Zuranolone Clinical Trials (2026): 4 Studies for Depression, Postpartum & Major Depressive Disorder
Hipa.ai Research · Source: ClinicalTrials.gov / AACT
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4 Zuranolone clinical trials are catalogued on Hipa.ai from the AACT mirror of ClinicalTrials.gov, spanning 4 indications (including Depression, Postpartum & Major Depressive Disorder) and 425 total planned enrollment. 3 Zuranolone clinical trials are actively recruiting at 3 U.S. sites across 3 states. Most recent activity: NCT07398469 (Mar 2027).
Where to Participate: All Zuranolone Trial Sites in the U.S. (3 sites across 3 states)
Every actively recruiting Zuranolonetrial site, sorted by state then city. Each row links to the trial detail page (eligibility, contacts, full study record). Sites no longer enrolling at the location level are excluded. ClinicalTrials.gov / AACT does not provide street-level addresses; the map link uses the facility's geocoded coordinates where available.
| State | Facility | City | Trial | Map |
|---|---|---|---|---|
| MA | Biogen | Cambridge02142 | NCT07398469 | Map |
| NC | Duke South Neurology Clinic 1L | Durham27710-0400 | NCT06759558 | Map |
| RI | CVS Health | Woonsocket02895 | NCT07047820 | Map |
Zuranolone clinical trials at a glance: phase × recruitment status
| Phase | recruiting | completed | Total |
|---|---|---|---|
| P1 | 1 | 1 | |
| P2 | 1 | 1 | |
| N/A | 2 | 2 |
Recruiting Zuranolone clinical trials (3)
Studies currently enrolling participants. Click any NCT ID to view the trial detail page (eligibility, sites, contacts).
| NCT ID | Title | Phase | Indication | Enrollment | Started |
|---|---|---|---|---|---|
| NCT07398469 | A Long-Term Study of Patient-Reported Changes in Postpartum Depression Symptoms in People Starting Zuranolone | — | Postpartum Depression | 200 | Dec 2025 |
| NCT07047820 | A Study to Learn More About How Zuranolone Affects Postpartum Depression Symptoms in Participants Who Took it Within 1 Year After The End of Their Pregnancy | — | Depression, Postpartum | 200 | Jun 2025 |
| NCT06759558 | ALLO in PSDAllopregnanolone (Zuranolone) in Post-stroke Depression | P2 | Post Stroke Depression | 6 | Jan 2026 |
Zuranolone clinical trials by indication
Post Stroke Depression (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT06759558 | ALLO in PSD | P2 | recruiting | Allopregnanolone (Zuranolone) in Post-stroke Depression |
Postpartum Depression (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT07398469 | — | N/A | recruiting | A Long-Term Study of Patient-Reported Changes in Postpartum Depression Symptoms in People Starting Zuranolone |
Depression, Postpartum (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT07047820 | — | N/A | recruiting | A Study to Learn More About How Zuranolone Affects Postpartum Depression Symptoms in Participants Who Took it Within 1 Year After The End of Their Pregnancy |
Major Depressive Disorder (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT05655507 | PK | P1 | completed | Zuranolone Pharmacokinetics (PK) and Safety Study Adolescent Participants With Major Depressive Disorder (MDD) |
Zuranolone pivotal trial highlights (Phase 2/3/4)
Phase-2/3/4 studies with named acronyms — the registration-grade trials most cited in label discussions and Wikipedia.
| Acronym | NCT | Phase | Status | Indication | Enrollment | PubMed |
|---|---|---|---|---|---|---|
| ALLO in PSD | NCT06759558 | P2 | recruiting | Post Stroke Depression | 6 | PMID 34482541 |
All Zuranolone trials (4)
Sorted by most recent activity (completion → start → posted date). Each row links to the trial detail page on Hipa.ai.
| NCT ID | Acronym | Title | Phase | Status | Enrollment | Sponsor | Started |
|---|---|---|---|---|---|---|---|
| NCT07398469 | A Long-Term Study of Patient-Reported Changes in Postpartum Depression Symptoms in People Starting Zuranolone | — | recruiting | 200 | Biogen | Dec 2025 | |
| NCT07047820 | A Study to Learn More About How Zuranolone Affects Postpartum Depression Symptoms in Participants Who Took it Within 1 Year After The End of Their Pregnancy | — | recruiting | 200 | Biogen | Jun 2025 | |
| NCT06759558 | ALLO in PSD | Allopregnanolone (Zuranolone) in Post-stroke Depression | P2 | recruiting | 6 | Duke University | Jan 2026 |
| NCT05655507 | PK | Zuranolone Pharmacokinetics (PK) and Safety Study Adolescent Participants With Major Depressive Disorder (MDD) | P1 | completed | 19 | Biogen | Apr 2023 |
Zuranolone clinical trials: frequently asked questions
- How many Zuranolone clinical trials are there?
- 4 Zuranolone clinical trials are catalogued on Hipa.ai, sourced from the AACT mirror of ClinicalTrials.gov. 3 are actively recruiting participants. 1 is marked completed.
- Are Zuranolone clinical trials recruiting in 2026?
- Yes — 3 Zuranolone trials are actively recruiting in 2026, with 3 U.S. sites across 3 states. See the recruiting trials and the per-state site list further down this page.
- What conditions is Zuranolone being studied for?
- Zuranolone is being studied for Depression, Postpartum, Major Depressive Disorder, Post Stroke Depression, Postpartum Depression. The trials are grouped by indication on this page.
- What phase is Zuranolone in?
- Zuranolone clinical trials span 1 Phase 2, 1 Phase 1. The phase × status matrix at the top of this page breaks down counts by phase and recruitment status.
- Who sponsors Zuranolone clinical trials?
- The lead sponsor across the most Zuranolone trials is Biogen, with 1 additional lead sponsor listed in the data. Each trial row links to the full study detail page including sponsor information.
Sources and methodology
Trial inventory derived from the AACT mirror of ClinicalTrials.gov. Trials are filtered to those naming Zuranoloneas an intervention. Phase, status, enrollment, sponsor, and dates are taken from the source `studies` table; primary indication is the first listed condition. Acronyms are extracted from each trial's brief title where present. PubMed links are populated for trials whose published primary outcomes have been indexed in our evidence cache.
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