The PERSEVERE Study

Part of paid clinical trials in New Haven, Connecticut.

Sponsor
Inari Medical
Study ID
NCT06588634
Status
Recruiting
Apply to this trial

Conditions

  • Pulmonary Embolism
  • Pulmonary Thromboembolism

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • FlowTriever System — DEVICE
    Mechanical thrombectomy for pulmonary embolism
  • Standard of Care — PROCEDURE
    Standard of care treatment for pulmonary embolism

Study Details

Randomized Controlled Trial of High-Risk Pulmonary Embolism Comparing FlowTriever System vs. Standard of Care

Key Dates

Start date
Dec 16, 2024
Status verified
Jun 2026
Primary completion
Nov 30, 2027
Completion
Feb 29, 2028

Study Design

Enrollment
200 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Active Comparator: FlowTriever
  • Active Comparator: Standard of Care

Primary Outcome Measure

Composite clinical endpoint of the following adjudicated events: [ Time Frame: The earlier of initial hospital discharge or 7 days after randomization ]

Central Contacts

Locations (13)

FacilityCityStateZIPSite coordinators
Yale UniversityNew HavenConnecticut06519
Christopher Moore, MD
Orlando Health Regional Medical CenterOrlandoFlorida32806
Joel Garcia-Fernandez, MD
Sarasota Memorial HospitalSarasotaFlorida34239
Clinton Wrigley, MD
Emory UniversityAtlantaGeorgia30322
Wissam Jaber, MD
University of Mississippi Medical CenterJacksonMississippi39216
Gabriel Hernandez, MD
Northwell HealthBay ShoreNew York11706
Wally Omar, MD
SUNY, The University at BuffaloBuffaloNew York14203
David Zlotnick, MD
Summa AkronAkronOhio44304
Mark Rea, MD
UPHS Penn Health SystemPhiladelphiaPennsylvania19104
Taisei Kobayashi, MD
Russell Rosenberg, MD
Allegheny General HospitalPittsburghPennsylvania15212
Mithun Chakravarthy, MD
HCA Tristar/CentennialNashvilleTennessee37203
Samuel Horr, MD
HCA Medical City Heart & SpineDallasTexas75039
Srinivas Yallapragada, MD
HCA Methodist Health San AntonioSan AntonioTexas78229
Chandra Kunavarapu, MD

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Yale University· New Haven, CTOrlando Health Regional Medical Center· Orlando, FLSarasota Memorial Hospital· Sarasota, FLEmory University· Atlanta, GAUniversity of Mississippi Medical Center· Jackson, MSNorthwell Health· Bay Shore, NY

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