Paid Clinical Trials in North Carolina

North Carolina has 2,930 paid clinical trials enrolling now across cities including Durham, Chapel Hill and Winston-Salem. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in North Carolina include Duke University Medical Center, UNC Health and Wake Forest Baptist, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

Filter results

Filter results

State

City

Phase

Study type

Intervention

Recruitment status

Condition

Sex

Age

Healthy volunteers only

2,930 clinical trials

↓ Download CSV

A Study to Assess the Efficacy and Safety of Induction and Maintenance Therapy With Afimkibart (RO7790121) in Participants With Moderately to Severely Active Crohn's Disease

for Moderately to Severely Active Crohns Disease

Drug: Afimkibart

92 locations incl. Dothan

Sponsor: Hoffmann-La Roche

Sex: All·Age: 16 - 80

Code: NCT06819878·Phase 3·Recruiting

Apply to this trial

Breastfeeding Intervention to Prevent Obesity Among Children

for Breastfeeding Self-Efficacy

2 locations incl. Greensboro

Sponsor: University of North Carolina, Greensboro

Sex: All·Age: 5 Days+·Accepts healthy volunteers

Code: NCT06921382·Recruiting

Apply to this trial

A Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) as Monotherapy and in Combination With Pembrolizumab (MK-3475) in Participants With Triple-Negative Breast Cancer (MK-2870-011/TroFuse-011)

for Triple Negative Breast Neoplasms

38 locations incl. Mobile

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT06841354·Phase 3·Recruiting

Apply to this trial

Intra-Articular Catheter Total Knee Arthroplasty

for Continuous Local Infiltration Analgesia

1 location in Charlotte

Sponsor: OrthoCarolina Research Institute, Inc.

Sex: All·Age: 18+

Code: NCT06580899·Phase 4·Enrolling By Invitation

Testing the Addition of the Anti-Cancer Drug Tivozanib to Immunotherapy (Pembrolizumab) After Surgery to Remove All Known Sites of Kidney Cancer

for Clear Cell Renal Cell Carcinoma

414 locations incl. Phoenix

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+

Code: NCT06661720·Phase 3·Recruiting

Apply to this trial

Phase III Study Investigating Heart Failure and Cardiovascular Death With Baxdrostat in Combination With Dapagliflozin

for Heart Failure

Drug: Dapagliflozin

194 locations incl. Birmingham

Sponsor: AstraZeneca

Sex: All·Age: 40+

Code: NCT06677060·Phase 3·Recruiting

Apply to this trial

Adding Neurocognitive Component to Balance Test

for Anterior Cruciate Ligament Injuries

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18 - 25·Accepts healthy volunteers

Code: NCT06827483·Enrolling By Invitation

Belumosudil to Block Chronic Lung Allograft Dysfunction (CLAD) in High Risk Lung Transplant Recipients

for Lung Transplant

11 locations incl. Los Angeles

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 12+

Code: NCT06476132·Phase 2·Recruiting

Apply to this trial

Testing Olaparib for One or Two Years, With or Without Bevacizumab, to Treat Ovarian Cancer

for Fallopian Tube Endometrioid Adenocarcinoma

Drug: Bevacizumab

658 locations incl. Birmingham

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT06580314·Phase 3·Recruiting

Apply to this trial

A Study to Compare the Efficacy and Safety of BMS-986393 Versus Standard Regimens in Adult Participants With Relapsed or Refractory and Lenalidomide-exposed Multiple Myeloma (QUINTESSENTIAL-2)

for Relapsed or Refractory Multiple Myeloma (RRMM)

22 locations incl. Birmingham

Sponsor: Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

Sex: All·Age: 18+

Code: NCT06615479·Phase 3·Recruiting

Apply to this trial

Patient Descriptors Of Cancer-Related Fatigue: A Mixed Methods Pilot Study Of Cancer Survivors

for Cancer

3 locations incl. Charlotte

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT06634381·Recruiting

Apply to this trial

A Phase 2a Proof of Concept Open-Label, Randomized, Controlled Study to Evaluate the Safety and Efficacy of MDI-1228-mesylate Gel Compared With Standard of Care Alone in Patients With Diabetic Foot Ulcers

for Diabetic Foot Ulcer

1 location in Durham

Sponsor: Zhuhai Rui-Inno Pharmaceutical Technology Co., Ltd.

Sex: All·Age: 18 - 75

Code: NCT06852976·Phase 2·Recruiting

Apply to this trial

Stress Trajectories and Anhedonia in Adolescence Research Study

for Anhedonia

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 13 - 15·Accepts healthy volunteers

Code: NCT07040449·Recruiting

Apply to this trial

A Study to Learn About the Study Medicine Called Rimegepant in Women When Used for Intermittent Prevention of Menstrual Migraine

for Menstrual Migraine

Drug: Rimegepant

32 locations incl. Phoenix

Sponsor: Pfizer

Sex: Female·Age: 18 - 45

Code: NCT06641466·Phase 3·Recruiting

Apply to this trial

BMS-986489 (Atigotatug + Nivolumab) vs Durvalumab in Limited-stage Small-cell Lung Cancer (TIGOS-LS)

for Limited Stage Small Cell Lung Cancer

Drug: Durvalumab

33 locations incl. Daphne

Sponsor: SCRI Development Innovations, LLC

Sex: All·Age: 18+

Code: NCT06773910·Phase 2·Recruiting

Apply to this trial

A Study to Investigate the Safety and Efficacy of IOV-3001 in Adults With Advanced Melanoma Who Will Receive Lifileucel

for Unresectable Melanoma

Drug: Lifileucel

3 locations incl. Denver

Sponsor: Iovance Biotherapeutics, Inc.

Sex: All·Age: 18 - 70

Code: NCT06940739·Phase 1, Phase 2·Recruiting

Apply to this trial

Preventing Suicidal Behavior With Diverse High-Risk Youth in Acute Care Settings

for Suicide, Attempted

6 locations incl. St. Petersburg

Sponsor: Johns Hopkins University

Sex: All·Age: 12 - 24

Code: NCT06151158·Recruiting

Apply to this trial

Peer Support for Adolescents and Emerging Adults With Sickle Cell Pain

for Pain

14 locations incl. Mobile

Sponsor: University of Pittsburgh

Sex: All·Age: 16 - 30

Code: NCT06374238·Recruiting

Apply to this trial

A Study of Zasocitinib in Adults With Psoriatic Arthritis Who Have or Have Not Been Treated With Biologic Medicines

for Psoriatic Arthritis

Drug: Zasocitinib

21 locations incl. Mesa

Sponsor: Takeda

Sex: All·Age: 18+

Code: NCT06671496·Phase 3·Recruiting

Apply to this trial

Multi-Site Detection of Barrett's Esophagus in Patients Without Chronic GERD Symptoms

for Barrett Esophagus

5 locations incl. Aurora

Sponsor: Case Comprehensive Cancer Center

Sex: All·Age: 50+·Accepts healthy volunteers

Code: NCT06687603·Recruiting

Apply to this trial

Alleviant ALLAY-HFrEF Study

for Heart Failure

35 locations incl. Los Angeles

Sponsor: Alleviant Medical, Inc.

Sex: All·Age: 18+

Code: NCT06812533·Enrolling By Invitation

A Safety and Efficacy Study Evaluating CTX112 in Adult Subjects With Refractory Autoimmune Disease

for SLE (Systemic Lupus)

6 locations incl. Redwood City

Sponsor: CRISPR Therapeutics

Sex: All·Age: 18 - 70

Code: NCT06925542·Phase 1·Recruiting

Apply to this trial

Phase 2 Study of ALXN2030 in Patients With Antibody-Mediated Rejection After Kidney Transplantation

for Antibody-Mediated Rejection

23 locations incl. Birmingham

Sponsor: Alexion Pharmaceuticals, Inc.

Sex: All·Age: 18 - 75

Code: NCT06744647·Phase 2·Recruiting

Apply to this trial

A Study of VRC07-523LS, PGT121.414.LS, and PGDM1400LS Broadly Neutralizing Monoclonal Antibodies Given Intravenously in Adult Participants Without HIV

for HIV

13 locations incl. Birmingham

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT06812494·Phase 2·Recruiting

Apply to this trial

VisR Ultrasound for Noninvasively Interrogating Stromal Collagen Organization in Women as a Breast Cancer Biomarker: Evaluation of Anisotropy in Cancer Patients

for Breast Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: Female·Age: 20 - 90

Code: NCT06878547·Recruiting

Apply to this trial

APOL1 Genotyping CTA Clinical Performance Study

for APOL1-mediated Kidney Disease

1 location in Durham

Sponsor: Almac Diagnostic Services LLC

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT06839833·Recruiting

Apply to this trial

Remote Ischemic Conditioning and Spinal Reflex Modulation

for Healthy Young Adults

1 location in Greenville

Sponsor: East Carolina University

Sex: All·Age: 18 - 40·Accepts healthy volunteers

Code: NCT06860464·Enrolling By Invitation

A Study to Investigate Effectiveness of Tirzepatide Following Initiation of Ixekizumab in Participants With Active Psoriatic Arthritis and Overweight or Obesity in Clinical Practice (TOGETHER AMPLIFY-PsA)

for Psoriatic Arthritis

Drug: Tirzepatide

53 locations incl. Avondale

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT06864026·Phase 4·Recruiting

Apply to this trial

Ultrasound Simulation Case-based Workshop Implementation and Impact Assessment

for Point-of-care Ultrasound

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06960837·Recruiting

Apply to this trial

A Study to Investigate the Efficacy and Safety of Sonrotoclax Plus Zanubrutinib Compared With Placebo Plus Zanubrutinib in Adults With Relapsed/Refractory Mantle Cell Lymphoma (CELESTIAL-RRMCL)

for Mantle Cell Lymphoma

Drug: Sonrotoclax

37 locations incl. Birmingham

Sponsor: BeOne Medicines

Sex: All·Age: 18+

Code: NCT06742996·Phase 3·Recruiting

Apply to this trial

Dose-Ranging Safety, Tolerability, and Efficacy Study of AZD2373 in Participants With APOL1-Mediated Kidney Disease

for APOL1-Mediated Kidney Disease

67 locations incl. Alabaster

Sponsor: AstraZeneca

Sex: All·Age: 18 - 65

Code: NCT06824987·Phase 2·Recruiting

Apply to this trial

A Study to Learn About Study Medicine ALTA3263 in Adults With Advanced Solid Tumors With KRAS Mutations

for Cancer

12 locations incl. Orlando

Sponsor: Alterome Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT06835569·Phase 1·Recruiting

Apply to this trial

INHANCE Stemless Reverse Shoulder IDE

for Arthroplasty

19 locations incl. Irvine

Sponsor: DePuy Orthopaedics

Sex: All·Age: 22+

Code: NCT06323980·Recruiting

Apply to this trial

An Ophthalmic Safety Study in Patients With Breast Cancer

for Ophthalmic Safety in Patients With Breast Cancer

12 locations incl. La Jolla

Sponsor: AstraZeneca

Sex: All·Age: 18 - 130

Code: NCT06767462·Recruiting

Apply to this trial

A Study of Mocertatug Rezetecan in Combination With Anti-cancer Therapies for Advanced Solid Tumors

for Tumours, Gynecological

4 locations incl. La Jolla

Sponsor: GlaxoSmithKline

Sex: All·Age: 18+

Code: NCT06796907·Phase 1, Phase 2·Recruiting

Apply to this trial

Effectiveness of Central Oncology Navigation and the Use of an ORN

for Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT06618274·Recruiting

Apply to this trial

A Study of Zasocitinib in Adults With Psoriatic Arthritis Who Have Not Taken Biologic Medicines

for Psoriatic Arthritis

Drug: Zasocitinib

54 locations incl. Chandler

Sponsor: Takeda

Sex: All·Age: 18+

Code: NCT06671483·Phase 3·Recruiting

Apply to this trial

A Phase III Renal Outcomes and Cardiovascular Mortality Study to Investigate the Efficacy and Safety of Baxdrostat in Combination With Dapagliflozin in Participants With Chronic Kidney Disease and High Blood Pressure

for Chronic Kidney Disease and Hypertension

Drug: Dapagliflozin

132 locations incl. Fairhope

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06742723·Phase 3·Recruiting

Apply to this trial

A Study to Evaluate ALN-4324 in Overweight to Obese Healthy Volunteers and in Overweight to Obese Patients With T2DM

for Obese or Overweight Healthy Volunteers

7 locations incl. Montclair

Sponsor: Alnylam Pharmaceuticals

Sex: All·Age: 18 - 75·Accepts healthy volunteers

Code: NCT06845202·Phase 1, Phase 2·Recruiting

Apply to this trial

EIM Via the Myolex mScan as an ALS Biomarker

for Amyotrophic Lateral Sclerosis

6 locations incl. Phoenix

Sponsor: Beth Israel Deaconess Medical Center

Sex: All·Age: 18+

Code: NCT06491732·Recruiting

Apply to this trial