An Open-label Dose Escalation and Expansion, Followed by a Phase II Study of Tulmimetostat (DZR123) and JSB462 (Luxdegalutamide) in Patients With Progressive Metastatic Castrate Resistant Prostate Cancer (mCRPC) (TulmiSTAR-01)for Progressive Metastatic Castrate Resistant Prostate CancerDrug: Tulmimetostat6 locations incl. DenverSponsor: Novartis PharmaceuticalsSex: Male·Age: 18+Code: NCT07206056·Phase 1, Phase 2·RecruitingApply to this trial
Safety of RSV Preventive Monoclonal Antibodyfor Fever6 locations incl. OaklandSponsor: Duke UniversitySex: All·Age: 6 Weeks - 30 Weeks·Accepts healthy volunteersCode: NCT07158814·Phase 4·RecruitingApply to this trial
Study of COYA 302 for the Treatment of ALSfor Amyotrophic Lateral Sclerosis (ALS)21 locations incl. PhoenixSponsor: Coya TherapeuticsSex: All·Age: 18 - 80Code: NCT07161999·Phase 2·RecruitingApply to this trial
A Study of Tarlatamab in Combination With AB248 in Participants With Extensive Stage Small Cell Lung Cancer (DeLLphi-311)for Extensive Stage Small Cell Lung CancerDrug: Tarlatamab13 locations incl. GilbertSponsor: AmgenSex: All·Age: 18 - 90Code: NCT07037758·Phase 1·RecruitingApply to this trial
Communicating About Nicotine Reduction in Cigarettesfor Tobacco Products2 locations incl. AtlantaSponsor: Georgia State UniversitySex: All·Age: 21+·Accepts healthy volunteersCode: NCT06787937·RecruitingApply to this trial
JAK Signaling in Depressionfor Major Depressive Disorder1 location in AtlantaSponsor: Emory UniversitySex: All·Age: 25 - 55Code: NCT07003997·Phase 2·RecruitingApply to this trial
Phase 2 Study of Inhaled SNG001 in Mechanically Ventilated Patients With Respiratory Viral Infectionfor Viral Pneumonia22 locations incl. SacramentoSponsor: Synairgen Research Ltd.Sex: All·Age: 18+Code: NCT06999603·Phase 2·RecruitingApply to this trial
A Follow-up Study of Mezagitamab in Adults With Chronic Primary Immune Thrombocytopeniafor Immune Thrombocytopenic Purpura (ITP)17 locations incl. Los AngelesSponsor: TakedaSex: All·Age: 18+Code: NCT06948318·Phase 3·RecruitingApply to this trial
Assess Performance Attributes and Acceptability of Non-medicated Intravaginal Rings Among Sexually Active Women in Atlanta, GAfor Contraceptive Usage1 location in AtlantaSponsor: Population CouncilSex: Female·Age: 18 - 49·Accepts healthy volunteersCode: NCT07039591·EARLY_Phase 1·RecruitingApply to this trial
AMG 410 Alone and in Combination With Other Agents in Participants With KRAS Altered Advanced or Metastatic Solid Tumorsfor KRAS Altered Advanced or Metastatic Solid Tumors9 locations incl. DuarteSponsor: AmgenSex: All·Age: 18+Code: NCT07094113·Phase 1·RecruitingApply to this trial
RE104 Safety and Efficacy Study in Adjustment Disorder in Cancer and Other Medical Illnessesfor Adjustment Disorder30 locations incl. BirminghamSponsor: Reunion Neuroscience IncSex: All·Age: 18 - 80Code: NCT07002034·Phase 2·RecruitingApply to this trial
A Study of Intravenous L-Citrulline in Patients Aged 6-21 Years Old With Sickle Cell Disease Presenting to Emergency Departments in Acute Vaso-Occlusive Crisisfor Sickle Cell Disease6 locations incl. Washington D.C.Sponsor: Asklepion Pharmaceuticals, LLCSex: All·Age: 6 - 21Code: NCT06989567·Phase 3·Not Yet Recruiting
Voice Technology-Based Self-Management Interventionfor Mild Cognitive Impairment1 location in AtlantaSponsor: Emory UniversitySex: All·Age: 55+Code: NCT06982261·RecruitingApply to this trial
ELEVATE-HFpEF Clinical Studyfor Heart Failure With Preserved Ejection Fraction (HFpEF)25 locations incl. PhoenixSponsor: Medtronic Cardiac Rhythm and Heart FailureSex: All·Age: 40+Code: NCT06678841·RecruitingApply to this trial
Clinical and Biomarker Effects of Depot Medroxyprogesterone Acetate in Females With Sickle Cell Diseasefor Sickle Cell Disease (SCD)2 locations incl. AtlantaSponsor: University of PennsylvaniaSex: Female·Age: 18 - 50Code: NCT06665997·Phase 4·RecruitingApply to this trial
Alpha Radiation Emitters Device (DaRT) With Chemotherapy for the Treatment of Locally Advanced and Metastatic Pancreatic Cancerfor Pancreatic Cancer13 locations incl. GilbertSponsor: Alpha Tau Medical LTD.Sex: All·Age: 18 - 120Code: NCT06698458·RecruitingApply to this trial
Neonatal Platelet Transfusion Threshold Trialfor Thrombocytopenia20 locations incl. BirminghamSponsor: NICHD Neonatal Research NetworkSex: All·Age: 1 Hour - 48 Hours·Accepts healthy volunteersCode: NCT06676904·RecruitingApply to this trial
Milrinone for Prevention of Post-ligation Cardiac Syndrome Trialfor Post-ligation Cardiac Syndrome19 locations incl. BirminghamSponsor: NICHD Neonatal Research NetworkSex: All·Age: Up to 3 MonthsCode: NCT06679855·Phase 3·RecruitingApply to this trial
VIZ ACCESS HCM - Multi-Site Registryfor Hypertrophic Cardiomyopathy3 locations incl. AtlantaSponsor: Viz.ai, Inc.Sex: All·Age: 18+Code: NCT07103057·RecruitingApply to this trial
The AIRTIVITY™ Study: A Study to Find Out Whether BI 1291583 Helps People With Bronchiectasisfor Bronchiectasis80 locations incl. BirminghamSponsor: Boehringer IngelheimSex: All·Age: 12+Code: NCT06872892·Phase 3·RecruitingApply to this trial
A Study of TAK-411 in Adults With Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP)for Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP)13 locations incl. La JollaSponsor: TakedaSex: All·Age: 18+Code: NCT06798012·Phase 2·RecruitingApply to this trial
Restarting Triple Therapy With Robust Monitoring for Adverse Events (RETRIAL)for Cystic Fibrosis18 locations incl. BirminghamSponsor: Boston Children's HospitalSex: All·Age: 6+Code: NCT06683092·RecruitingApply to this trial
A Study of Mezagitamab in Adults With Chronic Primary Immune Thrombocytopeniafor Immune Thrombocytopenic Purpura (ITP)18 locations incl. Los AngelesSponsor: TakedaSex: All·Age: 18+Code: NCT06722235·Phase 3·RecruitingApply to this trial
Open-label Study Comparing AAA817 Versus Standard of Care in the Treatment of Previously Treated PSMA-positive mCRPC Adults Who Have Disease Progressed on or After [177Lu]Lu-PSMA Targeted Therapyfor Prostate Cancer27 locations incl. Los AngelesSponsor: Novartis PharmaceuticalsSex: Male·Age: 18 - 100Code: NCT06780670·Phase 2, Phase 3·RecruitingApply to this trial
Youth Participatory Action Research to Prevent Community Violence Among Black Youthfor Community Violence2 locations incl. AtlantaSponsor: Emory UniversitySex: All·Age: 12 - 17·Accepts healthy volunteersCode: NCT06886204·RecruitingApply to this trial
PCORI Comparative Effectiveness Study-Esketamine (Spravato) vs. Ketamine-Equivalence Studyfor Depression6 locations incl. MilfordSponsor: Yale UniversitySex: All·Age: 18+Code: NCT06713616·Phase 3·RecruitingApply to this trial
A Study to Evaluate the Safety and Efficacy of Ruxolitinib Cream in Pediatric Participants With Nonsegmental Vitiligofor NonSegmental VitiligoDrug: Ruxolitinib80 locations incl. BirminghamSponsor: Incyte CorporationSex: All·Age: 2 - 11Code: NCT06548360·Phase 3·RecruitingApply to this trial
DeciPHer-ILD: A Real-world Patient Registry in Group 3 Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD)for Pulmonary Hypertension Due to Lung Diseases and Hypoxia66 locations incl. BirminghamSponsor: United TherapeuticsSex: All·Age: 18+Code: NCT06388421·RecruitingApply to this trial
A Phase 2 Study and Open-Label Extension of NEU-411 in Companion Diagnostic-Positive Participants With Early Parkinson's Diseasefor Parkinson Disease45 locations incl. Sun CitySponsor: Neuron23 Inc.Sex: All·Age: 40 - 80Code: NCT06680830·Phase 2·RecruitingApply to this trial
A Trial to Evaluate the Safety and Activity of Fruquintinib in Minority Populations With Advanced, Previously Treated Colorectal Cancerfor Colorectal Cancer44 locations incl. BirminghamSponsor: TakedaSex: All·Age: 18+Code: NCT06562543·Phase 4·RecruitingApply to this trial
RESTORE: REducing Future fractureS and Improving ouTcOmes of fRagility fracturEfor Osteoporosis23 locations incl. BirminghamSponsor: University of Alabama at BirminghamSex: All·Age: 50+Code: NCT06455085·RecruitingApply to this trial
The PERSEVERE Studyfor Pulmonary Embolism13 locations incl. New HavenSponsor: Inari MedicalSex: All·Age: 18+Code: NCT06588634·RecruitingApply to this trial
Study to Evaluate Ultevursen in Subjects With Retinitis Pigmentosa (RP) Due to Mutations in Exon 13 of the USH2A Genefor Retinitis Pigmentosa (RP)11 locations incl. San FranciscoSponsor: Laboratoires TheaSex: All·Age: 8+Code: NCT06627179·Phase 2·RecruitingApply to this trial
The JenaValve ALIGN-AR LVAD Registryfor Aortic Regurgitation15 locations incl. Los AngelesSponsor: JenaValve Technology, Inc.Sex: All·Age: 18+Code: NCT06594705·RecruitingApply to this trial
A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset AD Caused by a Genetic Mutationfor Alzheimers Disease12 locations incl. BirminghamSponsor: Washington University School of MedicineSex: All·Age: 18+·Accepts healthy volunteersCode: NCT05552157·Phase 2, Phase 3·RecruitingApply to this trial
A Study of a Potential Disease Modifying Treatment in Individuals at Risk for or With a Type of Early Onset AD Caused by a Genetic Mutationfor Alzheimers Disease12 locations incl. BirminghamSponsor: Washington University School of MedicineSex: All·Age: 18+·Accepts healthy volunteersCode: NCT06647498·Phase 2, Phase 3·RecruitingApply to this trial
Chronic Subdural Hematoma Treatment With Embolization Versus Surgery Studyfor Chronic Subdural Hematoma31 locations incl. PhoenixSponsor: The University of Texas Medical Branch, GalvestonSex: All·Age: 40 - 90Code: NCT06347796·RecruitingApply to this trial
A Long-term Extension (LTE) Study of Guselkumab in Pediatric Participantsfor Crohns DiseaseDrug: Guselkumab5 locations incl. AtlantaSponsor: Janssen Research & Development, LLCSex: All·Age: 3+Code: NCT06663332·Phase 3·RecruitingApply to this trial
Investigation of the BrioVAD System for the Treatment of Left Ventricular Heart Failurefor Cardiovascular Diseases37 locations incl. Little RockSponsor: BrioHealth Solutions, Inc.Sex: All·Age: 18 - 100Code: NCT06310031·RecruitingApply to this trial
Study to Evaluate Avacopan in Combination With a Rituximab or Cyclophosphamide-containing Regimen, in Children From 6 Years to < 18 Years of Age With AAV.for VasculitisDrug: Rituximab10 locations incl. AtlantaSponsor: AmgenSex: All·Age: 6 - 17Code: NCT06321601·Phase 3·RecruitingApply to this trial