Clinical Trials at Massachusetts General Hospital

As of June 2026, 726 paid clinical trials are recruiting at Massachusetts General Hospital, located at Faustman Lab at Massachusetts General Hospital, 149 13th St #3602, Boston, MA 02129, phone (617) 726-4084 in Boston, Massachusetts. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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726 clinical trials at Massachusetts General Hospital

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Positive Emotions Following Acute Cardiac Events

for Acute Coronary Syndrome

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 95

Code: NCT05412862·Recruiting

Apply to this trial

Extension Study of Inhaled Treprostinil in Subjects With Fibrotic Lung Disease

for Idiopathic Pulmonary Fibrosis

86 locations incl. Birmingham

Sponsor: United Therapeutics

Sex: All·Age: 40+

Code: NCT04905693·Phase 3·Enrolling By Invitation

Low-field MRI for Breast Cancer Screening

for Breast Benign

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: Female·Age: 20 - 80·Accepts healthy volunteers

Code: NCT05486520·Enrolling By Invitation

Study of mRNA-4359 Administered Alone and in Combination With Immune Checkpoint Blockade in Participants With Advanced Solid Tumors

for Advanced Solid Tumors

16 locations incl. Los Angeles

Sponsor: ModernaTX, Inc.

Sex: All·Age: 12+

Code: NCT05533697·Phase 1, Phase 2·Recruiting

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North American Prodromal Synucleinopathy Consortium Stage 2

for REM Sleep Behavior Disorder

8 locations incl. Los Angeles

Sponsor: Washington University School of Medicine

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05826457·Enrolling By Invitation

Cerebrospinal Fluid Biomarkers of Myotonic Dystrophy

for Myotonic Dystrophy Type 1

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06075693·Recruiting

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Brain Stimulation for Severe Depression

for Depression Severe

2 locations incl. Boston

Sponsor: Inner Cosmos Inc

Sex: All·Age: 21 - 80

Code: NCT05393622·Recruiting

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Impact of Bromocriptine on Clinical Outcomes for Peripartum Cardiomyopathy

for Peripartum Cardiomyopathy, Postpartum

64 locations incl. Birmingham

Sponsor: Dennis M. McNamara, MD, MS

Sex: Female·Age: 18+

Code: NCT05180773·Phase 4·Recruiting

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The FLOTILLA Study: Providing Continued Access to The Study Medicines Encorafenib and Binimetinib for Participants in Prior Clinical Trials

for Solid Tumors

18 locations incl. Phoenix

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT05203172·Phase 4·Recruiting

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Abatacept in Immune Checkpoint Inhibitor Myocarditis

for Myocarditis Acute

29 locations incl. Los Angeles

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT05335928·Phase 3·Recruiting

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Ketamine Treatment of Youth Suicide Attempters

for Suicide, Attempted

2 locations incl. Boston

Sponsor: Tatiana Falcone, MD

Sex: All·Age: 14 - 30

Code: NCT04763343·Phase 3·Recruiting

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A Study to Assess the Effects of ACI-24.060 in Alzheimer's Disease and in Down Syndrome (ABATE Study)

for Amyloid Plaque

13 locations incl. Phoenix

Sponsor: AC Immune SA

Sex: All·Age: 35 - 85

Code: NCT05462106·Phase 1, Phase 2·Recruiting

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Validation of Early Prognostic Data for Recovery Outcome After Stroke for Future, Higher Yield Trials

for Stroke

45 locations incl. Birmingham

Sponsor: University of Cincinnati

Sex: All·Age: 18+

Code: NCT05338697·Recruiting

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Mocravimod as Adjunctive and Maintenance Treatment in AML Patients Undergoing Allo-HCT

for Adult Acute Myeloid Leukemia

21 locations incl. Birmingham

Sponsor: Priothera SAS

Sex: All·Age: 18 - 75

Code: NCT05429632·Phase 3·Recruiting

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Testing Tumor Tissue and Blood to Help Select Personalized Treatments for Patients With Suspected Lung Cancers

for NSCLC

21 locations incl. Davis

Sponsor: Lung Cancer Mutation Consortium

Sex: All·Age: All ages

Code: NCT04712877·Recruiting

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A Study of Neladalkib (NVL-655) in Patients With Advanced NSCLC and Other Solid Tumors Harboring ALK Rearrangement or Activating ALK Mutation (ALKOVE-1)

for Locally Advanced Solid Tumor

21 locations incl. Orange

Sponsor: Nuvalent Inc.

Sex: All·Age: 12+

Code: NCT05384626·Phase 1, Phase 2·Recruiting

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Specialty Compared to Oncology Delivered Palliative Care for Patients With Acute Myeloid Leukemia

for Relapsed Adult AML

20 locations incl. Birmingham

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 120·Accepts healthy volunteers

Code: NCT05237258·Recruiting

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Intraoperative Tumor Margin Identification With ICG Dye Imaging

for Benign Neoplasm

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT04752137·Phase 2·Recruiting

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Studying the Neuronal Basis of Human Social Cognition

for Neurosciences

2 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05324579·Recruiting

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Multidisciplinary Ventricular Assist Device Clinic

for Heart Failure

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT05388019·Enrolling By Invitation

Psychophysical and Neural Mechanisms Contributing to Chronic Post-Surgical Pain in Adolescents and Adults

for Chronic Post-surgical Pain

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 12+

Code: NCT05304286·Recruiting

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The ExTINGUISH Trial of Inebilizumab in NMDAR Encephalitis

for Autoimmune Encephalitis

Drug: Inebilizumab

35 locations incl. Birmingham

Sponsor: University of Utah

Sex: All·Age: 12+

Code: NCT04372615·Phase 2·Recruiting

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Extended vs Short-term Abatacept Dosing for Graft Versus Host Disease Prophylaxis

for Graft Vs Host Disease

15 locations incl. Duarte

Sponsor: Boston Children's Hospital

Sex: All·Age: 2+

Code: NCT04380740·Phase 2·Recruiting

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4D-710 in Adult Patients With Cystic Fibrosis

for Cystic Fibrosis Lung

20 locations incl. Birmingham

Sponsor: 4D Molecular Therapeutics

Sex: All·Age: 18+

Code: NCT05248230·Phase 2·Recruiting

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Assess Fibrin in Brains With AD/ADRD

for Alzheimer Disease

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 55 - 90·Accepts healthy volunteers

Code: NCT05336695·Phase 1, Phase 2·Recruiting

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Ruxolitinib in Thrombocythemia and Polycythemia Vera

for Essential Thrombocythemia

Drug: Ruxolitinib

4 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT04644211·Phase 2·Recruiting

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A Long-term Study for Participants Previously Treated With Ciltacabtagene Autoleucel

for Multiple Myeloma

28 locations incl. Phoenix

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT05201781·Phase 4·Recruiting

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FIH Study of RGT-419B Alone and With Endocrine Therapy in HR-Positive, HER2-Negative Advanced/Metastatic Breast Cancer

for Breast Cancer

8 locations incl. La Jolla

Sponsor: Regor Pharmaceuticals Inc.

Sex: All·Age: 18+

Code: NCT05304962·Phase 1·Recruiting

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A Phase 1/2 Study of Enzomenib (DSP-5336) in Patients With Acute Leukemia (Horizen-1)

for Leukemia, Myeloid, Acute

33 locations incl. Newport Beach

Sponsor: Sumitomo Pharma America, Inc.

Sex: All·Age: 12+

Code: NCT04988555·Phase 1, Phase 2·Recruiting

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MTX-001 for the Treatment of Non-Healing Venous Stasis Ulcers

for Venous Stasis Ulcer

10 locations incl. Tucson

Sponsor: Merakris Therapeutics

Sex: All·Age: 18+

Code: NCT04647240·Phase 2·Recruiting

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Percutaneous or Surgical Repair In Mitral Prolapse And Regurgitation for ≥60 Year-olds (PRIMARY)

for Mitral Valve Regurgitation

24 locations incl. Los Angeles

Sponsor: Annetine Gelijns

Sex: All·Age: 60+

Code: NCT05051033·Recruiting

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Prospective Study of Sensation and Satisfaction in Cancer and Transgender Mastectomy Patients

for Sensation Disorders

2 locations incl. Boston

Sponsor: Weill Medical College of Cornell University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06094257·Recruiting

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The Impact of Overnight Nutrition Support on Sleep and Circadian Rhythm Disruption in the ICU

for Feeding Patterns

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT04737200·Recruiting

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Assessment of CCM in HF With Higher Ejection Fraction

for Heart Failure

105 locations incl. Birmingham

Sponsor: Impulse Dynamics

Sex: All·Age: 18+

Code: NCT05064709·Recruiting

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Intermittent Fasting for NAFLD in Adults

for Fatty Liver

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT04899102·Recruiting

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An Ethical Approach to Detecting Covert Consciousness

for Disorder of Consciousness

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT05010265·Recruiting

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A Phase 1/2a Study of DB-1303/BNT323 in Advanced/Metastatic Solid Tumors

for HER2-positive Advanced Solid Tumor

Drug: DB-1303/BNT323

35 locations incl. Cerritos

Sponsor: DualityBio Inc.

Sex: All·Age: 18+

Code: NCT05150691·Phase 1, Phase 2·Recruiting

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Study of STK-012 Alone and With Other Treatments in Patients With Advanced Lung Cancer and Other Cancers

for Advanced Solid Tumor

27 locations incl. Tucson

Sponsor: Synthekine

Sex: All·Age: 18+

Code: NCT05098132·Phase 1, Phase 2·Recruiting

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Cannabidiol for Reduction of Brain Neuroinflammation

for Back Pain

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 75

Code: NCT05066308·Phase 2·Recruiting

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Efficacy of the COronary SInus Reducer in Patients With Refractory Angina II

for Refractory Angina

70 locations incl. Phoenix

Sponsor: Shockwave Medical, Inc.

Sex: All·Age: 18+

Code: NCT05102019·Recruiting

Apply to this trial