Necitumumab Clinical Trials (2026): 21 Studies for Metastatic Lung Non-Small Cell Carcinoma & Non Small Cell Lung Cancer

Hipa.ai Research · Source: ClinicalTrials.gov / AACT

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21 Necitumumab clinical trials are catalogued on Hipa.ai from the AACT mirror of ClinicalTrials.gov, spanning 18 indications (including Metastatic Lung Non-Small Cell Carcinoma & Non Small Cell Lung Cancer) and 3,043 total planned enrollment. 2 Phase 3 Necitumumab trials and 10 Phase 2 are listed. Most recent activity: NCT04285671 (Dec 2027).

Necitumumab clinical trials at a glance: phase × recruitment status

Phaseactive not recruitingcompletedterminatedwithdrawnTotal
P11416
P1/P21113
P2162110
P322

Necitumumab clinical trials by indication

Metastatic Lung Non-Small Cell Carcinoma (2)

NCTAcronymPhaseStatusTitle
NCT04285671EGFRP1/P2active not recruitingNecitumumab and Trastuzumab in Combination With Osimertinib for the Treatment of Refractory Epidermal Growth Factor Receptor (EGFR)-Mutated Stage IV Non-small Cell Lung Cancer
NCT02496663P1active not recruitingOsimertinib and Necitumumab in Treating Patients With EGFR-Mutant Stage IV or Recurrent Non-small Cell Lung Cancer Who Have Progressed on a Previous EGFR Tyrosine Kinase Inhibitor

Non-small Cell Lung Cancer (2)

NCTAcronymPhaseStatusTitle
NCT02789345LY3009806P1completedA Study of Ramucirumab (LY3009806) or Necitumumab (LY3012211) Plus Osimertinib in Participants With Lung Cancer
NCT01788566P2completedA Study of Gemcitabine-Cisplatin Chemotherapy Plus Necitumumab in the First-Line Treatment of Participants With Squamous Lung Cancer

Non Small Cell Lung Cancer (2)

NCTAcronymPhaseStatusTitle
NCT00981058SQUIREP3completedFirst-line Treatment of Participants With Stage IV Squamous Non-Small Cell Lung Cancer With Necitumumab and Gemcitabine-Cisplatin
NCT00982111INSPIREP3completedFirst-line Treatment of Patients With Stage IV Nonsquamous Non-Small Cell Lung Cancer With Necitumumab (IMC-11F8) and Pemetrexed-Cisplatin

Non-Small Cell Lung Cancer (1)

NCTAcronymPhaseStatusTitle
NCT03944772ORCHARDP2active not recruitingPhase 2 Platform Study in Patients With Advanced Non-Small Lung Cancer Who Progressed on First-Line Osimertinib Therapy (ORCHARD)

Squamous Cell Lung Cancer (1)

NCTAcronymPhaseStatusTitle
NCT03574818P2terminatedNecitumumab in the Neoadjuvant Setting With Gemcitabine in Surgically Resectable - 14X-US-I001

Squamous Cell Carcinoma (1)

NCTAcronymPhaseStatusTitle
NCT03387111SCCP1/P2terminatedQUILT-3.090: NANT Squamous Cell Carcinoma (SCC) Vaccine: Subjects With SCC Who Have Progressed

Solid Tumor, Adult (1)

NCTAcronymPhaseStatusTitle
NCT03360734GATTOP1completedCombination of Gatipotuzumab and Tomuzotuximab in Patients With Solid Tumors

Non-Small Cell Lung Carcinoma (1)

NCTAcronymPhaseStatusTitle
NCT03054038P1terminatedAfatinib and Necitumumab in Patients With EGFR Mutation Positive Advanced or Metastatic Non-small Cell Lung Cancer

Locally Advanced Squamous Non-Small Cell Lung Cancer (1)

NCTAcronymPhaseStatusTitle
NCT02941601LY3012211P2withdrawnA Study of Gemcitabine-Carboplatin Plus Necitumumab (LY3012211) in Chemotherapy-Naïve Participants With Locally Advanced or Metastatic Squamous Non-Small Cell Lung Cancer (NSCLC)

Carcinoma, Non-Small Cell Lung Cancer (NSCLC) (1)

NCTAcronymPhaseStatusTitle
NCT02392507LY3012211P2completedA Study of Nab-Paclitaxel and Carboplatin Plus Necitumumab (LY3012211) in Participants With Stage IV Squamous NSCLC

Stage IV Non-Small Cell Lung Cancer (1)

NCTAcronymPhaseStatusTitle
NCT02451930LY3012211P1completedA Study of the Combination of Necitumumab (LY3012211) and Pembrolizumab (MK3475) in Participants With NSCLC

Non-small Cell Lung Cancer Metastatic (1)

NCTAcronymPhaseStatusTitle
NCT02443337P2terminatedA Study of LY3023414 and Necitumumab in Squamous Lung Cancer

Carcinoma, Non-Small-Cell Lung (1)

NCTAcronymPhaseStatusTitle
NCT02411591NSCLCP1completedA Study of Necitumumab and Abemaciclib in Participants With Non-Small Cell Lung Cancer (NSCLC)

Squamous Non-small Cell Lung Cancer (1)

NCTAcronymPhaseStatusTitle
NCT01763788NSCLCP1/P2completedA Study of Necitumumab in the First-Line Treatment of Stage IV Squamous Non-Small Cell Lung Cancer (NSCLC)

Squamous Non Small Cell Lung Cancer (1)

NCTAcronymPhaseStatusTitle
NCT01769391P2completedA Study of Necitumumab and Chemotherapy in Participants With Stage IV Squamous Non-Small Cell Lung Cancer

Malignant Solid Tumor (1)

NCTAcronymPhaseStatusTitle
NCT01606748IMC-11F8P2completedA Drug-Interaction Study of Necitumumab (IMC-11F8) in Combination With Gemcitabine-Cisplatin

Solid Tumors (1)

NCTAcronymPhaseStatusTitle
NCT01624467P2completedA Study of Necitumumab Monotherapy and the QT/QTc Interval in Patient With Advanced Solid Tumors

Metastatic Colorectal Cancer (1)

NCTAcronymPhaseStatusTitle
NCT00835185P2completedStudy of IMC-11F8 in Participants With Colorectal Cancer

Necitumumab pivotal trial highlights (Phase 2/3/4)

Phase-2/3/4 studies with named acronyms — the registration-grade trials most cited in label discussions and Wikipedia.

AcronymNCTPhaseStatusIndicationEnrollmentPubMed
SQUIRENCT00981058P3completedNon Small Cell Lung Cancer1,093PMID 26045340
INSPIRENCT00982111P3completedNon Small Cell Lung Cancer633PMID 25701171
ORCHARDNCT03944772P2active not recruitingNon-Small Cell Lung Cancer247PMID 34389237
LY3012211NCT02392507P2completedCarcinoma, Non-Small Cell Lung Cancer (NSCLC)54
LY3012211NCT02941601P2withdrawnLocally Advanced Squamous Non-Small Cell Lung Cancer0
IMC-11F8NCT01606748P2completedMalignant Solid Tumor35

Terminated and withdrawn Necitumumab trials (5)

Studies that ended before completion. Reasons are filed in each trial's ClinicalTrials.gov entry.

All Necitumumab trials (21)

Sorted by most recent activity (completion → start → posted date). Each row links to the trial detail page on Hipa.ai.

NCT IDAcronymTitlePhaseStatusEnrollmentSponsorStarted
NCT04285671EGFRNecitumumab and Trastuzumab in Combination With Osimertinib for the Treatment of Refractory Epidermal Growth Factor Receptor (EGFR)-Mutated Stage IV Non-small Cell Lung CancerP1/P2active not recruiting30Jonsson Comprehensive Cancer CenterJan 2021
NCT02496663Osimertinib and Necitumumab in Treating Patients With EGFR-Mutant Stage IV or Recurrent Non-small Cell Lung Cancer Who Have Progressed on a Previous EGFR Tyrosine Kinase InhibitorP1active not recruiting138National Cancer Institute (NCI)May 2016
NCT03944772ORCHARDPhase 2 Platform Study in Patients With Advanced Non-Small Lung Cancer Who Progressed on First-Line Osimertinib Therapy (ORCHARD)P2active not recruiting247AstraZenecaJun 2019
NCT00981058SQUIREFirst-line Treatment of Participants With Stage IV Squamous Non-Small Cell Lung Cancer With Necitumumab and Gemcitabine-CisplatinP3completed1,093Eli Lilly and CompanyJan 2010
NCT02789345LY3009806A Study of Ramucirumab (LY3009806) or Necitumumab (LY3012211) Plus Osimertinib in Participants With Lung CancerP1completed29Eli Lilly and CompanyOct 2016
NCT03054038Afatinib and Necitumumab in Patients With EGFR Mutation Positive Advanced or Metastatic Non-small Cell Lung CancerP1terminated22Vanderbilt-Ingram Cancer CenterJul 2017
NCT03387111SCCQUILT-3.090: NANT Squamous Cell Carcinoma (SCC) Vaccine: Subjects With SCC Who Have ProgressedP1/P2terminated4ImmunityBio, Inc.Jan 2018
NCT00982111INSPIREFirst-line Treatment of Patients With Stage IV Nonsquamous Non-Small Cell Lung Cancer With Necitumumab (IMC-11F8) and Pemetrexed-CisplatinP3completed633Eli Lilly and CompanyNov 2009
NCT03360734GATTOCombination of Gatipotuzumab and Tomuzotuximab in Patients With Solid TumorsP1completed50Glycotope GmbHNov 2017
NCT02392507LY3012211A Study of Nab-Paclitaxel and Carboplatin Plus Necitumumab (LY3012211) in Participants With Stage IV Squamous NSCLCP2completed54Eli Lilly and CompanyOct 2015
NCT03574818Necitumumab in the Neoadjuvant Setting With Gemcitabine in Surgically Resectable - 14X-US-I001P2terminated1Montefiore Medical CenterMay 2018
NCT02451930LY3012211A Study of the Combination of Necitumumab (LY3012211) and Pembrolizumab (MK3475) in Participants With NSCLCP1completed71Eli Lilly and CompanySep 2015
NCT02411591NSCLCA Study of Necitumumab and Abemaciclib in Participants With Non-Small Cell Lung Cancer (NSCLC)P1completed66Eli Lilly and CompanyJun 2015
NCT02941601LY3012211A Study of Gemcitabine-Carboplatin Plus Necitumumab (LY3012211) in Chemotherapy-Naïve Participants With Locally Advanced or Metastatic Squamous Non-Small Cell Lung Cancer (NSCLC)P2withdrawn0Eli Lilly and CompanyNov 2016
NCT01763788NSCLCA Study of Necitumumab in the First-Line Treatment of Stage IV Squamous Non-Small Cell Lung Cancer (NSCLC)P1/P2completed192Eli Lilly and CompanyMay 2013
NCT02443337A Study of LY3023414 and Necitumumab in Squamous Lung CancerP2terminated31Eli Lilly and CompanyJul 2015
NCT01769391A Study of Necitumumab and Chemotherapy in Participants With Stage IV Squamous Non-Small Cell Lung CancerP2completed167Eli Lilly and CompanyJan 2013
NCT01606748IMC-11F8A Drug-Interaction Study of Necitumumab (IMC-11F8) in Combination With Gemcitabine-CisplatinP2completed35Eli Lilly and CompanyAug 2012
NCT01788566A Study of Gemcitabine-Cisplatin Chemotherapy Plus Necitumumab in the First-Line Treatment of Participants With Squamous Lung CancerP2completed61Eli Lilly and CompanyMar 2013
NCT01624467A Study of Necitumumab Monotherapy and the QT/QTc Interval in Patient With Advanced Solid TumorsP2completed75Eli Lilly and CompanyAug 2012
NCT00835185Study of IMC-11F8 in Participants With Colorectal CancerP2completed44Eli Lilly and CompanyAug 2007

Necitumumab clinical trials: frequently asked questions

How many Necitumumab clinical trials are there?
21 Necitumumab clinical trials are catalogued on Hipa.ai, sourced from the AACT mirror of ClinicalTrials.gov. 13 are marked completed.
Are Necitumumab clinical trials recruiting in 2026?
No active Necitumumab trials are recruiting on ClinicalTrials.gov as of the current AACT refresh. Trials may resume; this page is updated daily.
What conditions is Necitumumab being studied for?
Necitumumab is being studied for Metastatic Lung Non-Small Cell Carcinoma, Non Small Cell Lung Cancer, Non-small Cell Lung Cancer, Malignant Solid Tumor, Metastatic Colorectal Cancer and 21 more. The trials are grouped by indication on this page.
What phase is Necitumumab in?
Necitumumab clinical trials span 2 Phase 3, 10 Phase 2, 6 Phase 1. The phase × status matrix at the top of this page breaks down counts by phase and recruitment status.
Who sponsors Necitumumab clinical trials?
The lead sponsor across the most Necitumumab trials is Eli Lilly and Company, with 7 additional lead sponsors listed in the data. Each trial row links to the full study detail page including sponsor information.

Sources and methodology

Trial inventory derived from the AACT mirror of ClinicalTrials.gov. Trials are filtered to those naming Necitumumabas an intervention. Phase, status, enrollment, sponsor, and dates are taken from the source `studies` table; primary indication is the first listed condition. Acronyms are extracted from each trial's brief title where present. PubMed links are populated for trials whose published primary outcomes have been indexed in our evidence cache.

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