Clinical Trials at Houston Methodist Hospital

As of June 2026, 146 paid clinical trials are recruiting at Houston Methodist Hospital, located at 6550 FANNIN ST., SM1661, HOUSTON, TX 77030-2717, phone (713) 441-6172 in Houston, Texas. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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146 clinical trials at Houston Methodist Hospital

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FORWARD CAD IDE Study

for Coronary Arterial Disease (CAD)

28 locations incl. La Jolla

Sponsor: Shockwave Medical, Inc.

Sex: All·Age: 18+

Code: NCT06662500·Recruiting

Apply to this trial

Surgical Site Infection Outcomes in Natural Orifice Intracorporeal Anastomosis and Extraction (NICE) Procedure - The NICE Trial

for Diverticulitis

1 location in Houston

Sponsor: The Methodist Hospital Research Institute

Sex: All·Age: 18+

Code: NCT06957236·Enrolling By Invitation

Study of Olomorasib (LY3537982) in Combination With Standard of Care in Participants With Resected or Unresectable KRAS G12C-mutant Non-Small Cell Lung Cancer

for Carcinoma, Non-Small-Cell Lung

Drug: LY3537982

85 locations incl. Huntsville

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT06890598·Phase 3·Recruiting

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Study of Patritumab Deruxtecan Plus Pembrolizumab With Other Anticancer Agents in Participants With High-Risk Early-Stage Triple-Negative or Hormone Receptor-Low Positive/HER-2 Negative Breast Cancer (MK-1022-010, HERTHENA-Breast-03)

for Breast Neoplasms

8 locations incl. Santa Monica

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT06797635·Phase 2·Recruiting

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Testing the Addition of the Anti-Cancer Drug Tivozanib to Immunotherapy (Pembrolizumab) After Surgery to Remove All Known Sites of Kidney Cancer

for Clear Cell Renal Cell Carcinoma

414 locations incl. Phoenix

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+

Code: NCT06661720·Phase 3·Recruiting

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Phase 2 Study Evaluating Rapcabtagene Autoleucel in Participants With Severe Active GPA or MPA

for ANCA Associated Vasculitis (AAV)

11 locations incl. Aurora

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18 - 75

Code: NCT06868290·Phase 2·Recruiting

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Testing Olaparib for One or Two Years, With or Without Bevacizumab, to Treat Ovarian Cancer

for Fallopian Tube Endometrioid Adenocarcinoma

Drug: Bevacizumab

658 locations incl. Birmingham

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT06580314·Phase 3·Recruiting

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A Study to Investigate the Efficacy, Safety and Tolerability of Remibrutinib Versus Placebo in Adult Patients With Generalized Myasthenia Gravis

for Generalized Myasthenia Gravis

Drug: Remibrutinib

24 locations incl. Phoenix

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18 - 75

Code: NCT06744920·Phase 3·Recruiting

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REdo tranScatheter Aortic Valve Replacement for Transcatheter aOrtic Valve failuRE

for Aortic Stenosis

71 locations incl. Birmingham

Sponsor: Medtronic Cardiovascular

Sex: All·Age: 18 - 105

Code: NCT06777368·Recruiting

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Blood Flow Restriction (BFR) Training on the Ulnar Collateral Ligament (UCL)

for Healthy

1 location in Houston

Sponsor: The Methodist Hospital Research Institute

Sex: All·Age: 18 - 50·Accepts healthy volunteers

Code: NCT06664827·Recruiting

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Utility of Random Biopsies in Patients With Inflammatory Bowel Disease

for Inflammatory Bowel Diseases

20 locations incl. Birmingham

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT06560021·Enrolling By Invitation

Personalized Transcranial Direct Current Stimulation in Stroke Recovery

for Stroke

1 location in Houston

Sponsor: The Methodist Hospital Research Institute

Sex: All·Age: 18 - 80

Code: NCT06286800·Recruiting

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ViewFlex X ICE First-in-Human Study

for Cardiac Arrhythmias

8 locations incl. Jonesboro

Sponsor: Abbott Medical Devices

Sex: All·Age: 18+

Code: NCT06772493·Recruiting

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Home Tele Rehabilitation Therapy for Vascular Dementia

for Dementia, Vascular

1 location in Houston

Sponsor: The Methodist Hospital Research Institute

Sex: All·Age: 18 - 110

Code: NCT06289569·Recruiting

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Outcomes of Low-Risk Endometrial Cancer With Isolated Tumor Cells in the Sentinel Lymph Nodes: A Prospective, Multicenter, Single-Arm Observational Study

for FIGO Grade 1 Endometrial Endometrioid Adenocarcinoma

3 locations incl. Rochester

Sponsor: Mayo Clinic

Sex: All·Age: All ages

Code: NCT06689956·Recruiting

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Intraosseous vs. Intravenous Vancomycin Administration in Total Ankle Arthroplasty

for Infections

1 location in Houston

Sponsor: The Methodist Hospital Research Institute

Sex: All·Age: 18+

Code: NCT06384651·Phase 4·Recruiting

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A Clinical Study of Molnupiravir to Prevent Severe Illness From Coronavirus Disease 2019 (COVID-19) in People Who Are High Risk (MK-4482-023)

for Coronavirus Disease (COVID-19)

71 locations incl. Cullman

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT06667700·Phase 3·Recruiting

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Thymalfasin (Thymosin Alpha 1; Ta1) as an Enhancer of Vaccine Response Among Older Adults Receiving Booster Doses of COVID-19 Vaccine

for Vaccine Response

1 location in Houston

Sponsor: The Methodist Hospital Research Institute

Sex: All·Age: 65 - 100·Accepts healthy volunteers

Code: NCT06821100·Phase 1·Recruiting

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Quizartinib or Placebo Plus Chemotherapy in Newly Diagnosed Patients With FLT3-ITD Negative AML

for Leukemia

53 locations incl. Goodyear

Sponsor: Daiichi Sankyo

Sex: All·Age: 18 - 70

Code: NCT06578247·Phase 3·Recruiting

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Efficacy and Safety of Obefazimod in Subjects With Moderately to Severely Active Crohn's Disease

for Moderately to Severely Active Crohn Disease

43 locations incl. Fairhope

Sponsor: Abivax S.A.

Sex: All·Age: 18 - 75

Code: NCT06456593·Phase 2·Recruiting

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J-Valve Transfemoral Pivotal Study

for Aortic Valve Regurgitation

34 locations incl. Scottsdale

Sponsor: JC Medical, Inc., an affiliate of Edwards Lifesciences LLC

Sex: All·Age: 18+

Code: NCT06455787·Recruiting

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Study of Targeted Therapies for the Treatment of Adult Participants With Moderate to Severe Crohn's Disease

for Crohn's Disease

64 locations incl. Dothan

Sponsor: AbbVie

Sex: All·Age: 18 - 75

Code: NCT06548542·Phase 2·Recruiting

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A Study of Rapcabtagene Autoleucel in Active, Refractory Systemic Lupus Erythematosus (SLE) or Lupus Nephritis (LN) Patients (AUTOGRAPH - SLE/LN)

for Lupus Erythematosus, Systemic

19 locations incl. Birmingham

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18 - 75

Code: NCT06581198·Phase 2·Recruiting

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KYSA-6: A Study of Anti-CD19 Chimeric Antigen Receptor T-Cell Therapy, in Patients With Generalized Myasthenia Gravis

for Myasthenia Gravis

8 locations incl. Orange

Sponsor: Kyverna Therapeutics

Sex: All·Age: 18 - 75

Code: NCT06193889·Phase 2, Phase 3·Recruiting

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VECTORS - A Study to Evaluate Transmural Healing as a Treatment Target in Crohn's Disease

for Moderately to Severely Active Crohn's Disease

3 locations incl. Los Angeles

Sponsor: Alimentiv Inc.

Sex: All·Age: 18 - 80

Code: NCT06257706·Phase 4·Recruiting

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A Study Evaluating Atezolizumab, With or Without Bevacizumab, in Participants With Unresectable Hepatocellular Carcinoma and Child-pugh B7 and B8 Cirrhosis

for Hepatocellular Carcinoma

Drug: Atezolizumab

60 locations incl. Tucson

Sponsor: Genentech, Inc.

Sex: All·Age: 18+

Code: NCT06096779·Phase 2·Recruiting

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Comparing Dara-VCD Chemotherapy Plus Stem Cell Transplant to Dara-VCD Chemotherapy Alone for People Who Have Newly Diagnosed AL Amyloidosis

for AL Amyloidosis

117 locations incl. Goodyear

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT06022939·Phase 3·Recruiting

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MRI Guided Management of Occlusive Peripheral Arterial Disease

for Peripheral Vascular Diseases

1 location in Houston

Sponsor: The Methodist Hospital Research Institute

Sex: All·Age: 18+

Code: NCT06782100·Recruiting

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ARTEMIS - A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With a Heart Attack

for Cardiovascular Risk

Drug: Ziltivekimab

208 locations incl. Alexander City

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18+

Code: NCT06118281·Phase 3·Recruiting

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Modifying the Inpatient Environment to Reduce Delirium in Older Adults

for Delirium

5 locations incl. Baytown

Sponsor: Farhaan S. Vahidy

Sex: All·Age: 70+

Code: NCT06736951·Recruiting

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CBD for Pain Following Orthopedic Shoulder Surgery

for Shoulder Osteoarthritis

1 location in Houston

Sponsor: The Methodist Hospital Research Institute

Sex: All·Age: 18+

Code: NCT06381791·Phase 1, Phase 2·Recruiting

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IMPRoving Outcomes in Vascular DisEase - Aortic Dissection

for Type B Aortic Dissection

61 locations incl. Birmingham

Sponsor: Duke University

Sex: All·Age: 21+

Code: NCT06087029·Recruiting

Apply to this trial

Study to Evaluate Adverse Events, Optimal Dose, and Change in Disease Activity, With Livmoniplimab in Combination With Budigalimab Plus Chemotherapy Versus IV Infused Pembrolizumab Plus Chemotherapy in Adult Participants With Untreated Metastatic Non-Squamous Non-Small Cell Lung Cancer (NSCLC)

for Non-Small Cell Lung Cancer

Drug: Livmoniplimab

19 locations incl. La Jolla

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT06236438·Phase 2, Phase 3·Recruiting

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Endoscopic Sleeve Gastroplasty (ESG) for the Treatment of Obesity

for Endoscopic Sleeve Gastroplasty

2 locations incl. Houston

Sponsor: The Methodist Hospital Research Institute

Sex: All·Age: 18+

Code: NCT06339320·Recruiting

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A Study of Raludotatug Deruxtecan (R-DXd) in Subjects With Platinum-resistant, High-grade Ovarian, Primary Peritoneal, or Fallopian Tube Cancer

for Solid Cancer

43 locations incl. Anchorage

Sponsor: Daiichi Sankyo

Sex: All·Age: 18+

Code: NCT06161025·Phase 2, Phase 3·Recruiting

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A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer

for Carcinoma, Non-Small-Cell Lung

Drug: LY3537982

91 locations incl. Huntsville

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT06119581·Phase 3·Recruiting

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MAGNITUDE: A Phase 3 Study of NTLA-2001 in Participants With Transthyretin Amyloidosis With Cardiomyopathy (ATTR-CM)

for Transthyretin Amyloidosis (ATTR) With Cardiomyopathy

38 locations incl. Tucson

Sponsor: Intellia Therapeutics

Sex: All·Age: 18 - 90

Code: NCT06128629·Phase 3·Recruiting

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Harnessing Neuroplasticity of Postural Sensorimotor Networks Using Non-Invasive Spinal Neuromodulation to Maximize Functional Recovery After Spinal Cord Injury

for Spinal Cord Injuries

1 location in Houston

Sponsor: The Methodist Hospital Research Institute

Sex: All·Age: 22 - 75

Code: NCT06213012·Recruiting

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Neuromodulating Cortical Regions Involved in Neurogenic Bladder in MS

for Neurogenic Bladder

1 location in Houston

Sponsor: The Methodist Hospital Research Institute

Sex: Female·Age: 18+

Code: NCT06072703·Recruiting

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Clinical Study of Ivonescimab for First-line Treatment of Metastatic NSCLC Patients

for Non-Small Cell Lung Cancer

Drug: Ivonescimab

76 locations incl. Phoenix

Sponsor: Summit Therapeutics

Sex: All·Age: 18+

Code: NCT05899608·Phase 3·Recruiting

Apply to this trial