Relatlimab Evidence: Trial Results and Peer-Reviewed Publications

Hipa.ai Research · Source: PubMed & ClinicalTrials.gov / AACT · Last updated:

The clinical evidence base for Relatlimab comprises 92 peer-reviewed publications across 15 journals, 2 pivotal-trial primary-outcome rows reported to ClinicalTrials.gov, spanning indications including Melanoma, Stomach Neoplasms, Neoplasms by Site, and Carcinoma, Non-Small-Cell Lung. Most recent publication: Next-Generation Immune Checkpoints and Tumor Microenvironment Modulation in Cancer Immunotherapy., J Immunol Res, 2026.

Top peer-reviewed publications

Curated set of pivotal-trial result papers and recent publications in high-tier journals.

  1. Neoadjuvant nivolumab with or without relatlimab in resectable non-small-cell lung cancer: a randomized phase 2 trial.
    Schuler M, Cuppens K, Plönes T, et al. · Nat Med · 2024
    PubMed: PMID 38689060 · NCT04205552 (NEOpredict) · Carcinoma, Non-Small-Cell Lung
  2. Relatlimab and Nivolumab versus Nivolumab in Untreated Advanced Melanoma.
    Tawbi HA, Schadendorf D, Lipson EJ, et al. · N Engl J Med · 2022
  3. Nivolumab with or without ipilimumab in patients with recurrent or metastatic cervical cancer (CheckMate 358): a phase 1-2, open-label, multicohort trial.
    Oaknin A, Moore K, Meyer T, et al. · Lancet Oncol · 2024
  4. The NCI-MATCH trial: lessons for precision oncology.
    O'Dwyer PJ, Gray RJ, Flaherty KT, et al. · Nat Med · 2023
  5. Neoadjuvant triplet immune checkpoint blockade in newly diagnosed glioblastoma.
    Long GV, Shklovskaya E, Satgunaseelan L, et al. · Nat Med · 2025
  6. Adjuvant nivolumab and relatlimab in stage III/IV melanoma: the randomized phase 3 RELATIVITY-098 trial.
    Long GV, Garnett-Benson C, Dolfi S, et al. · Nat Med · 2025
  7. Neoadjuvant nivolumab or nivolumab plus LAG-3 inhibitor relatlimab in resectable esophageal/gastroesophageal junction cancer: a phase Ib trial and ctDNA analyses.
    Kelly RJ, Landon BV, Zaidi AH, et al. · Nat Med · 2024
    PubMed: PMID 38504015 · NCT03044613 · Stomach Neoplasms
  8. Next-Generation Immune Checkpoints and Tumor Microenvironment Modulation in Cancer Immunotherapy.
    Bautista J, Echeverría CE, Maldonado-Noboa I, et al. · J Immunol Res · 2026

Primary-outcome results across pivotal trials

Per-arm reported values from Phase 2/3 and Phase 3 trials with results posted to ClinicalTrials.gov.

TrialIndicationPrimary endpointArmValue
NCT03470922
RELATIVITY-047
MelanomaProgression Free Survival (PFS)
From randomization to date of first documented tumor progression or death (up to approximately 33 months)
Arm A: Relatlimab + Nivolumab10.12 Months
Arm B: Nivolumab4.63 Months
NCT05002569
RELATIVITY-098
MelanomaRecurrence Free Survival (RFS)
Approximately 27.5 Months
Treatment 1NA Months
Treatment 233.84 Months

Publications by year

19922026: 92 publications.

1992
1
1999
1
2000
1
2002
1
2004
1
2005
1
2006
1
2007
2
2008
2
2009
2
2011
1
2012
4
2013
2
2014
4
2015
6
2016
7
2017
7
2018
3
2019
2
2020
1
2021
5
2022
8
2023
8
2024
7
2025
13
2026
1

Publications by indication

Melanoma (27)

  • Next-Generation Immune Checkpoints and Tumor Microenvironment Modulation in Cancer Immunotherapy.
    J Immunol Res · 2026 · PMID 41811823 · NCT03470922
  • Phase II Study of Vismodegib in Patients With SMO- or PTCH1-Mutated Tumors: Results From the National Cancer Institute Molecular Analysis for Therapy Choice Eastern Cooperative Oncology Group-American College of Radiology Imaging Network Trial (EAY131) Subprotocol T.
    JCO Precis Oncol · 2025 · PMID 41066729 · NCT02465060
  • Three-Year Overall Survival With Nivolumab Plus Relatlimab in Advanced Melanoma From RELATIVITY-047.
    J Clin Oncol · 2025 · PMID 39671533 · NCT03470922
  • Analysis of treatment-free survival of patients with advanced melanoma receiving nivolumab as monotherapy or in combination with relatlimab in RELATIVITY-047.
    J Immunother Cancer · 2025 · PMID 40940136 · NCT03470922
  • Adjuvant nivolumab and relatlimab in stage III/IV melanoma: the randomized phase 3 RELATIVITY-098 trial.
    Nat Med · 2025 · PMID 41109920 · NCT05002569

Stomach Neoplasms (20)

  • Evolving Therapeutics for Resectable Esophageal Adenocarcinoma.
    J Natl Compr Canc Netw · 2025 · PMID 40340830 · NCT04062656
  • Neoadjuvant nivolumab or nivolumab plus LAG-3 inhibitor relatlimab in resectable esophageal/gastroesophageal junction cancer: a phase Ib trial and ctDNA analyses.
    Nat Med · 2024 · PMID 38504015 · NCT03044613
  • Patterns of PD-L1 expression and CD8 T cell infiltration in gastric adenocarcinomas and associated immune stroma.
    Gut · 2017 · PMID 26801886 · NCT03044613
  • Pembrolizumab for patients with PD-L1-positive advanced gastric cancer (KEYNOTE-012): a multicentre, open-label, phase 1b trial.
    Lancet Oncol · 2017 · PMID 27157491 · NCT03044613
  • Expression of costimulatory molecules B7-H1, B7-H4 and Foxp3+ Tregs in gastric cancer and its clinical significance.
    Int J Clin Oncol · 2016 · PMID 24804867 · NCT03044613

Neoplasms by Site (4)

  • Effect of prior and first-line immunotherapy on baseline immune biomarkers and modulation of the tumor microenvironment in response to nivolumab and relatlimab combination therapy in patients with melanoma from RELATIVITY-020.
    J Immunother Cancer · 2025 · PMID 40010775 · NCT01968109
  • Single-cell characterization of anti-LAG-3 and anti-PD-1 combination treatment in patients with melanoma.
    J Clin Invest · 2023 · PMID 36719749 · NCT01968109
  • Nivolumab and Relatlimab in Patients With Advanced Melanoma That Had Progressed on Anti-Programmed Death-1/Programmed Death Ligand 1 Therapy: Results From the Phase I/IIa RELATIVITY-020 Trial.
    J Clin Oncol · 2023 · PMID 36780608 · NCT01968109
  • Coexisting Alterations of MHC Class I Antigen Presentation and IFNγ Signaling Mediate Acquired Resistance of Melanoma to Post-PD-1 Immunotherapy.
    Cancer Immunol Res · 2022 · PMID 35969233 · NCT01968109

Carcinoma, Non-Small-Cell Lung (1)

  • Neoadjuvant nivolumab with or without relatlimab in resectable non-small-cell lung cancer: a randomized phase 2 trial.
    Nat Med · 2024 · PMID 38689060 · NCT04205552

Lymphoma, Large B-Cell, Diffuse (1)

  • Chimeric antigen receptor (CAR) T-cell therapy for people with relapsed or refractory diffuse large B-cell lymphoma.
    Cochrane Database Syst Rev · 2021 · PMID 34515338 · NCT03310619

Publications by journal

Trial-results highlights

Clinical trials have been conducted to investigate Relatlimab for patients with melanoma. One key study, NCT03470922, known as RELATIVITY-047, explored the outcome of Progression Free Survival (PFS). PFS measures the length of time patients live without their disease getting worse or without dying, from the point of randomization, and was followed for up to approximately 33 months in this study. In RELATIVITY-047, patients were assigned to different treatment groups. The median PFS for patients who received the combination of Relatlimab and Nivolumab (Arm A) was reported as 10.12 Months. For patients in the Nivolumab-alone arm (Arm B), the median PFS was 4.63 Months.

Another study, NCT05002569, referred to as RELATIVITY-098, also investigated outcomes for melanoma, specifically focusing on Recurrence Free Survival (RFS). RFS measures the length of time after treatment that a patient remains free of the disease or its return, and this endpoint was evaluated over approximately 27.5 months. In RELATIVITY-098, among the different treatment approaches studied, the median RFS for Treatment 2 was observed to be 33.84 Months.

All values presented here are sourced from primary registry reporting. For clinical decisions, individual published papers should be consulted.

All Relatlimab publications (92)

2026 (1 paper)

  1. Next-Generation Immune Checkpoints and Tumor Microenvironment Modulation in Cancer Immunotherapy.
    Bautista J, Echeverría CE, Maldonado-Noboa I, et al. · J Immunol Res · 2026 · Derived

2025 (13 papers)

  1. Phase II Study of Vismodegib in Patients With SMO- or PTCH1-Mutated Tumors: Results From the National Cancer Institute Molecular Analysis for Therapy Choice Eastern Cooperative Oncology Group-American College of Radiology Imaging Network Trial (EAY131) Subprotocol T.
    Tsao AS, Song Z, Ho AL, et al. · JCO Precis Oncol · 2025 · Derived
  2. Three-Year Overall Survival With Nivolumab Plus Relatlimab in Advanced Melanoma From RELATIVITY-047.
    Tawbi HA, Hodi FS, Lipson EJ, et al. · J Clin Oncol · 2025 · Derived
  3. Analysis of treatment-free survival of patients with advanced melanoma receiving nivolumab as monotherapy or in combination with relatlimab in RELATIVITY-047.
    Regan MM, Ascierto PA, Lipson EJ, et al. · J Immunother Cancer · 2025 · Derived
  4. Rationale and feasibility of a rapid integral biomarker program that informs immune-oncology clinical trials: the ADVISE trial.
    Luke JJ, Bever K, Hodi FS, et al. · J Immunother Cancer · 2025 · Derived
  5. Neoadjuvant triplet immune checkpoint blockade in newly diagnosed glioblastoma.
    Long GV, Shklovskaya E, Satgunaseelan L, et al. · Nat Med · 2025 · Derived
  6. Adjuvant nivolumab and relatlimab in stage III/IV melanoma: the randomized phase 3 RELATIVITY-098 trial.
    Long GV, Garnett-Benson C, Dolfi S, et al. · Nat Med · 2025 · Derived
  7. Nivolumab plus relatlimab in advanced melanoma: RELATIVITY-047 4-year update.
    Lipson EJ, Stephen Hodi F, Tawbi H, et al. · Eur J Cancer · 2025 · Derived
  8. Evolving Therapeutics for Resectable Esophageal Adenocarcinoma.
    Klute KA, Shah MA · J Natl Compr Canc Netw · 2025 · Derived
  9. PIK3CB Inhibitor GSK2636771 in Cancers With PTEN Mutation/Deletion or Loss of PTEN Protein Expression: Results From the NCI-MATCH ECOG-ACRIN Trial (EAY131) Subprotocols N and P.
    Janku F, Jegede OA, Puhalla SL, et al. · JCO Precis Oncol · 2025 · Derived
  10. Phase II Study of Copanlisib in Patients With PTEN Loss: Results From NCI-MATCH ECOG-ACRIN Trial (EAY131) Subprotocols Z1G and Z1H.
    Gouda MA, Wei Z, Rodon J, et al. · JCO Precis Oncol · 2025 · Derived
  11. Long-Term Survival and Biomarker Analysis Evaluating Neoadjuvant Plus Adjuvant Relatlimab (anti-LAG3) and Nivolumab (anti-PD1) in Patients With Resectable Melanoma.
    Burton EM, Milton DR, Tetzlaff MT, et al. · J Clin Oncol · 2025 · Derived
  12. Nivolumab With or Without Ipilimumab in Patients With Recurrent or Metastatic Merkel Cell Carcinoma: A Nonrandomized, Open-Label, International, Multicenter Phase I/II Study.
    Bhatia S, Topalian SL, Sharfman W, et al. · J Clin Oncol · 2025 · Derived
  13. Effect of prior and first-line immunotherapy on baseline immune biomarkers and modulation of the tumor microenvironment in response to nivolumab and relatlimab combination therapy in patients with melanoma from RELATIVITY-020.
    Ascierto PA, Tang H, Dolfi S, et al. · J Immunother Cancer · 2025 · Derived
    PubMed: PMID 40010775 · NCT01968109 · Neoplasms by Site

2024 (7 papers)

  1. Neoadjuvant nivolumab with or without relatlimab in resectable non-small-cell lung cancer: a randomized phase 2 trial.
    Schuler M, Cuppens K, Plönes T, et al. · Nat Med · 2024 · Trial result
    PubMed: PMID 38689060 · NCT04205552 (NEOpredict) · Carcinoma, Non-Small-Cell Lung
  2. Revolutionizing cancer drug development: Harnessing the potential of basket trials.
    Subbiah V, Burris HA, Kurzrock R, et al. · Cancer · 2024 · Derived
  3. Circulating cancer-specific CD8 T cell frequency is associated with response to PD-1 blockade in Merkel cell carcinoma.
    Pulliam T, Jani S, Jing L, et al. · Cell Rep Med · 2024 · Derived
  4. Nivolumab with or without ipilimumab in patients with recurrent or metastatic cervical cancer (CheckMate 358): a phase 1-2, open-label, multicohort trial.
    Oaknin A, Moore K, Meyer T, et al. · Lancet Oncol · 2024 · Derived
  5. Overall Survival and Response with Nivolumab and Relatlimab in Advanced Melanoma.
    Long GV, Stephen Hodi F, Lipson EJ, et al. · NEJM Evid · 2024 · Derived
  6. Neoadjuvant nivolumab or nivolumab plus LAG-3 inhibitor relatlimab in resectable esophageal/gastroesophageal junction cancer: a phase Ib trial and ctDNA analyses.
    Kelly RJ, Landon BV, Zaidi AH, et al. · Nat Med · 2024 · Derived
    PubMed: PMID 38504015 · NCT03044613 · Stomach Neoplasms
  7. Phase II Study of Sunitinib in Tumors With c-KIT Mutations: Results From the NCI MATCH ECOG-ACRIN Trial (EAY131) Subprotocol V.
    Gien LT, Song Z, Poklepovic A, et al. · JCO Precis Oncol · 2024 · Derived

2023 (8 papers)

  1. Trametinib in Patients With NF1-, GNAQ-, or GNA11-Mutant Tumors: Results From the NCI-MATCH ECOG-ACRIN Trial (EAY131) Subprotocols S1 and S2.
    Wisinski KB, Flamand Y, Wilson MA, et al. · JCO Precis Oncol · 2023 · Derived
  2. Health-related quality of life with nivolumab plus relatlimab versus nivolumab monotherapy in patients with previously untreated unresectable or metastatic melanoma: RELATIVITY-047 trial.
    Schadendorf D, Tawbi H, Lipson EJ, et al. · Eur J Cancer · 2023 · Derived
  3. Relatlimab and nivolumab in untreated advanced melanoma: insight into RELATIVITY.
    Raschi E, Comito F, Massari F, et al. · Immunotherapy · 2023 · Derived
  4. The NCI-MATCH trial: lessons for precision oncology.
    O'Dwyer PJ, Gray RJ, Flaherty KT, et al. · Nat Med · 2023 · Derived
  5. Single-cell characterization of anti-LAG-3 and anti-PD-1 combination treatment in patients with melanoma.
    Huuhtanen J, Kasanen H, Peltola K, et al. · J Clin Invest · 2023 · Derived
    PubMed: PMID 36719749 · NCT01968109 · Neoplasms by Site
  6. Neoadjuvant treatment for stage III and IV cutaneous melanoma.
    Gorry C, McCullagh L, O'Donnell H, et al. · Cochrane Database Syst Rev · 2023 · Derived
  7. Nivolumab and Relatlimab in Patients With Advanced Melanoma That Had Progressed on Anti-Programmed Death-1/Programmed Death Ligand 1 Therapy: Results From the Phase I/IIa RELATIVITY-020 Trial.
    Ascierto PA, Lipson EJ, Dummer R, et al. · J Clin Oncol · 2023 · Derived
    PubMed: PMID 36780608 · NCT01968109 · Neoplasms by Site
  8. Long-term follow-up of anti-PD-1 naïve patients with metastatic melanoma treated with IDO/PD-L1 targeting peptide vaccine and nivolumab.
    Lorentzen CL, Kjeldsen JW, Ehrnrooth E, et al. · J Immunother Cancer · 2023 · Background

2022 (8 papers)

  1. Relatlimab and Nivolumab versus Nivolumab in Untreated Advanced Melanoma.
    Tawbi HA, Schadendorf D, Lipson EJ, et al. · N Engl J Med · 2022 · Derived
  2. Platelet p110β mediates platelet-leukocyte interaction and curtails bacterial dissemination in pneumococcal pneumonia.
    Schrottmaier WC, Kral-Pointner JB, Salzmann M, et al. · Cell Rep · 2022 · Derived
  3. Coexisting Alterations of MHC Class I Antigen Presentation and IFNγ Signaling Mediate Acquired Resistance of Melanoma to Post-PD-1 Immunotherapy.
    Nielsen M, Presti M, Sztupinszki Z, et al. · Cancer Immunol Res · 2022 · Derived
    PubMed: PMID 35969233 · NCT01968109 · Neoplasms by Site
  4. Phase II Study of Taselisib in PIK3CA-Mutated Solid Tumors Other Than Breast and Squamous Lung Cancer: Results From the NCI-MATCH ECOG-ACRIN Trial (EAY131) Subprotocol I.
    Krop IE, Jegede OA, Grilley-Olson JE, et al. · JCO Precis Oncol · 2022 · Derived
  5. Adoptive Cellular Therapy for Pediatric Solid Tumors: Beyond Chimeric Antigen Receptor-T Cell Therapy.
    Hensel J, Metts J, Gupta A, et al. · Cancer J · 2022 · Derived
  6. Phase II Study of Copanlisib in Patients With Tumors With PIK3CA Mutations: Results From the NCI-MATCH ECOG-ACRIN Trial (EAY131) Subprotocol Z1F.
    Damodaran S, Zhao F, Deming DA, et al. · J Clin Oncol · 2022 · Derived
  7. FRACTION-RCC: nivolumab plus ipilimumab for advanced renal cell carcinoma after progression on immuno-oncology therapy.
    Choueiri TK, Kluger H, George S, et al. · J Immunother Cancer · 2022 · Derived
  8. A phase 1/2 trial of an immune-modulatory vaccine against IDO/PD-L1 in combination with nivolumab in metastatic melanoma.
    Kjeldsen JW, Lorentzen CL, Martinenaite E, et al. · Nat Med · 2022 · Background

2021 (5 papers)

  1. Neoadjuvant Nivolumab for Patients With Resectable Merkel Cell Carcinoma in the CheckMate 358 Trial.
    Topalian SL, Bhatia S, Amin A, et al. · J Clin Oncol · 2021 · Derived
  2. Molecular Landscape and Actionable Alterations in a Genomically Guided Cancer Clinical Trial: National Cancer Institute Molecular Analysis for Therapy Choice (NCI-MATCH).
    Flaherty KT, Gray RJ, Chen AP, et al. · J Clin Oncol · 2021 · Derived
  3. Neoadjuvant nivolumab for patients with resectable HPV-positive and HPV-negative squamous cell carcinomas of the head and neck in the CheckMate 358 trial.
    Ferris RL, Spanos WC, Leidner R, et al. · J Immunother Cancer · 2021 · Derived
  4. Chimeric antigen receptor (CAR) T-cell therapy for people with relapsed or refractory diffuse large B-cell lymphoma.
    Ernst M, Oeser A, Besiroglu B, et al. · Cochrane Database Syst Rev · 2021 · Derived
    PubMed: PMID 34515338 · NCT03310619 (PLATFORM) · Lymphoma, Large B-Cell, Diffuse
  5. Phase II Study of AZD4547 in Patients With Tumors Harboring Aberrations in the FGFR Pathway: Results From the NCI-MATCH Trial (EAY131) Subprotocol W.
    Chae YK, Hong F, Vaklavas C, et al. · J Clin Oncol · 2021 · Derived

2020 (1 paper)

  1. Safety and Efficacy of Nivolumab Monotherapy in Recurrent or Metastatic Cervical, Vaginal, or Vulvar Carcinoma: Results From the Phase I/II CheckMate 358 Trial.
    Naumann RW, Hollebecque A, Meyer T, et al. · J Clin Oncol · 2020 · Derived

2019 (2 papers)

  1. Fatal enteric plexus neuropathy after one dose of ipilimumab plus nivolumab: a case report.
    Appelbaum J, Wells D, Hiatt JB, et al. · J Immunother Cancer · 2019 · Derived
  2. The Dynamic and Transient Immune Microenvironment in Locally Advanced Esophageal Adenocarcinoma Post Chemoradiation.
    Kelly RJ, Zaidi AH, Smith MA, et al. · Ann Surg · 2019 · Background

2018 (3 papers)

  1. Atezolizumab versus docetaxel in patients with previously treated non-small-cell lung cancer (OAK): a phase 3, open-label, multicentre randomised controlled trial.
    Rittmeyer A, Barlesi F, Waterkamp D, et al. · Lancet · 2018 · Background
  2. Nivolumab in patients with advanced gastric or gastro-oesophageal junction cancer refractory to, or intolerant of, at least two previous chemotherapy regimens (ONO-4538-12, ATTRACTION-2): a randomised, double-blind, placebo-controlled, phase 3 trial.
    Kang YK, Boku N, Satoh T, et al. · Lancet · 2018 · Background
  3. Abundant PD-L1 expression in Epstein-Barr Virus-infected gastric cancers.
    Derks S, Liao X, Chiaravalli AM, et al. · Oncotarget · 2018 · Background

2017 (7 papers)

  1. PI3K/mTOR Dual Inhibitor, LY3023414, Demonstrates Potent Antitumor Efficacy Against Esophageal Adenocarcinoma in a Rat Model.
    Zaidi AH, Kosovec JE, Matsui D, et al. · Ann Surg · 2017 · Background
  2. Suppression of Type I IFN Signaling in Tumors Mediates Resistance to Anti-PD-1 Treatment That Can Be Overcome by Radiotherapy.
    Wang X, Schoenhals JE, Li A, et al. · Cancer Res · 2017 · Background
  3. Patterns of PD-L1 expression and CD8 T cell infiltration in gastric adenocarcinomas and associated immune stroma.
    Thompson ED, Zahurak M, Murphy A, et al. · Gut · 2017 · Background
    PubMed: PMID 26801886 · NCT03044613 · Stomach Neoplasms
  4. Pembrolizumab for patients with PD-L1-positive advanced gastric cancer (KEYNOTE-012): a multicentre, open-label, phase 1b trial.
    Muro K, Chung HC, Shankaran V, et al. · Lancet Oncol · 2017 · Background
    PubMed: PMID 27157491 · NCT03044613 · Stomach Neoplasms
  5. Preclinical Study of AUY922, a Novel Hsp90 Inhibitor, in the Treatment of Esophageal Adenocarcinoma.
    Kosovec JE, Zaidi AH, Kelly LA, et al. · Ann Surg · 2017 · Background
  6. Local consolidative therapy versus maintenance therapy or observation for patients with oligometastatic non-small-cell lung cancer without progression after first-line systemic therapy: a multicentre, randomised, controlled, phase 2 study.
    Gomez DR, Blumenschein GR, Lee JJ, et al. · Lancet Oncol · 2017 · Background
  7. Evolution of Neoantigen Landscape during Immune Checkpoint Blockade in Non-Small Cell Lung Cancer.
    Anagnostou V, Smith KN, Forde PM, et al. · Cancer Discov · 2017 · Background

2016 (7 papers)

  1. Is the NCI MATCH trial a match for gynecologic oncology?
    Moore KN, Mannel RS · Gynecol Oncol · 2016 · Derived
  2. MicroRNA signature characterizes primary tumors that metastasize in an esophageal adenocarcinoma rat model.
    Zaidi AH, Saldin LT, Kelly LA, et al. · PLoS One · 2016 · Background
  3. Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade.
    McGranahan N, Furness AJ, Rosenthal R, et al. · Science · 2016 · Background
  4. Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomised controlled trial.
    Herbst RS, Baas P, Kim DW, et al. · Lancet · 2016 · Background
  5. Expression of costimulatory molecules B7-H1, B7-H4 and Foxp3+ Tregs in gastric cancer and its clinical significance.
    Geng Y, Wang H, Lu C, et al. · Int J Clin Oncol · 2016 · Background
    PubMed: PMID 24804867 · NCT03044613 · Stomach Neoplasms
  6. Epithelial PD-L2 Expression Marks Barrett's Esophagus and Esophageal Adenocarcinoma.
    Derks S, Nason KS, Liao X, et al. · Cancer Immunol Res · 2016 · Background
  7. Role of Local Radiation Therapy in Cancer Immunotherapy.
    Demaria S, Golden EB, Formenti SC, et al. · JAMA Oncol · 2016 · Background

2015 (6 papers)

  1. Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer.
    Twyman-Saint Victor C, Rech AJ, Maity A, et al. · Nature · 2015 · Background
    PubMed: PMID 25754329 · NCT03044613 · Stomach Neoplasms
  2. Microbially driven TLR5-dependent signaling governs distal malignant progression through tumor-promoting inflammation.
    Rutkowski MR, Stephen TL, Svoronos N, et al. · Cancer Cell · 2015 · Background
    PubMed: PMID 25533336 · NCT03044613 · Stomach Neoplasms
  3. The vigorous immune microenvironment of microsatellite instable colon cancer is balanced by multiple counter-inhibitory checkpoints.
    Llosa NJ, Cruise M, Tam A, et al. · Cancer Discov · 2015 · Background
  4. PD-1 Blockade in Tumors with Mismatch-Repair Deficiency.
    Le DT, Uram JN, Wang H, et al. · N Engl J Med · 2015 · Background
    PubMed: PMID 26028255 · NCT03044613 · Stomach Neoplasms
  5. Local radiotherapy and granulocyte-macrophage colony-stimulating factor to generate abscopal responses in patients with metastatic solid tumours: a proof-of-principle trial.
    Golden EB, Chhabra A, Chachoua A, et al. · Lancet Oncol · 2015 · Background
  6. Nivolumab versus Docetaxel in Advanced Squamous-Cell Non-Small-Cell Lung Cancer.
    Brahmer J, Reckamp KL, Baas P, et al. · N Engl J Med · 2015 · Background

2014 (4 papers)

  1. Up-regulation of PD-L1, IDO, and T(regs) in the melanoma tumor microenvironment is driven by CD8(+) T cells.
    Spranger S, Spaapen RM, Zha Y, et al. · Sci Transl Med · 2014 · Background
  2. Correlation between infiltration of FOXP3+ regulatory T cells and expression of B7-H1 in the tumor tissues of gastric cancer.
    Hou J, Yu Z, Xiang R, et al. · Exp Mol Pathol · 2014 · Background
    PubMed: PMID 24657498 · NCT03044613 · Stomach Neoplasms
  3. Using synthetic templates to design an unbiased multiplex PCR assay.
    Carlson CS, Emerson RO, Sherwood AM, et al. · Nat Commun · 2014 · Background
  4. Comprehensive molecular characterization of gastric adenocarcinoma.
    Cancer Genome Atlas Research Network · Nature · 2014 · Background

2013 (2 papers)

  1. Prevention of Barrett esophagus and esophageal adenocarcinoma by smoothened inhibitor in a rat model of gastroesophageal reflux disease.
    Gibson MK, Zaidi AH, Davison JM, et al. · Ann Surg · 2013 · Background
  2. Signatures of mutational processes in human cancer.
    Alexandrov LB, Nik-Zainal S, Wedge DC, et al. · Nature · 2013 · Background
    PubMed: PMID 23945592 · NCT03044613 · Stomach Neoplasms

2012 (4 papers)

  1. Preoperative chemoradiotherapy for esophageal or junctional cancer.
    van Hagen P, Hulshof MC, van Lanschot JJ, et al. · N Engl J Med · 2012 · Background
    PubMed: PMID 22646630 · NCT03044613 · Stomach Neoplasms
  2. Colocalization of inflammatory response with B7-h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape.
    Taube JM, Anders RA, Young GD, et al. · Sci Transl Med · 2012 · Background
    PubMed: PMID 22461641 · NCT03044613 · Stomach Neoplasms
  3. The blockade of immune checkpoints in cancer immunotherapy.
    Pardoll DM · Nat Rev Cancer · 2012 · Background
    PubMed: PMID 22437870 · NCT03044613 · Stomach Neoplasms
  4. The confluence of stereotactic ablative radiotherapy and tumor immunology.
    Finkelstein SE, Timmerman R, McBride WH, et al. · Clin Dev Immunol · 2012 · Background

2011 (1 paper)

  1. Extensive personal human gut microbiota culture collections characterized and manipulated in gnotobiotic mice.
    Goodman AL, Kallstrom G, Faith JJ, et al. · Proc Natl Acad Sci U S A · 2011 · Background
    PubMed: PMID 21436049 · NCT03044613 · Stomach Neoplasms

2009 (2 papers)

  1. Phase III comparison of preoperative chemotherapy compared with chemoradiotherapy in patients with locally advanced adenocarcinoma of the esophagogastric junction.
    Stahl M, Walz MK, Stuschke M, et al. · J Clin Oncol · 2009 · Background
    PubMed: PMID 19139439 · NCT03044613 · Stomach Neoplasms
  2. Comprehensive assessment of T-cell receptor beta-chain diversity in alphabeta T cells.
    Robins HS, Campregher PV, Srivastava SK, et al. · Blood · 2009 · Background

2008 (2 papers)

  1. High-resolution, small animal radiation research platform with x-ray tomographic guidance capabilities.
    Wong J, Armour E, Kazanzides P, et al. · Int J Radiat Oncol Biol Phys · 2008 · Background
  2. Vaccine impedes the development of reflux-induced esophageal cancer in a surgical rat model: efficacy of the vaccine in a Pre-Barrett's esophagus setting.
    Miyashita T, Shah FA, Marti G, et al. · J Gastrointest Surg · 2008 · Background

2007 (2 papers)

  1. PET to assess early metabolic response and to guide treatment of adenocarcinoma of the oesophagogastric junction: the MUNICON phase II trial.
    Lordick F, Ott K, Krause BJ, et al. · Lancet Oncol · 2007 · Background
    PubMed: PMID 17693134 · NCT03044613 · Stomach Neoplasms
  2. Cytogenetic characterization and gene expression profiling in the rat reflux-induced esophageal tumor model.
    Bonde P, Sui G, Dhara S, et al. · J Thorac Cardiovasc Surg · 2007 · Background

2006 (1 paper)

  1. Immunohistochemical localization of programmed death-1 ligand-1 (PD-L1) in gastric carcinoma and its clinical significance.
    Wu C, Zhu Y, Jiang J, et al. · Acta Histochem · 2006 · Background
    PubMed: PMID 16530813 · NCT03044613 · Stomach Neoplasms

2005 (1 paper)

  1. Barrett's oesophagus is characterized by a predominantly humoral inflammatory response.
    Moons LM, Kusters JG, Bultman E, et al. · J Pathol · 2005 · Background
    PubMed: PMID 16177953 · NCT03044613 · Stomach Neoplasms

2004 (1 paper)

  1. Structural and functional analysis of the costimulatory receptor programmed death-1.
    Zhang X, Schwartz JC, Guo X, et al. · Immunity · 2004 · Background
    PubMed: PMID 15030777 · NCT03044613 · Stomach Neoplasms

2002 (1 paper)

  1. Inflammatory gradient in Barrett's oesophagus: implications for disease complications.
    Fitzgerald RC, Abdalla S, Onwuegbusi BA, et al. · Gut · 2002 · Background
    PubMed: PMID 12171950 · NCT03044613 · Stomach Neoplasms

2000 (1 paper)

  1. Duodenal-content reflux esophagitis induces the development of glandular metaplasia and adenosquamous carcinoma in rats.
    Pera M, Brito MJ, Poulsom R, et al. · Carcinogenesis · 2000 · Background

1999 (1 paper)

  1. Antigen-specific T cell activation and proliferation during oral tolerance induction.
    Sun J, Dirden-Kramer B, Ito K, et al. · J Immunol · 1999 · Background

1992 (1 paper)

  1. Duodenoesophageal reflux and the development of esophageal adenocarcinoma in rats.
    Attwood SE, Smyrk TC, DeMeester TR, et al. · Surgery · 1992 · Background

Sources and methodology

This page summarizes published evidence for general reference and does not constitute medical advice. For clinical decisions, consult the linked primary publications and your healthcare provider. Data sourced from PubMed and the ClinicalTrials.gov / AACT database maintained by the Clinical Trials Transformation Initiative (CTTI).