Clinical Trials at UT Southwestern Medical Center

As of June 2026, 184 paid clinical trials are recruiting at UT Southwestern Medical Center, located at UT Southwestern Medical Center: Research Department, 6000 Harry Hines Blvd, Dallas, TX 75235, phone (214) 633-0022 in Dallas, Texas. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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184 clinical trials at UT Southwestern Medical Center

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Efficacy of LoDoCo in Improving Exercise Capacity Among Patients With HFpEF and Inflammation

for Heart Failure

1 location in Dallas

Sponsor: University of Texas Southwestern Medical Center

Sex: All·Age: 50+

Code: NCT06130059·Phase 2·Recruiting

Apply to this trial

EffCaMgCit to Prevent Mineral Metabolism and Renal Complications of Chronic PPI Therapy

for Osteoporosis

2 locations incl. Dallas

Sponsor: University of Texas Southwestern Medical Center

Sex: All·Age: 21 - 99·Accepts healthy volunteers

Code: NCT05998863·Phase 3·Recruiting

Apply to this trial

Study of Circadian Focused Light Therapy in Progressive Multiple Sclerosis

for Progressive Multiple Sclerosis

1 location in Dallas

Sponsor: University of Texas Southwestern Medical Center

Sex: All·Age: 18+

Code: NCT06261528·Phase 1·Enrolling By Invitation

Pivotal Trial of the Boomerang Catheter for pDVA

for Chronic Limb-Threatening Ischemia

19 locations incl. Sylmar

Sponsor: Aveera Medical, Inc.

Sex: All·Age: 18+

Code: NCT06311773·Enrolling By Invitation

IMPRoving Outcomes in Vascular DisEase - Aortic Dissection

for Type B Aortic Dissection

61 locations incl. Birmingham

Sponsor: Duke University

Sex: All·Age: 21+

Code: NCT06087029·Recruiting

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A Study of Sacituzumab Tirumotecan (MK-2870) as a Single Agent and in Combination With Pembrolizumab (MK-3475) Versus Treatment of Physician's Choice in Participants With HR+/HER2- Unresectable Locally Advanced or Metastatic Breast Cancer (MK-2870-010)

for Breast Neoplasms

46 locations incl. Chandler

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT06312176·Phase 3·Recruiting

Apply to this trial

Deep Brain Stimulation for Psychosis

for Treatment-Refractory Schizophrenia

1 location in Dallas

Sponsor: Bradley Lega

Sex: All·Age: 22 - 70

Code: NCT06257056·Recruiting

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A Study Evaluating the Safety and Efficacy of Inhaled AP01 in Participants With Progressive Pulmonary Fibrosis

for Pulmonary Fibrosis

59 locations incl. Birmingham

Sponsor: Avalyn Pharma Inc.

Sex: All·Age: 18+

Code: NCT06329401·Phase 2·Recruiting

Apply to this trial

Promoting Shared Decision Making for Severe Aortic Stenosis

for Aortic Stenosis

8 locations incl. San Francisco

Sponsor: Massachusetts General Hospital

Sex: All·Age: 65 - 85

Code: NCT06171737·Enrolling By Invitation

A Study of Participants With Cerebral Adrenoleukodystrophy (CALD) Treated With Elivaldogene Autotemcel

for Cerebral Adrenoleukodystrophy (CALD)

3 locations incl. Boston

Sponsor: Genetix Biotherapeutics Inc.

Sex: Male·Age: All ages

Code: NCT06224413·Recruiting

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Study of Arlocabtagene Autoleucel (BMS-986393) a GPRC5D-directed CAR T Cell Therapy in Adult Participants With Relapsed or Refractory Multiple Myeloma

for Multiple Myeloma

41 locations incl. Birmingham

Sponsor: Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

Sex: All·Age: 18+

Code: NCT06297226·Phase 2·Recruiting

Apply to this trial

Polypill for Prevention of Cardiomyopathy

for Type 2 Diabetes

1 location in Dallas

Sponsor: University of Texas Southwestern Medical Center

Sex: All·Age: 18 - 100

Code: NCT06143566·Phase 1, Phase 2·Recruiting

Apply to this trial

Study of Pembrolizumab and Lenvatinib in Metastatic and Recurrent Cervix Cancer (LenPem Cervix)

for Cervix Cancer

1 location in Dallas

Sponsor: University of Texas Southwestern Medical Center

Sex: Female·Age: 18+

Code: NCT06266338·Phase 2·Recruiting

Apply to this trial

PSMA PET Response Guided SabR in High Risk Pca

for Prostate Adenocarcinoma

2 locations incl. Dallas

Sponsor: University of Texas Southwestern Medical Center

Sex: Male·Age: 18 - 99

Code: NCT06044857·Phase 1·Recruiting

Apply to this trial

Phenotyping of Postural Orthostatic Tachycardia Syndrome (POTS)

for Postural Orthostatic Tachycardia Syndrome

1 location in Dallas

Sponsor: University of Texas Southwestern Medical Center

Sex: All·Age: 14+·Accepts healthy volunteers

Code: NCT06292104·Recruiting

Apply to this trial

A Study of Valemetostat Tosylate in Combination With DXd ADCs in Subjects With Solid Tumors

for Advanced Solid Tumor

20 locations incl. Irvine

Sponsor: Daiichi Sankyo

Sex: All·Age: 18+

Code: NCT06244485·Phase 1·Recruiting

Apply to this trial

Phase 1/2a Study of Belantamab Mafodotin in Relapsed or Refractory AL Amyloidosis

for AL Amyloidosis

Drug: Belantamab mafodotin

3 locations incl. Nashville

Sponsor: University of Texas Southwestern Medical Center

Sex: All·Age: 18+

Code: NCT05145816·Phase 1, Phase 2·Recruiting

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A Study of AK117 in Combination With Azacitidine in Patients With Myelodysplastic Syndromes

for Higher-risk Myelodysplastic Syndromes

14 locations incl. Los Angeles

Sponsor: Akeso

Sex: All·Age: 18+

Code: NCT06196203·Phase 2·Recruiting

Apply to this trial

A Phase 2 Study Evaluating Safety and Tolerability of RCT2100 (CFTR mRNA) in Healthy Participants and in Participants With CF

for Cystic Fibrosis

13 locations incl. Birmingham

Sponsor: ReCode Therapeutics

Sex: All·Age: 18 - 60·Accepts healthy volunteers

Code: NCT06237335·Phase 2·Recruiting

Apply to this trial

Long Term Efficacy and Safety of Orlistat for Type 1 Hyperlipoproteinemia

for Type 1 Hyperlipoprotenemia

1 location in Dallas

Sponsor: University of Texas Southwestern Medical Center

Sex: All·Age: 8+

Code: NCT05816343·Phase 2·Recruiting

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A Long Term, Post-marketing Study of Immune Response in Patients Receiving Palynziq Treatment for PKU (PALisade)

for Phenylketonuria (PKU)

11 locations incl. Aurora

Sponsor: BioMarin Pharmaceutical

Sex: All·Age: All ages

Code: NCT06305234·Recruiting

Apply to this trial

Phase 2 Study of Combination Tivozanib and Nivolumab in Advanced Non-Clear Cell Renal Cell Carcinoma

for Renal Cell Carcinoma

Drug: Nivolumab

6 locations incl. Irvine

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT06053658·Phase 2·Recruiting

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Sequential Treatment of Cabozantinib for Advanced Renal Cell Carcinoma (RCC)

for RCC

Drug: Cabozantinib

1 location in Dallas

Sponsor: University of Texas Southwestern Medical Center

Sex: All·Age: 18+

Code: NCT05931393·Phase 2·Recruiting

Apply to this trial

Hydroxycitrate: A Novel Therapy for Calcium Phosphate Urinary Stones

for Calcium Phosphate Kidney Stones

1 location in Dallas

Sponsor: University of Texas Southwestern Medical Center

Sex: All·Age: 21 - 99

Code: NCT06003348·Phase 4·Recruiting

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A Study of Intismeran Autogene (V940) Plus Pembrolizumab (MK-3475) Versus Placebo Plus Pembrolizumab in Participants With Non-small Cell Lung Cancer (V940-002)

for Non-small Cell Lung Cancer

Drug: Intismeran autogene

68 locations incl. Anchorage

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT06077760·Phase 3·Recruiting

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Nuwiq for Perioperative Management Of Patients With Haemophilia A on Emicizumab Regular Prophylaxis Study

for Severe Hemophilia A

1 location in Dallas

Sponsor: Octapharma

Sex: Male·Age: 12+

Code: NCT05935358·Phase 4·Recruiting

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Intravitreal Faricimab Injections or Fluocinolone Acetonide (0.19 mg) Intravitreal Implants vs Observation for Prevention of VA Loss Due to Radiation Retinopathy

for Radiation Retinopathy

23 locations incl. Palo Alto

Sponsor: Jaeb Center for Health Research

Sex: All·Age: 18+

Code: NCT05844982·Phase 3·Recruiting

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Replacing Invasive Cystoscopy With Urine Testing for Non-muscle Invasive Bladder Cancer Surveillance

for Non-muscle-invasive Bladder Cancer

9 locations incl. West Haven

Sponsor: White River Junction Veterans Affairs Medical Center

Sex: All·Age: 18+

Code: NCT05796375·Phase 2·Recruiting

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uTRACT Jelmyto Registry: A Registry of Patients With Upper Tract Urothelial Cancer (UTUC) Treated With Jelmyto

for Urothelial Carcinoma

22 locations incl. Santa Monica

Sponsor: UroGen Pharma Ltd.

Sex: All·Age: 18+

Code: NCT05874921·Recruiting

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Home OCT-Guided Treatment Versus Treat and Extend for the Management of Neovascular AMD

for Neovascular Age-related Macular Degeneration

63 locations incl. Glendale

Sponsor: Jaeb Center for Health Research

Sex: All·Age: 50+

Code: NCT05904028·Phase 3·Recruiting

Apply to this trial

Fontan Udenafil Exercise Longitudinal Assessment Trial - 2

for Single Ventricle Heart Disease

37 locations incl. Phoenix

Sponsor: Mezzion Pharma Co. Ltd

Sex: All·Age: 12 - 18

Code: NCT05918211·Phase 3·Recruiting

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Clinical Study of Ivonescimab for First-line Treatment of Metastatic NSCLC Patients

for Non-Small Cell Lung Cancer

Drug: Ivonescimab

76 locations incl. Phoenix

Sponsor: Summit Therapeutics

Sex: All·Age: 18+

Code: NCT05899608·Phase 3·Recruiting

Apply to this trial

A Long-Term Extension Study to Learn More About the Safety of Litifilimab (BIIB059) Injections and Whether They Can Improve Symptoms of Adult Participants Who Have Active Cutaneous Lupus Erythematosus

for Subacute Cutaneous Lupus Erythematosus

13 locations incl. Birmingham

Sponsor: Biogen

Sex: All·Age: 18+

Code: NCT06044337·Phase 3·Enrolling By Invitation

Study of Efficacy and Safety of Iptacopan in Participants With IC-MPGN

for IC-MPGN

Drug: Iptacopan

22 locations incl. Los Angeles

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 12 - 60

Code: NCT05755386·Phase 3·Recruiting

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A Safety and Efficacy Study of HCB101, Fc-fusion Protein Targeting SIRPα-CD47 Pathway, in Solid or Hematological Tumors

for Advanced Solid Tumor

4 locations incl. Port Saint Lucie

Sponsor: FBD Biologics Limited

Sex: All·Age: 18+

Code: NCT05892718·Phase 1·Recruiting

Apply to this trial

Gene Signatures to Guide HR+MBC Therapy in a Diverse Cohort

for Invasive Mammary Carcinoma

3 locations incl. Birmingham

Sponsor: Sonya Reid

Sex: All·Age: 18+

Code: NCT05693766·Phase 2·Recruiting

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A Study of CC-97540, CD-19-Targeted Nex-T CAR T Cells, in Participants With Severe, Refractory Autoimmune Diseases (Breakfree-1)

for Systemic Lupus Erythematosus

31 locations incl. Aurora

Sponsor: Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

Sex: All·Age: 18+

Code: NCT05869955·Phase 1·Recruiting

Apply to this trial

Cerebral Autoregulation, Brain Perfusion, and Neurocognitive Outcomes After Traumatic Brain Injury

for Traumatic Brain Injury With Loss of Consciousness

3 locations incl. Dallas

Sponsor: University of Texas Southwestern Medical Center

Sex: All·Age: 18 - 80

Code: NCT06480838·Recruiting

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Treatment of Obstructive Sleep Apnea With Personalized Surgery in Children With Down Syndrome (TOPS-DS)

for Obstructive Sleep Apnea

7 locations incl. Aurora

Sponsor: Oregon Health and Science University

Sex: All·Age: 2 - 17

Code: NCT05508971·Recruiting

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Targeting Breathing Limitations to Improve Functional Outcomes in HFpEF

for Heart Failure With Preserved Ejection Fraction

1 location in Dallas

Sponsor: University of Texas Southwestern Medical Center

Sex: All·Age: 55 - 90·Accepts healthy volunteers

Code: NCT05723679·Recruiting

Apply to this trial