Petosemtamab Clinical Trials (2026): 3 Studies for Head and Neck Squamous Cell Carcinoma & Lung Cancer - Non Small Cell Non-Squamous

Hipa.ai Research · Source: ClinicalTrials.gov / AACT

Synced daily from ClinicalTrials.gov via AACT. Last sync: .

3 Petosemtamab clinical trials are catalogued on Hipa.ai from the AACT mirror of ClinicalTrials.gov, spanning 2 indications (including Head and Neck Squamous Cell Carcinoma & Lung Cancer - Non Small Cell Non-Squamous) and 1,480 total planned enrollment. 2 Phase 3 Petosemtamab trials and 1 Phase 2 are listed. 3 Petosemtamab clinical trials are actively recruiting at 102 U.S. sites across 31 states. Most recent activity: NCT07353957 (Feb 2031).

Where to Participate: All Petosemtamab Trial Sites in the U.S. (102 sites across 31 states)

Every actively recruiting Petosemtamabtrial site, sorted by state then city. Each row links to the trial detail page (eligibility, contacts, full study record). Sites no longer enrolling at the location level are excluded. ClinicalTrials.gov / AACT does not provide street-level addresses; the map link uses the facility's geocoded coordinates where available.

StateFacilityCityTrialMap
ALSite 160Mobile36608NCT06496178Map
ALSite 164Mobile36607NCT06525220Map
AZSite 125Scottsdale85054NCT06496178Map
CASite 82Duarte91010NCT06496178Map
CASite 25La Jolla92037NCT06496178Map
CASite 36La Jolla92037NCT06525220Map
CASite 27Los Angeles90033NCT06525220Map
CASite 173Orange92868NCT06496178Map
CASite 16Palo Alto94304NCT06525220Map
CASite 28Palo Alto94304NCT06496178Map
CASite 127Sacramento95817NCT06496178Map
CASite 46San Francisco94158NCT06496178Map
COSite 130Lone Tree80124NCT06496178Map
DESite 19Newark19713NCT06525220Map
DCSite 104Washington D.C.20010NCT06496178Map
DCSite 108Washington D.C.20010NCT06525220Map
FLSite 12Fort Myers33901NCT06496178Map
FLSite 14Fort Myers33901NCT06525220Map
FLSite 123Jacksonville32224NCT06496178Map
FLSite 8Orlando32827NCT06525220Map
FLSite 9Orlando32827NCT06496178Map
FLFlorida Cancer Specialists - NorthSt. Petersburg33701-4553NCT07353957Map
FLSite 21St. Petersburg33705NCT06525220Map
FLSite 138Tampa33612NCT06496178Map
FLSite 20West Palm Beach33401NCT06525220Map
GASite 171Atlanta30322NCT06525220Map
GASite 187Atlanta30322NCT06496178Map
GASite 207Atlanta30341NCT06496178Map
ILSite 152Chicago60607NCT06496178Map
ILSite 197Chicago60611NCT06525220Map
ILSite 213Chicago60611NCT06496178Map
ILSite 50Chicago60637NCT06525220Map
ILSite 68Chicago60637NCT06496178Map
INSite 31Indianapolis46202NCT06496178Map
KYSite 2Louisville40202NCT06525220Map
KYSite 8Louisville40202NCT06496178Map
LASite 162Baton Rouge70809NCT06525220Map
LASite 40Baton Rouge70809NCT06496178Map
LASite 100New Orleans70121NCT06496178Map
MDSite 153Columbia21044NCT06496178Map
MASite 77Boston02215NCT06496178Map
MISite 103Ann Arbor48109NCT06496178Map
MISite 5Detroit48201NCT06496178Map
MNSite 49Maple Grove55369NCT06496178Map
MNSite 155Minneapolis55417NCT06525220Map
MNSite 124Rochester55905NCT06496178Map
MOSite 168St Louis63108NCT06525220Map
MOSite 18St Louis63110NCT06496178Map
NJSite 86Hackensack07601NCT06496178Map
NJSite 94Hackensack07601NCT06525220Map
NMSite 15Albuquerque87131NCT06496178Map
NMSite 6Albuquerque87131NCT06525220Map
NYMemorial Sloan Kettering Cancer CenterLong Island City11101NCT07353957Map
NYSite 24New York10029NCT06496178Map
NYSite 214The Bronx10461NCT06496178Map
NCSite 98Chapel Hill27514NCT06496178Map
NCSite 113Durham27710NCT06525220Map
NCSite 122Durham27710NCT06496178Map
NCSite 118Winston-Salem27157NCT06525220Map
OHSite 23Cincinnati45219NCT06496178Map
OHSite 191Cleveland44195NCT06525220Map
OHSite 87Cleveland44195NCT06496178Map
OHSite 32Columbus43210NCT06496178Map
ORSite 26Portland97213NCT06496178Map
PASite 151Bensalem19020NCT06496178Map
PASite 153Philadelphia19107NCT06525220Map
PASite 154Philadelphia19114NCT06525220Map
PASite 158Philadelphia19107NCT06496178Map
PASite 159Philadelphia19114NCT06496178Map
PASite 43Philadelphia19104NCT06525220Map
SCSite 50Charleston29425NCT06496178Map
TNSite 60Chattanooga37404NCT06496178Map
TNSite 89Chattanooga37404NCT06525220Map
TNTennessee Site 2Chattanooga37403NCT07353957Map
TNSite 115Memphis38103NCT06525220Map
TNSite 54Memphis38103NCT06496178Map
TNSite 59Nashville37203NCT06496178Map
TNSite 67Nashville37232NCT06496178Map
TNSite 88Nashville37203NCT06525220Map
TNTennessee Site 1Nashville37209NCT07353957Map
TXSite 22Austin78745NCT06525220Map
TXSite 55Denison75020NCT06496178Map
TXSite 34El Paso79915NCT06496178Map
TXSite 1Houston77030NCT06525220Map
TXSite 51Houston77030NCT06496178Map
TXSite 7Houston77030NCT06496178Map
TXSite 94Pearland77584NCT06496178Map
TXSite 18Plano75075NCT06525220Map
TXSite 17Sugar Land77479NCT06525220Map
TXSite 15Tyler75702NCT06525220Map
UTSite 10Salt Lake City84112NCT06525220Map
UTSite 4Salt Lake City84112NCT06496178Map
VASite 10Blacksburg24060NCT06496178Map
VASite 12Blacksburg24060NCT06525220Map
VAVirginia Site 2Blacksburg24060NCT07353957Map
VASite 22Charlottesville22908NCT06496178Map
VAVirginia Site 1Fairfax22031NCT07353957Map
VASite 23Norfolk23502NCT06525220Map
VASite 156Winchester22601NCT06496178Map
WASite 163Seattle98109NCT06496178Map
WASite 6Spokane99202NCT06496178Map
WISite 216Madison53705NCT06496178Map

Petosemtamab clinical trials at a glance: phase × recruitment status

PhaserecruitingTotal
P211
P322

Recruiting Petosemtamab clinical trials (3)

Studies currently enrolling participants. Click any NCT ID to view the trial detail page (eligibility, sites, contacts).

NCT IDTitlePhaseIndicationEnrollmentStarted
NCT07353957Study to Investigate Petosemtamab in Adults With Metastatic Non-Small Cell Lung CancerP2Lung Cancer - Non Small Cell Squamous180Mar 2025
NCT06525220A Phase 3 Study to Evaluate Petosemtamab Plus Pembrolizumab vs Pembrolizumab in First-line Treatment of Head and Neck Cancer (LiGeR - HN1)P3Head and Neck Squamous Cell Carcinoma700Sep 2024
NCT06496178A Phase 3 Study to Evaluate Petosemtamab Compared With Investigator's Choice Monotherapy in Previously Treated Head and Neck Squamous Cell Carcinoma Patients (LiGeR-HN2)P3Head and Neck Squamous Cell Carcinoma600Jun 2024

Petosemtamab clinical trials by indication

Head and Neck Squamous Cell Carcinoma (2)

NCTAcronymPhaseStatusTitle
NCT06525220P3recruitingA Phase 3 Study to Evaluate Petosemtamab Plus Pembrolizumab vs Pembrolizumab in First-line Treatment of Head and Neck Cancer (LiGeR - HN1)
NCT06496178P3recruitingA Phase 3 Study to Evaluate Petosemtamab Compared With Investigator's Choice Monotherapy in Previously Treated Head and Neck Squamous Cell Carcinoma Patients (LiGeR-HN2)

Lung Cancer - Non Small Cell Squamous (1)

NCTAcronymPhaseStatusTitle
NCT07353957P2recruitingStudy to Investigate Petosemtamab in Adults With Metastatic Non-Small Cell Lung Cancer

All Petosemtamab trials (3)

Sorted by most recent activity (completion → start → posted date). Each row links to the trial detail page on Hipa.ai.

NCT IDAcronymTitlePhaseStatusEnrollmentSponsorStarted
NCT07353957Study to Investigate Petosemtamab in Adults With Metastatic Non-Small Cell Lung CancerP2recruiting180Merus B.V.Mar 2025
NCT06525220A Phase 3 Study to Evaluate Petosemtamab Plus Pembrolizumab vs Pembrolizumab in First-line Treatment of Head and Neck Cancer (LiGeR - HN1)P3recruiting700Merus B.V.Sep 2024
NCT06496178A Phase 3 Study to Evaluate Petosemtamab Compared With Investigator's Choice Monotherapy in Previously Treated Head and Neck Squamous Cell Carcinoma Patients (LiGeR-HN2)P3recruiting600Merus B.V.Jun 2024

Petosemtamab clinical trials: frequently asked questions

How many Petosemtamab clinical trials are there?
3 Petosemtamab clinical trials are catalogued on Hipa.ai, sourced from the AACT mirror of ClinicalTrials.gov. 3 are actively recruiting participants.
Are Petosemtamab clinical trials recruiting in 2026?
Yes — 3 Petosemtamab trials are actively recruiting in 2026, with 102 U.S. sites across 31 states. See the recruiting trials and the per-state site list further down this page.
What conditions is Petosemtamab being studied for?
Petosemtamab is being studied for Head and Neck Squamous Cell Carcinoma, Lung Cancer - Non Small Cell Non-Squamous, Lung Cancer - Non Small Cell Squamous. The trials are grouped by indication on this page.
What phase is Petosemtamab in?
Petosemtamab clinical trials span 2 Phase 3, 1 Phase 2. The phase × status matrix at the top of this page breaks down counts by phase and recruitment status.
Who sponsors Petosemtamab clinical trials?
The lead sponsor across the most Petosemtamab trials is Merus B.V.. Each trial row links to the full study detail page including sponsor information.

Sources and methodology

Trial inventory derived from the AACT mirror of ClinicalTrials.gov. Trials are filtered to those naming Petosemtamabas an intervention. Phase, status, enrollment, sponsor, and dates are taken from the source `studies` table; primary indication is the first listed condition. Acronyms are extracted from each trial's brief title where present. PubMed links are populated for trials whose published primary outcomes have been indexed in our evidence cache.

Last refreshed .

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