Clinical Trials at MD Anderson Cancer Center

As of June 2026, 425 paid clinical trials are recruiting at MD Anderson Cancer Center, located at 1515 HOLCOMBE BLVD, UNIT 1445, HOUSTON, TX 77030-4000, phone (713) 745-0496 in Houston, Texas. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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425 clinical trials at MD Anderson Cancer Center

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A Phase 2 Study of Zanidatamab in Patients With HER2-expressing Tumors

for Breast Cancer

17 locations incl. Prescott

Sponsor: Jazz Pharmaceuticals

Sex: All·Age: 18+

Code: NCT06695845·Phase 2·Recruiting

Apply to this trial

A Study of Evofosfamide in Combination with Zalifrelimab and Balstilimab

for Metastatic Prostate Cancer

1 location in Houston

Sponsor: ImmunoGenesis

Sex: All·Age: 18+

Code: NCT06782555·Phase 1, Phase 2·Recruiting

Apply to this trial

Hypophysectomy by Stereotactic Radiosurgery for Cancer-Related Pain

for Hypophysectomy

1 location in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT06287515·Phase 1·Recruiting

Apply to this trial

A Phase I Study Investigating the Combination of the Ziftomenib, Venetoclax and Azacitidine in Pediatric Relapsed and Refractory Acute Leukemias

for Refractory Acute Leukemia

Drug: Venetoclax

1 location in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 2 - 21

Code: NCT06397027·Phase 1·Recruiting

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A Randomized Controlled Trial to Assess the Impact of Live and Recorded Music-Based Interventions on Pre-operative Stress, Mood, Pain and Biomarkers, in Neurosurgical Patients (Music-STAR Trial)

for Stress

1 location in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT06536504·Recruiting

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Evaluate the Safety, Tolerability, Pharmacokinetic Profile, Efficacy of Bl-M11D1

for Relapsed/Refractory Acute Myeloid Leukemia

18 locations incl. Duarte

Sponsor: SystImmune Inc.

Sex: All·Age: 18+

Code: NCT06714591·Phase 1·Recruiting

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A Study of the ApricityCare Program for Early Detection and Management of Treatment-Related Adverse Events in Patients With Cancer

for Metastatic Cancer

1 location in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT06693687·Recruiting

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A Study of Amivantamab in Combination With Lazertinib, or Amivantamab in Combination With Platinum-Based Chemotherapy, for Common Epidermal Growth Factor Receptor (EGFR)-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)

for Carcinoma, Non-Small-Cell Lung

Drug: Amivantamab

150 locations incl. Daphne

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT06667076·Phase 2·Recruiting

Apply to this trial

Novel INPUT Screening Tool to Improve Illness Understanding in Patients With Metastatic or Incurable Lung Cancer

for Lung Carcinoma

1 location in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT06743308·Recruiting

Apply to this trial

Single Arm Pilot Trial of Letermovir for CMV Prophy in CAR T Cell

for Cell Therapy

1 location in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT06575374·Phase 2·Recruiting

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A Study of Amivantamab and FOLFIRI Versus Cetuximab/Bevacizumab and FOLFIRI in Participants With KRAS/NRAS and BRAF Wild-type Colorectal Cancer Who Have Previously Received Chemotherapy

for Colorectal Neoplasms

Drug: Amivantamab

70 locations incl. Chandler

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT06750094·Phase 3·Recruiting

Apply to this trial

A Phase 2 Trial of Mosunetuzumab and Zanubrutinib for Patients With Relapsed/Refractory Marginal Zone Lymphoma

for Lymphoma

Drug: Mosunetuzumab

1 location in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT06563505·Phase 2·Recruiting

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A Phase 2 Study Evaluating Olutasidenib in Patients With IDH1-mutated Clonal Cytopenia of Undetermined Significance and Lower-risk Myelodysplastic/Syndromes/Chronic Myelomonocytic Leukemia.

for Myelodysplastic Syndromes

1 location in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06566742·Phase 2·Recruiting

Apply to this trial

Study of 68Ga-R10602

for Locoregionally Recurrent Hormone-receptor Positive Breast Cancer

6 locations incl. Los Angeles

Sponsor: Radionetics Oncology

Sex: All·Age: 18+

Code: NCT06745804·Phase 1·Recruiting

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A Study to Evaluate the Efficacy and Safety of Autogene Cevumeran With Nivolumab Versus Nivolumab Alone in Participants With High-risk Muscle-invasive Urothelial Carcinoma (MIUC)

for Muscle-invasive Urothelial Carcinoma

Drug: Nivolumab

26 locations incl. Springdale

Sponsor: Hoffmann-La Roche

Sex: All·Age: 18+

Code: NCT06534983·Phase 2·Recruiting

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A Study of JNJ-90301900 in Combination With Chemoradiation Followed by Consolidation Immunotherapy for Non-Small Cell Lung Cancer (NSCLC)

for Carcinoma, Non-Small-Cell Lung

16 locations incl. Farmington

Sponsor: Johnson & Johnson Enterprise Innovation Inc.

Sex: All·Age: 18+

Code: NCT06667908·Phase 2·Recruiting

Apply to this trial

Intelligent Optical Probe for Guiding Core Needle Biopsy Procedures

for Needle Biopsy

1 location in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT06199492·Recruiting

Apply to this trial

Global Real World Data in Patients With Advanced Thyroid Cancer on Standard of Care and Specialized Interventions- Registry of Oncologic Outcomes With Testing and Treatment.

for Thyroid Cancer

1 location in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT06507878·Recruiting

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Dose Escalation and Expansion Study of TROP2 CAR Engineered IL-15- Transduced Cord Blood-derived NK Cells in Combination With Cetuximab in Patient With Colorectal Cancer (CRC) With Minimal Residual Disease (MRD)

for Colorectal Cancer

1 location in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT06358430·Phase 1·Recruiting

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Phase 2 Study of Ivonescimab in Patients With Cutaneous Squamous Cell Carcinoma

for Cutaneous Squamous Cell Carcinoma

Drug: Ivonescimab

1 location in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT06567314·Phase 2·Recruiting

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ADCE-T02, a Tissue Factor Targeted Antibody-Drug Conjugate, in Patients With Selected Advanced Solid Tumours

for Advanced Solid Tumor

5 locations incl. Rogers

Sponsor: Adcendo ApS

Sex: All·Age: 18+

Code: NCT06597721·Phase 1·Recruiting

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Cemiplimab and Cetuximab Prior Salvage Surgery in Patients With Recurrent Oral Cavity Squamous Cell Carcinoma (OCSCC).

for Locally Recurrent Oral Cavity Squamous Cell Carcinoma

Drug: Cemiplimab

1 location in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT06448026·Phase 2·Recruiting

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A Phase 1/2 Study of KSQ-004EX, Autologous Tumor Infiltrating Lymphocytes Engineered to Inactivate Genes Encoding SOCS1 and Regnase-1, in Patients With Select Advanced Solid Tumors

for Select Advanced Solid Tumors

1 location in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT06598371·Phase 1, Phase 2·Recruiting

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Communicating Health Options to Inform Care and Empower Strategic Care Planning (CHOICES): A Multi-layer Randomized Case Vignette Study.

for Health Options

1 location in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT06722846·Recruiting

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Phase I/II Trial of Pemigatinib in Combination With Atezolizumab and Bevacizumab for Treatment of Advanced Cholangiocarcinoma With FGFR2 Fusion

for Advanced Cholangiocarcinoma

Drug: Atezolizumab

1 location in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT06439485·Phase 1, Phase 2·Recruiting

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Risk Adapted Spinal Cord/Cauda Constraint Relaxation for High-risk Patients With Metastatic Epidural Spinal Cord Compression Undergoing Spine Stereotactic Radiosurgery

for Spinal Cord

1 location in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT06204315·Phase 2·Recruiting

Apply to this trial

Clinical and Molecular Features of Oral Premalignancy and Oral Cancer

for Oral Cancer

1 location in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT06550050·Recruiting

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Phase Ib Study of CBP-1019 in Combination With FOLFOX +/- Bevacizumab, Pembrolizumab, or Enzalutamide for Metastatic TRPV6-overexpressing Solid Tumors of Epithelial Origin

for Solid Tumor

Drug: Bevacizumab

1 location in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT06576037·Phase 1·Recruiting

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A Phase 1 Study of AJ1-11095 in Patients With Primary Myelofibrosis (PMF), Post-Polycythemia Vera Myelofibrosis (PPV-MF), or Post-Essential Thrombocythemia Myelofibrosis (PET-MF) Who Have Been Failed by a Type I JAK2 Inhibitor (JAK2i)

for Primary Myelofibrosis

13 locations incl. Palo Alto

Sponsor: Ajax Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT06343805·Phase 1·Recruiting

Apply to this trial

Extending Outcomes for Pancreas Cancer Patients With Nominal Oligometastatic Disease (EXPAND): A Randomized Phase III Trial

for Pancreas Cancer

3 locations incl. Camden

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT06593431·Phase 3·Recruiting

Apply to this trial

Comparison of Conspicuity of Masses and Architectural Distortions Between Wide- and Narrow-angle Digital Breast Tomosynthesis Systems

for Architectural Distortions

1 location in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: Female·Age: All ages

Code: NCT06373354·Recruiting

Apply to this trial

A Study of Amivantamab and mFOLFOX6 or FOLFIRI Versus Cetuximab and mFOLFOX6 or FOLFIRI as First-line Treatment in Participants With KRAS/NRAS and BRAF Wild-type Unresectable or Metastatic Left-sided Colorectal Cancer

for Colorectal Neoplasms

Drug: Amivantamab

79 locations incl. Gilbert

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT06662786·Phase 3·Recruiting

Apply to this trial

Phase Ib Study of AlpeliSib With PEmbroLizumab in Patients With mEtastatic Breast caNcer or melanomA (SELENA)

for Melanoma (Skin Cancer)

1 location in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT06545682·Phase 1·Recruiting

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Enfortumab Vedotin With Radiation for Locally Advanced Bladder Cancer (CONSOLIDATE)

for Advanced Bladder Cancer

1 location in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT06434350·Phase 1, Phase 2·Recruiting

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QuantifyHER: Quantitative Immunofluorescence and/or RT-qPCR for Measuring HER2 in HER2-low Metastatic Breast Cancer

for HER2-positive Metastatic Breast Cancer

37 locations incl. San Francisco

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT06551116·Recruiting

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Phase II Trial of Ubamatamab Alone or in Combination With Cemiplimab in MUC16-Expressing SMARCB1-Deficient Malignancies

for SMARCB1-Deficient Malignancies

Drug: Cemiplimab

1 location in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 12+

Code: NCT06444880·Phase 2·Recruiting

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Soquelitinib vs Standard of Care in Participants With Relapsed/Refractory Peripheral T-cell Lymphoma Not Otherwise Specified, Follicular Helper T-cell Lymphomas, or Systemic Anaplastic Large-cell Lymphoma

for Peripheral T-Cell Lymphoma, Not Otherwise Specified

Drug: Soquelitinib

21 locations incl. Duarte

Sponsor: Corvus Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT06561048·Phase 3·Recruiting

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High Dose Ruxolitinib and Allogeneic Stem Cell Transplantation in Myelofibrosis Patients With Splenomegaly

for Splenomegaly

Drug: Ruxolitinib

1 location in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18 - 75

Code: NCT06345495·Phase 2·Recruiting

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APVO436 Phase 1b/2 Study in Patients With Newly Diagnosed AML

for Acute Myeloid Leukemia (AML)

7 locations incl. Denver

Sponsor: Aptevo Therapeutics

Sex: All·Age: 18+

Code: NCT06634394·Phase 1·Recruiting

Apply to this trial

Lymphedema Prevention Through Immediate Lymphatic Reconstruction (LILY) Trial.

for Lymphedema

1 location in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT06989099·Phase 2·Recruiting

Apply to this trial