A Phase 2 Study of Zanidatamab in Patients With HER2-expressing Tumors

Part of paid clinical trials in Prescott, Arizona.

Sponsor
Jazz Pharmaceuticals
Study ID
NCT06695845
Phase
PHASE2
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Zanidatamab — DRUG
    Administered by intravenous (IV) infusion

Study Details

The purpose of this study is to evaluate the efficacy and safety of zanidatamab for the treatment of participants with previously treated solid tumors that have Human Epidermal Growth Factor Receptor 2 (HER2) Immunohistochemistry (IHC) 3+ overexpression.

Key Dates

Start date
Jan 14, 2025
Status verified
Jun 2026
Primary completion
Dec 31, 2026
Completion
Dec 31, 2027

Study Design

Enrollment
200 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Zanidatamab treatment arm
    Eligible participants receiving zanidatamab treatment

Primary Outcome Measure

Confirmed Objective Response Rate (cORR) per RECIST Version 1.1, as assessed by ICR [ Time Frame: Up to 2.5 years ]

Central Contacts

Locations (17)

FacilityCityStateZIPSite coordinators
Arizona Oncology Associates, PC - NAHOAPrescottArizona86301-
Rocky Mountain Cancer CenterLittletonColorado80120-
Florida Cancer Specialists - SouthFort MyersFlorida33901-
Florida Cancer Specialists - Lake NonaOrlandoFlorida32827-
Florida Cancer Specialists - NorthSt. PetersburgFlorida33705-
Florida Cancer Specialists - EastWest Palm BeachFlorida33401-
Affiliated OncologistsChicago RidgeIllinois60415-
Barbara Ann Karmanos Cancer InstituteDetroitMichigan48201-
Memorial Sloan Kettering Cancer CenterNew YorkNew York10065-
Alliance Cancer SpecialistsHorshamPennsylvania19044-
Tennessee Cancer SpecialistsKnoxvilleTennessee37909-
SCRI Oncology PartnersNashvilleTennessee37203-
Texas Oncology - West TexasAmarilloTexas79124-
Texas Oncology - DFWDallasTexas75246-
MD Anderson Cancer CenterHoustonTexas77030-
Texas Oncology - San AntonioSan AntonioTexas78217-
Blue Ridge Cancer CareRoanokeVirginia24014-

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Arizona Oncology Associates, PC - NAHOA· Prescott, AZRocky Mountain Cancer Center· Littleton, COFlorida Cancer Specialists - South· Fort Myers, FLFlorida Cancer Specialists - Lake Nona· Orlando, FLFlorida Cancer Specialists - North· St. Petersburg, FLFlorida Cancer Specialists - East· West Palm Beach, FL

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