Paid Clinical Trials in Massachusetts

Massachusetts has 3,602 paid clinical trials enrolling now across cities including Boston, Worcester and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Massachusetts include Mass General Hospital, Dana-Farber and Brigham and Women's, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 19, 2026.

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3,602 clinical trials

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Study of Efficacy and Safety of Iptacopan in Patients With C3 Glomerulopathy.

for C3G

Drug: Iptacopan

13 locations incl. Aurora

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 12 - 60

Code: NCT04817618·Phase 3·Recruiting

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Low-Intensity Focused Ultrasound Pulsation (LIFUP) for the Treatment of Generalized Anxiety Disorder (GAD)

for Generalized Anxiety Disorder

3 locations incl. Los Angeles

Sponsor: University of California, Los Angeles

Sex: All·Age: 18 - 65

Code: NCT04557891·Recruiting

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A Study to Evaluate the Benefits and Risks of Conversion of Existing Adolescent Kidney Transplant Recipients Aged 12 to <18 Years to a Belatacept-based Immunosuppressive Regimen as Compared to Continuation of a Calcineurin Inhibitor-based Regimen, and Their Adherence to Immunosuppressive Medications

for Renal Allograft Recipients

15 locations incl. Birmingham

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 12 - 17

Code: NCT04877288·Phase 3·Recruiting

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Targeted Therapy to Increase RAI Uptake in Metastatic DTC

for Papillary Thyroid Cancer

8 locations incl. San Francisco

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 0+

Code: NCT05024929·Recruiting

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A Study of Nipocalimab Administered to Adults With Generalized Myasthenia Gravis

for Myasthenia Gravis

Drug: Nipocalimab

24 locations incl. Paradise Valley

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT04951622·Phase 3·Recruiting

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Improving Cognitive Function Through High-intensity Interval Training in Breast Cancer Patients Undergoing Chemotherapy

for Breast Cancer

1 location in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: Female·Age: 18+

Code: NCT04724499·Recruiting

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Abatacept for the Treatment of Common Variable Immunodeficiency With Interstitial Lung Disease

for Interstitial Lung Disease

6 locations incl. San Francisco

Sponsor: Children's Hospital Medical Center, Cincinnati

Sex: All·Age: 4+

Code: NCT04925375·Phase 2·Recruiting

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A Study of a New Way to Treat Children and Young Adults With a Brain Tumor Called NGGCT

for Central Nervous System Nongerminomatous Germ Cell Tumor

149 locations incl. Birmingham

Sponsor: Children's Oncology Group

Sex: All·Age: 3 - 29

Code: NCT04684368·Phase 2·Recruiting

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The Role of Wearable Devices in Predicting and Detecting Complications and Adverse Events

for Recovery

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT04824066·Recruiting

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A Novel Vaccine (EO2463) as Monotherapy and in Combination, for Treatment of Patients With Indolent Non-Hodgkin Lymphoma

for Follicular Lymphoma

4 locations incl. Boston

Sponsor: Enterome

Sex: All·Age: 18+

Code: NCT04669171·Phase 1, Phase 2·Recruiting

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Avo In R/R And Previously Untreated MCL

for Mantle Cell Lymphoma

3 locations incl. Chicago

Sponsor: Austin I Kim

Sex: All·Age: 18+

Code: NCT04855695·Phase 1, Phase 2·Recruiting

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Risk-adapted Therapy in HPV+ Oropharyngeal Cancer Using Circulating Tumor (ct)HPV DNA Profile - The ReACT Study

for HPV-Associated Oropharyngeal Squamous Cell Carcinoma

2 locations incl. Boston

Sponsor: Jonathan Schoenfeld, MD, MPH

Sex: All·Age: 22+

Code: NCT04900623·Phase 2·Recruiting

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Contributions of mTBI to Neurodegeneration Due to Chronic Traumatic Encephalopathy (CTE) and Alzheimer's Disease (AD)

for Mild Traumatic Brain Injury

1 location in Boston

Sponsor: VA Office of Research and Development

Sex: All·Age: 30 - 90·Accepts healthy volunteers

Code: NCT04124029·Recruiting

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Detection of Small Fiber Neuropathy Using Skin Properties

for Small Fiber Neuropathy

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT04759443·Recruiting

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Veterans Affairs Seamless Phase II/III Randomized Trial of STAndard Systemic theRapy With or Without PET-directed Local Therapy for Oligometastatic pRosTate Cancer

for Prostate Cancer

20 locations incl. Long Beach

Sponsor: VA Office of Research and Development

Sex: Male·Age: 18+

Code: NCT04787744·Phase 2, Phase 3·Recruiting

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BostonGene-Integrated Genomic Registry (BIGR)

for Malignancy

1 location in Waltham

Sponsor: BostonGene

Sex: All·Age: 18+

Code: NCT04991922·Recruiting

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Folfox+Irinotecan+Chemort In Esophageal Cancer

for Gastroesophageal Junction Adenocarcinoma

Drug: Irinotecan

3 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT04656041·Phase 2·Recruiting

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Study of TJ033721 (Givastomig) in Subjects With Advanced or Metastatic Solid Tumors

for Solid Tumor

Drug: Givastomig

11 locations incl. Orange

Sponsor: I-Mab Biopharma US Limited

Sex: All·Age: 18+

Code: NCT04900818·Phase 1·Recruiting

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SEVENFACT® for Bleeding Events in Hemophilia With Inhibitors

for Hemophilia A With Inhibitor

21 locations incl. Phoenix

Sponsor: American Thrombosis and Hemostasis Network

Sex: All·Age: 12 - 100

Code: NCT04647227·Phase 4·Recruiting

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Study of the Long-Term Safety and Outcomes of Treating Pulmonary Embolism With the Indigo Aspiration System

for Pulmonary Embolism

57 locations incl. Long Beach

Sponsor: Penumbra Inc.

Sex: All·Age: 18+

Code: NCT04798261·Recruiting

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De-Escalation of Breast Radiation Trial for Hormone Sensitive, HER-2 Negative, Oncotype Recurrence Score Less Than or Equal to 18 Breast Cancer (DEBRA)

for Stage I Breast Cancer

812 locations incl. Birmingham

Sponsor: NRG Oncology

Sex: All·Age: 50 - 70

Code: NCT04852887·Phase 3·Recruiting

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A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Participants With Breast Cancer

for Inoperable, Locally Advanced or Metastatic, ER-positive Breast Cancer

12 locations incl. Duarte

Sponsor: Hoffmann-La Roche

Sex: Female·Age: 18+

Code: NCT04802759·Phase 1, Phase 2·Recruiting

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Distal Evaluation of Functional Performance with Intravascular Sensors to Assess the Narrowing Effect: Guided Physiologic Stenting

for Coronary Artery Disease

40 locations incl. Birmingham

Sponsor: Philips Clinical & Medical Affairs Global

Sex: All·Age: 18+

Code: NCT04451044·Enrolling By Invitation

ATEMPT 2.0: Adjuvant T-DM1 vs TH

for Breast Cancer

53 locations incl. San Francisco

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT04893109·Phase 2·Recruiting

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The Neonatal Hemorrhagic Risk Assessment in Thrombocytopenia

for Neonatal Thrombocytopenia

4 locations incl. Boston

Sponsor: Karolinska Institutet

Sex: All·Age: 1 Day+

Code: NCT04598750·Recruiting

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Protocol For Genomically Profiling, Collecting, Archiving And Distributing Blood And Bone Marrow Specimens From Children And Young Adults With Hematologic Malignancy

for Leukemia

8 locations incl. Hartford

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: Up to 30

Code: NCT04968834·Recruiting

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Effects of Neuromodulation in Laryngeal Dystonia

for Laryngeal Dystonia

1 location in Boston

Sponsor: MGH Institute of Health Professions

Sex: All·Age: 21 - 85·Accepts healthy volunteers

Code: NCT05095740·Recruiting

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A Study of Codrituzumab in Children and Young Adults With Solid Tumors and Have Not Responded to Treatment or Have Come Back After Treatment

for Primary Extra-cranial Solid Tumor

5 locations incl. Los Angeles

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: 1 - 21

Code: NCT04928677·Phase 1·Recruiting

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Isatuximab in Patients With Monoclonal Gammopathy of Renal Significance

for Monoclonal Gammopathy

2 locations incl. Boston

Sponsor: Columbia University

Sex: All·Age: 18+

Code: NCT04614558·Phase 2·Recruiting

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Testing if High Dose Radiation Only to the Sites of Brain Cancer Compared to Whole Brain Radiation That Avoids the Hippocampus is Better at Preventing Loss of Memory and Thinking Ability

for Metastatic Lung Small Cell Carcinoma

223 locations incl. Phoenix

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT04804644·Phase 3·Recruiting

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Trial-Ready Cohort-Down Syndrome (TRC-DS)

for Down Syndrome

18 locations incl. Phoenix

Sponsor: University of Southern California

Sex: All·Age: 25 - 55

Code: NCT04165109·Recruiting

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Refining Local-Regional Therapy for IBC

for Breast Cancer

1 location in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: Female·Age: 18+

Code: NCT04636710·Recruiting

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Avelumab or Hydroxychloroquine With or Without Palbociclib to Eliminate Dormant Breast Cancer

for Breast Cancer

7 locations incl. Washington D.C.

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT04841148·Phase 2·Recruiting

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Paxalisib (GDC-0084) In Recurrent Or Refractory PCNSL

for Primary Central Nervous System Lymphoma

2 locations incl. Boston

Sponsor: Lakshmi Nayak, MD

Sex: All·Age: 18+

Code: NCT04906096·Phase 2·Recruiting

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Target ALS Biomarker Study; Longitudinal Biofluids, Clinical Measures, and At Home Measures

for Amyotrophic Lateral Sclerosis

10 locations incl. Phoenix

Sponsor: Target ALS Foundation, Inc.

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05137665·Recruiting

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Endoscopic Ultrasound Shear Wave Elastography in Patients With Non-alcoholic Fatty Liver Disease

for Non-Alcoholic Fatty Liver Disease

2 locations incl. Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT05728697·Recruiting

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Nano-SMART: Nanoparticles With MR Guided SBRT in Centrally Located Lung Tumors and Pancreatic Cancer

for Non-small Cell Lung Cancer

2 locations incl. Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT04789486·Phase 1, Phase 2·Recruiting

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A Master Protocol (AMAZ): A Study of Mirikizumab (LY3074828) in Pediatric Participants With Ulcerative Colitis or Crohn's Disease (SHINE-ON)

for Ulcerative Colitis

11 locations incl. San Francisco

Sponsor: Eli Lilly and Company

Sex: All·Age: 2 - 19

Code: NCT04844606·Phase 3·Recruiting

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Effect of NSAIDs on Union, Opioid Utilization and Pain Management for Tibia Fractures: A Pragmatic, Randomized Controlled Trial

for Tibial Fractures

13 locations incl. Indianapolis

Sponsor: Major Extremity Trauma Research Consortium

Sex: All·Age: 18 - 80

Code: NCT07006675·Phase 3·Recruiting

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DALY II USA/ MB-CART2019.1 for DLBCL

for Refractory Diffuse Large B Cell Lymphoma (DLBCL)

23 locations incl. Gilbert

Sponsor: Miltenyi Biomedicine GmbH

Sex: All·Age: 18+

Code: NCT04792489·Phase 2·Recruiting

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