Clinical Trials at Cleveland Clinic

As of June 2026, 375 paid clinical trials are recruiting at Cleveland Clinic, located at Cleveland Clinic Mellen Center, 1950 E 89th St U Bldg, Cleveland, OH 44195, phone (216) 444-8600 in Cleveland, Ohio. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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375 clinical trials at Cleveland Clinic

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Pounce™ Thrombectomy System Retrospective Registry

for Peripheral Arterial Disease

9 locations incl. Peoria

Sponsor: SurModics, Inc.

Sex: All·Age: 18+

Code: NCT05868161·Recruiting

Apply to this trial

Neutrophil and Monocyte Deactivation Via the SeLective CytopheretIc Device - A Randomized Clinical Trial in Acute Kidney Injury

for Acute Kidney Injury

38 locations incl. Birmingham

Sponsor: SeaStar Medical

Sex: All·Age: 18+

Code: NCT05758077·Recruiting

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Study to Evaluate ARINA-1 in the Prevention of Bronchiolitis Obliterans Progression in Participants With Bilateral Lung Transplant

for Pre-Bronchiolitis Obliterans Syndrome

20 locations incl. Phoenix

Sponsor: Renovion, Inc.

Sex: All·Age: 18 - 75

Code: NCT05654922·Phase 3·Recruiting

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A Study of GEn-1124 in Subjects With Acute Respiratory Distress Syndrome (ARDS)

for Respiratory Distress Syndrome, Acute

11 locations incl. Washington D.C.

Sponsor: GEn1E Lifesciences

Sex: All·Age: 18 - 85

Code: NCT05795465·Phase 2·Recruiting

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Longitudinal Study for Central Nervous System Vasculitis

for Central Nervous System Vasculitis

4 locations incl. Rochester

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT05734404·Recruiting

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CRISPR-Edited Allogeneic Anti-BCMA CAR-T Cell Therapy in Patients With Relapsed/Refractory Multiple Myeloma

for Relapsed/Refractory Multiple Myeloma

16 locations incl. Birmingham

Sponsor: Caribou Biosciences, Inc.

Sex: All·Age: 18+

Code: NCT05722418·Phase 1·Recruiting

Apply to this trial

Pilot/Pivotal Study of DBS+Rehab After Stroke

for Stroke

10 locations incl. Phoenix

Sponsor: Enspire DBS Therapy, Inc.

Sex: All·Age: 21+

Code: NCT05701280·Recruiting

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Non-interventional Study of Seroprevalence of Pre-existing Antibodies Against Adenovirus-associated Virus Vector (AAV9) and the Progression of Disease in Patients With Plakophilin 2 (PKP2)-Associated Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC)

for Arrhythmogenic Right Ventricular Cardiomyopathy

8 locations incl. San Francisco

Sponsor: Tenaya Therapeutics

Sex: All·Age: 14 - 65

Code: NCT06311708·Recruiting

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A Study to See Iftolvaptan is Safe in Infants and Children Who at Enrollment Are 28 Days to Less Than 18 Years Old withAutosomal Recessive Polycystic Kidney Disease (ARPKD)

for Autosomal Recessive Polycystic Kidney (ARPKD)

12 locations incl. Washington D.C.

Sponsor: Otsuka Pharmaceutical Development & Commercialization, Inc.

Sex: All·Age: 28 Days - 18

Code: NCT04782258·Phase 3·Recruiting

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ONC201 in H3 K27M-mutant Diffuse Glioma Following Radiotherapy (the ACTION Study)

for H3 K27M

67 locations incl. Phoenix

Sponsor: Jazz Pharmaceuticals

Sex: All·Age: All ages

Code: NCT05580562·Phase 3·Recruiting

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Outpatient Antibiotics Following Previable Rupture of Membranes (pPPROM) Between 18 0/7 and 22 6/7 Weeks Gestational Age

for Pregnancy Preterm

3 locations incl. Cleveland

Sponsor: University Hospitals Cleveland Medical Center

Sex: Female·Age: 18+·Accepts healthy volunteers

Code: NCT05345457·Phase 4·Recruiting

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Alleviant ALLAY-HF Study

for Heart Failure

53 locations incl. Birmingham

Sponsor: Alleviant Medical, Inc.

Sex: All·Age: 40+

Code: NCT05685303·Enrolling By Invitation

DEFIANCE: RCT of ClotTriever System Versus Anticoagulation In Deep Vein Thrombosis

for Venous Thromboembolism

48 locations incl. Scottsdale

Sponsor: Inari Medical

Sex: All·Age: 18+

Code: NCT05701917·Recruiting

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JUPITER 4.0 - Risk Factors for Failure of Isolated Medial Patellofemoral Ligament Reconstruction

for Patellar Dislocation, Recurrent

16 locations incl. Redwood City

Sponsor: Hospital for Special Surgery, New York

Sex: All·Age: 10 - 35

Code: NCT06883396·Recruiting

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Screening for earlY Heart Failure Diagnosis and Management in Primary Care or at HOme Using Natriuretic Peptides and echocardiographY "SYMPHONY-HF"

for Heart Failure

1 location in Cleveland

Sponsor: NHS Greater Glasgow and Clyde

Sex: All·Age: 40+

Code: NCT05919342·Recruiting

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Genetic Testing to Select Therapy for the Treatment of Advanced or Metastatic Kidney Cancer, OPTIC RCC Study

for Advanced Clear Cell Renal Cell Carcinoma

6 locations incl. Duarte

Sponsor: Vanderbilt-Ingram Cancer Center

Sex: All·Age: 18+

Code: NCT05361720·Phase 2·Recruiting

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Intracardiac Echocardiography Guided Watchman Device Implant

for Atrial Fibrillation

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18+

Code: NCT06007872·Recruiting

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Subclinical Transthyretin Cardiac Amyloidosis in V122I TTR Carriers

for Amyloidosis, Hereditary

3 locations incl. New York

Sponsor: University of Texas Southwestern Medical Center

Sex: All·Age: 30 - 80

Code: NCT05489549·Recruiting

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A Multi-Institution Study of TGFβ Imprinted, Ex Vivo Expanded Universal Donor NK Cell Infusions as Adoptive Immunotherapy in Combination With Gemcitabine and Docetaxel in Patients With Relapsed or Refractory Pediatric Bone and Soft Tissue

for Pediatric Sarcoma, Refractory

22 locations incl. South Birmingham

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 2 - 40

Code: NCT05634369·Phase 1, Phase 2·Recruiting

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A Study of Amivantamab in Participants With Advanced or Metastatic Solid Tumors Including Epidermal Growth Factor Receptor (EGFR)-Mutated Non-Small Cell Lung Cancer

for Carcinoma, Non-small-Cell Lung

Drug: Amivantamab

26 locations incl. La Jolla

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT05498428·Phase 2·Recruiting

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Phase 2 Study for the Patient, Who Has Diagnosed With Small Cell Lung Cancer (SCLC) or Non Small Cell Lung Cancer (NSCLC) or Renal Cell Carcinoma (RCC) and Finished the First Line Stand Treatment , Need More Treatment

for Small Cell Lung Cancer

5 locations incl. Birmingham

Sponsor: Advenchen Pharmaceuticals, LLC.

Sex: All·Age: 18+

Code: NCT05363280·Phase 2·Recruiting

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Ultrasound-Guided Percutaneous Cryoneurolysis to Treat Postoperative Pain After Mastectomy

for Mastectomy

5 locations incl. Los Angeles

Sponsor: University of California, San Diego

Sex: All·Age: 18+

Code: NCT05444361·Enrolling By Invitation

Study of R289 in Patients With Lower-risk Myelodysplastic Syndromes (LR MDS)

for Low Risk Myelodysplastic Syndromes

15 locations incl. Los Angeles

Sponsor: Rigel Pharmaceuticals

Sex: All·Age: 18+

Code: NCT05308264·Phase 1, Phase 2·Recruiting

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Extension Study of Inhaled Treprostinil in Subjects With Fibrotic Lung Disease

for Idiopathic Pulmonary Fibrosis

86 locations incl. Birmingham

Sponsor: United Therapeutics

Sex: All·Age: 40+

Code: NCT04905693·Phase 3·Enrolling By Invitation

TVMR With the INNOVALVE System Trial - Early Feasibility Study

for Mitral Valve Regurgitation (Degenerative or Functional)

20 locations incl. Los Angeles

Sponsor: Edwards Lifesciences

Sex: All·Age: 18+

Code: NCT04919980·Recruiting

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HA35 Moderate Alcoholic Hepatitis (AH) Study

for Alcoholic Hepatitis

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 21 - 65

Code: NCT05018481·EARLY_Phase 1·Recruiting

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Efficacy & Safety of Olvi-Vec and Platinum-doublet + Bevacizumab Compared to Physician's Choice of Chemotherapy and Bevacizumab in Platinum-Resistant/Refractory Ovarian Cancer (PRROC) (OnPrime, GOG-3076)

for Platinum-resistant Ovarian Cancer

Drug: Bevacizumab

31 locations incl. Mobile

Sponsor: Genelux Corporation

Sex: Female·Age: 18+

Code: NCT05281471·Phase 3·Recruiting

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Evexomostat Plus PI3K or AKT Inhibitor and Fulvestrant in Patients With a PI3K Alteration and HR+/Her2- Breast Cancer

for HR+/HER2-negative Breast Cancer

10 locations incl. Loma Linda

Sponsor: SynDevRx, Inc.

Sex: All·Age: 18+

Code: NCT05455619·Phase 1, Phase 2·Recruiting

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A Prospective Registry Study to Assess Real-world Patient Characteristics, Treatment Patterns, and Longitudinal Outcomes in Patients Receiving Mavacamten and Other Treatments for Symptomatic Obstructive Hypertrophic Cardiomyopathy (Obstructive-HCM)

for Obstructive Hypertrophic Cardiomyopathy

Drug: Mavacamten

62 locations incl. Anchorage

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT05489705·Recruiting

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Impact of Bromocriptine on Clinical Outcomes for Peripartum Cardiomyopathy

for Peripartum Cardiomyopathy, Postpartum

64 locations incl. Birmingham

Sponsor: Dennis M. McNamara, MD, MS

Sex: Female·Age: 18+

Code: NCT05180773·Phase 4·Recruiting

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Robotic Versus Open Ventral Hernia Repair

for Ventral Hernia

4 locations incl. Gainesville

Sponsor: Lucas Beffa

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05472987·Recruiting

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Mesh Removal Versus No Mesh Removal for Chronic Groin Pain After Inguinal Hernia Repair

for Chronic Groin Pain

1 location in Cleveland

Sponsor: David Krpata

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05484635·Recruiting

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Study of INCB123667 in Subjects With Advanced Solid Tumors

for Solid Tumors

Drug: INCB123667

19 locations incl. Duarte

Sponsor: Incyte Corporation

Sex: All·Age: 18+

Code: NCT05238922·Phase 1·Recruiting

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A Study to Learn About the Study Medicine Called PF-07799933 in People With Advanced Solid Tumors With BRAF Alterations.

for Melanoma

31 locations incl. Fayetteville

Sponsor: Pfizer

Sex: All·Age: 16+

Code: NCT05355701·Phase 1·Recruiting

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Abatacept in Immune Checkpoint Inhibitor Myocarditis

for Myocarditis Acute

29 locations incl. Los Angeles

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT05335928·Phase 3·Recruiting

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A Single Dose of BRTX 100 for Patients With Chronic Lumbar Disc Disease (cLDD)

for Lumbar Disc Disease

19 locations incl. Birmingham

Sponsor: BioRestorative Therapies

Sex: All·Age: 18+

Code: NCT04042844·Phase 2·Recruiting

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Study of DISC-0974 (RALLY-MF) in Participants With Myelofibrosis or Myelodysplastic Syndrome and Anemia

for Myelofibrosis

22 locations incl. Duarte

Sponsor: Disc Medicine, Inc

Sex: All·Age: 18+

Code: NCT05320198·Phase 1, Phase 2·Recruiting

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A Study Investigating Oral Ozanimod (RPC1063) in Pediatric Participants With Moderate to Severe Active Ulcerative Colitis

for Colitis, Ulcerative

36 locations incl. Phoenix

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 2 - 17

Code: NCT05076175·Phase 2, Phase 3·Recruiting

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A Study of the Efficacy and Safety of DMX-200 in Patients With FSGS Who Are Receiving an ARB

for FSGS

54 locations incl. Birmingham

Sponsor: Dimerix Bioscience Pty Ltd

Sex: All·Age: 12 - 80

Code: NCT05183646·Phase 3·Recruiting

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The PIVATAL Study -Study of Ventricular Arrhythmia (VTA) Ablation in Left Ventricular Assist Device (LVAD) Patients

for Arrythmia

19 locations incl. Phoenix

Sponsor: University of Rochester

Sex: All·Age: 18+

Code: NCT05034432·Phase 4·Recruiting

Apply to this trial