Mezigdomide Clinical Trials (2026): 19 Studies for Multiple Myeloma & Recurrent Multiple Myeloma

Hipa.ai Research · Source: ClinicalTrials.gov / AACT

Synced daily from ClinicalTrials.gov via AACT. Last sync: .

19 Mezigdomide clinical trials are catalogued on Hipa.ai from the AACT mirror of ClinicalTrials.gov, spanning 11 indications (including Multiple Myeloma & Recurrent Multiple Myeloma) and 2,401 total planned enrollment. 2 Phase 3 Mezigdomide trials and 1 Phase 2 are listed. 11 Mezigdomide clinical trials are actively recruiting at 49 U.S. sites across 15 states. Most recent activity: NCT05519085 (Nov 2033).

Where to Participate: All Mezigdomide Trial Sites in the U.S. (49 sites across 15 states)

Every actively recruiting Mezigdomidetrial site, sorted by state then city. Each row links to the trial detail page (eligibility, contacts, full study record). Sites no longer enrolling at the location level are excluded. ClinicalTrials.gov / AACT does not provide street-level addresses; the map link uses the facility's geocoded coordinates where available.

StateFacilityCityTrialMap
ALUniversity of Alabama at BirminghamBirmingham35294-3300NCT06121843Map
ALUniversity of Alabama at BirminghamBirmingham35294NCT06988488Map
AZMayo Clinic in Arizona - PhoenixPhoenix85054NCT06121843Map
CACity of Hope Comprehensive Cancer CenterDuarte91010NCT06121843Map
CACity of Hope Medical CenterDuarte91010NCT06048250Map
CAUCSF Medical Center - Hematology and Blood and Marrow Transplant ClinicSan Francisco94143NCT05651932Map
CTYale New Haven Hospital-Smilow Cancer CenterNew Haven06510NCT06988488Map
FLMayo Clinic Hospital - FloridaJacksonville32224NCT05651932Map
FLMayo Clinic in FloridaJacksonville32224NCT06121843Map
GANorthside HospitalAtlanta30342NCT06121843Map
GAThe Winship Cancer Institute of Emory UniversityAtlanta30322NCT05651932Map
MABeth Israel Deaconess Medical CenterBoston02215NCT06121843Map
MADana-Farber Cancer InstituteBoston02215NCT05651932Map
MADana-Farber Cancer InstituteBoston02215NCT06121843Map
MAMassachusetts General HospitalBoston02114NCT05651932Map
MAMassachusetts General HospitalBoston02114NCT07032714Map
MNMayo Clinic - Transplant Center - RochesterRochester55905NCT05651932Map
MNMayo Clinic in Rochester, MinnesotaRochester55905NCT06121843Map
NEUniversity Of Nebraska Medical CenterOmaha68198NCT06121843Map
NJMemorial Sloan Kettering at Basking Ridge (All Protocol Activities)Basking Ridge07920NCT07356154Map
NJMemorial Sloan Kettering Basking Ridge (Limited Protocol Activities)Basking Ridge07920NCT07105059Map
NJHackensack University Medical CenterHackensack07601NCT05651932Map
NJHackensack University Medical CenterHackensack07601NCT06988488Map
NJJohn Theurer Cancer Center at Hackensack University Medical CenterHackensack07601NCT06121843Map
NJMemorial Sloan Kettering Monmouth (All Protocol Activities)Middletown07748NCT07356154Map
NJMemorial Sloan Kettering Monmouth (Limited Protocol Activities)Middletown07748NCT07105059Map
NJMemorial Sloan Kettering Bergen (All Protocol Activities)Montvale07645NCT07356154Map
NJMemorial Sloan Kettering Bergen (Limited Protocol Activities)Montvale07645NCT07105059Map
NYRoswell Park Cancer InstituteBuffalo14263NCT06121843Map
NYRoswell Park Cancer InstituteBuffalo14263NCT06627751Map
NYMemorial Sloan Kettering Suffolk - Commack (Limited Protocol Activities)Commack11725NCT07105059Map
NYMemorial Sloan Kettering Suffolk-Commack (All Protocol Activities)Commack11725NCT07356154Map
NYMemorial Sloan Kettering Westchester (Limited Protocol Activities)Harrison10604NCT07105059Map
NYMemorial Sloan Kettering Westchester (Limited Protocol Activities)Harrison10604NCT07356154Map
NYLaura and Isaac Perlmutter Cancer CenterNew York10016NCT06121843Map
NYMemorial Sloan Kettering Cancer CenterNew York10065NCT06121843Map
NYMemorial Sloan Kettering Cancer Center (All Protocol Activities)New York10065NCT07105059Map
NYMemorial Sloan Kettering Cancer Center (All Protocol Activities)New York10065NCT07356154Map
NYMemorial Sloan-Kettering Cancer CenterNew York10065NCT05651932Map
NYMemorial Sloan Kettering Nassau (All Protocol Activities)Rockville Centre11553NCT07356154Map
NYMemorial Sloan Kettering Nassau (Limited Protocol Activities)Uniondale11553NCT07105059Map
NCAtrium Health, Levine Cancer InstituteCharlotte28204NCT05651932Map
NCDuke University HospitalDurham27705NCT05651932Map
PAUniversity of PennsylvaniaPhiladelphia19104NCT05651932Map
TNTennessee OncologyNashville37203NCT05651932Map
TNTennessee OncologyNashville37203NCT06121843Map
TXUniversity of Texas Southwestern Harold C. Simmons Comprehensive Cancer CenterDallas75235NCT05651932Map
TXUniversity of Texas MD Anderson Cancer CenterHouston77030NCT06121843Map
TXUniversity of Texas MD Anderson Cancer CenterHouston77030NCT06988488Map

Mezigdomide clinical trials at a glance: phase × recruitment status

Phaserecruitingactive not recruitingcompletedterminatedwithdrawnnot yet recruitingavailableTotal
P15121110
P1/P23115
P211
P3112
N/A11

Recruiting Mezigdomide clinical trials (11)

Studies currently enrolling participants. Click any NCT ID to view the trial detail page (eligibility, sites, contacts).

NCT IDTitlePhaseIndicationEnrollmentStarted
NCT05519085SUCCESSOR-1A Study to Evaluate Mezigdomide, Bortezomib and Dexamethasone (MEZIVd) Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)P3Relapsed or Refractory Multiple Myeloma810Sep 2022
NCT06627751Mezigdomide, Carfilzomib, and Dexamethasone for the Treatment of Relapsed or Refractory Multiple Myeloma in Patients With Extramedullary DiseaseP2Extramedullary Disease in Multiple Myeloma28May 2025
NCT07356154A Study of Revumenib and Mezigdomide in People With LeukemiaP1/P2Leukemia52Jan 2026
NCT07105059A Study of Teclistamab and Mezigdomide in People With Multiple MyelomaP1Multiple Myeloma18Aug 2025
NCT06121843BMS-986393A Study to Evaluate the Safety, Effectiveness and Tolerable Dose of Arlocabtagene Autoleucel (BMS-986393) in Novel Combinations in Participants With Relapsed and/or Refractory Multiple MyelomaP1Multiple Myeloma147Feb 2024
NCT07032714MAGENTAMezigdomide and Talquetamab in Relapsed and Refractory Multiple MyelomaP1Relapsed Refractory Multiple Myeloma (RRMM)25Dec 2025
NCT05651932A Study of an MMSET Inhibitor in Patients With Relapsed and Refractory Multiple MyelomaP1Multiple Myeloma165Feb 2023
NCT07355335Ziftomenib + Mezigdomide in Adolesc. and Adults w/ R/R AMLP1KMT2A-rearranged24Jul 2026
NCT06645678MELT-MMMezigdomide and Elranatamab for Relapsed and/or Refractory Multiple MyelomaP1/P2Relapsed Refractory Multiple Myeloma (RRMM)75Nov 2024
NCT06988488A Study to Determine the Recommended Dose and Schedule, and Evaluate the Safety and Preliminary Efficacy of Mezigdomide in Combination With Elranatamab in Participants With Relapsed and/or Refractory Multiple MyelomaP1/P2Multiple Myeloma62Oct 2025
NCT06048250CC-92480Mezigdomide (CC-92480) Post Idecabtagene Vicleucel in Treating Patients With Relapsed Multiple MyelomaP1Multiple Myeloma15Apr 2024

Mezigdomide clinical trials by indication

Multiple Myeloma (7)

NCTAcronymPhaseStatusTitle
NCT07105059P1recruitingA Study of Teclistamab and Mezigdomide in People With Multiple Myeloma
NCT06121843BMS-986393P1recruitingA Study to Evaluate the Safety, Effectiveness and Tolerable Dose of Arlocabtagene Autoleucel (BMS-986393) in Novel Combinations in Participants With Relapsed and/or Refractory Multiple Myeloma
NCT05651932P1recruitingA Study of an MMSET Inhibitor in Patients With Relapsed and Refractory Multiple Myeloma
NCT06988488P1/P2recruitingA Study to Determine the Recommended Dose and Schedule, and Evaluate the Safety and Preliminary Efficacy of Mezigdomide in Combination With Elranatamab in Participants With Relapsed and/or Refractory Multiple Myeloma
NCT02343042STOMPP1/P2active not recruitingSelinexor and Backbone Treatments of Multiple Myeloma Patients
NCT06048250CC-92480P1recruitingMezigdomide (CC-92480) Post Idecabtagene Vicleucel in Treating Patients With Relapsed Multiple Myeloma
NCT06163898P1terminatedA Study to Evaluate Alnuctamab in Combination With Mezigdomide in Participants With Relapsed and/or Refractory Multiple Myeloma

Relapsed Refractory Multiple Myeloma (RRMM) (2)

NCTAcronymPhaseStatusTitle
NCT07032714MAGENTAP1recruitingMezigdomide and Talquetamab in Relapsed and Refractory Multiple Myeloma
NCT06645678MELT-MMP1/P2recruitingMezigdomide and Elranatamab for Relapsed and/or Refractory Multiple Myeloma

Relapsed or Refractory Multiple Myeloma (2)

NCTAcronymPhaseStatusTitle
NCT05519085SUCCESSOR-1P3recruitingA Study to Evaluate Mezigdomide, Bortezomib and Dexamethasone (MEZIVd) Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)
NCT05552976SUCCESSOR-2P3active not recruitingA Study to Evaluate Mezigdomide in Combination With Carfilzomib and Dexamethasone (MeziKD) Versus Carfilzomib and Dexamethasone (Kd) in Participants With Relapsed or Refractory Multiple Myeloma (SUCCESSOR-2)

KMT2A-rearranged (1)

NCTAcronymPhaseStatusTitle
NCT07355335P1not yet recruitingZiftomenib + Mezigdomide in Adolesc. and Adults w/ R/R AML

Leukemia (1)

NCTAcronymPhaseStatusTitle
NCT07356154P1/P2recruitingA Study of Revumenib and Mezigdomide in People With Leukemia

Extramedullary Disease in Multiple Myeloma (1)

NCTAcronymPhaseStatusTitle
NCT06627751P2recruitingMezigdomide, Carfilzomib, and Dexamethasone for the Treatment of Relapsed or Refractory Multiple Myeloma in Patients With Extramedullary Disease

Renal Impairment (1)

NCTAcronymPhaseStatusTitle
NCT06318676P1completedA Study to Evaluate the Drug Levels of Mezigdomide in Adult Participants With Renal Impairment

Recurrent Multiple Myeloma (1)

NCTAcronymPhaseStatusTitle
NCT05981209P1active not recruitingElotuzumab, CC-92480, and Dexamethasone for the Treatment of Relapsed or Refractory Myeloma After CD38- and BCMA-Targeted Therapies

Relapsed and Refractory Multiple Myeloma (1)

NCTAcronymPhaseStatusTitle
NCT06050512P1/P2withdrawnMezigdomide Plus Ixazomib and Dexamethasone for Relapsed and Refractory Multiple Myeloma

Hepatic Impairment (1)

NCTAcronymPhaseStatusTitle
NCT05707390P1completedA Study of Mezigdomide in Healthy Participants and Participants With Hepatic Impairment

Other (1)

NCTAcronymPhaseStatusTitle
NCT06994117N/AavailableExpanded Access for Mezigdomide

Mezigdomide pivotal trial highlights (Phase 2/3/4)

Phase-2/3/4 studies with named acronyms — the registration-grade trials most cited in label discussions and Wikipedia.

AcronymNCTPhaseStatusIndicationEnrollmentPubMed
SUCCESSOR-1NCT05519085P3recruitingRelapsed or Refractory Multiple Myeloma810
SUCCESSOR-2NCT05552976P3active not recruitingRelapsed or Refractory Multiple Myeloma606

Terminated and withdrawn Mezigdomide trials (2)

Studies that ended before completion. Reasons are filed in each trial's ClinicalTrials.gov entry.

All Mezigdomide trials (19)

Sorted by most recent activity (completion → start → posted date). Each row links to the trial detail page on Hipa.ai.

NCT IDAcronymTitlePhaseStatusEnrollmentSponsorStarted
NCT05519085SUCCESSOR-1A Study to Evaluate Mezigdomide, Bortezomib and Dexamethasone (MEZIVd) Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)P3recruiting810CelgeneSep 2022
NCT06627751Mezigdomide, Carfilzomib, and Dexamethasone for the Treatment of Relapsed or Refractory Multiple Myeloma in Patients With Extramedullary DiseaseP2recruiting28Roswell Park Cancer InstituteMay 2025
NCT05552976SUCCESSOR-2A Study to Evaluate Mezigdomide in Combination With Carfilzomib and Dexamethasone (MeziKD) Versus Carfilzomib and Dexamethasone (Kd) in Participants With Relapsed or Refractory Multiple Myeloma (SUCCESSOR-2)P3active not recruiting606Bristol-Myers SquibbJan 2023
NCT07356154A Study of Revumenib and Mezigdomide in People With LeukemiaP1/P2recruiting52Memorial Sloan Kettering Cancer CenterJan 2026
NCT07105059A Study of Teclistamab and Mezigdomide in People With Multiple MyelomaP1recruiting18Memorial Sloan Kettering Cancer CenterAug 2025
NCT06121843BMS-986393A Study to Evaluate the Safety, Effectiveness and Tolerable Dose of Arlocabtagene Autoleucel (BMS-986393) in Novel Combinations in Participants With Relapsed and/or Refractory Multiple MyelomaP1recruiting147Juno Therapeutics, Inc., a Bristol-Myers Squibb CompanyFeb 2024
NCT07032714MAGENTAMezigdomide and Talquetamab in Relapsed and Refractory Multiple MyelomaP1recruiting25Massachusetts General HospitalDec 2025
NCT05651932A Study of an MMSET Inhibitor in Patients With Relapsed and Refractory Multiple MyelomaP1recruiting165K36 Therapeutics, Inc.Feb 2023
NCT07355335Ziftomenib + Mezigdomide in Adolesc. and Adults w/ R/R AMLP1not yet recruiting24Massachusetts General HospitalJul 2026
NCT06645678MELT-MMMezigdomide and Elranatamab for Relapsed and/or Refractory Multiple MyelomaP1/P2recruiting75YOUNGIL KOHNov 2024
NCT06988488A Study to Determine the Recommended Dose and Schedule, and Evaluate the Safety and Preliminary Efficacy of Mezigdomide in Combination With Elranatamab in Participants With Relapsed and/or Refractory Multiple MyelomaP1/P2recruiting62CelgeneOct 2025
NCT02343042STOMPSelinexor and Backbone Treatments of Multiple Myeloma PatientsP1/P2active not recruiting300Karyopharm Therapeutics IncOct 2015
NCT05981209Elotuzumab, CC-92480, and Dexamethasone for the Treatment of Relapsed or Refractory Myeloma After CD38- and BCMA-Targeted TherapiesP1active not recruiting12Abdullah KhanDec 2023
NCT06050512Mezigdomide Plus Ixazomib and Dexamethasone for Relapsed and Refractory Multiple MyelomaP1/P2withdrawn0Kathleen DorritieOct 2023
NCT06048250CC-92480Mezigdomide (CC-92480) Post Idecabtagene Vicleucel in Treating Patients With Relapsed Multiple MyelomaP1recruiting15City of Hope Medical CenterApr 2024
NCT06163898A Study to Evaluate Alnuctamab in Combination With Mezigdomide in Participants With Relapsed and/or Refractory Multiple MyelomaP1terminated4CelgeneFeb 2024
NCT06994117Expanded Access for Mezigdomideavailable0Bristol-Myers Squibb
NCT06318676A Study to Evaluate the Drug Levels of Mezigdomide in Adult Participants With Renal ImpairmentP1completed26CelgeneMar 2024
NCT05707390A Study of Mezigdomide in Healthy Participants and Participants With Hepatic ImpairmentP1completed32Bristol-Myers SquibbFeb 2023

Mezigdomide clinical trials: frequently asked questions

How many Mezigdomide clinical trials are there?
19 Mezigdomide clinical trials are catalogued on Hipa.ai, sourced from the AACT mirror of ClinicalTrials.gov. 10 are actively recruiting participants. 2 are marked completed.
Are Mezigdomide clinical trials recruiting in 2026?
Yes — 10 Mezigdomide trials are actively recruiting in 2026, with 49 U.S. sites across 15 states. See the recruiting trials and the per-state site list further down this page.
What conditions is Mezigdomide being studied for?
Mezigdomide is being studied for Multiple Myeloma, Recurrent Multiple Myeloma, Relapsed or Refractory Multiple Myeloma, Relapsed Refractory Multiple Myeloma (RRMM), Refractory Multiple Myeloma and 16 more. The trials are grouped by indication on this page.
What phase is Mezigdomide in?
Mezigdomide clinical trials span 2 Phase 3, 1 Phase 2, 10 Phase 1. The phase × status matrix at the top of this page breaks down counts by phase and recruitment status.
Who sponsors Mezigdomide clinical trials?
The lead sponsor across the most Mezigdomide trials is Celgene, with 11 additional lead sponsors listed in the data. Each trial row links to the full study detail page including sponsor information.

Sources and methodology

Trial inventory derived from the AACT mirror of ClinicalTrials.gov. Trials are filtered to those naming Mezigdomideas an intervention. Phase, status, enrollment, sponsor, and dates are taken from the source `studies` table; primary indication is the first listed condition. Acronyms are extracted from each trial's brief title where present. PubMed links are populated for trials whose published primary outcomes have been indexed in our evidence cache.

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