Paid Clinical Trials in North Carolina

North Carolina has 2,944 paid clinical trials enrolling now across cities including Durham, Chapel Hill and Winston-Salem. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in North Carolina include Duke University Medical Center, UNC Health and Wake Forest Baptist, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 19, 2026.

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2,944 clinical trials

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A Study to Evaluate BMS-986470 in Healthy Volunteers and Participants With Sickle Cell Disease

for Anemia, Sickle Cell

20 locations incl. Birmingham

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06481306·Phase 1, Phase 2·Recruiting

Apply to this trial

Bomedemstat vs Hydroxyurea for Essential Thrombocythemia (MK-3543-007)

for Essential Thrombocythemia

22 locations incl. Glendale

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT06456346·Phase 3·Recruiting

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NIEHS Repository of Stored Biological Samples for Future Use

for Normal Physiology

1 location in Research Triangle Park

Sponsor: National Institute of Environmental Health Sciences (NIEHS)

Sex: All·Age: 18 - 100·Accepts healthy volunteers

Code: NCT05666739·Recruiting

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Comparison of Post-Inflammatory Pigment Alteration After Psoriasis Treatment (PIPA - Dermavant)

for ICD10 Code L40.9 for Psoriasis

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT05981118·Phase 2, Phase 3·Enrolling By Invitation

A Study Evaluating Atezolizumab, With or Without Bevacizumab, in Participants With Unresectable Hepatocellular Carcinoma and Child-pugh B7 and B8 Cirrhosis

for Hepatocellular Carcinoma

Drug: Atezolizumab

60 locations incl. Tucson

Sponsor: Genentech, Inc.

Sex: All·Age: 18+

Code: NCT06096779·Phase 2·Recruiting

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Lerapolturev (PVSRIPO) in GBM

for Recurrent Supratentorial Glioblastoma

1 location in Durham

Sponsor: Darell Bigner

Sex: All·Age: 18+

Code: NCT06177964·Phase 2·Recruiting

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Embo Registry; National Registry for Artery Embolization

for Chronic Pain

2 locations incl. Cary

Sponsor: Vascular Solutions of North Carolina

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06477965·Recruiting

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Predictors of Pain in Sickle Cell Disease

for Sickle Cell Disease

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 15 - 40

Code: NCT06139510·Recruiting

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A Study to Test the Effects and Safety of Riliprubart in People With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) for Which the Usual Treatments do Not Work

for Chronic Inflammatory Demyelinating Polyradiculoneuropathy

Drug: riliprubart

28 locations incl. Homewood

Sponsor: Sanofi

Sex: All·Age: 18+

Code: NCT06290128·Phase 3·Recruiting

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VO and Nivolumab vs Physician's Choice in Advanced Melanoma That Progressed on Anti-PD-1 & Anti-CTLA-4 Drugs [IGNYTE-3]

for Advanced Melanoma

Drug: Nivolumab

50 locations incl. Gilbert

Sponsor: Replimune, Inc.

Sex: All·Age: 12+

Code: NCT06264180·Phase 3·Recruiting

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Case Series on the Clinical Performance of VA Clavicle and Clavicle Hook Plate 2.7 Systems

for Clavicle

3 locations incl. Grand Rapids

Sponsor: AO Innovation Translation Center

Sex: All·Age: 18+

Code: NCT04921865·Recruiting

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Testing the Combination of the Anticancer Drug Durvalumab With Chemotherapy (Gemcitabine and Cisplatin) at Improving Outcomes for High-Risk Resectable Liver Cancer Before Surgery

for Resectable Intrahepatic Cholangiocarcinoma

Drug: Durvalumab

58 locations incl. Irvine

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06050252·Phase 2·Recruiting

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A Study to Test the Long-term Safety and Tolerability of Brivaracetam in Study Participants With Childhood Absence Epilepsy or Juvenile Absence Epilepsy

for Childhood Absence Epilepsy

5 locations incl. Birmingham

Sponsor: UCB Biopharma SRL

Sex: All·Age: 2+

Code: NCT06315322·Phase 3·Recruiting

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A Phase 1 Study of CTIM-76 in Patients With Recurring Ovarian Cancer and Other Advanced Solid Tumors

for Platinum-resistant Ovarian Cancer

13 locations incl. Little Rock

Sponsor: Context Therapeutics Inc.

Sex: All·Age: 18+

Code: NCT06515613·Phase 1·Recruiting

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STRW-T Intervention for Autistic Adolescents in 11th and 12th Grade

for Autism Spectrum Disorder

2 locations incl. Carrboro

Sponsor: Children's Hospital Medical Center, Cincinnati

Sex: All·Age: 15 - 21

Code: NCT06552286·Recruiting

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Ivosidenib in Participants With Locally Advanced or Metastatic Conventional Chondrosarcoma Untreated or Previously Treated With 1 Systemic Treatment Regimen

for Locally Advanced or Metastatic Conventional Chondrosarcoma With an IDH1 Mutation, Untreated or Previously Treated With 1 Systemic Treatment Regimen

22 locations incl. Los Angeles

Sponsor: Servier Bio-Innovation LLC

Sex: All·Age: 18+

Code: NCT06127407·Phase 3·Recruiting

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Evaluating Treatments for Suicidal Veterans With PTSD

for Self-directed Violence

4 locations incl. Minneapolis

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT05974631·Recruiting

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A Study to Assess Adverse Events, Change in Disease Activity, and How the Drug Moves Through the Body in Children With Juvenile Psoriatic Arthritis (jPsA) Receiving Subcutaneously Injected Risankizumab or Adalimumab

for Juvenile Psoriatic Arthritis

Drug: Risankizumab

10 locations incl. Little Rock

Sponsor: AbbVie

Sex: All·Age: 5 - 17

Code: NCT06100744·Phase 3·Recruiting

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Neoadjuvant Durvalumab and Tremelimumab With and Without Chemotherapy for Mesothelioma

for Mesothelioma

Drug: Tremelimumab

2 locations incl. Durham

Sponsor: Baylor College of Medicine

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05932199·Phase 1, Phase 2·Recruiting

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Continuation Protocol for Obstructive Sleep Apnea (OSA)

for OSA

93 locations incl. Birmingham

Sponsor: Apnimed

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06566820·Phase 3·Enrolling By Invitation

SOC Chemotherapy +/- Tocilizumab for Triple Negative and ER-low Breast Cancers

for Metastatic Breast Cancer

Drug: Tocilizumab

6 locations incl. Atlanta

Sponsor: Kathy Miller

Sex: All·Age: 18+

Code: NCT05846789·Phase 2·Recruiting

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RESET-SSc: An Open-Label Study to Evaluate the Safety and Efficacy of CABA-201, a CD19-CAR T Cell Therapy, in Subjects With Systemic Sclerosis

for Systemic Sclerosis

10 locations incl. New Haven

Sponsor: Cabaletta Bio

Sex: All·Age: 18 - 75

Code: NCT06328777·Phase 1, Phase 2·Recruiting

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Cereset Research for Performance Improvement in a Hospital Nursing Unit

for Health Personnel

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18 - 100·Accepts healthy volunteers

Code: NCT06378554·Enrolling By Invitation

Functional Incremental Stepping in Place Test (F-IST) Validation

for Intensive Care Medicine

2 locations incl. Boca Raton

Sponsor: Kirby Mayer

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06853236·Recruiting

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Comparing Dara-VCD Chemotherapy Plus Stem Cell Transplant to Dara-VCD Chemotherapy Alone for People Who Have Newly Diagnosed AL Amyloidosis

for AL Amyloidosis

117 locations incl. Goodyear

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT06022939·Phase 3·Recruiting

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Causal Role of Top-Down Theta Oscillations in Prioritization

for Working Memory

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18 - 80

Code: NCT06252532·Enrolling By Invitation

Observation of Environment and Reproductive-Endocrine Effects

for Hypogonadism

1 location in Research Triangle Park

Sponsor: National Institute of Environmental Health Sciences (NIEHS)

Sex: All·Age: 8 - 99

Code: NCT06280807·Recruiting

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Rifaximin for the Secondary Prevention of Recurrent Pouchitis

for Pouchitis

2 locations incl. New York

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18 - 74

Code: NCT06312683·Phase 4·Recruiting

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Dichoptic Treatment for Amblyopia in Children 4 to 7 Years of Age

for Amblyopia

73 locations incl. Birmingham

Sponsor: Jaeb Center for Health Research

Sex: All·Age: 4 - 7

Code: NCT06380517·Phase 3·Recruiting

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Intervention to Improve Communication and Medication Adherence in Lupus

for Systemic Lupus Erythematosus

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18 - 90

Code: NCT06458075·Recruiting

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Global Paradise System US Post Approval Study

for Hypertension

39 locations incl. Sacramento

Sponsor: ReCor Medical, Inc.

Sex: All·Age: 18+

Code: NCT06297291·Recruiting

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A Study of Efgartigimod PH20 SC in Children Between 2 and Less Than 18 Years of Age With Generalized Myasthenia Gravis

for Generalized Myasthenia Gravis

Drug: Efgartigimod PH20 SC

3 locations incl. Charlotte

Sponsor: argenx

Sex: All·Age: 2 - 17

Code: NCT06392386·Phase 2, Phase 3·Recruiting

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A Study of Assessment on Safety and Effectiveness of BWI Pulsed Field Ablation With OMNYPULSE Catheter for the Treatment of Paroxysmal Atrial Fibrillation (PAF)

for Atrial Fibrillation

43 locations incl. Phoenix

Sponsor: Biosense Webster, Inc.

Sex: All·Age: 18 - 80

Code: NCT06455098·Recruiting

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RSV Vaccine Pregnancy Registry

for Respiratory Syncytial Virus (RSV)

1 location in Wilmington

Sponsor: CorEvitas

Sex: Female·Age: 18 - 50·Accepts healthy volunteers

Code: NCT06521944·Recruiting

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RCT of Sensor-controlled Digital Game for Hypertension Self-care in a Native American Community

for Hypertension

1 location in Chapel Hill

Sponsor: University of Texas at Austin

Sex: All·Age: 18+

Code: NCT05671406·Recruiting

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Study of Autologous CAR-T Cells Targeting B7-H3 in TNBC iC9-CAR.B7-H3 T Cells

for Breast Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT06347068·Phase 1·Recruiting

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A Study to Learn About the Study Medicine PF-07934040 When Given Alone or With Other Anti-cancer Therapies in People With Advanced Solid Tumors That Have a Genetic Mutation.

for Carcinoma, Pancreatic Ductal

26 locations incl. Fayetteville

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT06447662·Phase 1·Recruiting

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BiVACOR® Total Artificial Heart Early Feasibility Study

for Heart Failure

4 locations incl. Phoenix

Sponsor: BiVACOR Inc.

Sex: All·Age: 18 - 70

Code: NCT06174103·Recruiting

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Neoadjuvant Chemotherapy, Excision And Observation vs Chemoradiotherapy For Rectal Cancer

for Rectal Cancer

101 locations incl. Phoenix

Sponsor: Canadian Cancer Trials Group

Sex: All·Age: 18+

Code: NCT06205485·Phase 3·Recruiting

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A Study Using Nivolumab, in Combination With Chemotherapy Drugs to Treat Nasopharyngeal Carcinoma (NPC)

for Stage II Nasopharyngeal Carcinoma AJCC v8

Drug: Nivolumab

76 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: Up to 21

Code: NCT06064097·Phase 2·Recruiting

Apply to this trial