ponsegromab Clinical Trials (2026): 4 Studies for Cachexia & Colorectal Cancer
Hipa.ai Research · Source: ClinicalTrials.gov / AACT
Synced daily from ClinicalTrials.gov via AACT. Last sync: .
4 ponsegromab clinical trials are catalogued on Hipa.ai from the AACT mirror of ClinicalTrials.gov, spanning 4 indications (including Cachexia & Colorectal Cancer) and 1,642 total planned enrollment. 1 ponsegromab clinical trial is actively recruiting at 67 U.S. sites across 19 states. Most recent activity: NCT06989437 (Dec 2029).
Where to Participate: All ponsegromab Trial Sites in the U.S. (67 sites across 19 states)
Every actively recruiting ponsegromabtrial site, sorted by state then city. Each row links to the trial detail page (eligibility, contacts, full study record). Sites no longer enrolling at the location level are excluded. ClinicalTrials.gov / AACT does not provide street-level addresses; the map link uses the facility's geocoded coordinates where available.
| State | Facility | City | Trial | Map |
|---|---|---|---|---|
| AL | The Kirklin Clinic of UAB Hospital | Birmingham35233 | NCT06989437 | Map |
| AL | The University of Alabama at Birmingham | Birmingham35294 | NCT06989437 | Map |
| AR | Central Arkansas Radiation Therapy Institute, dba CARTI | Bryant72022 | NCT06989437 | Map |
| AR | Central Arkansas Radiation Therapy Institute, dba CARTI | Conway72034 | NCT06989437 | Map |
| AR | CARTI Cancer Center | Little Rock72205 | NCT06989437 | Map |
| AR | Central Arkansas Radiation Therapy Institute, dba CARTI | North Little Rock72117 | NCT06989437 | Map |
| AR | Central Arkansas Radiation Therapy Institute, dba CARTI | Pine Bluff71603 | NCT06989437 | Map |
| CA | UC San Diego Medical Center - Encinitas | Encinitas92024 | NCT06989437 | Map |
| CA | Chao Family Comprehensive Cancer Center and Ambulatory Care | Irvine92612 | NCT06989437 | Map |
| CA | UCI Health - Irvine | Irvine92612 | NCT06989437 | Map |
| CA | UC San Diego Koman Family Outpatient Pavilion | La Jolla92037 | NCT06989437 | Map |
| CA | UC San Diego Medical Center - La Jolla (Jacobs Medical Center / Thornton Pavilion) | La Jolla92037 | NCT06989437 | Map |
| CA | UC San Diego Moores Cancer Center | La Jolla92037 | NCT06989437 | Map |
| CA | UC San Diego Sulpizio Cardiovascular Center | La Jolla92037 | NCT06989437 | Map |
| CA | Cedars-Sinai Cancer at Cedars-Sinai Medical Center | Los Angeles90048 | NCT06989437 | Map |
| CA | UCLA Department of Medicine - Hematology/Oncology | Los Angeles90095 | NCT06989437 | Map |
| CA | UC Irvine Health | Orange92868 | NCT06989437 | Map |
| CA | UC San Diego McGrath Outpatient Pavilion - Hillcrest | San Diego92103 | NCT06989437 | Map |
| CA | UC San Diego Medical Center - Bankers Hill | San Diego92101 | NCT06989437 | Map |
| CA | UC San Diego Medical Center - Hillcrest | San Diego92103 | NCT06989437 | Map |
| CA | UC San Diego Medical Center - Rancho Bernardo | San Diego92127 | NCT06989437 | Map |
| CA | UCLA Hematology/Oncology - Santa Monica | Santa Monica90404 | NCT06989437 | Map |
| CA | Providence Medical Foundation | Santa Rosa95403 | NCT06989437 | Map |
| CA | UC San Diego Medical Center - Vista | Vista92081 | NCT06989437 | Map |
| DC | Georgetown University Medical Center | Washington D.C.20007 | NCT06989437 | Map |
| DC | Georgetown University Medical Center - Department of Pharmacy, Oncology Pharmacy | Washington D.C.20007 | NCT06989437 | Map |
| GA | University Cancer & Blood Center, LLC | Athens30607 | NCT06989437 | Map |
| HI | Cardiology Associates, Inc | ‘Aiea96701 | NCT06989437 | Map |
| HI | Invision, LLC | Honolulu96813 | NCT06989437 | Map |
| HI | University of Hawaii Cancer Center | Honolulu96813 | NCT06989437 | Map |
| IL | Cancer Care Specialists of Illinois | Decatur62526 | NCT06989437 | Map |
| IL | Decatur Memorial Hospital | Decatur62526 | NCT06989437 | Map |
| IL | Hope and Healing Clinical Research LLC | Hinsdale60521 | NCT06989437 | Map |
| IL | Hope and Healing Clinical Research LLC New Lenox- Research Department | New Lenox60451 | NCT06989437 | Map |
| IL | Cancer Care Specialists of Illinois - Cancer Care Center of O'Fallon | O'Fallon62269 | NCT06989437 | Map |
| KS | United Imaging Consultants | Lenexa66215 | NCT06989437 | Map |
| KS | MidAmerica Cancer Care- American Oncology Partners | Merriam66204 | NCT06989437 | Map |
| KY | University of Kentucky Healthcare - Markey Cancer Center | Lexington40536 | NCT06989437 | Map |
| KY | University of Kentucky Medical Center | Lexington40536 | NCT06989437 | Map |
| KY | University of Kentucky Research Foundation | Lexington40506 | NCT06989437 | Map |
| KY | University of Kentucky, Markey Cancer Center Clinical Research Office (UK MCC CRO) | Lexington40536 | NCT06989437 | Map |
| MD | JHU Oncology Central Kit Services | Baltimore21205 | NCT06989437 | Map |
| MD | Johns Hopkins Hospital | Baltimore21287 | NCT06989437 | Map |
| MD | Oncology Investigational Drug Service (IDS) | Baltimore21287 | NCT06989437 | Map |
| MD | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Baltimore21287 | NCT06989437 | Map |
| MO | MidAmerica Cancer Care - American Oncology Partners | Kansas City64132 | NCT06989437 | Map |
| MO | Premier Imaging | Kansas City64114 | NCT06989437 | Map |
| MO | St. Joseph Medical Center | Kansas City64114 | NCT06989437 | Map |
| NE | Nebraska Medicine | Omaha68105 | NCT06989437 | Map |
| NE | Nebraska Medicine - Village Pointe | Omaha68118 | NCT06989437 | Map |
| NE | University of Nebraska Medical Center | Omaha68198 | NCT06989437 | Map |
| NV | Renown Health Medical Oncology | Reno89502 | NCT06989437 | Map |
| NV | Renown Office of Clinical Research | Reno89502 | NCT06989437 | Map |
| NV | Renown Regional Medical Center | Reno89502 | NCT06989437 | Map |
| NJ | Jack & Sheryl Morris Cancer Center | New Brunswick08901 | NCT06989437 | Map |
| NJ | Rutgers Cancer Institute | New Brunswick08901 | NCT06989437 | Map |
| NJ | Rwj University Hospital Somerset | Somerville08876 | NCT06989437 | Map |
| NJ | RWJ University Hospital Somerset, Steeplechase Cancer Center | Somerville08876 | NCT06989437 | Map |
| NY | University of Rochester Medical Center | Rochester14642 | NCT06989437 | Map |
| NC | UNC Hospitals, The University of North Carolina at Chapel Hill | Chapel Hill27514 | NCT06989437 | Map |
| NC | University of North Carolina Hospitals at Hillsborough | Hillsborough27278 | NCT06989437 | Map |
| OR | OHSU Center for Health & Healing 1 | Portland97239 | NCT06989437 | Map |
| OR | Oregon Health and Science University | Portland97239 | NCT06989437 | Map |
| OR | OSHU Center for Health and Healing 2 | Portland97239 | NCT06989437 | Map |
| TX | Houston Methodist Hospital | Houston77030 | NCT06989437 | Map |
| TX | Baylor Scott & White Vasicek Cancer Treatment Center | Temple76508 | NCT06989437 | Map |
| WA | Virginia Mason Medical Center | Seattle98101 | NCT06989437 | Map |
ponsegromab clinical trials at a glance: phase × recruitment status
| Phase | recruiting | completed | terminated | Total |
|---|---|---|---|---|
| P1 | 1 | 1 | ||
| P2 | 1 | 1 | 2 | |
| P2/P3 | 1 | 1 |
Recruiting ponsegromab clinical trials (1)
Studies currently enrolling participants. Click any NCT ID to view the trial detail page (eligibility, sites, contacts).
| NCT ID | Title | Phase | Indication | Enrollment | Started |
|---|---|---|---|---|---|
| NCT06989437 | A Study to Learn About the Medicine Ponsegromab in Adults With Cancer of the Pancreas Which Has Spread and Caused Significant Body Weight Loss and Fatigue | P2/P3 | Cachexia | 982 | Oct 2025 |
ponsegromab clinical trials by indication
Cachexia (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT06989437 | — | P2/P3 | recruiting | A Study to Learn About the Medicine Ponsegromab in Adults With Cancer of the Pancreas Which Has Spread and Caused Significant Body Weight Loss and Fatigue |
Healthy (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT05685264 | — | P1 | completed | A Study to Learn How the Study Medicine (Ponsegromab) is Changed and Eliminated From Healthy Chinese Adults |
Non-small Cell Lung Cancer (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT05546476 | PROACC-1 | P2 | completed | Study of the Efficacy and Safety of Ponsegromab in Patients With Cancer, Cachexia and Elevated GDF-15 |
Heart Failure (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT05492500 | GARDEN TIMI 74 | P2 | terminated | A Study of Ponsegromab in People With Heart Failure |
ponsegromab pivotal trial highlights (Phase 2/3/4)
Phase-2/3/4 studies with named acronyms — the registration-grade trials most cited in label discussions and Wikipedia.
| Acronym | NCT | Phase | Status | Indication | Enrollment | PubMed |
|---|---|---|---|---|---|---|
| PROACC-1 | NCT05546476 | P2 | completed | Non-small Cell Lung Cancer | 187 | PMID 38500292 |
| GARDEN TIMI 74 | NCT05492500 | P2 | terminated | Heart Failure | 455 | — |
Terminated and withdrawn ponsegromab trials (1)
Studies that ended before completion. Reasons are filed in each trial's ClinicalTrials.gov entry.
- NCT05492500terminatedA Study of Ponsegromab in People With Heart Failure
All ponsegromab trials (4)
Sorted by most recent activity (completion → start → posted date). Each row links to the trial detail page on Hipa.ai.
| NCT ID | Acronym | Title | Phase | Status | Enrollment | Sponsor | Started |
|---|---|---|---|---|---|---|---|
| NCT06989437 | A Study to Learn About the Medicine Ponsegromab in Adults With Cancer of the Pancreas Which Has Spread and Caused Significant Body Weight Loss and Fatigue | P2/P3 | recruiting | 982 | Pfizer | Oct 2025 | |
| NCT05546476 | PROACC-1 | Study of the Efficacy and Safety of Ponsegromab in Patients With Cancer, Cachexia and Elevated GDF-15 | P2 | completed | 187 | Pfizer | Nov 2022 |
| NCT05492500 | GARDEN TIMI 74 | A Study of Ponsegromab in People With Heart Failure | P2 | terminated | 455 | Pfizer | Sep 2022 |
| NCT05685264 | A Study to Learn How the Study Medicine (Ponsegromab) is Changed and Eliminated From Healthy Chinese Adults | P1 | completed | 18 | Pfizer | Jan 2023 |
ponsegromab clinical trials: frequently asked questions
- How many ponsegromab clinical trials are there?
- 4 ponsegromab clinical trials are catalogued on Hipa.ai, sourced from the AACT mirror of ClinicalTrials.gov. 1 is actively recruiting participants. 2 are marked completed.
- Are ponsegromab clinical trials recruiting in 2026?
- Yes — 1 ponsegromab trial is actively recruiting in 2026, with 67 U.S. sites across 19 states. See the recruiting trials and the per-state site list further down this page.
- What conditions is ponsegromab being studied for?
- ponsegromab is being studied for Cachexia, Colorectal Cancer, Fatigue, Healthy, Heart Failure and 4 more. The trials are grouped by indication on this page.
- What phase is ponsegromab in?
- ponsegromab clinical trials span 2 Phase 2, 1 Phase 1. The phase × status matrix at the top of this page breaks down counts by phase and recruitment status.
- Who sponsors ponsegromab clinical trials?
- The lead sponsor across the most ponsegromab trials is Pfizer. Each trial row links to the full study detail page including sponsor information.
Sources and methodology
Trial inventory derived from the AACT mirror of ClinicalTrials.gov. Trials are filtered to those naming ponsegromabas an intervention. Phase, status, enrollment, sponsor, and dates are taken from the source `studies` table; primary indication is the first listed condition. Acronyms are extracted from each trial's brief title where present. PubMed links are populated for trials whose published primary outcomes have been indexed in our evidence cache.
Last refreshed .
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