Solriamfetol Clinical Trials (2026): 19 Studies for Obstructive Sleep Apnea & Excessive Sleepiness

Hipa.ai Research · Source: ClinicalTrials.gov / AACT

Synced daily from ClinicalTrials.gov via AACT. Last sync: .

19 Solriamfetol clinical trials are catalogued on Hipa.ai from the AACT mirror of ClinicalTrials.gov, spanning 15 indications (including Obstructive Sleep Apnea & Excessive Sleepiness) and 6,310 total planned enrollment. 7 Phase 3 Solriamfetol trials and 4 Phase 2, 5 Phase 4 are listed. 7 Solriamfetol clinical trials are actively recruiting at 92 U.S. sites across 23 states. Most recent activity: NCT06413420 (Sep 2029).

Where to Participate: All Solriamfetol Trial Sites in the U.S. (92 sites across 23 states)

Every actively recruiting Solriamfetoltrial site, sorted by state then city. Each row links to the trial detail page (eligibility, contacts, full study record). Sites no longer enrolling at the location level are excluded. ClinicalTrials.gov / AACT does not provide street-level addresses; the map link uses the facility's geocoded coordinates where available.

StateFacilityCityTrialMap
ALClinical Research SiteCullman35055NCT06568367Map
AZClinical Research SiteChandler85224NCT06568367Map
AZClinical Research SiteTucson85704NCT06568367Map
ARClinical Research SiteLittle Rock72211NCT06568367Map
CAClinical Research SiteCerritos90703NCT06568367Map
CAClinical Research SiteChino91710NCT07484217Map
CAClinical Research SiteChula Vista91910NCT06568367Map
CAClinical Research SiteEncino91316NCT06413433Map
CAClinical Research SiteGarden Grove92845NCT06413433Map
CAClinical Research SiteHuntington Beach92647NCT06568367Map
CAClinical Research SiteLong Beach90805NCT06568367Map
CAClinical Research SiteLong Beach90806NCT06413433Map
CAClinical Research SiteNewport Beach92660NCT06413433Map
CAClinical Research SiteRedlands92374NCT07484217Map
CAClinical Research SiteSanta Ana92705NCT06568367Map
CAClinical Research SiteSanta Ana92705NCT06413433Map
CAClinical Research SiteWalnut Creek94596NCT06413433Map
CAClinical Research SiteWalnut Creek94596NCT07484217Map
CAClinical Research SiteWest Covina91790NCT06413433Map
COClinical Research SiteColorado Springs80918NCT06568367Map
COClinical Research SiteColorado Springs80910NCT06413433Map
CTClinical Research SiteCromwell06416NCT06413433Map
FLClinical Research SiteBrandon33511NCT06568367Map
FLClinical Research SiteFort Myers33912NCT06413433Map
FLClinical Research SiteHialeah33016NCT06568367Map
FLClinical Research SiteHialeah33012NCT06413433Map
FLClinical Research SiteJacksonville32256NCT06413433Map
FLClinical Research SiteJacksonville32256NCT07484217Map
FLClinical Research SiteLauderhill33319NCT06413433Map
FLClinical Research SiteMiami33135NCT06568367Map
FLClinical Research SiteMiami33144NCT06568367Map
FLClinical Research SiteMiami33176NCT06568367Map
FLClinical Research SiteMiami33145NCT06413433Map
FLClinical Research SiteMiami33176NCT06413433Map
FLClinical Research SiteMiami33176NCT07484217Map
FLClinical Research SiteMiami Lakes33016NCT06568367Map
FLClinical Research SiteOrlando32801NCT06413433Map
GAClinical Research SiteAtlanta30238NCT06568367Map
GAClinical Research SiteMarietta30060NCT06413433Map
GAClinical Research SiteStockbridge30281NCT06568367Map
KSClinical Research SiteOverland Park66210NCT06413433Map
MDJohns Hopkins UniversityBaltimore21287NCT06170970Map
MDClinical Research SiteTowson21286NCT06568367Map
MAClinical Research SiteBoston02115NCT06568367Map
MAClinical Research SiteBoston02131NCT06413433Map
MIClinical Research SiteLansing48911NCT06568367Map
MIClinical Research SiteNovi48377NCT06568367Map
MIClinical Research SiteSouthfield48075NCT06568367Map
MOClinical Research SiteChesterfield63017NCT06568367Map
MOClinical Research SiteSaint Charles63304NCT06413433Map
MOClinical Research SiteSt Louis63123NCT06568367Map
NVClinical Research SiteHenderson89052NCT06568367Map
NJClinical Research SiteCherry Hill08002NCT06413433Map
NJClinical Research SiteCherry Hill08002NCT07484217Map
NJClinical Research SiteMiddletown07748NCT06568367Map
NJClinical Research SitePrinceton08540NCT06413433Map
NJClinical Research SiteToms River08755NCT07484217Map
NYClinical Research SiteBrooklyn11235NCT07484217Map
NYClinical Research SiteMount Kisco10549NCT06413433Map
NYClinical Research SiteNew York10128NCT06413433Map
NYClinical Research SiteThe Bronx10464NCT07484217Map
NCClinical Research SiteDenver28037NCT06568367Map
NCClinical Research SiteFayetteville28304NCT06568367Map
NCClinical Research SiteHuntersville28078NCT06568367Map
NCEvidera, a PPD business unitMorrisville27560NCT06413420Map
NCClinical Research SiteRaleigh27607NCT06413433Map
NCPPD, Inc.Wilmington28401NCT06413420Map
OHClinical Research SiteCincinnati45212NCT06568367Map
OHClinical Research SiteCincinnati45245NCT06568367Map
OHClinical Research SiteCincinnati45215NCT06413433Map
OHClinical Research SiteCincinnati45215NCT07484217Map
OHClinical Research SiteMason45040NCT06413433Map
OHClinical Research SiteMiddleburg Heights44130NCT06413433Map
ORClinical Research SitePortland97210NCT06413433Map
ORClinical Research SitePortland97210NCT07484217Map
PAClinical Research SiteAllentown18104NCT06413433Map
PAClinical Research SiteMedia19063NCT06413433Map
PAClinical Research SiteWyomissing19610NCT06568367Map
SCClinical Research SiteCharleston29425NCT06568367Map
SCClinical Research SiteColumbia29201NCT06568367Map
SCClinical Research SiteGreenville29615NCT06413433Map
SCClinical Research SiteNorth Charleston29405NCT06413433Map
TNClinical Research SiteMemphis38119NCT06413433Map
TNClinical Research SiteMemphis38119NCT07484217Map
TXClinical Research SiteAustin73787NCT06413433Map
TXClinical Research SiteAustin78731NCT06413433Map
TXClinical Research SiteDallas75231NCT06413433Map
TXClinical Research SiteDallas75243NCT07484217Map
TXClinical Research SiteHouston77070NCT06568367Map
TXClinical Research SiteSan Antonio78229NCT06568367Map
TXClinical Research SiteSan Antonio78229NCT06413433Map
TXClinical Research SiteSugar Land77478NCT06568367Map

Solriamfetol clinical trials at a glance: phase × recruitment status

Phaserecruitingenrolling by invitationcompletedterminatednot yet recruitingunknownTotal
P111
P21214
P2/P311
P33137
P43115
N/A11

Recruiting Solriamfetol clinical trials (7)

Studies currently enrolling participants. Click any NCT ID to view the trial detail page (eligibility, sites, contacts).

NCT IDTitlePhaseIndicationEnrollmentStarted
NCT06413420SUNOSI® (Solriamfetol) Pregnancy RegistryNarcolepsy1,731Jul 2019
NCT07484217CLARITYClinical Assessment of Response in the Treatment of Depression With Daytime Sleepiness Using SolriamfetolP3Major Depressive Disorder With Excessive Daytime Sleepiness Symptoms508Feb 2026
NCT06590662SOLR-IHEfficacy and Tolerance of Solriamfetol in Patients Affected with Idiopathic Hypersomnia.P2Idiopathic Hypersomnia60Sep 2024
NCT06170970SOLARIMSSolriamfetol for the Treatment of Multiple Sclerosis FatigueP2Multiple Sclerosis46Jun 2024
NCT06878976Open-Label Safety Study of Solriamfetol in Subjects With Binge Eating DisorderP3Binge-Eating Disorder300Feb 2025
NCT06568367SUSTAINStudying Solriamfetol Modulation of TAAR-1, Dopamine, and Norepinephrine in Shift Work Disorder (SUSTAIN)P3Excessive Sleepiness520Aug 2024
NCT06413433ENGAGEElucidating TAAR-1, Dopamine, and Norepinephrine in Binge Eating Disorder Using SolriamfetolP3Binge-Eating Disorder450Apr 2024

Solriamfetol clinical trials by indication

Binge-Eating Disorder (2)

NCTAcronymPhaseStatusTitle
NCT06878976P3enrolling by invitationOpen-Label Safety Study of Solriamfetol in Subjects With Binge Eating Disorder
NCT06413433ENGAGEP3recruitingElucidating TAAR-1, Dopamine, and Norepinephrine in Binge Eating Disorder Using Solriamfetol

Long COVID (2)

NCTAcronymPhaseStatusTitle
NCT06404099RECOVER-SLEEPP2completedRECOVER-SLEEP: Platform Protocol, Appendix_A (Hypersomnia)
NCT06404086RECOVER-SLEEPP2completedRECOVER-SLEEP: Platform Protocol

Excessive Sleepiness (2)

NCTAcronymPhaseStatusTitle
NCT06568367SUSTAINP3recruitingStudying Solriamfetol Modulation of TAAR-1, Dopamine, and Norepinephrine in Shift Work Disorder (SUSTAIN)
NCT04788953P4terminatedClinical Trial of Solriamfetol for Excessive Sleepiness Related to Shift Work Disorder

Narcolepsy (2)

NCTAcronymPhaseStatusTitle
NCT06413420N/ArecruitingSUNOSI® (Solriamfetol) Pregnancy Registry
NCT05008341P1completedEvaluate Sunosi® PK in Breast Milk and Plasma of Healthy Postpartum Women Following Single Dose Oral Administration

Major Depressive Disorder With Excessive Daytime Sleepiness Symptoms (1)

NCTAcronymPhaseStatusTitle
NCT07484217CLARITYP3recruitingClinical Assessment of Response in the Treatment of Depression With Daytime Sleepiness Using Solriamfetol

Idiopathic Hypersomnia (1)

NCTAcronymPhaseStatusTitle
NCT06590662SOLR-IHP2not yet recruitingEfficacy and Tolerance of Solriamfetol in Patients Affected with Idiopathic Hypersomnia.

Multiple Sclerosis (1)

NCTAcronymPhaseStatusTitle
NCT06170970SOLARIMSP2recruitingSolriamfetol for the Treatment of Multiple Sclerosis Fatigue

Major Depressive Disorder (1)

NCTAcronymPhaseStatusTitle
NCT06360419PARADIGMP3completedProgressing TAAR-1, Dopamine, and Norepinephrine in Depression Using Solriamfetol

Sleep Apnea, Obstructive (1)

NCTAcronymPhaseStatusTitle
NCT06103825EDSP3completedA Twelve-week, Double-blind, Placebo-controlled, Randomized, Parallel-group, Multicenter Study to Evaluate the Efficacy and Safety of Solriamfetol in the Treatment of Excessive Daytime Sleepiness (EDS) in Patients with Obstructive Sleep Apnea (OSA)

Insomnia (1)

NCTAcronymPhaseStatusTitle
NCT05838430P4completedSolriamfetol and CBT-I in Patients With Insomnia Disorder

ADHD (1)

NCTAcronymPhaseStatusTitle
NCT05972044FOCUSP3completedA Study to Assess the Efficacy and Safety of Solriamfetol in Subjects With ADHD (FOCUS)

Attention Deficit Hyperactivity Disorder (1)

NCTAcronymPhaseStatusTitle
NCT04839562ADHDP2/P3completedA Controlled Study of Solriamfetol for Attention Deficit Hyperactivity Disorder (ADHD) in Adults

Binge Eating Disorder (1)

NCTAcronymPhaseStatusTitle
NCT04602936P4unknownSolriamfetol in Binge Eating Disorder

Excessive Daytime Sleepiness (1)

NCTAcronymPhaseStatusTitle
NCT04789174SHARPP4completedSolriamfetol's Effect on Cognitive Health in Apnea Participants During a Randomized Placebo-controlled Study

Chronic Fatigue Syndrome (1)

NCTAcronymPhaseStatusTitle
NCT04622293P4completedA Trial of Solriamfetol in the Treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Solriamfetol pivotal trial highlights (Phase 2/3/4)

Phase-2/3/4 studies with named acronyms — the registration-grade trials most cited in label discussions and Wikipedia.

AcronymNCTPhaseStatusIndicationEnrollmentPubMed
SHARPNCT04789174P4completedExcessive Daytime Sleepiness59PMID 39528111
CLARITYNCT07484217P3recruitingMajor Depressive Disorder With Excessive Daytime Sleepiness Symptoms508
SUSTAINNCT06568367P3recruitingExcessive Sleepiness520
ENGAGENCT06413433P3recruitingBinge-Eating Disorder450
PARADIGMNCT06360419P3completedMajor Depressive Disorder346
FOCUSNCT05972044P3completedADHD516
EDSNCT06103825P3completedSleep Apnea, Obstructive204PMID 41128833
SOLR-IHNCT06590662P2not yet recruitingIdiopathic Hypersomnia60
SOLARIMSNCT06170970P2recruitingMultiple Sclerosis46
RECOVER-SLEEPNCT06404099P2completedLong COVID361
RECOVER-SLEEPNCT06404086P2completedLong COVID830

Terminated and withdrawn Solriamfetol trials (1)

Studies that ended before completion. Reasons are filed in each trial's ClinicalTrials.gov entry.

All Solriamfetol trials (19)

Sorted by most recent activity (completion → start → posted date). Each row links to the trial detail page on Hipa.ai.

NCT IDAcronymTitlePhaseStatusEnrollmentSponsorStarted
NCT06413420SUNOSI® (Solriamfetol) Pregnancy Registryrecruiting1,731Axsome Therapeutics, Inc.Jul 2019
NCT07484217CLARITYClinical Assessment of Response in the Treatment of Depression With Daytime Sleepiness Using SolriamfetolP3recruiting508Axsome Therapeutics, Inc.Feb 2026
NCT06590662SOLR-IHEfficacy and Tolerance of Solriamfetol in Patients Affected with Idiopathic Hypersomnia.P2not yet recruiting60University Hospital, MontpellierSep 2024
NCT06170970SOLARIMSSolriamfetol for the Treatment of Multiple Sclerosis FatigueP2recruiting46Johns Hopkins UniversityJun 2024
NCT06878976Open-Label Safety Study of Solriamfetol in Subjects With Binge Eating DisorderP3enrolling by invitation300Axsome Therapeutics, Inc.Feb 2025
NCT06568367SUSTAINStudying Solriamfetol Modulation of TAAR-1, Dopamine, and Norepinephrine in Shift Work Disorder (SUSTAIN)P3recruiting520Axsome Therapeutics, Inc.Aug 2024
NCT05838430Solriamfetol and CBT-I in Patients With Insomnia DisorderP4completed115University of PennsylvaniaJul 2023
NCT06404099RECOVER-SLEEPRECOVER-SLEEP: Platform Protocol, Appendix_A (Hypersomnia)P2completed361Duke UniversityAug 2024
NCT06404086RECOVER-SLEEPRECOVER-SLEEP: Platform ProtocolP2completed830Duke UniversityJul 2024
NCT06413433ENGAGEElucidating TAAR-1, Dopamine, and Norepinephrine in Binge Eating Disorder Using SolriamfetolP3recruiting450Axsome Therapeutics, Inc.Apr 2024
NCT06360419PARADIGMProgressing TAAR-1, Dopamine, and Norepinephrine in Depression Using SolriamfetolP3completed346Axsome Therapeutics, Inc.Mar 2024
NCT05972044FOCUSA Study to Assess the Efficacy and Safety of Solriamfetol in Subjects With ADHD (FOCUS)P3completed516Axsome Therapeutics, Inc.Jul 2023
NCT04602936Solriamfetol in Binge Eating DisorderP4unknown64Lindner Center of HOPEJun 2021
NCT04622293A Trial of Solriamfetol in the Treatment of Myalgic Encephalomyelitis/Chronic Fatigue SyndromeP4completed44Rochester Center for Behavioral MedicineApr 2021
NCT06103825EDSA Twelve-week, Double-blind, Placebo-controlled, Randomized, Parallel-group, Multicenter Study to Evaluate the Efficacy and Safety of Solriamfetol in the Treatment of Excessive Daytime Sleepiness (EDS) in Patients with Obstructive Sleep Apnea (OSA)P3completed204Ignis Therapeutics (Suzhou) LimitedAug 2023
NCT04788953Clinical Trial of Solriamfetol for Excessive Sleepiness Related to Shift Work DisorderP4terminated84Charles A. Czeisler, PhD, MDJul 2021
NCT04839562ADHDA Controlled Study of Solriamfetol for Attention Deficit Hyperactivity Disorder (ADHD) in AdultsP2/P3completed66Massachusetts General HospitalAug 2021
NCT04789174SHARPSolriamfetol's Effect on Cognitive Health in Apnea Participants During a Randomized Placebo-controlled StudyP4completed59Axsome Therapeutics, Inc.May 2021
NCT05008341Evaluate Sunosi® PK in Breast Milk and Plasma of Healthy Postpartum Women Following Single Dose Oral AdministrationP1completed6Axsome Therapeutics, Inc.Aug 2021

Solriamfetol clinical trials: frequently asked questions

How many Solriamfetol clinical trials are there?
19 Solriamfetol clinical trials are catalogued on Hipa.ai, sourced from the AACT mirror of ClinicalTrials.gov. 6 are actively recruiting participants. 10 are marked completed.
Are Solriamfetol clinical trials recruiting in 2026?
Yes — 6 Solriamfetol trials are actively recruiting in 2026, with 92 U.S. sites across 23 states. See the recruiting trials and the per-state site list further down this page.
What conditions is Solriamfetol being studied for?
Solriamfetol is being studied for Obstructive Sleep Apnea, Excessive Sleepiness, Narcolepsy, Long COVID-19, Hypersomnia and 21 more. The trials are grouped by indication on this page.
What phase is Solriamfetol in?
Solriamfetol clinical trials span 5 Phase 4, 7 Phase 3, 4 Phase 2, 1 Phase 1. The phase × status matrix at the top of this page breaks down counts by phase and recruitment status.
Who sponsors Solriamfetol clinical trials?
The lead sponsor across the most Solriamfetol trials is Axsome Therapeutics, Inc., with 9 additional lead sponsors listed in the data. Each trial row links to the full study detail page including sponsor information.

Sources and methodology

Trial inventory derived from the AACT mirror of ClinicalTrials.gov. Trials are filtered to those naming Solriamfetolas an intervention. Phase, status, enrollment, sponsor, and dates are taken from the source `studies` table; primary indication is the first listed condition. Acronyms are extracted from each trial's brief title where present. PubMed links are populated for trials whose published primary outcomes have been indexed in our evidence cache.

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