Zuranolone Evidence: Trial Results and Peer-Reviewed Publications

Stroke (30)

• Efficacy and safety of zuranolone in the treatment of major depressive disorder: a meta-analysis.
  Front Neurosci · 2024 · PMID 38292895 · NCT06759558
• Depression following small vessel stroke is common and more prevalent in women.
  J Stroke Cerebrovasc Dis · 2024 · PMID 38395097 · NCT06759558
• White Matter Microstructure Is Associated with Serum Neuroactive Steroids and Psychological Functioning.
  J Neurotrauma · 2023 · PMID 36324218 · NCT06759558
• Zuranolone for the Treatment of Adults With Major Depressive Disorder: A Randomized, Placebo-Controlled Phase 3 Trial.
  Am J Psychiatry · 2023 · PMID 37132201 · NCT06759558
• Neurosteroids: A novel promise for the treatment of stroke and post-stroke complications.
  J Neurochem · 2022 · PMID 34482541 · NCT06759558

2024 (2 papers)

1. Efficacy and safety of zuranolone in the treatment of major depressive disorder: a meta-analysis.
   Wang S, Zhang W, Liu Z, et al. · Front Neurosci · 2024 · Background
   PubMed: PMID 38292895 · NCT06759558 (ALLO in PSD) · Stroke
2. Depression following small vessel stroke is common and more prevalent in women.
   Dymm B, Goldstein LB, Unnithan S, et al. · J Stroke Cerebrovasc Dis · 2024 · Background
   PubMed: PMID 38395097 · NCT06759558 (ALLO in PSD) · Stroke

2023 (2 papers)

1. White Matter Microstructure Is Associated with Serum Neuroactive Steroids and Psychological Functioning.
   Umminger LF, Rojczyk P, Seitz-Holland J, et al. · J Neurotrauma · 2023 · Background
   PubMed: PMID 36324218 · NCT06759558 (ALLO in PSD) · Stroke
2. Zuranolone for the Treatment of Adults With Major Depressive Disorder: A Randomized, Placebo-Controlled Phase 3 Trial.
   Clayton AH, Lasser R, Parikh SV, et al. · Am J Psychiatry · 2023 · Background
   PubMed: PMID 37132201 · NCT06759558 (ALLO in PSD) · Stroke

2022 (6 papers)

1. Neurosteroids: A novel promise for the treatment of stroke and post-stroke complications.
   Xu J, Zhou Y, Yan C, et al. · J Neurochem · 2022 · Background
   PubMed: PMID 34482541 · NCT06759558 (ALLO in PSD) · Stroke
2. Association of in-hospital depression and anxiety symptoms following stroke with 3 months- depression, anxiety and functional outcome.
   Redmond C, Bushnell C, Duncan P, et al. · J Clin Neurosci · 2022 · Background
   PubMed: PMID 35180502 · NCT06759558 (ALLO in PSD) · Stroke
3. Allopregnanolone in Postpartum Depression.
   Pinna G, Almeida FB, Davis JM, et al. · Front Glob Womens Health · 2022 · Background
   PubMed: PMID 35558166 · NCT06759558 (ALLO in PSD) · Stroke
4. Allopregnanolone: An overview on its synthesis and effects.
   Diviccaro S, Cioffi L, Falvo E, et al. · J Neuroendocrinol · 2022 · Background
   PubMed: PMID 34189791 · NCT06759558 (ALLO in PSD) · Stroke
5. Effect of Zuranolone vs Placebo in Postpartum Depression: A Randomized Clinical Trial.
   Deligiannidis KM, Meltzer-Brody S, Gunduz-Bruce H, et al. · JAMA Psychiatry · 2022 · Background
   PubMed: PMID 34190962 · NCT06759558 (ALLO in PSD) · Stroke
6. Allopregnanolone in mood disorders: Mechanism and therapeutic development.
   Chen S, Gao L, Li X, et al. · Pharmacol Res · 2022 · Background
   PubMed: PMID 34019980 · NCT06759558 (ALLO in PSD) · Stroke

2021 (3 papers)

1. Neuroendocrine biomarkers of prolonged exposure treatment response in military-related PTSD.
   Rauch SAM, Sripada R, Burton M, et al. · Psychoneuroendocrinology · 2021 · Background
   PubMed: PMID 32554173 · NCT06759558 (ALLO in PSD) · Stroke
2. Serum Neurosteroid Levels Are Associated With Cortical Thickness in Individuals Diagnosed With Posttraumatic Stress Disorder and History of Mild Traumatic Brain Injury.
   Kinzel P, Marx CE, Sollmann N, et al. · Clin EEG Neurosci · 2021 · Background
   PubMed: PMID 32186207 · NCT06759558 (ALLO in PSD) · Stroke
3. Allopregnanolone Promotes Neuronal and Oligodendrocyte Differentiation In Vitro and In Vivo: Therapeutic Implication for Alzheimer's Disease.
   Chen S, Wang T, Yao J, et al. · Neurotherapeutics · 2021 · Background
   PubMed: PMID 32632771 · NCT06759558 (ALLO in PSD) · Stroke

2020 (2 papers)

1. Allopregnanolone: From molecular pathophysiology to therapeutics. A historical perspective.
   Paul SM, Pinna G, Guidotti A, et al. · Neurobiol Stress · 2020 · Background
   PubMed: PMID 32435665 · NCT06759558 (ALLO in PSD) · Stroke
2. The role of allopregnanolone in depressive-like behaviors: Focus on neurotrophic proteins.
   Almeida FB, Nin MS, Barros HMT, et al. · Neurobiol Stress · 2020 · Background
   PubMed: PMID 32435667 · NCT06759558 (ALLO in PSD) · Stroke

2018 (1 paper)

1. Depression Status Is Associated with Functional Decline Over 1-Year Following Acute Stroke.
   El Husseini N, Goldstein LB, Peterson ED, et al. · J Stroke Cerebrovasc Dis · 2018 · Background
   PubMed: PMID 28389192 · NCT06759558 (ALLO in PSD) · Stroke

2017 (2 papers)

1. Poststroke Depression: A Scientific Statement for Healthcare Professionals From the American Heart Association/American Stroke Association.
   Towfighi A, Ovbiagele B, El Husseini N, et al. · Stroke · 2017 · Background
   PubMed: PMID 27932603 · NCT06759558 (ALLO in PSD) · Stroke
2. Lower allopregnanolone during pregnancy predicts postpartum depression: An exploratory study.
   Osborne LM, Gispen F, Sanyal A, et al. · Psychoneuroendocrinology · 2017 · Background
   PubMed: PMID 28278440 · NCT06759558 (ALLO in PSD) · Stroke

2016 (1 paper)

1. Post-stroke depression and post-stroke anxiety: prevalence and predictors.
   Schöttke H, Giabbiconi CM · Int Psychogeriatr · 2016 · Background
   PubMed: PMID 26178418 · NCT06759558 (ALLO in PSD) · Stroke

2015 (1 paper)

1. Low serum allopregnanolone is associated with symptoms of depression in late pregnancy.
   Hellgren C, Åkerud H, Skalkidou A, et al. · Neuropsychobiology · 2015 · Background
   PubMed: PMID 24776841 · NCT06759558 (ALLO in PSD) · Stroke

2014 (2 papers)

1. The role of allopregnanolone in depression and anxiety.
   Schüle C, Nothdurfter C, Rupprecht R, et al. · Prog Neurobiol · 2014 · Background
   PubMed: PMID 24215796 · NCT06759558 (ALLO in PSD) · Stroke
2. The role of neuroendocrine pathways in prognosis after stroke.
   El Husseini N, Laskowitz DT · Expert Rev Neurother · 2014 · Background
   PubMed: PMID 24428141 · NCT06759558 (ALLO in PSD) · Stroke

2013 (2 papers)

1. Allopregnanolone elevations following pregnenolone administration are associated with enhanced activation of emotion regulation neurocircuits.
   Sripada RK, Marx CE, King AP, et al. · Biol Psychiatry · 2013 · Background
   PubMed: PMID 23348009 · NCT06759558 (ALLO in PSD) · Stroke
2. Altered stress responsiveness and hypothalamic-pituitary-adrenal axis function in male rat offspring of socially isolated parents.
   Pisu MG, Garau A, Olla P, et al. · J Neurochem · 2013 · Background
   PubMed: PMID 23600845 · NCT06759558 (ALLO in PSD) · Stroke

2012 (2 papers)

1. Neurosteroids and GABA-A Receptor Function.
   Wang M · Front Endocrinol (Lausanne) · 2012 · Background
   PubMed: PMID 22654809 · NCT06759558 (ALLO in PSD) · Stroke
2. Depression and antidepressant use after stroke and transient ischemic attack.
   El Husseini N, Goldstein LB, Peterson ED, et al. · Stroke · 2012 · Background
   PubMed: PMID 22461330 · NCT06759558 (ALLO in PSD) · Stroke

2010 (1 paper)

1. Progesterone and allopregnanolone attenuate blood-brain barrier dysfunction following permanent focal ischemia by regulating the expression of matrix metalloproteinases.
   Ishrat T, Sayeed I, Atif F, et al. · Exp Neurol · 2010 · Background
   PubMed: PMID 20816826 · NCT06759558 (ALLO in PSD) · Stroke

2008 (1 paper)

1. Decreased corticolimbic allopregnanolone expression during social isolation enhances contextual fear: A model relevant for posttraumatic stress disorder.
   Pibiri F, Nelson M, Guidotti A, et al. · Proc Natl Acad Sci U S A · 2008 · Background
   PubMed: PMID 18391192 · NCT06759558 (ALLO in PSD) · Stroke

2006 (1 paper)

1. Anti-apoptotic effects of allopregnanolone on P19 neurons.
   Xilouri M, Papazafiri P · Eur J Neurosci · 2006 · Background
   PubMed: PMID 16420414 · NCT06759558 (ALLO in PSD) · Stroke

2004 (1 paper)

1. Progesterone and allopregnanolone reduce inflammatory cytokines after traumatic brain injury.
   He J, Evans CO, Hoffman SW, et al. · Exp Neurol · 2004 · Background
   PubMed: PMID 15380490 · NCT06759558 (ALLO in PSD) · Stroke