Paid Clinical Trials in California

California has 6,520 paid clinical trials enrolling now across cities including Los Angeles, San Francisco and San Diego. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in California include Stanford Medicine, UCLA Health and UCSF, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 19, 2026.

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6,520 clinical trials

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Testing the Addition of Anti-Cancer Drug, Cetuximab, to Standard of Care Treatment (Pembrolizumab) for Returning or Spreading Head and Neck Cancer After Previous Treatment

for Metastatic Head and Neck Squamous Cell Carcinoma

177 locations incl. Little Rock

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06589804·Phase 3·Recruiting

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A Study of Ifinatamab Deruxtecan in Subjects With Pretreated Advanced or Metastatic Esophageal Squamous Cell Carcinoma (ESCC) (IDeate-Esophageal01)

for Esophageal Squamous Cell Carcinoma

6 locations incl. Fullerton

Sponsor: Daiichi Sankyo

Sex: All·Age: 18+

Code: NCT06644781·Phase 3·Recruiting

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A Study of Ziftomenib in Combination With Imatinib in Patients With Advanced Gastrointestinal Stromal Tumors (GIST)

for Gastrointestinal Stromal Tumor (GIST)

32 locations incl. Birmingham

Sponsor: Kura Oncology, Inc.

Sex: All·Age: 18+

Code: NCT06655246·Phase 1·Recruiting

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First in Human Study to Evaluate AZD9793 in Participants With Advanced or Metastatic Solid Tumours

for Hepatocellular Carcinoma

6 locations incl. La Jolla

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06795022·Phase 1, Phase 2·Recruiting

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Kintsugi Voice Device Pivotal Study

for Depression

1 location in Berkeley

Sponsor: Kintsugi Mindful Wellness, Inc.

Sex: All·Age: 22+·Accepts healthy volunteers

Code: NCT06809907·Recruiting

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A Pivotal Study to Evaluate the Effectiveness of Isometric Handgrip Therapy in Elevated Blood Pressure and Hypertensive Subjects

for Elevated Blood Pressure

5 locations incl. Valley Village

Sponsor: Zona Health, Inc

Sex: All·Age: 22+

Code: NCT06843577·Recruiting

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Study of Olomorasib (LY3537982) in Combination With Standard of Care in Participants With Resected or Unresectable KRAS G12C-mutant Non-Small Cell Lung Cancer

for Carcinoma, Non-Small-Cell Lung

Drug: LY3537982

88 locations incl. Huntsville

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT06890598·Phase 3·Recruiting

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DESTINY-Endometrial01: A Phase III Study of Trastuzumab Deruxtecan Plus Rilvegostomig or Pembrolizumab as First-Line Treatment of HER2-Expressing (IHC 3+/2+), Mismatch Repair Proficient (pMMR) Endometrial Cancer

for Endometrial Cancer

Drug: Rilvegostomig

60 locations incl. Tucson

Sponsor: AstraZeneca

Sex: Female·Age: 18+

Code: NCT06989112·Phase 3·Recruiting

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Intracept Minimally-invasive PROcedure for VErtebrogenic Back Pain

for Chronic Low-back Pain

18 locations incl. Flagstaff

Sponsor: Boston Scientific Corporation

Sex: All·Age: 18+

Code: NCT06827262·Recruiting

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Dose Range Finding Study to Assess Efficacy and Safety of Tozorakimab in Adults With Uncontrolled Asthma on Medium-to-High Dose Inhaled Corticosteroids

for Asthma

55 locations incl. Bakersfield

Sponsor: AstraZeneca

Sex: All·Age: 18 - 75

Code: NCT06932263·Phase 2·Recruiting

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A Study to Investigate the Efficacy and Safety of Tezepelumab in Adult Participants With Moderate to Very Severe COPD (D5241C00007)

for Chronic Obstructive Pulmonary Disease (COPD)

68 locations incl. Cullman

Sponsor: AstraZeneca

Sex: All·Age: 40 - 80

Code: NCT06878261·Phase 3·Recruiting

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A Study With NKT5097 for Adults With Advanced/Metastatic Solid Tumors

for HR+ Breast Cancer

14 locations incl. La Jolla

Sponsor: NiKang Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT07029399·Phase 1·Recruiting

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Durability of Suppl. Rod Constructs-SuppleMentAry Rod Technique for Long-segment Posterior Instrumented Spinal Fusions

for Spinal Fusion

9 locations incl. Redwood City

Sponsor: AO Foundation, AO Spine

Sex: All·Age: 45+

Code: NCT06368245·Recruiting

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Exercise and Movement to Enhance Resiliency in Cancer Patients

for Gynecologic Cancer

1 location in San Francisco

Sponsor: University of California, San Francisco

Sex: Female·Age: 18+

Code: NCT06809933·Recruiting

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Safety and Tolerability of TNG456 Alone and in Combination With Abemaciclib in Patients With Solid Tumors With MTAP Loss

for Non Small Cell Lung Cancer

15 locations incl. Scottsdale

Sponsor: Tango Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT06810544·Phase 1, Phase 2·Recruiting

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A Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of ALD-102 Solution in Subjects With Alopecia Areata

for Alopecia Areata (AA)

4 locations incl. Thousand Oaks

Sponsor: Aldena Therapeutics

Sex: All·Age: 18 - 55

Code: NCT06826196·Phase 1, Phase 2·Recruiting

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A Study of Invikafusp Alfa (STAR0602), a Selective T Cell Receptor (TCR)-Targeting, Bifunctional Antibody-fusion Molecule, in Combination With Sacituzumab Govitecan in Participants With Advanced Solid Tumors

for Triple Negative Locally Advanced Non-resectable Breast Cancer

6 locations incl. Los Angeles

Sponsor: Marengo Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT06827613·Phase 1, Phase 2·Recruiting

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Diagnosing Obstructive Sleep Apnea Using Electromyography of the Muscles of the Mouth

for Obstructive Sleep Apnea (OSA)

1 location in San Diego

Sponsor: University of California, San Diego

Sex: All·Age: 18 - 80·Accepts healthy volunteers

Code: NCT06944782·Recruiting

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eMOTION: Examining Implicit Attitudes in Physical Activity Engagement

for Physical Activity

1 location in Los Angeles

Sponsor: University of Southern California

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07044570·Recruiting

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PEEL-224, Vincristine and Temozolomide in Pediatric Solid Tumors

for Refractory Solid Tumors

7 locations incl. Los Angeles

Sponsor: Theodore Laetsch

Sex: All·Age: 1 - 30

Code: NCT06721689·Phase 1, Phase 2·Recruiting

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A Comparison of NeuroSpan Bridge, NeuraGen Nerve Guide, and Nerve Autograft for Peripheral Nerve Repair

for Peripheral Nerve Injuries

6 locations incl. San Francisco

Sponsor: Auxilium Biotechnologies

Sex: All·Age: 18 - 80

Code: NCT06529835·Recruiting

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Testing a Standardized Approach to Surgery and Chemotherapy for Type I Pleuropulmonary Blastoma or the Addition of an Anti-cancer Drug, Topotecan, to the Usual Treatment for Types II and III Pleuropulmonary Blastoma

for Pleuropulmonary Blastoma

76 locations incl. Birmingham

Sponsor: Children's Oncology Group

Sex: All·Age: Up to 21

Code: NCT06647953·Phase 3·Recruiting

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Mechanistic and Clinical Outcomes of a Surgical Innovation Aimed at Minimizing GERD Associated With VSG (INNOVATE-VSG)

for Obesity

2 locations incl. Orange

Sponsor: University of California, Irvine

Sex: All·Age: 18 - 65

Code: NCT06783751·Recruiting

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Tarlatamab in Advanced Delta-like 3 (DLL3)-Expressing Tumors Including Neuroendocrine Neoplasms

for DLL3-expressing Tumors

Drug: Tarlatamab

5 locations incl. Davis

Sponsor: Jonsson Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT06788938·Phase 2·Recruiting

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Efficacy of Fusidic Acid 1% in the Treatment of Bacterial Conjunctivitis

for Bacterial Conjunctivitis

38 locations incl. Little Rock

Sponsor: Baxis Pharmaceuticals, Inc.

Sex: All·Age: All ages

Code: NCT06911424·Phase 3·Recruiting

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A Study of PRMT5 Inhibitor BAY 3713372 in Participants With MTAP-deleted Solid Tumors

for MTAP-deleted Solid Tumors

17 locations incl. Birmingham

Sponsor: Bayer

Sex: All·Age: 18+

Code: NCT06914128·Phase 1, Phase 2·Recruiting

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A Study to Assess Deucravacitinib Safety in Pregnancy

for Psoriasis (PsO)

Drug: Deucravacitinib

1 location in La Jolla

Sponsor: Bristol-Myers Squibb

Sex: Female·Age: All ages·Accepts healthy volunteers

Code: NCT07017699·Recruiting

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Fluoxetine for the Modification of Colorectal Tumor Immune Cells Before Surgery in Patients With Colorectal Cancer

for Colorectal Adenocarcinoma

1 location in Los Angeles

Sponsor: Jonsson Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT06225011·Phase 1·Recruiting

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Pembrolizumab (MK-3475) Plus Investigational Agents in Resectable Non-small Cell Lung Cancer (NSCLC) (MK-3475-01E/KEYMAKER-U01)

for Lung Neoplasm Malignant

8 locations incl. Daphne

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT06788912·Phase 2·Recruiting

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Study of Patritumab Deruxtecan Plus Pembrolizumab With Other Anticancer Agents in Participants With High-Risk Early-Stage Triple-Negative or Hormone Receptor-Low Positive/HER-2 Negative Breast Cancer (MK-1022-010, HERTHENA-Breast-03)

for Breast Neoplasms

8 locations incl. Santa Monica

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT06797635·Phase 2·Recruiting

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A Study of Navenibart in Participants With Hereditary Angioedema

for Hereditary Angioedema (HAE)

Drug: navenibart

19 locations incl. Birmingham

Sponsor: Astria Therapeutics, Inc.

Sex: All·Age: 12+

Code: NCT06842823·Phase 3·Enrolling By Invitation

Study of Trastuzumab Deruxtecan With Bevacizumab Versus Bevacizumab Monotherapy for First-line Maintenance in HER2-Expressing Ovarian Cancer (DESTINY-Ovarian01)

for Ovarian Cancer

Drug: Bevacizumab

28 locations incl. La Jolla

Sponsor: Daiichi Sankyo

Sex: Female·Age: 18+

Code: NCT06819007·Phase 3·Recruiting

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TTVR STRONG Under Coverage With Evidence Development (CED) Study

for Tricuspid Regurgitation

1 location in Irvine

Sponsor: Edwards Lifesciences

Sex: All·Age: 65+

Code: NCT06833476·Recruiting

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A Study to Investigate the Effectiveness of Tirzepatide (LY3298176) Following Initiation of Ixekizumab (LY2439821) in Participants With Moderate-to-Severe Plaque PsO and Obesity or Overweight in Clinical Practice (TOGETHER AMPLIFY-PsO)

for Psoriasis

Drug: Tirzepatide

40 locations incl. Phoenix

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT06857942·Phase 4·Recruiting

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Child Bipolar Network Ketogenic Diet Approach to Bipolar Disorder in Adolescents

for Bipolar Disorder (BD)

4 locations incl. Los Angeles

Sponsor: University of California, Los Angeles

Sex: All·Age: 12 - 21

Code: NCT06920940·Recruiting

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Personalized Antibody-Drug Conjugate Therapy Based on RNA and Protein Testing for the Treatment of Advanced or Metastatic Solid Tumors (The ADC MATCH Screening and Treatment Trial)

for Advanced Malignant Solid Neoplasm

27 locations incl. Duarte

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06311214·Phase 2·Recruiting

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Ziftomenib in Combination With Chemotherapy for Children With Relapsed/Refractory Acute Leukemia

for Relapsed/Refractory KMT2A-r Acute Leukemia

11 locations incl. Los Angeles

Sponsor: PedAL BCU, LLC

Sex: All·Age: 0 - 21

Code: NCT06376162·Phase 1·Recruiting

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Induction Chemotherapy Response-Guided Radiation for EBV-Associated Nasopharyngeal Carcinoma

for Nasopharyngeal Carcinoma

1 location in San Francisco

Sponsor: University of California, San Francisco

Sex: All·Age: 18+

Code: NCT06682442·Recruiting

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A Study to Investigate the Efficacy and Safety of Tezepelumab in Adult Participants With Moderate to Very Severe COPD (D5241C00006)

for Chronic Obstructive Pulmonary Disease (COPD)

67 locations incl. Foley

Sponsor: AstraZeneca

Sex: All·Age: 40 - 80

Code: NCT06883305·Phase 3·Recruiting

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An Open-Label Study of Azetukalner in Major Depressive Disorder

for Major Depressive Disorder

63 locations incl. Phoenix

Sponsor: Xenon Pharmaceuticals Inc.

Sex: All·Age: 18+

Code: NCT06922110·Phase 3·Enrolling By Invitation