Clinical Trials at Massachusetts General Hospital

As of June 2026, 726 paid clinical trials are recruiting at Massachusetts General Hospital, located at Faustman Lab at Massachusetts General Hospital, 149 13th St #3602, Boston, MA 02129, phone (617) 726-4084 in Boston, Massachusetts. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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726 clinical trials at Massachusetts General Hospital

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Short-Term Linvoseltamab Treatment on Top of Chronic Dupilumab Treatment for Adults With Severe Immunoglobulin E (IgE)-Mediated Food Allergy

for Food Allergy

Drug: Linvoseltamab

5 locations incl. Tampa

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 18 - 50

Code: NCT06369467·Phase 1·Recruiting

Apply to this trial

Boosting Resources for Tracheostomy Care at Home

for Tracheostomy

6 locations incl. La Jolla

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06283953·Enrolling By Invitation

A Study of PARG Inhibitor ETX-19477 in Patients With Advanced Solid Malignancies

for Advanced or Metastatic Solid Tumors

14 locations incl. Phoenix

Sponsor: 858 Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT06395519·Phase 1, Phase 2·Recruiting

Apply to this trial

Safety and Efficacy of realSKIN® to Provide Complete Wound Closure of Burn Wounds as an Alternative to Autografting

for Burns Degree Third

4 locations incl. Phoenix

Sponsor: XenoTherapeutics, Inc.

Sex: All·Age: 18+

Code: NCT06223269·Phase 3·Recruiting

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Safety and Tolerability Study of GIM-531 in Advanced Solid Tumors

for Melanoma Stage IV

11 locations incl. Scottsdale

Sponsor: Georgiamune Inc

Sex: All·Age: 18+

Code: NCT06425926·Phase 1, Phase 2·Recruiting

Apply to this trial

A Retrospective and Prospective Natural History of Genetic Vasculopathies

for Multisystemic Smooth Muscle Dysfunction Syndrome

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 29 Days+

Code: NCT06552052·Recruiting

Apply to this trial

Polygenic Risk Stratification Combined With mpMRI to Identify Clinically Relevant Prostate Cancer

for Prostate Cancer

5 locations incl. Washington D.C.

Sponsor: Adam S. Kibel, MD

Sex: Male·Age: 40 - 69·Accepts healthy volunteers

Code: NCT06398639·Recruiting

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A Follow-up Study to Test Long-term Treatment With Nerandomilast in People With Pulmonary Fibrosis Who Took Part in a Previous Study With Nerandomilast

for Idiopathic Pulmonary Fibrosis

Drug: Nerandomilast

58 locations incl. Birmingham

Sponsor: Boehringer Ingelheim

Sex: All·Age: 18+

Code: NCT06238622·Phase 3·Recruiting

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Global Prospective, Observational Cohort of Adult Patients With Primary Sclerosing Cholangitis (WIND-PSC Study)

for PSC

11 locations incl. Sacramento

Sponsor: PSC Partners Seeking a Cure

Sex: All·Age: 18 - 75

Code: NCT06297993·Recruiting

Apply to this trial

Developing a Peer Support Intervention for Depression in SCD

for Subjective Cognitive Decline

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 60+

Code: NCT06358404·Recruiting

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Study of REM-422 in Patients With AML or Higher Risk MDS

for Myelodysplastic Syndromes

5 locations incl. Duarte

Sponsor: Remix Therapeutics

Sex: All·Age: 18+

Code: NCT06297941·Phase 1·Recruiting

Apply to this trial

Pemigatinib + Afatinib in Advanced Refractory Solid Tumors

for Advanced Solid Tumor

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06302621·Phase 1·Recruiting

Apply to this trial

The Artisse™ Intrasaccular Device is Indicated for the Treatment of Wide-neck Bifurcating Intracranial Aneurysms (IAs).

for Intracranial Aneurysm

22 locations incl. Englewood

Sponsor: Medtronic Neurovascular Clinical Affairs

Sex: All·Age: 18 - 75

Code: NCT02998229·Recruiting

Apply to this trial

Pivotal Trial of the Boomerang Catheter for pDVA

for Chronic Limb-Threatening Ischemia

19 locations incl. Sylmar

Sponsor: Aveera Medical, Inc.

Sex: All·Age: 18+

Code: NCT06311773·Enrolling By Invitation

Platform Clinical Study for Conquering Scleroderma

for Interstitial Lung Disease Due to Systemic Disease

34 locations incl. Birmingham

Sponsor: Scleroderma Research Foundation, Inc.

Sex: All·Age: 18+

Code: NCT06195072·Phase 2·Recruiting

Apply to this trial

IMPRoving Outcomes in Vascular DisEase - Aortic Dissection

for Type B Aortic Dissection

61 locations incl. Birmingham

Sponsor: Duke University

Sex: All·Age: 21+

Code: NCT06087029·Recruiting

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Aptis PRUJ Prosthesis for the Treatment of Patients With Proximal Radial Ulna Joint Disorders.

for Arthritis

6 locations incl. Carmel

Sponsor: Aptis Medical

Sex: All·Age: 18 - 85·Accepts healthy volunteers

Code: NCT05796908·Recruiting

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AAA-SHAPE Pivotal Trial: Abdominal Aortic Aneurysm Sac Healing and Prevention of Expansion

for Aortic Aneurysm, Abdominal

39 locations incl. Birmingham

Sponsor: Shape Memory Medical, Inc.

Sex: All·Age: 18+

Code: NCT06029660·Recruiting

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Promoting Shared Decision Making for Severe Aortic Stenosis

for Aortic Stenosis

8 locations incl. San Francisco

Sponsor: Massachusetts General Hospital

Sex: All·Age: 65 - 85

Code: NCT06171737·Enrolling By Invitation

A Phase 1/1b Study of IAM1363 in HER2 Cancers

for HER2 Mutation-Related Tumors

29 locations incl. La Jolla

Sponsor: Iambic Therapeutics, Inc

Sex: All·Age: 18+

Code: NCT06253871·Phase 1·Recruiting

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Development of a Transdiagnostic Intervention for Adolescents at Risk for Serious Mental Illness

for Anxiety Disorders

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 14 - 19

Code: NCT05962879·Recruiting

Apply to this trial

COffee and Metabolites Modulating the Gut MicrobiomE in Colorectal caNCER

for Colorectal Cancer

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT05692024·Phase 1, Phase 2·Recruiting

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Study of Arlocabtagene Autoleucel (BMS-986393) a GPRC5D-directed CAR T Cell Therapy in Adult Participants With Relapsed or Refractory Multiple Myeloma

for Multiple Myeloma

41 locations incl. Birmingham

Sponsor: Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

Sex: All·Age: 18+

Code: NCT06297226·Phase 2·Recruiting

Apply to this trial

Strategy for Improving Stroke Treatment Response

for Ischemic Stroke

52 locations incl. Birmingham

Sponsor: Translational Sciences, Inc.

Sex: All·Age: 18+

Code: NCT05948566·Phase 2·Recruiting

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ENVISION IDE Trial: Safety and Effectiveness of NAVITOR in Transcatheter Aortic Valve Implantation

for Aortic Valve Stenosis

67 locations incl. Birmingham

Sponsor: Abbott Medical Devices

Sex: All·Age: 18+

Code: NCT05932615·Enrolling By Invitation

Targeting Specific Brain Networks to Treat Specific Symptoms in Depression

for Major Depressive Disorder

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT05523817·Recruiting

Apply to this trial

GLUCOSE-MGH: Genetic Links Understood Through Challenge With Oral Semaglutide Exposure at MGH

for Genetic Predisposition

Drug: Semaglutide

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT06003153·Phase 4·Recruiting

Apply to this trial

Elranatamab in R/R Multiple Myeloma

for Refractory Multiple Myeloma

Drug: Elranatamab

3 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06138275·Phase 2·Recruiting

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A Multicenter Trial Assessing the Impact of Lipoprotein(a) Lowering With Pelacarsen (TQJ230) on the Progression of Calcific Aortic Valve Stenosis

for Aortic Stenosis

Drug: Pelacarsen

37 locations incl. Huntsville

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 50 - 80

Code: NCT05646381·Phase 2·Recruiting

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A Randomized Comparison of Stage-Based Care Versus Risk Factor-Based Care for Prevention of Cardiovascular Events

for Diabetes Mellitus, Type 2

124 locations incl. Chandler

Sponsor: Cleerly, Inc.

Sex: All·Age: 55+·Accepts healthy volunteers

Code: NCT06112418·Recruiting

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Study of Single Doses of SBT777101 in Subjects With Rheumatoid Arthritis

for Rheumatoid Arthritis

8 locations incl. Scottsdale

Sponsor: Sonoma Biotherapeutics, Inc.

Sex: All·Age: 18 - 70

Code: NCT06201416·Phase 1·Recruiting

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Nitric Oxide Consumption as a Predictor of Vasospasm in Subarachnoid Hemorrhage

for Aneurysmal Subarachnoid Hemorrhage

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07614906·Recruiting

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Project 4: Ambulatory Biofeedback and Voice Therapy for Patients With Vocal Hyperfunction

for Voice Disorders

2 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 65

Code: NCT05970562·EARLY_Phase 1·Recruiting

Apply to this trial

Incremental Hemodialysis: The TwoPlus Trial

for End-Stage Kidney Disease

10 locations incl. Jacksonville

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT05828823·Recruiting

Apply to this trial

First-in-Human Study of OKI-219 in Advanced Solid Tumors and Advanced Breast Cancer

for Advanced Cancer

13 locations incl. Encinitas

Sponsor: OnKure, Inc.

Sex: All·Age: 18+

Code: NCT06239467·Phase 1·Recruiting

Apply to this trial

Treat-to-Target Serum Urate Versus Treat-to-Avoid Symptoms in Gout

for Gout

7 locations incl. South Birmingham

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 90

Code: NCT04875702·Phase 4·Recruiting

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Pulmonary Artery DenerVation Clinical Study Using the Gradient Denervation System in Heart Failure Patients With Pulmonary Hypertension Group 2 (PreVail-PH2 Study)

for Group 2 Pulmonary Hypertension

8 locations incl. Chicago

Sponsor: Gradient Denervation Technologies

Sex: All·Age: 22 - 85

Code: NCT06052072·Enrolling By Invitation

RESET-SLE: A Phase 1/2 Open-Label Study to Evaluate the Safety and Efficacy of CABA-201 in Subjects With Active Systemic Lupus Erythematosus

for Systemic Lupus Erythematosus

21 locations incl. Orange

Sponsor: Cabaletta Bio

Sex: All·Age: 18 - 65

Code: NCT06121297·Phase 1, Phase 2·Recruiting

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A Study to Evaluate Avacopan in Participants With ANCA-associated Vasculitis

for Antineutrophil Cytoplasmic Antibody-associated Vasculitis

60 locations incl. Anchorage

Sponsor: Amgen

Sex: All·Age: 18 - 100

Code: NCT06072482·Phase 4·Recruiting

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Phase I Study of Tolododekin Alfa (ANK-101) in Advanced Solid Tumors

for Advanced Solid Tumor

4 locations incl. Bethesda

Sponsor: Ankyra Therapeutics, Inc

Sex: All·Age: 18+

Code: NCT06171750·Phase 1·Recruiting

Apply to this trial