammatory Myopathies (Polymyositis and Dermatomyositis)

for Polymyositis, Dermatomyositis

43 locations incl. Phoenix

Sponsor: AstraZeneca

Sex: All·Age: 18 - 75

Code: NCT06455449·Phase 3·Recruiting

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A Study Comparing Niraparib With Temozolomide in Adult Participants With Newly-diagnosed, MGMT Unmethylated Glioblastoma

for Glioblastoma

Drug: Niraparib

32 locations incl. Birmingham

Sponsor: Ivy Brain Tumor Center

Sex: All·Age: 18+

Code: NCT06388733·Phase 3·Recruiting

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A Study to Evaluate the Safety and Efficacy of BEAM-302 in Adult Patients With Alpha-1 Antitrypsin Deficiency (AATD)

for Alpha 1-Antitrypsin Deficiency

3 locations incl. Birmingham

Sponsor: Beam Therapeutics Inc.

Sex: All·Age: 18 - 70

Code: NCT06389877·Phase 1, Phase 2·Recruiting

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MYELOMATCH: A Screening Study to Assign People With Myeloid Cancer to a Treatment Study or Standard of Care Treatment Within myeloMATCH (MyeloMATCH Screening Trial)

for Acute Myeloid Leukemia

335 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT05564390·Phase 2·Recruiting

Apply to this trial

Transcranial Magnetic Stimulation for MCI

for Mild Cognitive Impairment

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 60 - 85

Code: NCT05992831·Recruiting

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A Study to Investigate APL-5125 in Adults With Advanced Solid Tumors

for Colorectal Cancer

9 locations incl. Duarte

Sponsor: Apollo Therapeutics Ltd

Sex: All·Age: 18+

Code: NCT06399757·Phase 1, Phase 2·Recruiting

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A Long-Term Follow-Up Study of Participants With Sickle Cell Disease or Transfusion Dependent β-Thalassemia Who Received EDIT-301

for Sickle Cell Disease

16 locations incl. Oakland

Sponsor: Editas Medicine, Inc.

Sex: All·Age: 12 - 50

Code: NCT06363760·Enrolling By Invitation

A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Heart Failure

for Heart Failure

Drug: Empagliflozin

95 locations incl. Mobile

Sponsor: Boehringer Ingelheim

Sex: All·Age: 18+

Code: NCT06424288·Phase 3·Recruiting

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A Study of Upadacitinib in Adult Participants With Moderate-to-Severe Atopic Dermatitis and Inadequate Response to Dupilumab

for Atopic Dermatitis

Drug: Upadacitinib

83 locations incl. Birmingham

Sponsor: AbbVie

Sex: All·Age: 18 - 63

Code: NCT06389136·Phase 3·Recruiting

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Trauma Screening/Referral and Interpersonal Violence Prevention for Women with Substance Use Disorders

for Substance Use Disorders

2 locations incl. Greenville

Sponsor: Clemson University

Sex: Female·Age: 18+·Accepts healthy volunteers

Code: NCT06608979·Recruiting

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A Trial to Evaluate the Efficacy and Safety of Tralokinumab in Combination With Topical Corticosteroids in Children and Infants With Moderate-to-severe Atopic Dermatitis

for Atopic Dermatitis

15 locations incl. Birmingham

Sponsor: LEO Pharma

Sex: All·Age: 6 Months - 11

Code: NCT06311682·Phase 3·Recruiting

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The Pediatric Lupus Nephritis Mycophenolate Mofetil (PLUMM) Study

for Lupus Nephritis

19 locations incl. San Francisco

Sponsor: Children's Hospital Medical Center, Cincinnati

Sex: All·Age: 8 - 20

Code: NCT05538208·Phase 2·Recruiting

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EXActDNA-003 / NSABP B-64: Study of Molecular Residual Disease Detection in Breast Cancer (MRD)

for Breast Cancer

53 locations incl. Anchorage

Sponsor: Exact Sciences Corporation

Sex: All·Age: 18+

Code: NCT06401421·Recruiting

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IMC-F106C Regimen Versus Nivolumab Regimens in Previously Untreated Advanced Melanoma (PRISM-MEL-301)

for Advanced Melanoma

Drug: Nivolumab

37 locations incl. Tucson

Sponsor: Immunocore Ltd

Sex: All·Age: 18+

Code: NCT06112314·Phase 3·Recruiting

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Prospective Registry of Patients Undergoing Cardiac CT With NAEOTOM Alpha PCD-CT Before TAVI Procedure

for Coronary Artery Disease

1 location in Charleston

Sponsor: Semmelweis University

Sex: All·Age: 18+

Code: NCT07016477·Recruiting

Apply to this trial