Paid Clinical Trials in Largo, FL
As of June 2026, 52 paid clinical trials are recruiting in Largo, Florida. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.
Largo offers studies at sites including HCA Florida Largo Hospital for conditions such as Heart Failure, Atrial Fibrillation, Breast Cancer, Dry Eye Disease. Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
Trials by specialty in Largo
Trials by drug in Largo
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50 clinical trials
↓ Download CSVEfficacy of PP-01 in Mitigating Cannabis Withdrawal Symptoms in Adults With Cannabis Use Disorder
Pivotal Trial to Evaluate the Safety and Effectiveness of the P&F TricValve® Transcatheter Bicaval Valve System
Study of QLS-111-FDC in Open-Angle Glaucoma or Ocular Hypertension
DSLT for Reducing Medication in Glaucoma
A Study to Assess Adverse Events and Change in Disease Activity of Oral Icalcaprant in Adult Participants With Bipolar I or II Disorder
Symbiotic-Lung-01 : A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer
Symbiotic-GI-03: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Metastatic Colorectal Cancer
ACP-211 Monotherapy for Major Depressive Disorder With Inadequate Antidepressant Response
A Study of Dato-DXd in Inoperable or Metastatic Hormone Receptor-positive, HER2 IHC 0 Breast Cancer
A Study Evaluating the Safety and Efficacy of a Fixed-Dose Combination for Dry Eye Disease
A Master Protocol of Multiple Agents in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (SYNERGY-Outcomes)
Inclisiran Versus Placebo for the Prevention of Major Adverse Cardiovascular and Limb Events in Patients Undergoing Percutaneous Coronary Intervention or Peripheral Endovascular Intervention
A Study of Disitamab Vedotin in Adults With HER2 Expressing Advanced Breast Cancer
Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity
A Phase III Study of AZD0780 on Major Adverse CV Events in Patients With a History of ASCVD Events or at High Risk for a First Event
Study to Assess Adverse Events and Change in Disease Activity When Oral ABBV-932 is Added to Antidepressant Therapies in Adult Participants With Generalized Anxiety Disorder
Efficacy of Fusidic Acid 1% in the Treatment of Bacterial Conjunctivitis
An Open-Label Study of Azetukalner in Major Depressive Disorder
An Investigational Study Examining the Efficacy of QbMobile in Treatment Monitoring in Individuals With ADHD
An Investigational Study Examining the Cross-Validation of QbMobile in ADHD and Normative Populations
A Clinical Trial to Assess the Efficacy, Safety, and Tolerability of a Repeat Dose of Fasedienol Nasal Spray for the Acute Treatment of Anxiety in Adults With Social Anxiety Disorder
A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder
Trial of Therapeutic Cancer Vaccine OSE2101 in Patients With Non-Small Cell Lung Cancer and Secondary Resistance to Immune Checkpoint Inhibitor
A Clinical Study of Molnupiravir to Prevent Severe Illness From Coronavirus Disease 2019 (COVID-19) in People Who Are High Risk (MK-4482-023)
Trial of Nadofaragene Firadenovec vs. Observation in Participants With Intermediate Risk Non-Muscle Invasive Bladder Cancer
Evaluation of Efficacy and Safety of Suzetrigine for Pain Associated With Diabetic Peripheral Neuropathy
Phase 2 Study to Evaluate Safety and Efficacy of Cretostimogene Grenadenorepvec in High-Risk NMIBC
A Study Evaluating Efruxifermin in Subjects With Compensated Cirrhosis Due to NASH/MASH
Phase 3 Study of Adjunctive Treatment With Seltorexant in Adult and Elderly Participants With Major Depressive Disorder and Insomnia Symptoms
TRIcvalve biCAVal Valve System for Severe Tricuspid Regurgitation (TRICAV-I)
A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Heart Failure
Evaluating the Efficacy and Safety of PT027 Compared With PT007 Administered As Needed in Participants 12 to < 18 Years of Age With Asthma
A Research Study Looking Into How Ziltivekimab Works Compared to Placebo in Participants With Heart Failure and Inflammation
ENVISION IDE Trial: Safety and Effectiveness of NAVITOR in Transcatheter Aortic Valve Implantation
Study of Tilpisertib Fosmecarbil in Participants With Moderately to Severely Active Ulcerative Colitis
A Study Evaluating Efruxifermin in Subjects With Non-Cirrhotic Nonalcoholic Steatohepatitis (NASH)/Metabolic Dysfunction-Associated Steatohepatitis (MASH) and Fibrosis
The Fourth Left Atrial Appendage Occlusion Study
The PEERLESS II Study
SELUTION 4 De Novo Small Vessel IDE Trial
About research studies in Largo
Largo has approximately 52 recruiting research studies across a wide range of therapeutic areas. Florida hosts major research centers including Mayo Clinic Jacksonville, Moffitt Cancer Center, University of Miami Health System, and Nicklaus Children's Hospital, with strong programs in oncology and cardiovascular research.
Top Research Study Locations in Largo
Researchers run research studies in Largo, FL at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| HCA Florida Largo Hospital | Heart Valve Diseases, Aortic Valve Disease, Aortic Valve Stenosis | 3 |
| Clearwater Cardiovascular Consultants | Heart Failure, Heart Failure With Mildly Reduced Ejection Fraction, Heart Failure With Preserved Ejection Fraction | 2 |
| Accel Research Sites - St. Petersburg-Largo | Major Depressive Disorder | 2 |
| Advanced Urology Institute | Metastatic Castration-Resistant Prostate Cancer (mCRPC), Non-Muscle Invasive Bladder Neoplasms | 2 |
| Akero Clinical Study Site | MASH - Metabolic Dysfunction-Associated Steatohepatitis, MASH With Fibrosis, NASH - Nonalcoholic Steatohepatitis | 2 |
| Bokhari Medical Consortium | Attention Deficit Disorder (ADD), Attention Deficit Disorder With Hyperactivity (ADHD), Attention Deficit Hyperactivity Disorder (ADHD) | 2 |
| Florida Cancer Specialists | Advanced Non-Small Cell Lung Cancer, Breast Cancer, Breast Neoplasms | 2 |
| Largo Medical Center | Atrial Fibrillation, Stroke, Tricuspid Regurgitation | 2 |
| Local Institution - 1127 | Psychosis Associated With Alzheimer's Disease | 2 |
| The Eye Institute of West Florida | Cataract, Ocular Hypertension, Primary Open Angle Glaucoma | 2 |
| Accel Research Sites Network - St. Pete | Generalized Anxiety Disorder (GAD), Bipolar I Disorder, Bipolar II Disorder | 2 |
| Accel Research - St. Petersburg-Largo | Diabetic Peripheral Neuropathic Pain | 1 |
| Accel Research Sites Network - St. Pete-Largo Clinical Research Unit | Coronavirus Disease (COVID-19) | 1 |
| Advanced Urology Institute (Solaris) | High-Risk Non-Muscle-Invasive Bladder Cancer | 1 |
| Advanced Urology institute - Pinellas | Intermediate Risk Non-Muscle Invasive Bladder Cancer | 1 |
| Alcanza Clinical Research | Depressive Disorder, Major | 1 |
| Baxis | Bacterial Conjunctivitis | 1 |
| Clearwater Cardiovascular Consultants-Largo-69917 | Heart Failure | 1 |
| Clearwater Cardiovascular and Interventional Consultants- Bardmoor | Percutaneous Coronary Intervention, Peripheral Endovascular Intervention | 1 |
| Comprehensive Hematology Oncology | Colonic Diseases, Colorectal Neoplasms, Digestive System Diseases | 1 |
| Comprehensive Hematology Oncology - Largo Clinic | Patients With Non-Small Cell Lung Cancer | 1 |
| Elios Vision Clinical Site | Glaucoma, Primary Open Angle | 1 |
| Florida Behavioral Psych | Treatment Resistant Depression | 1 |
| Florida Cancer Specialists North / Sarah Cannon Research Institute | Advanced Solid Tumors, Lymphoma, Non-Hodgkin, Multiple Myeloma | 1 |
| Florida Research Institute | Ulcerative Colitis | 1 |
Active & Upcoming Studies in Largo (2026)
Recruiting trials in Largo grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cardiovascular (12 active studies)
- Pivotal Trial to Evaluate the Safety and Effectiveness of the P&F TricValve® Transcatheter Bicaval Valve System · P+F Products + Features USA Inc.
- Study of QLS-111-FDC in Open-Angle Glaucoma or Ocular Hypertension · Phase 2, Phase 3 · Qlaris Bio, Inc.
Cancer & tumors (8 active studies)
- Symbiotic-Lung-01 : A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer · Phase 3 · Pfizer
- A Study of Dato-DXd in Inoperable or Metastatic Hormone Receptor-positive, HER2 IHC 0 Breast Cancer · Phase 3 · AstraZeneca
Eye & vision (6 active studies)
- Lacrifill for Ocular Surface Optimization in Cataract Surgery · The Eye Institute of West Florida
- Study of QLS-111-FDC in Open-Angle Glaucoma or Ocular Hypertension · Phase 2, Phase 3 · Qlaris Bio, Inc.
Mental health & behavior (4 active studies)
- A Study to Assess Adverse Events and Change in Disease Activity of Oral Icalcaprant in Adult Participants With Bipolar I or II Disorder · Phase 2 · AbbVie
- Study to Assess Adverse Events and Change in Disease Activity When Oral ABBV-932 is Added to Antidepressant Therapies in Adult Participants With Generalized Anxiety Disorder · Phase 2 · AbbVie
Diabetes & metabolic (3 active studies)
- Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity · Phase 3 · Amgen
- A Study Evaluating Efruxifermin in Subjects With Compensated Cirrhosis Due to NASH/MASH · Phase 3 · Akero Therapeutics, Inc
Neurology & pain (3 active studies)
- Evaluation of Efficacy and Safety of Suzetrigine for Pain Associated With Diabetic Peripheral Neuropathy · Phase 3 · Vertex Pharmaceuticals Incorporated
- The Fourth Left Atrial Appendage Occlusion Study · Hamilton Health Sciences Corporation
Vaccines (1 active study)
- A Clinical Study of Molnupiravir to Prevent Severe Illness From Coronavirus Disease 2019 (COVID-19) in People Who Are High Risk (MK-4482-023) · Phase 3 · Merck Sharp & Dohme LLC
Common conditions studied in Largo
- Heart Failure (3 active studies). Heart failure trials explore SGLT-2 inhibitors, novel myosin modulators, and device-based therapies for both reduced and preserved ejection fraction.
- Atrial Fibrillation (2 active studies). Atrial fibrillation studies investigate next-generation anticoagulants, ablation technologies, and left atrial appendage closure devices.
- Breast Cancer (2 active studies). Breast cancer trials evaluate new hormone therapies, targeted drugs, and immunotherapy combinations aimed at improving survival and reducing recurrence.
- Dry Eye Disease (2 active studies). Recruiting Dry Eye Disease studies evaluate investigational treatments, diagnostics, and supportive care approaches to improve patient outcomes.
- Heart Valve Diseases (2 active studies). Recruiting Heart Valve Diseases studies evaluate investigational treatments, diagnostics, and supportive care approaches to improve patient outcomes.
- Major Depressive Disorder (2 active studies). Major depressive disorder research examines rapid-acting agents, augmentation strategies, and digital therapeutics for treatment-resistant cases.
Leading research sponsors in Largo
- AbbVie
- AstraZeneca
- Pfizer
- Akero Therapeutics, Inc
- Inari Medical
Local regulations and guidelines
Clinical trials in Florida are governed by U.S. Food and Drug Administration (FDA) regulations, Office for Human Research Protections (OHRP) standards, and federal HIPAA privacy rules. Every study is reviewed by an Institutional Review Board (IRB) to protect participant safety and ensure informed consent. Florida research must also comply with the Florida Information Protection Act (FIPA) and additional oversight from the Florida Department of Health.
Compensation & what to expect
- How payment typically works
- Compensation is most often provided through reloadable electronic study cards or direct deposit, paid out per completed visit rather than as a lump sum. Amounts vary by the time required, the number of visits, and the study's complexity — overnight stays and inpatient pharmacology studies generally pay more than short outpatient surveys. The exact amount is disclosed in writing during informed consent before any visit.
- Healthy volunteers
- Healthy participants aged 18 and older can earn compensation by joining vaccine, pharmacology, and biomarker studies in Largo. These trials check how a new drug or vaccine behaves in healthy bodies before later-phase testing. Many sites maintain a healthy-volunteer registry so you hear about new opportunities first.
- What's included beyond payment
- Most trials cover study-related medical care at no cost — physical exams, lab work, imaging, the investigational treatment itself, and follow-up visits with the research team. Insurance is not required to participate. Free check-ups and access to specialists are common reasons participants return for additional studies.
- Travel and time
- Many sponsors reimburse travel, parking, mileage, and lost wages for visit days. Long-running studies and trials that require frequent visits often raise stipends accordingly. Ask the study coordinator for the visit schedule and reimbursement policy before you commit.
- Asking about compensation
- Compensation is set per protocol and per site, so figures are not published in trial registries. The fastest way to confirm payment for a specific study is to contact the recruiting site listed on the study record. Coordinators are accustomed to this question and will quote the per-visit and total amounts up front.
How to find a clinical trial in Largo
Hipa.ai aggregates every recruiting study in Largo from ClinicalTrials.gov and refreshes the list daily. Use the filters above to narrow by condition, facility, age, phase, or healthy-volunteer eligibility, then click any study title to view full details — eligibility criteria, intervention, location, and sponsor contact information. To enroll, reach out to the central study contact listed on the study detail page; the research coordinator will walk you through the screening process.
Frequently asked questions
How many paid clinical trials are currently recruiting in Largo?
There are approximately 52 recruiting clinical trials in Largo, Florida listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Largo pay participants?
Most recruiting trials in Largo compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Largo?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Largo?
The most common conditions under active study in Largo include Heart Failure (3), Atrial Fibrillation (2), Breast Cancer (2), Dry Eye Disease (2), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Largo?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Largo on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Largo?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Largo?
Recruiting research sites in Largo include HCA Florida Largo Hospital, Clearwater Cardiovascular Consultants, Accel Research Sites - St. Petersburg-Largo, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Largo right now?
The largest active categories in Largo are Cardiovascular (12), Cancer & tumors (8), Eye & vision (6). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.