Clinical Trials at Cleveland Clinic

As of June 2026, 375 paid clinical trials are recruiting at Cleveland Clinic, located at Cleveland Clinic Mellen Center, 1950 E 89th St U Bldg, Cleveland, OH 44195, phone (216) 444-8600 in Cleveland, Ohio. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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375 clinical trials at Cleveland Clinic

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Exercise Physiology in Patients With Aortic Aneurysm and Its Correlation With Mechanical Properties of Aortic Tissue

for Aortic Aneurysm

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06789809·Recruiting

Apply to this trial

Everglade Stem, World Cup and World Liner Post Market Clinical Follow-up

for Hip Disease

1 location in Cleveland

Sponsor: Signature Orthopaedics

Sex: All·Age: 18 - 75

Code: NCT06153940·Recruiting

Apply to this trial

A Study Comparing Two Doses of AGTC-501 in Male Participants With X-linked Retinitis Pigmentosa Caused by RPGR Mutations (DAWN)

for X-Linked Retinitis Pigmentosa

7 locations incl. Jacksonville

Sponsor: Beacon Therapeutics

Sex: Male·Age: 12+

Code: NCT06275620·Phase 2·Enrolling By Invitation

Phase 1 Study of Intratumoral Administration of VAX014 With Expansion in Combination With a Checkpoint Inhibitor in Subjects With Advanced Solid Tumors

for Advanced Solid Tumor

7 locations incl. Tucson

Sponsor: Vaxiion Therapeutics

Sex: All·Age: 18+

Code: NCT05901285·Phase 1·Recruiting

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Evaluation of Lasofoxifene Combined With Abemaciclib Compared With Fulvestrant Combined With Abemaciclib in Locally Advanced or Metastatic ER+/HER2- Breast Cancer With an ESR1 Mutation

for Metastatic Breast Cancer

36 locations incl. Scottsdale

Sponsor: LeonaBio

Sex: All·Age: 18+

Code: NCT05696626·Phase 3·Recruiting

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A Study Assessing KB707 for the Treatment of Locally Advanced or Metastatic Solid Tumors

for Cancer

15 locations incl. Los Angeles

Sponsor: Krystal Biotech, Inc.

Sex: All·Age: 18+

Code: NCT05970497·Phase 1, Phase 2·Recruiting

Apply to this trial

Fontan Udenafil Exercise Longitudinal Assessment Trial - 2

for Single Ventricle Heart Disease

37 locations incl. Phoenix

Sponsor: Mezzion Pharma Co. Ltd

Sex: All·Age: 12 - 18

Code: NCT05918211·Phase 3·Recruiting

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Clinical Study of Ivonescimab for First-line Treatment of Metastatic NSCLC Patients

for Non-Small Cell Lung Cancer

Drug: Ivonescimab

76 locations incl. Phoenix

Sponsor: Summit Therapeutics

Sex: All·Age: 18+

Code: NCT05899608·Phase 3·Recruiting

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Nectero EAST System Clinical Study

for Abdominal Aortic Aneurysm

37 locations incl. Scottsdale

Sponsor: Nectero Medical, Inc.

Sex: All·Age: 21 - 85

Code: NCT06001918·Phase 2, Phase 3·Recruiting

Apply to this trial

PRIMARY Ancillary Substudy

for Mitral Valve Prolapse

16 locations incl. Los Angeles

Sponsor: Annetine Gelijns

Sex: All·Age: 60+

Code: NCT07103733·Recruiting

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Global Multicenter Registry on Transcatheter TRIcuspid Valve RePLACEment

for Tricuspid Regurgitation

5 locations incl. Phoenix

Sponsor: Montefiore Medical Center

Sex: All·Age: 18+

Code: NCT06033274·Recruiting

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Comparative Effectiveness of ECT vs. KETAMINE Over the Lifespan

for Acute Suicidal Depression (ASD)

9 locations incl. San Francisco

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18 - 90

Code: NCT06034821·Phase 4·Enrolling By Invitation

Cognitive Enhancement Intervention for Creating a Healthy L.I.F.E (Lifestyle Interventions for Epilepsy)

for Epilepsy

1 location in Cleveland

Sponsor: Kayela Arrotta

Sex: All·Age: 18 - 60

Code: NCT05954182·Recruiting

Apply to this trial

Analysis of Lumbar Spine Stenosis Specimens for Identification of Transthyretin Cardiac Amyloidosis

for Lumbar Spinal Stenosis

6 locations incl. Beverly Hills

Sponsor: Columbia University

Sex: All·Age: 50+·Accepts healthy volunteers

Code: NCT06034405·Recruiting

Apply to this trial

CTSN Embolic Protection Trial

for Delirium

24 locations incl. North Little Rock

Sponsor: Icahn School of Medicine at Mount Sinai

Sex: All·Age: 60+

Code: NCT06027788·Recruiting

Apply to this trial

Left vs Left Randomized Clinical Trial

for Heart Failure

57 locations incl. Gilbert

Sponsor: Baylor College of Medicine

Sex: All·Age: 18+

Code: NCT05650658·Recruiting

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A Study of CC-97540, CD-19-Targeted Nex-T CAR T Cells, in Participants With Severe, Refractory Autoimmune Diseases (Breakfree-1)

for Systemic Lupus Erythematosus

31 locations incl. Aurora

Sponsor: Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

Sex: All·Age: 18+

Code: NCT05869955·Phase 1·Recruiting

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A Multicenter, Postmarket Surveillance Study of Subjects With the Canary canturioTM te Tibial Extension

for Knee Osteoarthritis

7 locations incl. Fayetteville

Sponsor: Canary Medical

Sex: All·Age: 18+

Code: NCT06040827·Recruiting

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Patient-Centered Approach for Treatment Decisions in Mitral Valve Prolapse

for Mitral Valve Prolapse

5 locations incl. Los Angeles

Sponsor: Northwell Health

Sex: All·Age: 21+

Code: NCT06738537·Recruiting

Apply to this trial

Phenotypic Classification of FMR With CMR

for Nonischemic Congestive Cardiomyopathy

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18+

Code: NCT05965258·Recruiting

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Randomized Controlled Trial of Miniaturized Percutaneous Nephrolithotomy With Vacuum-Assisted Access Sheaths Versus Conventional Sheaths for Treatment of Nephrolithiasis

for Kidney Stone

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18+

Code: NCT05993546·Recruiting

Apply to this trial

Personalized Real-Time DBS and PD Mechanisms

for Parkinson Disease

1 location in Cleveland

Sponsor: David Escobar

Sex: All·Age: 18 - 80

Code: NCT06013956·Phase 4·Recruiting

Apply to this trial

A Registry of Cardiac PET and CardioFlux Magnetocardiography in Patients With Suspected Coronary Ischemia.

for Coronary

2 locations incl. Cleveland

Sponsor: Genetesis Inc.

Sex: All·Age: 40+

Code: NCT05868902·Recruiting

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Multi-center, Open-label, Single-ascending Dose Study of Safety and Tolerability of TN-201 in Adults With Symptomatic MYBPC3 Mutation-associated HCM

for Hypertrophic Cardiomyopathy

10 locations incl. La Jolla

Sponsor: Tenaya Therapeutics

Sex: All·Age: 18 - 75

Code: NCT05836259·Phase 1, Phase 2·Recruiting

Apply to this trial

Persona OsseoTi Keel Compatibility Study (Total Knee Arthroplasty)

for Knee Pain Chronic

16 locations incl. Parker

Sponsor: Zimmer Biomet

Sex: All·Age: 18+

Code: NCT05787821·Recruiting

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Physiology-guided vs Angiography-guided Non-culprit Lesion Complete Revascularization for Acute MI & Multivessel Disease

for Acute Myocardial Infarction

13 locations incl. Los Angeles

Sponsor: Population Health Research Institute

Sex: All·Age: 18+

Code: NCT05701358·Recruiting

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A Study to Compare Iberdomide Maintenance Versus Lenalidomide Maintenance Therapy Following Autologous Stem Cell Transplant in Participants With Newly Diagnosed Multiple Myeloma

for Multiple Myeloma

Drug: Iberdomide

44 locations incl. Aurora

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT05827016·Phase 3·Recruiting

Apply to this trial

Recruitment and Engagement in Care to Impact Practice Enhancement (RECIPE) for Sickle Cell Disease

for Sickle Cell Disease

9 locations incl. Birmingham

Sponsor: RTI International

Sex: All·Age: 18+

Code: NCT06385886·Recruiting

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Home Versus Office Removal of Percutaneous Nerve Evaluation (PNE) Lead

for Overactive Bladder

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: Female·Age: 18+

Code: NCT05799313·Recruiting

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SIGMA (Safusidenib in IDH1 Mutant Glioma Maintenance)

for Glioma

40 locations incl. Birmingham

Sponsor: Nuvation Bio Inc.

Sex: All·Age: 18+

Code: NCT05303519·Phase 3·Recruiting

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A Study of Sacituzumab Govitecan (IMMU-132) in Patients With Recurrent or Persistent Cervical Cancer

for Cervical Cancer

2 locations incl. New Haven

Sponsor: Yale University

Sex: Female·Age: 18+

Code: NCT05838521·Phase 2·Recruiting

Apply to this trial

Molecular Mechanism of Exercise in Cirrhosis

for Cirrhosis, Liver

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 21 - 65

Code: NCT05982769·Recruiting

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A Study to Evaluate the Safety and Therapeutic Activity of GI-102 As a Single Agent and in Combination with Conventional Anti-cancer Drugs, Pembrolizumab or Trastuzumab Deruxtecan(T-DXd) in Patients with Advanced Solid Tumors (KEYNOTE-G08)

for Advanced Solid Tumor

5 locations incl. Scottsdale

Sponsor: GI Innovation, Inc.

Sex: All·Age: 18+

Code: NCT05824975·Phase 1, Phase 2·Recruiting

Apply to this trial

FOG-001 in Locally Advanced or Metastatic Solid Tumors

for Cancer

31 locations incl. Phoenix

Sponsor: Parabilis Medicines, Inc.

Sex: All·Age: 18+

Code: NCT05919264·Phase 1, Phase 2·Recruiting

Apply to this trial

A Study to Understand How the Study Medicine (PF-06823859) Works in People With Active Idiopathic Inflammatory Myopathies [Dermatomyositis (DM) and Polymyositis (PM)]

for Myositis

47 locations incl. Glendale

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT05895786·Phase 3·Recruiting

Apply to this trial

LIVEBETTER: A Trial Comparing Medications in Older Adults With Stable Angina and Multiple Chronic Conditions

for Angina

10 locations incl. New Haven

Sponsor: Yale University

Sex: All·Age: 65+

Code: NCT05786417·Phase 4·Recruiting

Apply to this trial

A Randomized Study of XEN1101 Versus Placebo in Focal-Onset Seizures (X-TOLE3)

for Focal Onset Seizures

19 locations incl. Little Rock

Sponsor: Xenon Pharmaceuticals Inc.

Sex: All·Age: 18+

Code: NCT05716100·Phase 3·Recruiting

Apply to this trial

Study of Rondecabtagene Autoleucel in Aggressive Large B-Cell Lymphoma

for Relapsed Non-Hodgkin Lymphoma

32 locations incl. Irvine

Sponsor: Lyell Immunopharma, Inc.

Sex: All·Age: 18+

Code: NCT05826535·Phase 1, Phase 2·Recruiting

Apply to this trial

Platform of Randomized Adaptive Clinical Trials in Critical Illness

for Respiratory Insufficiency

26 locations incl. Tucson

Sponsor: University Health Network, Toronto

Sex: All·Age: 18+

Code: NCT05440851·Recruiting

Apply to this trial

A SkeleTal Muscle Recovery Intervention With Dietary Protein in Heart Failure

for Heart Failure

2 locations incl. Boston

Sponsor: Tufts Medical Center

Sex: All·Age: 18 - 100

Code: NCT05627440·Recruiting

Apply to this trial