Clinical Trials at M D Anderson Cancer Center

As of June 2026, 335 paid clinical trials are recruiting at M D Anderson Cancer Center, located at 1515 HOLCOMBE BLVD, HOUSTON, TX 77030-4009, phone (713) 792-2121 in Houston, Texas. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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335 clinical trials at M D Anderson Cancer Center

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Phase I/II Open Label Study of Belumosudil Mesylate Alone, and in Combination With Dexamethasone, in Patients With Relapsed/Refractory Multiple Myeloma

for Multiple Myeloma

1 location in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT06105554·Phase 1, Phase 2·Recruiting

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A Phase III Randomized Trial Comparing Stereotactic Body Radiation Therapy (SBRT) vs Conventional Palliative Radiation Therapy for Painful Bone Metastases

for Bone Metastases

1 location in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06065449·Phase 3·Recruiting

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Comparing the Effectiveness of the Immunotherapy Agents Rituximab or Mosunetuzumab in Patients With Nodular Lymphocyte-Predominant Hodgkin Lymphoma, NORM Trial

for Nodular Lymphocyte Predominant B-Cell Lymphoma

Drug: Mosunetuzumab

35 locations incl. Duarte

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT05886036·Phase 2·Recruiting

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Open-label Phase 1b Study of Ulixertinib and Cetuximab or Ulixertinib in Combination With Cetuximab and Encorafenib in Patients With Unresectable or Metastatic Colorectal Cancer Who Have Previously Received EGFR or BRAF-directed Therapy

for Metastatic Colorectal Cancer

1 location in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT05985954·Phase 1·Recruiting

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A Single-Arm Study of Pembrolizumab With Gemcitabine and Cisplatin as Perioperative Therapy for Potentially Resectable Intrahepatic Cholangiocarcinoma

for Cholangiocarcinoma

1 location in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT05967182·Phase 2·Recruiting

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Phase 2 Trial of Epcoritamab in Combination With Rituximab-mini CVP for Older Unfit/Frail Patients or Anthracycline-Ineligible Adult Patients With Newly Diagnosed Diffuse Large B-cell Lymphoma

for Large B-cell Lymphoma

Drug: Epcoritamab

1 location in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT06045247·Phase 2·Recruiting

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Phase 2 Study of Combination Tivozanib and Nivolumab in Advanced Non-Clear Cell Renal Cell Carcinoma

for Renal Cell Carcinoma

Drug: Nivolumab

6 locations incl. Irvine

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT06053658·Phase 2·Recruiting

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Testing the Anti-cancer Drug Erdafitinib for Brain Cancers That Have Returned or Progressed Following Treatment

for Recurrent Glioma

27 locations incl. Aurora

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT05859334·Phase 2·Recruiting

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Tafasitamab, Lenalidomide and Venetoclax for the Treatment of Relapsed or Refractory Mantle Cell Lymphoma

for Recurrent Mantle Cell Lymphoma

Drug: Tafasitamab

2 locations incl. Rochester

Sponsor: Academic and Community Cancer Research United

Sex: All·Age: 18+

Code: NCT05910801·Phase 2·Recruiting

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Testing the Safety and Effectiveness of Radiation-based Treatment (Lutetium Lu 177 Dotatate) for Metastatic Prostate Cancer That Has Neuroendocrine Cells

for Metastatic Prostate Adenocarcinoma With Neuroendocrine Differentiation

13 locations incl. Duarte

Sponsor: National Cancer Institute (NCI)

Sex: Male·Age: 18+

Code: NCT05691465·Phase 2·Recruiting

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Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With High Risk Prostate Cancer

for Prostate Adenocarcinoma

388 locations incl. Birmingham

Sponsor: NRG Oncology

Sex: Male·Age: 18+

Code: NCT05946213·Phase 3·Recruiting

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A Prospective Feasibility Study Using ctDNA to Tailor Neoadjuvant Chemotherapy for Patients With Colorectal or Appendiceal Adenocarcinoma

for Appendiceal Adenocarcinoma

1 location in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT05947838·Recruiting

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A Pilot Presurgical Trial of REGN5678 (Anti-PSMA x CD28) in Patients With High-risk, Localized Prostate Cancer Followed by Radical Prostatectomy

for Prostate Cancer

1 location in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: Male·Age: 18+

Code: NCT06085664·Phase 1, Phase 2·Recruiting

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A Study to Learn More About the Health of Persons With Down Syndrome After Treatment for Acute Leukemia

for B Acute Lymphoblastic Leukemia Associated With Down Syndrome

69 locations incl. Birmingham

Sponsor: Children's Oncology Group

Sex: All·Age: 6 - 39

Code: NCT05702645·Recruiting

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Ph I/II Trial of Cord Blood-derived NK Cells With NY-ESO-1 TCR/IL-15 for R/R Myeloma

for Relapsed/Refractory Myeloma

1 location in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18 - 80

Code: NCT06066359·Phase 1, Phase 2·Recruiting

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Adding an Immunotherapy Drug, MEDI4736 (Durvalumab), to the Usual Chemotherapy Treatment (Paclitaxel, Cyclophosphamide, and Doxorubicin) for Stage II-III Breast Cancer

for Anatomic Stage II Breast Cancer AJCC v8

Drug: Durvalumab

536 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06058377·Phase 3·Recruiting

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Safety and Efficacy of Targeting PP2A in Ovarian Clear Cell Carcinoma Using Dostarlimab and LB-100

for Ovarian Clear Cell Carcinoma

Drug: Dostarlimab

1 location in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT06065462·Phase 1, Phase 2·Recruiting

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A Randomized Trial of Maintenance Systemic Therapy After Radiation for Oligometastatic Renal Cell Carcinoma (ASTROs)

for Oligometastatic Renal Cell Carcinoma

1 location in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT06004336·Phase 2·Recruiting

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Prevención en Sus Manos: Feasibility of a Novel Community-Based Strategy to Improve Access to Cervical Cancer Screening

for HPV

2 locations incl. Austin

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT06109870·Recruiting

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Phase 1 Dose Escalation and Expansion Study of TROP2 CAR Engineered IL15-transduced Cord Blood-derived NK Cells in Patients With Advanced Solid Tumors (TROPIKANA)

for Solid Tumors

1 location in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT06066424·Phase 1·Recruiting

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Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25

for Breast Cancer

1208 locations incl. Birmingham

Sponsor: NRG Oncology

Sex: Female·Age: 18 - 60

Code: NCT05879926·Phase 3·Recruiting

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Comparing Combinations of Drugs to Treat Newly Diagnosed Multiple Myeloma (NDMM) When a Stem Cell Transplant is Not a Medically Suitable Treatment

for Plasma Cell Myeloma

397 locations incl. Anchorage

Sponsor: SWOG Cancer Research Network

Sex: All·Age: All ages

Code: NCT05561387·Phase 3·Recruiting

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Opioid-Sparing Effects of Nurse-Delivered Hypnosis During Breast Cancer Surgery

for Breast Cancer

1 location in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT05766891·Phase 2, Phase 3·Recruiting

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Study of TROP2 CAR Engineered IL15-transduced Cord Blood-derived NK Cells Delivered Intraperitoneally for the Management of Platinum Resistant Ovarian Cancer, Mesonephric-like Adenocarcinoma, and Pancreatic Cancer

for Pancreatic Cancer

1 location in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT05922930·Phase 1, Phase 2·Recruiting

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Accelerated Recovery After MIS Hepatectomy (ARAMIS Hep) to Support Early Discharge for Patients Undergoing Minimally Invasive Liver Resection

for Liver

1 location in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT05879159·Recruiting

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Temporal Immunologic Changes With Hypofractionated Radiation-Induced DNA Damage in Breast Cancer

for Breast Carcinoma

1 location in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT05406232·Recruiting

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A First-In-Human Phase 1 Trial of T-Cell Membrane-Anchored Tumor Targeted Il12 (Attil12)- T-Cell Therapy in Subjects With Advanced/Metastatic Soft Tissue and Bone Sarcoma

for Soft Tissue Sarcoma

1 location in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 12+

Code: NCT05621668·Phase 1·Recruiting

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A Phase II Study of Perioperative Paclitaxel in Patients With Gastric Adenocarcinoma and Carcinomatosis or Positive Cytology

for Gastric Adenocarcinoma

1 location in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT05977998·Phase 2·Recruiting

Apply to this trial

Spanish Decision Tool for Ovarian Cancer Maintenance Therapy

for Ovarian Cancer

1 location in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT06036810·Recruiting

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Cultural Tailoring and Pilot Testing of an Inpatient Yoga Therapy Program for Cancer Patients Undergoing Hematopoietic Stem Cell Transplantation in India, Tanzania, and the United States

for Hematopoietic Stem Cell Transplantation

1 location in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT05681026·Recruiting

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Data Collection Protocol for Patients With Von Hippel Lindau Disease

for Von Hippel Lindau Disease

1 location in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT05955014·Recruiting

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Study Using Hyperpolarized 13C-Pyruvate Magnetic Resonance Spectroscopic Imaging in Patients With Pancreatic Cysts Undergoing Surgical Resection

for Pancreatic Cyst

1 location in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT05873699·Phase 1·Recruiting

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Post-Transplant Maintenance Therapy With Isatuximab Plus Lenalidomide for High-Risk Multiple Myeloma Patients

for Multiple Myeloma

1 location in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18 - 72

Code: NCT05776979·Phase 2·Recruiting

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Alteplase Through an Indwelling Pleural Catheter for the Management of Symptomatic Septated Malignant Pleural Effusion

for Hematopoietic and Lymphoid Cell Neoplasm

1 location in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT06184321·EARLY_Phase 1·Recruiting

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A Phase Ib Trial of Eribulin in Combination With Irinotecan and Temozolamide in Children With Relapsed or Refractory Solid Tumors

for Refractory Solid Tumors

Drug: Irinotecan

1 location in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 1 - 25

Code: NCT06006273·Phase 1·Recruiting

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Testing the Safety and Efficacy of the Combination of Two Anti-cancer Drugs, ZEN003694 and Abemaciclib, for Adult and Pediatric Patients (12-17 Years) With Metastatic or Unresectable NUT Carcinoma, Breast Cancer and Other Solid Tumors

for Anatomic Stage III Breast Cancer AJCC v8

7 locations incl. Los Angeles

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 12+

Code: NCT05372640·Phase 1·Recruiting

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Peripheral Nerve Stimulation of Genicular Nerves Versus Conventional Therapy With Intra-articular Steroid Injection for Chronic Knee Pain: A Prospective, Randomized Pilot Study

for Peripheral Nerve Stimulation

1 location in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT06004882·Recruiting

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Safety, Tolerability, and Efficacy of Enteral Nutrition Versus Standard of Care Nutrition in Hematopoietic Stem Cell Transplant Patients: A Pilot Study

for Stem Cell

1 location in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT06004063·Recruiting

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Phase II Trial of Sacituzumab Govitecan in Recurrent and/or Metastatic Secretory Gland Cancers

for Gland

1 location in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT05884320·Phase 2·Recruiting

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Phase I Trial Testing the Safety and Tolerability of Chemoradiation Followed by Chemotherapy + Dostarlimab for Stage IIIC, Node Positive, Endometrial Cancer

for Endometrial Cancer

Drug: Dostarlimab

1 location in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: Female·Age: 18+

Code: NCT05819892·Phase 1·Recruiting

Apply to this trial