Paid Clinical Trials in North Carolina

North Carolina has 2,944 paid clinical trials enrolling now across cities including Durham, Chapel Hill and Winston-Salem. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in North Carolina include Duke University Medical Center, UNC Health and Wake Forest Baptist, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 19, 2026.

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2,944 clinical trials

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Metastatic Castrate-Resistant Prostate Cancer Subjects Treated With PROVENGE® + One Infusion of Sipuleucel-T

for Metastatic Castration-Resistant Prostate Cancer (mCRPC)

31 locations incl. Tuscon

Sponsor: Dendreon

Sex: Male·Age: 18+

Code: NCT06134232·Phase 2·Recruiting

Apply to this trial

Restoration of Normative Postural Control

for Lower Limb Amputation Below Knee (Injury)

1 location in Raleigh

Sponsor: North Carolina State University

Sex: All·Age: 18 - 99

Code: NCT06452186·Recruiting

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Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of Budesonide Extended-release Tablets in Pediatric Subjects Aged 5 to 17 Years With Active, Mild to Moderate Ulcerative Colitis

for Ulcerative Colitis

4 locations incl. Garden Grove

Sponsor: Bausch Health Americas, Inc.

Sex: All·Age: 5 - 17

Code: NCT04314375·Phase 4·Recruiting

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Odevixibat Pregnancy and Lactation Surveillance Program: A Study to Evaluate the Safety of Odevixibat During Pregnancy and/or Lactation

for Pregnancy Related

1 location in Wilmington

Sponsor: Ipsen

Sex: Female·Age: All ages

Code: NCT06258902·Recruiting

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Targeted Alpha-Particle Therapy for Advanced Somatostatin Receptor Type 2 (SSTR2) Positive Tumors

for Neuroendocrine Tumors Unresectable

19 locations incl. Jacksonville

Sponsor: Perspective Therapeutics

Sex: All·Age: 18 - 90

Code: NCT05636618·Phase 1, Phase 2·Recruiting

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A Long-term Follow-up Study of Participants Who Received Delandistrogene Moxeparvovec (SRP-9001) in a Previous Clinical Study

for Duchenne Muscular Dystrophy

22 locations incl. Little Rock

Sponsor: Sarepta Therapeutics, Inc.

Sex: Male·Age: All ages

Code: NCT05967351·Phase 3·Enrolling By Invitation

First-In-Human Study of STX-721/PFL-721 in Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer Harboring EGFR or HER2 Exon 20 Insertion Mutations

for Non-Small Cell Lung Cancer

9 locations incl. Duarte

Sponsor: Pierre Fabre Medicament

Sex: All·Age: 18+

Code: NCT06043817·Phase 1, Phase 2·Recruiting

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Feasibility and Efficacy Study of the CardioPulmonary Management (CPM) System in Patients With Chronic Heart Failure

for Heart Failure

7 locations incl. Palm Springs

Sponsor: Analog Device, Inc.

Sex: All·Age: 18+

Code: NCT05650541·Recruiting

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An Extension Study of the Long-Term Safety, Tolerability, and Efficacy of Tividenofusp Alfa (DNL310) in Participants With Mucopolysaccharidosis Type II (MPS II) From Study DNLI-E-0002 or Study DNLI-E-0007

for Mucopolysaccharidosis II

8 locations incl. Oakland

Sponsor: Denali Therapeutics Inc.

Sex: All·Age: Up to 18

Code: NCT06075537·Phase 2, Phase 3·Enrolling By Invitation

A Trial to Learn How Well Linvoseltamab Works Compared to the Combination of Elotuzumab, Pomalidomide and Dexamethasone for Adult Participants With Relapsed/Refractory Multiple Myeloma

for Relapsed Refractory Multiple Myeloma (RRMM)

Drug: Linvoseltamab

10 locations incl. Los Angeles

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 18+

Code: NCT05730036·Phase 3·Recruiting

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CTSN Embolic Protection Trial

for Delirium

24 locations incl. North Little Rock

Sponsor: Icahn School of Medicine at Mount Sinai

Sex: All·Age: 60+

Code: NCT06027788·Recruiting

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Shorter Chemo-Immunotherapy Without Anthracycline Drugs for Early-Stage Triple Negative Breast Cancer

for Anatomic Stage I Breast Cancer AJCC v8

955 locations incl. Birmingham

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT05929768·Phase 3·Recruiting

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Testing a Device for Automatically TRacking Urine and STool in an Inpatient HCT Setting (Project TRUST)

for Fluid Output

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18 - 80

Code: NCT05520346·Recruiting

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Left vs Left Randomized Clinical Trial

for Heart Failure

57 locations incl. Gilbert

Sponsor: Baylor College of Medicine

Sex: All·Age: 18+

Code: NCT05650658·Recruiting

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A Study of Tegavivint (BC2059) in Patients With Advanced Hepatocellular Carcinoma

for Advanced Hepatocellular Carcinoma

7 locations incl. Duarte

Sponsor: Iterion Therapeutics

Sex: All·Age: 18+

Code: NCT05797805·Phase 1, Phase 2·Recruiting

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Intermittent Fasting Using a Fasting-Mimicking Diet to Improve Prostate Cancer Control and Metabolic Outcomes

for Prostate Adenocarcinoma

3 locations incl. Duarte

Sponsor: Stephen Freedland

Sex: Male·Age: All ages

Code: NCT05832086·Phase 2·Recruiting

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A Study of CC-97540, CD-19-Targeted Nex-T CAR T Cells, in Participants With Severe, Refractory Autoimmune Diseases (Breakfree-1)

for Systemic Lupus Erythematosus

31 locations incl. Aurora

Sponsor: Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

Sex: All·Age: 18+

Code: NCT05869955·Phase 1·Recruiting

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Trajectories of Recovery After Intravenous Propofol Versus Inhaled VolatilE Anesthesia Trial

for Surgery-Complications

20 locations incl. Little Rock

Sponsor: Washington University School of Medicine

Sex: All·Age: 18+

Code: NCT05991453·Recruiting

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Study to Compare Maternal, Fetal, and Infant Outcomes of Women With Mild to Moderate Atopic Dermatitis Exposed to Ruxolitinib Cream During Pregnancy With an Unexposed Control Population

for Pregnancy Related

Drug: Ruxolitinib

1 location in Morrisville

Sponsor: Incyte Corporation

Sex: Female·Age: 15 - 50

Code: NCT06259669·Recruiting

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A Study to Assess the Long-term Safety and Efficacy of a Subcutaneous Formulation of Efgartigimod in Adults With Active Idiopathic Inflammatory Myopathy

for Myositis

18 locations incl. Phoenix

Sponsor: argenx

Sex: All·Age: 18+

Code: NCT05979441·Phase 3·Enrolling By Invitation

Effect of Flavored on!® Nicotine Pouch Products on Smoking Behaviors: a SMART Study

for Cigarette Smoking Behavior

1 location in Raleigh

Sponsor: Altria Client Services LLC

Sex: All·Age: 22 - 65·Accepts healthy volunteers

Code: NCT06072547·Recruiting

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Efficacy and Safety of Trimodulin (BT588) in Subjects With Severe Community-acquired Pneumonia (sCAP)

for Community-acquired Pneumonia

19 locations incl. Mobile

Sponsor: Biotest

Sex: All·Age: 18+

Code: NCT05722938·Phase 3·Recruiting

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Comparison of Uncomplicated Candidemia Therapy Duration in Children

for Invasive Candidiasis

21 locations incl. Birmingham

Sponsor: Arkansas Children's Hospital Research Institute

Sex: All·Age: 120 Days+

Code: NCT05763251·Recruiting

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A Study to Evaluate the Efficacy and Safety of Inavolisib in Combination With Phesgo Versus Placebo in Combination With Phesgo in Participants With PIK3CA-Mutated HER2-Positive Locally Advanced or Metastatic Breast Cancer

for Metastatic Breast Cancer

20 locations incl. Gilbert

Sponsor: Hoffmann-La Roche

Sex: All·Age: 18+

Code: NCT05894239·Phase 3·Recruiting

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The NOTICE Study: Neurosurgery and OrThopedIcs Communication Evaluation Study Following Lumbar Fusions

for Lumbar Spine Degeneration

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT04140344·Recruiting

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To Compare the Efficacy and Safety of the ATEV With AVF in Female Patients With End-Stage Renal Disease Requiring Hemodialysis

for End Stage Renal Disease (ESRD)

32 locations incl. Scottsdale

Sponsor: Humacyte, Inc.

Sex: Female·Age: 18+

Code: NCT05908084·Phase 3·Recruiting

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Study of RMC-9805 in Participants With KRAS G12D-Mutant Solid Tumors

for Non-small Cell Lung Cancer (NSCLC)

17 locations incl. Sacramento

Sponsor: Revolution Medicines, Inc.

Sex: All·Age: 18+

Code: NCT06040541·Phase 1·Recruiting

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Seladelpar in Subjects With Primary Biliary Cholangitis (PBC) and Compensated Cirrhosis

for Primary Biliary Cholangitis

49 locations incl. Birmingham

Sponsor: Gilead Sciences

Sex: All·Age: 18+

Code: NCT06051617·Phase 3·Recruiting

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D2C7-IT and 2141-V11 in Newly Diagnosed GBM Patients

for Newly Diagnosed MGMT Unmethylated Glioblastoma

1 location in Durham

Sponsor: Darell Bigner

Sex: All·Age: 18+

Code: NCT05734560·Phase 1, Phase 2·Recruiting

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Excision of Lymph Node Trial (EXCILYNT) (Mel69)

for Melanoma

7 locations incl. Atlanta

Sponsor: Craig L Slingluff, Jr

Sex: All·Age: 18+

Code: NCT05839912·Recruiting

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Virtual Reality Mindfulness Meditation After ACL Reconstruction

for Anterior Cruciate Ligament Injury

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: Female·Age: 14 - 25

Code: NCT05527171·Recruiting

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Finger Movement Training After Stroke

for Stroke

1 location in Raleigh

Sponsor: North Carolina State University

Sex: All·Age: 21+

Code: NCT05621980·Recruiting

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A Study of Peluntamig (PT217) in Patients With Neuroendocrine Carcinomas Expressing DLL3 (the SKYBRIDGE Study)

for Small Cell Lung Cancer (SCLC)

12 locations incl. Duarte

Sponsor: Phanes Therapeutics

Sex: All·Age: 18+

Code: NCT05652686·Phase 1, Phase 2·Recruiting

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SPEARHEAD-3 Pediatric Study

for Synovial Sarcoma

10 locations incl. Palo Alto

Sponsor: USWM CT, LLC

Sex: All·Age: 2 - 21

Code: NCT05642455·Phase 1, Phase 2·Recruiting

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Reducing Risk for Infective Endocarditis

for Bacteremia

6 locations incl. Boston

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05721781·Recruiting

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HELIOS: Open-Label, Long-Term Extension Study to Investigate the Safety, Tolerability, and Efficacy of DISC-1459 (Bitopertin) in Participants With EPP or XLP

for Erythropoietic Protoporphyria

11 locations incl. Birmingham

Sponsor: Disc Medicine, Inc

Sex: All·Age: 12+

Code: NCT05883748·Phase 2, Phase 3·Enrolling By Invitation

Reducing the Incidence of Symptomatic Brain Metastases With MRI Surveillance

for Brain Metastases

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT05692635·Phase 2·Recruiting

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Long-term Follow-up Study of Male Adults With Hemophilia B Previously Treated With Etranacogene Dezaparvovec (CSL222)

for Hemophilia B

15 locations incl. Phoenix

Sponsor: CSL Behring

Sex: Male·Age: 18+

Code: NCT05962398·Enrolling By Invitation

A Phase 1, Dose Escalation Trial of RP-A601 in Subjects With PKP2 Variant-Mediated Arrhythmogenic Cardiomyopathy (PKP2-ACM)

for PKP2 Arrhythmogenic Cardiomyopathy (PKP2-ACM)

3 locations incl. La Jolla

Sponsor: Rocket Pharmaceuticals Inc.

Sex: All·Age: 18+

Code: NCT05885412·Phase 1·Recruiting

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US National OCS Heart Perfusion (OHP) Registry

for Heart Transplant

37 locations incl. Phoenix

Sponsor: TransMedics

Sex: All·Age: All ages

Code: NCT05915299·Recruiting

Apply to this trial