Paid Clinical Trials in Orange, CA

As of June 2026, 539 paid clinical trials are recruiting in Orange, California. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.

Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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539 clinical trials

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Testing the Addition of an Anti-cancer Drug, DT2216, to the Usual Chemotherapy Treatment for Relapsed or Refractory Solid Tumors and Fibrolamellar Carcinoma

for Childhood Fibrolamellar Carcinoma

21 locations incl. Birmingham

Sponsor: Children's Oncology Group

Sex: All·Age: 1 - 39

Code: NCT06620302·Phase 1, Phase 2·Recruiting

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A Study to Investigate Progression-Free Survival With Sonrotoclax Plus Obinutuzumab Or Sonrotoclax Plus Rituximab Compared With Venetoclax Plus Rituximab Treatment In Patients With Relapsed and/or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CELESTIAL-RRCLL)

for Chronic Lymphocytic Leukemia

Drug: Sonrotoclax

34 locations incl. Laguna Hills

Sponsor: BeOne Medicines

Sex: All·Age: 18+

Code: NCT06943872·Phase 3·Recruiting

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A Study to Evaluate the Efficacy and Safety of KarXT for the Treatment of Manic Episodes in Bipolar-I Disorder

for Bipolar-I Disorder With Mania or Mania With Mixed Features

Drug: KarXT

22 locations incl. Bentonville

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18 - 65

Code: NCT06951698·Phase 3·Recruiting

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JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS- Cohort B: Paridiprubart

for Acute Respiratory Distress Syndrome (ARDS)

Drug: Cohort B: paridiprubart

40 locations incl. Birmingham

Sponsor: PPD Development, LP

Sex: All·Age: 18+

Code: NCT06701669·Phase 2·Recruiting

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JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS (Master Record)

for Acute Respiratory Distress Syndrome (ARDS)

40 locations incl. Birmingham

Sponsor: PPD Development, LP

Sex: All·Age: 18+

Code: NCT06703073·Phase 2·Recruiting

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A Study to Evaluate Del-brax (Also Referred to as AOC 1020) in Participants With FSHD

for Facioscapulohumeral Muscular Dystrophy

14 locations incl. Orange

Sponsor: Avidity Biosciences, Inc.

Sex: All·Age: 16 - 70

Code: NCT07038200·Phase 3·Recruiting

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ANCHOR Study: A Study to Assess the Safety and Efficacy of ABBV-CLS-628 in Adult Participants With Autosomal Dominant Polycystic Kidney Disease (ADPKD)

for Autosomal Dominant Polycystic Kidney Disease

35 locations incl. Garden Grove

Sponsor: Calico Life Sciences LLC

Sex: All·Age: 18 - 55

Code: NCT06902558·Phase 2·Recruiting

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Testing the Addition of the Anti-cancer Drug Venetoclax and/or the Anti-cancer Immunotherapy Blinatumomab to the Usual Chemotherapy Treatment for Infants With Newly Diagnosed KMT2A-rearranged or KMT2A-non-rearranged Leukemia

for Acute Leukemia of Ambiguous Lineage

Drug: Venetoclax

112 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: Up to 365 Days

Code: NCT06317662·Phase 2·Recruiting

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A Double-blind Study Evaluating the Efficacy, Safety, and Tolerability of Zorevunersen in Patients With Dravet Syndrome

for Dravet Syndrome

Drug: zorevunersen

31 locations incl. Phoenix

Sponsor: Stoke Therapeutics, Inc

Sex: All·Age: 2 - 17

Code: NCT06872125·Phase 3·Recruiting

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TIDES 2.0: Prevalence and Longitudinal Course of Depression, Anxiety, and Behavior Problems in Children With Cystic Fibrosis Under 12 Years of Age

for Cystic Fibrosis (CF)

13 locations incl. Orange

Sponsor: State University of New York at Buffalo

Sex: All·Age: 18 Months - 11

Code: NCT07048574·Recruiting

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A Study Testing the Combination of Dasatinib or Imatinib to Chemotherapy Treatment With Blinatumomab for Children, Adolescents, and Young Adults With Philadelphia Chromosome Positive (Ph+) or ABL-Class Philadelphia Chromosome-Like (Ph-Like) B-cell Acute Lymphoblastic Leukemia (B-ALL)

for B Acute Lymphoblastic Leukemia

137 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 366 Days - 46

Code: NCT06124157·Phase 2·Recruiting

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Docetaxel to Androgen Receptor Pathway Inhibitors in Patients With Metastatic Castration Sensitive Prostate Cancer and Suboptimal PSA Response

for Prostate Cancer (Adenocarcinoma)

350 locations incl. Anchorage

Sponsor: Canadian Cancer Trials Group

Sex: Male·Age: 18+

Code: NCT06592924·Phase 3·Recruiting

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A Study to Evaluate the Safety and Tolerability of Eravacycline in Pediatric Patients Aged 8 to 17 With Complicated Intra-abdominal Infections (cIAI)

for Complicated Intra-abdominal Infections (cIAI)

5 locations incl. Los Angeles

Sponsor: Tetraphase Pharmaceuticals, Inc

Sex: All·Age: 8 - 17

Code: NCT06794541·Phase 2·Recruiting

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A Study to Compare Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) Versus Pembrolizumab Alone as Treatment in Participants With Mismatch Repair Proficient Endometrial Cancer (MK-2870-033/TroFuse-033/GOG-3119/ENGOT-en29)

for Endometrial Cancer

44 locations incl. Mobile

Sponsor: Merck Sharp & Dohme LLC

Sex: Female·Age: 18+

Code: NCT06952504·Phase 3·Recruiting

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A Clinical Study of Ifinatamab Deruxtecan (I-DXd) in People With Metastatic Prostate Cancer (MK-2400-001)

for Prostate Cancer

50 locations incl. Phoenix

Sponsor: Merck Sharp & Dohme LLC

Sex: Male·Age: 18+

Code: NCT06925737·Phase 3·Recruiting

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Lung Cancer Screening of Family Members of Patients With Mutation-Driven Lung Cancer

for Lung Cancer

1 location in Orange

Sponsor: University of California, Irvine

Sex: All·Age: 18 - 80

Code: NCT07062172·Recruiting

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Investigating an mRNA CAR T-cell Therapy, Known as Descartes-08, as a Potential Approach to Treat Myasthenia Gravis

for Myasthaenia Gravis

23 locations incl. Tucson

Sponsor: Cartesian Therapeutics

Sex: All·Age: 18+

Code: NCT06799247·Phase 3·Recruiting

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Recombinant Factor VIIa (rFVIIa) for Hemorrhagic Stroke Trial - Part 2

for Intracerebral Hemorrhage

48 locations incl. Birmingham

Sponsor: Joseph Broderick, MD

Sex: All·Age: 18 - 80

Code: NCT07227246·Phase 3·Recruiting

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Pembrolizumab Plus CA-4948 for the Treatment of Patients With Progressive Metastatic Urothelial Cancer Despite Prior Immunotherapy

for Metastatic Urothelial Carcinoma

11 locations incl. Duarte

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06439836·Phase 1·Recruiting

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Impact of Sodium Bicarbonate on 24-hour Urine Parameters in Hypocitriuric and Uric Acid Stone Formers

for Uric Acid Stones

1 location in Orange

Sponsor: University of California, Irvine

Sex: All·Age: 18 - 80

Code: NCT06335537·Phase 1·Recruiting

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A Phase 1 Study of Anitocabtagene Autoleucel for the Treatment of Subjects With Non-oncology Plasma Cell-related Diseases

for Muscular Diseases

13 locations incl. Los Angeles

Sponsor: Arcellx, Inc.

Sex: All·Age: 18+

Code: NCT06626919·Phase 1·Recruiting

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Trial of Single Protein Encapsulated Doxorubicin, SPEDOX-6 in Advanced Malignancies

for Soft-tissue Sarcoma

1 location in Orange

Sponsor: University of California, Irvine

Sex: All·Age: 18+

Code: NCT07064018·Phase 1, Phase 2·Recruiting

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Study to Assess Safety, Efficacy, and Cellular Kinetics of YTB323 in Generalized Myasthenia Gravis

for Generalized Myasthenia Gravis

3 locations incl. Orange

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18 - 65

Code: NCT06704269·Phase 1, Phase 2·Recruiting

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Testing the Addition of an Anti-Cancer Drug, Abemaciclib, to the Usual Chemotherapy Treatment (5-Fluorouracil) for Metastatic, Refractory Colorectal Cancer

for Metastatic Microsatellite Stable Colorectal Carcinoma

8 locations incl. Irvine

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06654037·Phase 1·Recruiting

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Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

for Major Depressive Disorder

Drug: NBI-1065845

40 locations incl. Huntsville

Sponsor: Neurocrine Biosciences

Sex: All·Age: 18+

Code: NCT06966401·Phase 3·Recruiting

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A Study Using Risk Factors to Determine Treatment for Children With Favorable Histology Wilms Tumors (FHWT)

for Stage I Mixed Cell Type Kidney Wilms Tumor

146 locations incl. Birmingham

Sponsor: Children's Oncology Group

Sex: All·Age: Up to 30

Code: NCT06401330·Phase 3·Recruiting

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A Study to Assess Adverse Events and Change in Disease Activity of Intravenously (IV) Infused ABBV-324 in Adult Participants With Hepatocellular Cancer (HCC) or Squamous-Cell Non-Small Cell Lung Cancer (LUSC)

for Hepatocellular Cancer

10 locations incl. Duarte

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT06858813·Phase 1·Recruiting

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An Efficacy and Safety Study of Clemizole HCl in Patients With Lennox-Gastaut Syndrome

for Lennox Gastaut Syndrome

20 locations incl. Little Rock

Sponsor: Epygenix

Sex: All·Age: 2 - 55

Code: NCT05066217·Phase 3·Recruiting

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Suramin for the Treatment of Autism Trial: KZ101 in a Male Pediatric Population With Autism Spectrum Disorder (ASD)

for Autism Spectrum Disorder (ASD)

3 locations incl. Phoenix

Sponsor: Children's Hospital of Orange County

Sex: Male·Age: 5 - 14

Code: NCT06866275·Phase 2·Recruiting

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A Study of Efimosfermin Alfa in Participants With Biopsy-confirmed Cirrhosis (Compensated) Due to MASH

for Metabolic Dysfunction-Associated Steatohepatitis

35 locations incl. Chandler

Sponsor: Boston Pharmaceuticals

Sex: All·Age: 18 - 75

Code: NCT06920043·Phase 2·Recruiting

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A Phase 1 Dose Escalation Study of ZG006 in Patients With Small Cell Lung Cancer

for Small Cell Lung Cancer

6 locations incl. Orange

Sponsor: Suzhou Zelgen Biopharmaceuticals Co.,Ltd

Sex: All·Age: 18 - 75

Code: NCT06592638·Phase 1·Recruiting

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A Study of Vedolizumab in Adults With Ulcerative Colitis or Crohn's Disease in the Community Setting

for Ulcerative Colitis

100 locations incl. Birmingham

Sponsor: Takeda

Sex: All·Age: 18 - 80

Code: NCT06581328·Phase 4·Recruiting

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A Study of Ziftomenib in Combination With Imatinib in Patients With Advanced Gastrointestinal Stromal Tumors (GIST)

for Gastrointestinal Stromal Tumor (GIST)

32 locations incl. Birmingham

Sponsor: Kura Oncology, Inc.

Sex: All·Age: 18+

Code: NCT06655246·Phase 1·Recruiting

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Study of Olomorasib (LY3537982) in Combination With Standard of Care in Participants With Resected or Unresectable KRAS G12C-mutant Non-Small Cell Lung Cancer

for Carcinoma, Non-Small-Cell Lung

Drug: LY3537982

85 locations incl. Huntsville

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT06890598·Phase 3·Recruiting

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Mechanistic and Clinical Outcomes of a Surgical Innovation Aimed at Minimizing GERD Associated With VSG (INNOVATE-VSG)

for Obesity

2 locations incl. Orange

Sponsor: University of California, Irvine

Sex: All·Age: 18 - 65

Code: NCT06783751·Recruiting

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An Open-Label Study of Azetukalner in Major Depressive Disorder

for Major Depressive Disorder

63 locations incl. Phoenix

Sponsor: Xenon Pharmaceuticals Inc.

Sex: All·Age: 18+

Code: NCT06922110·Phase 3·Enrolling By Invitation

Imeroprubart in Adult Participants With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)

for Chronic Inflammatory Demyelinating Polyneuropathy

31 locations incl. Tucson

Sponsor: Immunovant Sciences GmbH

Sex: All·Age: 18+

Code: NCT07032662·Phase 2·Recruiting

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Testing the Addition of the Anti-Cancer Drug Tivozanib to Immunotherapy (Pembrolizumab) After Surgery to Remove All Known Sites of Kidney Cancer

for Clear Cell Renal Cell Carcinoma

414 locations incl. Phoenix

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+

Code: NCT06661720·Phase 3·Recruiting

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A Study to Compare the Efficacy and Safety of BMS-986393 Versus Standard Regimens in Adult Participants With Relapsed or Refractory and Lenalidomide-exposed Multiple Myeloma (QUINTESSENTIAL-2)

for Relapsed or Refractory Multiple Myeloma (RRMM)

22 locations incl. Birmingham

Sponsor: Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

Sex: All·Age: 18+

Code: NCT06615479·Phase 3·Recruiting

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Phase 2 Study of ALXN2030 in Patients With Antibody-Mediated Rejection After Kidney Transplantation

for Antibody-Mediated Rejection

23 locations incl. Birmingham

Sponsor: Alexion Pharmaceuticals, Inc.

Sex: All·Age: 18 - 75

Code: NCT06744647·Phase 2·Recruiting

Apply to this trial