Paid Clinical Trials in Minnesota

Minnesota has 2,364 paid clinical trials enrolling now across cities including Rochester, Minneapolis and Saint Paul. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Minnesota include Mayo Clinic and University of Minnesota Medical Center, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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2,364 clinical trials

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Group Meaning-Centered Psychotherapy for the Improvement of Wellbeing in Caregivers of Patients With Serious Illness

for Advanced Malignant Solid Neoplasm

2 locations incl. Jacksonville

Sponsor: Mayo Clinic

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06630351·Enrolling By Invitation

Measuring if Immunotherapy Plus Chemotherapy is Better Than Chemotherapy Alone for Patients With Aggressive Poorly Differentiated Sarcomas

for Metastatic Dedifferentiated Liposarcoma

245 locations incl. Phoenix

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06422806·Phase 3·Recruiting

Apply to this trial

Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)

for Treatment Resistant Depression

24 locations incl. Birmingham

Sponsor: Abbott Medical Devices

Sex: All·Age: 22 - 70

Code: NCT06423430·Recruiting

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The TRICURE EFS Study

for Tricuspid Valve Regurgitation

8 locations incl. Atlanta

Sponsor: TRiCares

Sex: All·Age: 18+

Code: NCT06506942·Recruiting

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A Phase II Study of Ensifentrine in Non-Cystic Fibrosis Bronchiectasis

for Non-cystic Fibrosis Bronchiectasis

29 locations incl. Birmingham

Sponsor: Verona Pharma, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA

Sex: All·Age: 18 - 80

Code: NCT06559150·Phase 2·Recruiting

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mHealth Estimate-based Algorithms Signaling Upcoming Recurrence of Episodes in Bipolar Disorders

for Bipolar Disorder

1 location in Minneapolis

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT06204705·Recruiting

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A Study With Combinations of Anti-LAG-3 and Anti-PD-1 Antibodies in Adult Participants With Advanced or Metastatic Melanoma (Harmony Head-to-Head)

for Melanoma

104 locations incl. Chandler

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 18+

Code: NCT06246916·Phase 3·Recruiting

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A Study of Vemurafenib and Obinutuzumab Compared to Cladribine and Rituximab in People With Hairy Cell Leukemia (HCL)

for Hairy Cell Leukemia

Drug: Rituximab

10 locations incl. Boston

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: 18+

Code: NCT06561360·Phase 2·Recruiting

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Mayo Clinic Tapestry 2.0: Applying Multi-Omics for Scientific Discovery

for Genetic Predisposition

3 locations incl. Scottsdale

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT06456320·Enrolling By Invitation

Evaluating the Effects of a Fermented Diet on Microbiome Diversity in Individuals With Long COVID

for Long COVID

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06560554·Enrolling By Invitation

Safety and Efficacy Study of TX103 CAR-T Cell Therapy for Recurrent or Progressive Grade 4 Glioma.

for High-grade Glioma

3 locations incl. Phoenix

Sponsor: Tcelltech Inc.

Sex: All·Age: 18 - 75

Code: NCT06482905·Phase 1·Recruiting

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A Study Evaluating Efruxifermin in Subjects With Compensated Cirrhosis Due to NASH/MASH

for NASH - Nonalcoholic Steatohepatitis

Drug: Efruxifermin

168 locations incl. Birmingham

Sponsor: Akero Therapeutics, Inc

Sex: All·Age: 18 - 80

Code: NCT06528314·Phase 3·Recruiting

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Study of Targeted Therapies for the Treatment of Adult Participants With Moderate to Severe Crohn's Disease

for Crohn's Disease

64 locations incl. Dothan

Sponsor: AbbVie

Sex: All·Age: 18 - 75

Code: NCT06548542·Phase 2·Recruiting

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A Study of TX000045 in Patients With Pulmonary Hypertension Secondary to Heart Failure With Preserved Ejection Fraction (the APEX Study)

for Pulmonary Hypertension

31 locations incl. Phoenix

Sponsor: Tectonic Therapeutic

Sex: All·Age: 18 - 83

Code: NCT06616974·Phase 2·Recruiting

Apply to this trial

Prospective Multicenter Research on Donor and Recipient Management Strategies to Improve Lung Transplant Outcomes

for Lung Transplant

18 locations incl. Los Angeles

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT06399302·Recruiting

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PIvotal Trial of the KARDION Cory P4 MechANical Circulatory SupporT SystEm

for Coronary Artery Disease

18 locations incl. Chandler

Sponsor: Kardion Inc

Sex: All·Age: 18 - 90

Code: NCT06445608·Recruiting

Apply to this trial

AltaValve Pivotal Trial

for Mitral Regurgitation

20 locations incl. Phoenix

Sponsor: 4C Medical Technologies, Inc.

Sex: All·Age: 18+

Code: NCT06465745·Recruiting

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Methadone Versus Intrathecal Hydromorphone for Postoperative Pain Relief in Gynecologic Cancer Undergoing Surgery

for Malignant Female Reproductive System Neoplasm

1 location in Rochester

Sponsor: Mayo Clinic

Sex: Female·Age: All ages

Code: NCT06525740·Phase 4·Recruiting

Apply to this trial

Titanium vs. PEEK Fusion Devices in 1 Level TLIF

for Spine Fusion

1 location in Minneapolis

Sponsor: Twin Cities Spine Center

Sex: All·Age: 18 - 70

Code: NCT05691062·Phase 4·Enrolling By Invitation

Helmsley 3.0: Abbreviated MRE

for Crohn's Disease

2 locations incl. Rochester

Sponsor: Children's Hospital Medical Center, Cincinnati

Sex: All·Age: 10+

Code: NCT06533228·Recruiting

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EASi-KIDNEY™ (The Studies of Heart & Kidney Protection With BI 690517 in Combination With Empagliflozin)

for Kidney Disease, Chronic

Drug: Empagliflozin

41 locations incl. Huntsville

Sponsor: Boehringer Ingelheim

Sex: All·Age: 18+

Code: NCT06531824·Phase 3·Recruiting

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A Study of Bleeding and Treatment in Participants With Von Willebrand Disease

for Von Willebrand Disease (VWD)

13 locations incl. Phoenix

Sponsor: Hemab ApS

Sex: All·Age: 16+

Code: NCT06610201·Recruiting

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LMN-201 for Prevention of C. Difficile Infection Recurrence

for Clostridioides Difficile Infection

16 locations incl. Escondido

Sponsor: Lumen Bioscience, Inc.

Sex: All·Age: 18+

Code: NCT05330182·Phase 2, Phase 3·Recruiting

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A Study to Learn More About How Well Sevabertinib Works and How Safe it is Compared With Standard Treatment, in Participants Who Have Advanced Non-small Cell Lung Cancer (NSCLC) With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2)

for Advanced Non-small Cell Lung Cancer

27 locations incl. Newport Beach

Sponsor: Bayer

Sex: All·Age: 18+

Code: NCT06452277·Phase 3·Recruiting

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A Study Comparing Anitocabtagene Autoleucel to Standard of Care Therapy in Participants With Relapsed/ Refractory Multiple Myeloma

for Multiple Myeloma

50 locations incl. Gilbert

Sponsor: Kite, A Gilead Company

Sex: All·Age: 18+

Code: NCT06413498·Phase 3·Recruiting

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Study of Targeted Therapy vs. Chemotherapy in Patients With Thyroid Cancer

for Refractory Differentiated Thyroid Gland Carcinoma

301 locations incl. Anchorage

Sponsor: ECOG-ACRIN Cancer Research Group

Sex: All·Age: 18+

Code: NCT06475989·Phase 3·Recruiting

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HAPPINESS: cHAnging the Perceived Pain INtEnSity in Populations With Spinal Cord Injury and With Health Disparities: A Feasibility Study

for Spinal Cord Injuries

3 locations incl. Miami

Sponsor: University of Minnesota

Sex: All·Age: 18+

Code: NCT06140355·Recruiting

Apply to this trial

Social Support Counseling Intervention for Kidney Transplant Candidates

for Kidney Transplant

1 location in Minneapolis

Sponsor: Hennepin Healthcare Research Institute

Sex: All·Age: 18+

Code: NCT06147076·Recruiting

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Adaptive Radiation Therapy (ART) Stereotactic Ablative Body Radiotherapy (SABR) for Primary Localized Prostate Cancer

for Localized Prostate Adenocarcinoma

5 locations incl. Albert Lea

Sponsor: Mayo Clinic

Sex: Male·Age: 18+

Code: NCT06325046·Recruiting

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Addition of a Pectoserratus Block to Interscalene Block in Patients Undergoing Total Shoulder Replacement

for Total Shoulder Arthroplasty

1 location in Minneapolis

Sponsor: University of Minnesota

Sex: All·Age: 18 - 85

Code: NCT06143306·Phase 4·Recruiting

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A Phase I/II, Dose Finding and Optimization Study of [177Lu]Lu-NeoB in Combination With Capecitabine in Patients With GRPR+, ER+, HER2- Metastatic Breast Cancer After Progression on Previous Endocrine Therapy in Combination With a CDK4/6 Inhibitor.

for Breast Cancer

5 locations incl. Los Angeles

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18 - 100

Code: NCT06247995·Phase 1, Phase 2·Recruiting

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Concurrent Aerobic Exercise and Cognitive Training to Prevent Alzheimer's in At-risk Older Adults (The Exergames Telerehabilitation Study)

for At Risk for AD-dementia, With Subjective Cognitive Decline

1 location in Minneapolis

Sponsor: University of Minnesota

Sex: All·Age: 65 - 99·Accepts healthy volunteers

Code: NCT06340659·Recruiting

Apply to this trial

EFS of the DUO System for Tricuspid Regurgitation

for Tricuspid Regurgitation

12 locations incl. Phoenix

Sponsor: CroiValve Limited

Sex: All·Age: 18+

Code: NCT05913908·Recruiting

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A Study Comparing the Efficacy and Safety of Zanidatamab to Trastuzumab, Each in Combination With Physician's Choice Chemotherapy, for the Treatment of Participants With Metastatic HER2-positive Breast Cancer

for Metastatic HER2-positive Breast Cancer

48 locations incl. Phoenix

Sponsor: Jazz Pharmaceuticals

Sex: All·Age: 18+

Code: NCT06435429·Phase 3·Recruiting

Apply to this trial

SuperSaturated Oxygen Comprehensive Observational Registry

for STEMI - ST Elevation Myocardial Infarction

25 locations incl. Fountain Valley

Sponsor: TherOx

Sex: All·Age: 18 - 80

Code: NCT06438315·Recruiting

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Phase 3 Study of T-DXd and Rilvegostomig Versus SoC in Advanced HER2-expressing Biliary Tract Cancer

for Biliary Tract Cancer

Drug: Rilvegostomig

48 locations incl. Scottsdale

Sponsor: AstraZeneca

Sex: All·Age: 18 - 99

Code: NCT06467357·Phase 3·Recruiting

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Melodi Matrix™ in Breast Reconstruction

for Breast Reconstruction

10 locations incl. Palo Alto

Sponsor: Melodi Health, Inc.

Sex: Female·Age: 22+

Code: NCT06027996·Recruiting

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Targeted Treatment for Advanced Non-Small Cell Lung Cancer That Has a MET Exon 14 Skipping Gene Change (An Expanded Lung-MAP Treatment Trial)

for Recurrent Lung Non-Small Cell Carcinoma

266 locations incl. Daphne

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18 Minutes+

Code: NCT06031688·Phase 2·Recruiting

Apply to this trial

A Study to Assess Growth in Children With Idiopathic Short Stature

for Idiopathic Short Stature

40 locations incl. Phoenix

Sponsor: BioMarin Pharmaceutical

Sex: All·Age: 2 - 16

Code: NCT06309979·Recruiting

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Crohn's Disease: Efficacy, Safety, and Pharmacokinetics of Upadacitinib in Pediatric Subjects With Moderately to Severely Active Crohn's Disease

for Crohn's Disease

Drug: Upadacitinib

12 locations incl. Oakland

Sponsor: AbbVie

Sex: All·Age: 2 - 17

Code: NCT06332534·Phase 3·Recruiting

Apply to this trial