An Adaptive Study to Match Patients With Solid Tumors to Various Immunotherapy Combinations Based Upon a Broad Biomarker Assessment

Part of paid clinical trials in Chicago, Illinois.

Sponsor
Bristol-Myers Squibb
Study ID
NCT03335540
Phase
PHASE1
Status
Completed

Conditions

  • Advanced Cancer

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Nivolumab — BIOLOGICAL
    Specified dose on specified day
  • Relatlimab — BIOLOGICAL
    Specified dose on specified day
  • Cabiralizumab — BIOLOGICAL
    Specified dose on specified day
  • Ipilimumab — BIOLOGICAL
    Specified dose on specified day
  • IDO1 Inhibitor — DRUG
    Specified dose on specified day
  • Radiation Therapy — RADIATION
    Specified dose on specified day

Study Details

The purpose of this study is to evaluate the treatment of solid tumors with various immunotherapy combinations. The treatment will be determined based upon a broad biomarker assessment.

Key Dates

Start date
May 7, 2018
Status verified
Sep 2022
Primary completion
Mar 31, 2021
Completion
Aug 25, 2021

Study Design

Enrollment
20 participants (actual)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Arm B
    Combination therapy determined by biomarker assessment
  • Experimental: Arm C
    Combination therapy determined by biomarker assessment
  • Experimental: Arm D
    Combination therapy determined by biomarker assessment
  • Experimental: Arm F
    Combination therapy determined by biomarker assessment
  • Experimental: Arm G
    Combination therapy determined by biomarker assessment

Primary Outcome Measure

Number of participants with qualified tumor biopsy specimen at baseline [ Time Frame: Up to 28 days ]

Locations (4)

FacilityCityStateZIPSite coordinators
Local Institution - 0001ChicagoIllinois60637-
University of ChicagoChicagoIllinois60637-
Local Institution - 0002BaltimoreMaryland21287-
Local Institution - 0003PittsburghPennsylvania15232-

Find similar trials in Chicago, IL

By research site
Local Institution - 0001· Chicago, ILUniversity of Chicago· Chicago, ILLocal Institution - 0002· Baltimore, MDLocal Institution - 0003· Pittsburgh, PA

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