Paid Clinical Trials in Massachusetts

Massachusetts has 3,587 paid clinical trials enrolling now across cities including Boston, Worcester and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Massachusetts include Mass General Hospital, Dana-Farber and Brigham and Women's, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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3,587 clinical trials

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Breaking Silence Through Story: A Narrative Medicine Intervention for Parents of Children With Urogenital Conditions

for DSD

1 location in Boston

Sponsor: Sarah Schlegel

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06989593·Recruiting

Apply to this trial

Ivonescimab in Comb. With FOLFOX in Advanced HER2 Neg. GEA

for Stomach Cancer Stage IV

Drug: Ivonescimab

2 locations incl. Santa Monica

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07070466·Phase 2·Recruiting

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Early Feasibility Study (EFS) Evaluating Percutaneous Repair of the Atrial Septum With a Novel PFO Occluder: The PROTEA-PFO Study

for PFO

5 locations incl. Los Angeles

Sponsor: Recross Cardio, Inc.

Sex: All·Age: 18 - 65

Code: NCT07172464·Recruiting

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Social Needs Screening and Chronic Diseases Study (WE CARE)

for Hyperlipidemias

3 locations incl. Worcester

Sponsor: University of Massachusetts, Worcester

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT06903897·Recruiting

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An Induction Study to Investigate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Active Ulcerative Colitis

for Ulcerative Colitis

Drug: Duvakitug

91 locations incl. Peoria

Sponsor: Sanofi

Sex: All·Age: 16 - 80

Code: NCT07184996·Phase 3·Recruiting

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Advancing Student Suicide Interventions With Scalable Technologies

for Suicidal Ideation

1 location in Amherst

Sponsor: University of Massachusetts, Amherst

Sex: All·Age: 18+

Code: NCT07211373·Enrolling By Invitation

Substrates for Post-Stroke Arm Rehabilitation

for Stroke Rehabilitation

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06998485·Recruiting

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Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients Receiving the Usual Chemotherapy Treatment for Bladder Cancer, ARCHER Study

for Muscle Invasive Bladder Urothelial Carcinoma

211 locations incl. Fort Smith

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT07097142·Phase 3·Recruiting

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Study Evaluating the Safety, Tolerability, and Efficacy of Xaluritamig in Combination With Androgen Receptor Pathway Inhibitors in Participants With Metastatic Hormone-sensitive Prostate Cancer

for Metastatic Hormone-sensitive Prostate Cancer (mHSPC)

6 locations incl. San Francisco

Sponsor: Amgen

Sex: Male·Age: 18+

Code: NCT07140900·Phase 1·Recruiting

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Food Access, Value, and Optimization of Resources

for Food Insecurity

1 location in Jamaica Plain

Sponsor: Boston Children's Hospital

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07149350·Enrolling By Invitation

A Trial to Evaluate the Efficacy and Safety of Ninerafaxstat in Patients With Symptomatic Non-obstructive Hypertrophic Cardiomyopathy

for Non-obstructive Hypertrophic Cardiomyopathy

22 locations incl. La Jolla

Sponsor: Imbria Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT07023614·Phase 2·Recruiting

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PDAC-PATHWAYS: A Digital Informational and Supportive Care App for Patients Initiating Neoadjuvant Therapy for Pancreatic Ductal Adenocarcinoma

for PDAC - Pancreatic Ductal Adenocarcinoma

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07047807·Recruiting

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Two Post-Operative Pain Protocols at Discharge for Orthopaedic Patients

for Orthopaedic Related Pain (Musculoskeletal Pain)

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07265557·Recruiting

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Personalized Risk Estimation for Crohn's Disease (PRE-Crohn's): Implementation and Feasibility

for Inflammatory Bowel Diseases

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 14+·Accepts healthy volunteers

Code: NCT05332639·Recruiting

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Evaluating the Acceptability, Feasibility and Usability of Various Conversational Data Collection Software

for Chronic Pain

1 location in Cambridge

Sponsor: AugMend Health Inc.

Sex: All·Age: 18+

Code: NCT07336537·Recruiting

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The HIgh-fidelity Hydraulic couPling Upper-arm Cuff Assessment of Limits, Safety, and Effectiveness (HIPULSE) Trial

for Non-cardiac Surgical

3 locations incl. Boston

Sponsor: Philips Clinical & Medical Affairs Global

Sex: All·Age: 18+

Code: NCT06895590·Recruiting

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BEACON-1: Study of AVZO-103 as a Single Agent and in Combination Therapy in Patients With Locally Advanced or Metastatic Urothelial Cancer or Other Solid Tumors (AVZO-103-1001)

for Solid Tumor Cancer

10 locations incl. San Francisco

Sponsor: Avenzo Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT07193511·Phase 1, Phase 2·Recruiting

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CLEOPATTRA: A Research Study to Look at the Effects of Treatment With a Medicine Called Coramitug (NNC6019-0001) in People With Heart Failure Due to Transthyretin Amyloid (ATTR) Amyloidosis

for Transthyretin Amyloid Cardiomyopathy (ATTR CM)

Drug: Coramitug

61 locations incl. Phoenix

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18+

Code: NCT07207811·Phase 3·Recruiting

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A Safety and Feasibility Trial Protocol of Metformin in Infants After Perinatal Brain Injury

for Hypoxic-Ischemic Encephalopathy

1 location in Boston

Sponsor: Boston Children's Hospital

Sex: All·Age: 3 Months - 6 Months

Code: NCT06429007·Phase 1·Enrolling By Invitation

Visual Arts Interventions With Older Adults

for Feasibility Study

1 location in Boston

Sponsor: Northeastern University

Sex: All·Age: 55 - 85·Accepts healthy volunteers

Code: NCT06645652·Recruiting

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Developing and Testing a Trauma-Informed Exercise Intervention for Women Veterans With Histories of Sexual Violence

for Sexual Violence

1 location in Boston

Sponsor: VA Office of Research and Development

Sex: Female·Age: 21 - 65·Accepts healthy volunteers

Code: NCT06746740·Recruiting

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Drug Screening of Cutaneous Lesions of Squamous Cell Carcinoma

for Squamous Cell Carcinoma of the Skin

1 location in Boston

Sponsor: Oliver Jonas

Sex: All·Age: 18+

Code: NCT06782399·EARLY_Phase 1·Enrolling By Invitation

Targeted Palliative Care Intervention for Patients With Metastatic Breast Cancer

for Metastatic Breast Cancer

3 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06795529·Recruiting

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Using Non-invasive Brain Stimulation to Treat Word Finding Difficulty in Chronic Traumatic Brain Injury

for Traumatic Brain Injury

1 location in Boston

Sponsor: Beth Israel Deaconess Medical Center

Sex: All·Age: 18 - 85

Code: NCT06848140·Recruiting

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Losartan to Improve Outcomes After Multi-ligament Knee Injury

for Multi-ligament Knee Injury

3 locations incl. Lexington

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18 - 40

Code: NCT06933706·Phase 2·Recruiting

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Perineal Massage Using A Pelvic Wand During Pregnancy

for Pregnancy Related

1 location in Boston

Sponsor: Beth Israel Deaconess Medical Center

Sex: Female·Age: 18+

Code: NCT06986824·Phase 4·Recruiting

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Evaluation of the Paramedic Evaluation for Acute COPD Exacerbation

for COPD (Chronic Obstructive Pulmonary Disease)

1 location in Worcester

Sponsor: University of Massachusetts, Worcester

Sex: All·Age: 18+

Code: NCT07072039·Recruiting

Apply to this trial

Striae Distensae Treatment Using Deep Skin Abrasion

for Striae Distensae

1 location in Boston

Sponsor: Boston Children's Hospital

Sex: All·Age: 18 - 70

Code: NCT07087405·Recruiting

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Optimal Ventilation for Cardiac Arrest

for Cardiac Arrest (CA)

20 locations incl. Orange

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 37 Weeks - 18

Code: NCT07114510·Recruiting

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Study of COYA 302 for the Treatment of ALS

for Amyotrophic Lateral Sclerosis (ALS)

21 locations incl. Phoenix

Sponsor: Coya Therapeutics

Sex: All·Age: 18 - 80

Code: NCT07161999·Phase 2·Recruiting

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Study of AZD0516 as Monotherapy and in Combination in Participants With Metastatic Prostate Cancer

for Metastatic Prostate Cancer

11 locations incl. Fayetteville

Sponsor: AstraZeneca

Sex: Male·Age: 18 - 130

Code: NCT07181161·Phase 1, Phase 2·Recruiting

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An Induction Study to Investigate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Active Crohn's Disease

for Crohn's Disease

Drug: Duvakitug

93 locations incl. Peoria

Sponsor: Sanofi

Sex: All·Age: 16 - 80

Code: NCT07184931·Phase 3·Recruiting

Apply to this trial

Imagined Acupuncture for Postoperative Pain After Spinal Surgery

for Pain Management

1 location in Boston

Sponsor: Jingping Wang, MD, Ph.D.

Sex: All·Age: 18+

Code: NCT07197710·Recruiting

Apply to this trial

OpenEvidence Safety and Comparative Efficacy of Four LLM's in Clinical Practice

for AI (Artificial Intelligence)

1 location in Cambridge

Sponsor: Cambridge Health Alliance

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT07199231·Enrolling By Invitation

Implementing Scalable, PAtient-centered, Team-based, Technology-enabled Care for Adults With Type 2 Diabetes (iPATH)

for Diabetes Mellitus, Type 2

3 locations incl. Stanford

Sponsor: Stanford University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06251323·Recruiting

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Study of Novel Therapeutics for Acute Remedy of Colitis

for Ulcerative Colitis

2 locations incl. Chestnut Hill

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18 - 75

Code: NCT06420492·Phase 2·Recruiting

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Clinical Course Of Disease In Participants With FA-CM

for Friedreich Ataxia

8 locations incl. La Jolla

Sponsor: Lexeo Therapeutics

Sex: All·Age: 6+

Code: NCT06865482·Recruiting

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Circulating Tumor DNA

for ER+ Breast Cancer

7 locations incl. New Haven

Sponsor: Yale University

Sex: All·Age: 18+

Code: NCT06923527·Phase 2·Recruiting

Apply to this trial

Biomarkers to Enhance Early Schizophrenia Treatment

for Schizophenia Disorder

3 locations incl. La Jolla

Sponsor: Northwell Health

Sex: All·Age: 18 - 35

Code: NCT06969755·Phase 4·Recruiting

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A Study to Evaluate the Incidence of Clinically Suspicious Lambert-Eaton Myasthenic Syndrome (LEMS) in Subjects Diagnosed With Small Cell Lung Cancer (SCLC)

for Small Cell Lung Cancer ( SCLC )

1 location in Boston

Sponsor: Addario Lung Cancer Medical Institute

Sex: All·Age: 18+

Code: NCT07075627·Not Yet Recruiting